DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vig and Habp4

DIOPT Version :9

Sequence 1:	NP_523572.1	Gene:	vig / 34885	FlyBaseID:	FBgn0024183	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_064370.2	Gene:	Habp4 / 56541	MGIID:	1891713	Length:	412	Species:	Mus musculus

Alignment Length:	423	Identity:	118/423 - (27%)
Similarity:	176/423 - (41%)	Gaps:	73/423 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NRYELLFMDDDVSDPLDNL--------------VAPTAAAAAAAAGKK--KQPSAAAAAATKTTA 55
            ||:..|.  ||.|||.|.|              ....|||||:.||.:  :.|:.|:........
Mouse    26 NRFHQLL--DDESDPFDILREAEHRRQQQLQRKRRDEAAAAASGAGHRGGRSPAVASGHRPGAGG 88

  Fly    56 NKVANSNNKANAGSNIGGPNAKKPNQAEKENKPNNALNKTDGKKFTPSADNKQQQFNNNASSNYK 120
            .:.:....|:.|.|     .|::|:.......|        |:|.||.. .:||.:|:|..::..
Mouse    89 RRESQKERKSLAAS-----GAQQPDSPGGPQPP--------GQKRTPRR-GEQQGWNDNRGTDVV 139

  Fly   121 QQGAPRQGGGANRTREFGSGQGQGQGQGGQQQRSVNFRQQNGNAETREQRNNR-RNVRENVGAPD 184
            .:.|.|:.     .||:         :..:.:|..:...:....|....|.:| |.:|...|...
Mouse   140 LERAERRS-----YREY---------RPYETERQADLPVEKFTDEKPVDRFDRDRPLRGRGGPRG 190

  Fly   185 GQQSRPYRGPGGGPGAGGDRPQRQNRNYDG--QNRKREFDRQSGSDRTGVKSIDKRDGAGSHNWG 247
            |.:||...|||             ||.:|.  |..||:|:|.|.:|:|. :..|...|.|...||
Mouse   191 GLRSRGRGGPG-------------NRAFDSFDQRGKRDFERYSSNDKTN-RMEDSMGGCGIRPWG 241

  Fly   248 SVKEAID-DVNKNESETNVTNAEGGAKADESGTEPQNEQATAEEEAKELTLDEWKAQQGQ-RIKP 310
            |.|:..| :......||::.....||..:||..:....:...|.:.:|:||||||..|.| |.||
Mouse   242 SGKDTSDTEPPAPMEETSMMEECQGALDEESAAKVPELEVEEENQVQEMTLDEWKNLQEQTRPKP 306

  Fly   311 TFNIRKAGEGEDTTQWKKMVVLTSNKKKENDSEEELEYDPALYPQRVGRQQRVLDIQFNFNDGRR 375
            .|||||.   |.|...|.:|:   :|.:..|...:.:|:...:..|.........::.||.:..|
Mouse   307 EFNIRKP---ESTVPSKAVVI---HKSRYRDDMVKEDYEDESHVFRKAANDITSQLEINFGNLPR 365

  Fly   376 GGPGGFGG-RGGRGGPRPGGFGGGPRSEGGNRD 407
            .|.|..|. |||||..|... ..|||:|...:|
Mouse   366 PGRGARGSTRGGRGRMRRTE-NYGPRAEVVTQD 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vig	NP_523572.1	HABP4_PAI-RBP1	217..319	CDD:282609	39/103 (38%)
Habp4	NP_064370.2	IHABP4_N	16..131	CDD:292792	31/120 (26%)
		HABP4_PAI-RBP1	212..315	CDD:282609	39/106 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..319		12/24 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	359..412		17/40 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837162
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2945
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4516
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48663
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002116
OrthoInspector	1	1.000	-	-		mtm8776
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12299
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1570
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.860