Protein Alignment wwk and ano5

DIOPT Version :10

• Sequence 1: NP_609738.1
• Gene: wwk / 34886
• FlyBaseID: FBgn0028879
• Length: 1338
• Species: Drosophila melanogaster
• Sequence 2: XP_031756250.1
• Gene: ano5 / 100489787
• XenbaseID: XB-GENE-5952827
• Length: 928
• Species: Xenopus tropicalis
• Alignment Length: 920
• Identity: 207/920 - (22%)
• Similarity: 342/920 - (37%)
• Gaps: 274/920 - (29%)

  Fly    43 PRDGGED---DFTDDNNFESNLRRRKGKIISCAKETIENASRQLRRKVPYAGHLMTPRRLWLNKI 104
            |...|||   ...|:|:...:......:.:|..:.|...::.|...|     |..:...::....
 Frog    30 PDSAGEDINGSLLDNNSITDSELPGNSEGLSSTESTFLISNHQRIDK-----HAQSKDSVFFWDG 89

  Fly   105 PTQCDVVIEFPEDAPDEALRWLLARIRSQ---PPAGLGLLVQVKAHESTRRNAFYVS--APVNVL 164
            ..:.|.|:.:.||...:|.:....|...:   ..:||.|..:.| .||.....::|.  ||..||
 Frog    90 SRRIDFVLSYTEDTGKDAEKKAERRREFELNLQKSGLELETEDK-KESENGKTYFVKIHAPWEVL 153

  Fly   165 FKAAEEARLPKRLRPD---------LGGALREFTTRESHCF--------------QQLRGDVGST 206
            ...||...|...|:.|         |...|:.|...:...:              |:|.......
 Frog   154 TTYAEVLNLKMPLKADDLKDDSENILSHVLKLFKLPQEVMYPEPDYFTAPFRKDKQELFRTEERE 218

  Fly   207 ALFTSQERQWLVLQVLQGLRAGCSDIEALHGRAAVAEGQSIVATWQESGLITQVFPLHEPSSLTQ 271
            ..||...|..:|..:|.....|..:.:...|          :.....:|.....:|||:.....:
 Frog   219 KFFTPSTRNRIVYYILSRCHYGEEEGKKKFG----------IKRLLTNGSYLDAYPLHDCQYWKK 273

  Fly   272 ----------LQTHWVK--QIFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGVPAVFG--TILY 322
                      |.|||.|  :.:..||||.|..|:|.|:.:||||||.||..|...||.|  ..||
 Frog   274 TDERNCERYTLYTHWAKFTRFYKEQPLDLIRKYYGEKIGIYFAWLGFYTEMLFYAAVVGFFCFLY 338

  Fly   323 --------------------------------CILWGKGQTAQ---------DMGHVLFSLFNVA 346
                                            |..|....|.:         ::..:.|::|...
 Frog   339 GWITMDDSISSKEICDPNIGGQIIMCPLCDKRCEFWRLNSTCEPSQYSHMFDNVATLFFAIFMGI 403

  Fly   347 WASLYLEAWKRYSVELAFRWGTLSTPPELLEPPRPLYKGPLEENNVTGRLEPKEAPAWQ------ 405
            |.:|:||.|||....|.:.|..:    :..|..:.|...|..|:..|   |.|:.|..|
 Frog   404 WVTLFLEFWKRRQARLEYEWDLV----DFEEEQQQLQLRPEYESKCT---EKKKNPVTQENELVI 461

  Fly   406 -RRAFRYLVSFPIIGCCLCVVF------AVMFLMLRFQDW--------WDSKL---PEESVL--- 449
             :.|..:|..  :..|.:.|:|      |.:..::.::.|        .|:.|   |..::|
 Frog   462 KQTACNFLAK--MFWCWMSVLFWIALIIASIIAIIVYRLWVYAAFASIMDNNLALKPVSNLLTPQ 524

  Fly   450 CCLSVIPKVLLAGAITLMDEAYFKLAVWLNDRENYRLQSKYENHLIAKVALFQFVNSFLSLFYIA 514
            ...||...||....|.:::..|.::|:|:.|.|..|...:|||.|..|:.||||||.:.|.||:|
 Frog   525 LATSVTASVLNFVTIMILNFLYERVAIWITDMEIPRTHLEYENRLTMKMFLFQFVNYYSSCFYVA 589

  Fly   515 F-------------YL----RDEE--------KLKEQLAGLLISRQIIGNLRESAIPYFLEQWKL 554
            |             ||    |:||        :|..||..::..:||.||::|:.:|:
 Frog   590 FFKGKFVGYPADYSYLFGKWRNEECDPAGCLIELTTQLTIVMAGKQIWGNIQEAFVPW------- 647

  Fly   555 AKLSFNMWGALSPTQNVTRSLAEELATAEAELKAESTGTPTKSQQPESSSKRNIGQAEIESSLYK 619
                  .|..|                              |.::..:..:....:.|.:..|..
 Frog   648 ------TWNWL------------------------------KRRKARNHPQNLYSRWEHDGDLQT 676

  Fly   620 YD--GTFSDHLEMLVQMGYVVLFSAAFPLAGVCALINNLMEIRSDAFKLAHVHQRPFGQRVANIG 682
            :.  |.|:::|||:||.|::.||.|:||||.:.||:||::|||.|::||....:||...:..:||
 Frog   677 FGGLGLFNEYLEMVVQFGFITLFVASFPLAPLLALLNNILEIRVDSWKLTTQFKRPVAAKAHSIG 741

  Fly   683 TWQNALSILSLAAVIVNCALIG----------------------LSGQVS--------------- 710
            .||..|:.:::.:|:.|..::.                      :||.:.
 Frog   742 VWQEILNGIAILSVVTNAFIVAFTSDMIPRLVYYYAYSQDEGTPMSGYIGSSLSVFNVSDFKEQS 806

  Fly   711 -----------------RLWPG------LT------TAQTIILIVTLEHIMLGLRQALTWLLPEL 746
                             |..||      :|      .|..:..|:.:||::..::..:.||:|::
 Frog   807 MPMENDMNVISCRYRDYRYPPGHEKEYQVTMQYWHILAAKMAFIIIMEHVVFLVKFFVAWLIPDV 871

  Fly   747 PSWLAAEIAR 756
            ||.:.|.:.|
 Frog   872 PSEVKARVKR 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wwk	NP_609738.1	Anoctamin	289..756	CDD:461349	148/629 (24%)
ano5	XP_031756250.1	Anoct_dimer	85..300	CDD:465044	44/225 (20%)
		Anoctamin	303..882	CDD:461349	149/631 (24%)