DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vig and serbp1b

DIOPT Version :9

Sequence 1:	NP_523572.1	Gene:	vig / 34885	FlyBaseID:	FBgn0024183	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_005171185.1	Gene:	serbp1b / 797732	ZFINID:	ZDB-GENE-031118-196	Length:	410	Species:	Danio rerio

Alignment Length:	521	Identity:	154/521 - (29%)
Similarity:	206/521 - (39%)	Gaps:	162/521 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NRYELLFMDDDVSDPLDNLVAPTAAAAAAAAGKKKQPSAAAAAATKTTANKVANSNNKANAGSNI 71
            ||::.|.  ||.|||.:.|        .||..|||  .|||:..:||.|..
Zfish    15 NRFDQLL--DDESDPFEIL--------KAAENKKK--DAAASGGSKTAAQA-------------- 53

  Fly    72 GGPNAKKPNQAEKENKPNNALNKTDGKKFTPSADNKQQQFNNNASSNYKQQG-APRQGGGANRTR 135
                ||:|.:..::::.|.|.:|.:  ...|....|::..........:||| |..|..|
Zfish    54 ----AKQPKKESQKDRKNTAQDKKE--DIQPPVPLKKEGMRRVGRKPEQQQGPASSQHPG----- 107

  Fly   136 EFGSGQGQGQGQGGQQQRSVNFRQQNGNAETREQRNNRRNVREN------VGAPDGQQ------- 187
                  |.|:|:.|                  ::|.:||..||.      ...|:|..
Zfish   108 ------GPGEGRPG------------------DRRPDRRPPRERRFDKPADEKPEGGDFSADKPI 148

  Fly   188 -SRPYRGPGGGPGAG-GDRPQRQNRNYDG--QNRKREFDRQSGSDRTGVKSIDKRDGAGSHNWGS 248
             .:|.||.|||.|.| |.|.:...|. ||  ...||:|||.||:|:...|..:||.|:||||||.
Zfish   149 GDKPSRGRGGGRGMGRGGRGRGMGRG-DGFDSRGKRDFDRHSGNDKARQKGEEKRSGSGSHNWGG 212

  Fly   249 VKEAIDDVNKNESETNVTNAEGGAKADESGTEPQNEQATAEEEAKELTLDEWKAQQG-QRIKPTF 312
            |||...:::::.:...|...|..|.||....|.:.|: ..:|..||:|||||||.|. :|.|..|
Zfish   213 VKEETSELDQSAAPEPVPEGEEHAPADSENKENEVEE-VKDEGPKEMTLDEWKAMQDKERAKVEF 276

  Fly   313 NIRKAGEGEDTTQWKKMVVLTSNKKKENDSEEEL---------EYDPALYPQ---------RVGR 359
            ||||..||.| .||||..||..:|.:|..:..|.         :.||..:.:         |...
Zfish   277 NIRKPNEGND-GQWKKGYVLHKSKSEEVGTVGERHAGSVIEAGDVDPDSFHKAEEGGDHHFRKPA 340

  Fly   360 QQRVLDIQFNFNDGRRGGPGGFGGRGGRGGPRPGGFGGGPRSEGGNRDGGNREGGRDNREGGNRG 424
            ......::.||.|..|.|.|..|.|||||| |.||.|.|              |||.:|.||
Zfish   341 NDITSQLEINFGDLGRPGRGRGGSRGGRGG-RGGGGGSG--------------GGRPSRGGG--- 387

  Fly   425 PRDGQQHNNEGGGSSAQNQRPPIDRRGPGNNQNNNQNSGPGPNKRFERQQNTAPKVNDERQFPTL 489
                  .:.:|||.|                                     .|.|:|...||.|
Zfish   388 ------RSEKGGGVS-------------------------------------VPNVDDPEAFPAL 409

  Fly   490 A 490
            |
Zfish   410 A 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vig	NP_523572.1	HABP4_PAI-RBP1	217..319	CDD:282609	46/102 (45%)
serbp1b	XP_005171185.1	IHABP4_N	5..97	CDD:292792	28/113 (25%)
serbp1b	XP_005171185.1	HABP4_PAI-RBP1	181..283	CDD:282609	46/102 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580738
Domainoid	1	1.000	97	1.000	Domainoid score	I7158
eggNOG	1	0.900	-	-		E1_KOG2945
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	156	1.000	Inparanoid score	I4255
OMA	1	1.010	-	-		QHG48663
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002116
OrthoInspector	1	1.000	-	-		mtm6592
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12299
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5307
SonicParanoid	1	1.000	-	-		X1570
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.980