DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vig and serbp1a

DIOPT Version :9

Sequence 1:	NP_523572.1	Gene:	vig / 34885	FlyBaseID:	FBgn0024183	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_009300781.1	Gene:	serbp1a / 335449	ZFINID:	ZDB-GENE-030131-7389	Length:	392	Species:	Danio rerio

Alignment Length:	505	Identity:	157/505 - (31%)
Similarity:	204/505 - (40%)	Gaps:	148/505 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NRYELLFMDDDVSDPLDNLVAPTAAAAAAAAGKKKQPSAAAAAATKTTANKVANSNNKANAGSNI 71
            ||::.||  ||..||.:.|        ..|..|||..:...||.|...|.|
Zfish    15 NRFDQLF--DDEEDPFEVL--------KQAEKKKKDATVPGAAKTAAQAAK-------------- 55

  Fly    72 GGPNAKKPNQAEKENKPNNALNKTDGKKFTPSADNKQQQFNNNASSNYKQQGAPRQGGGANRTRE 136
               ..||.:|.|:.|               |..|.|::   ..|....|:.|..:.|   .|..:
Zfish    56 ---QPKKESQKERRN---------------PLPDKKEE---TQAPVPLKKDGMRKMG---RRPEQ 96

  Fly   137 FGSGQGQGQGQGGQQQRSVNFRQQNGNAETR---EQRNNRRNVRE--------NVGAPDGQQS-- 188
                |||...|..|||:.|. :||.|..|.|   ::|.:||..||        ...|..|:.|
Zfish    97 ----QGQQGSQQQQQQQQVP-QQQAGQGEGRPPADRRPDRRPPRERRFDKPADEKPAEGGEFSVE 156

  Fly   189 -----RPYRGPGGGPGAGGDRPQRQNRNYDG--QNRKREFDRQSGSDRTGVKSIDKRDGAGSHNW 246
                 ||:||.||..|..|.|.:...|. ||  ...||||||.|||||:.:|:.:||.|:|||||
Zfish   157 KTMGDRPFRGRGGPRGGRGGRGRGVGRT-DGFDSRGKREFDRHSGSDRSSLKAEEKRGGSGSHNW 220

  Fly   247 GSVKEAIDDVNKNESETNVTNAEGGAKADESGTEPQNEQATAEEEAKELTLDEWKAQQG-QRIKP 310
            |:||:.:.:::::....:....|....||....|.:.|:| .||..||::||||||||. :|.|.
Zfish   221 GTVKDELSELDQSNVTEDTPEGEEHPPADSENKENEVEEA-KEEGPKEMSLDEWKAQQDKERAKV 284

  Fly   311 TFNIRKAGEGEDTTQWKKMVVLTSNKKKENDSEEELEYDPALYPQRVGRQQRVLDIQFNFNDGRR 375
            .||||||.||.|   |||..||..:|      .|:...|.|.......:....:..|...|.|..
Zfish   285 EFNIRKANEGAD---WKKGYVLHKSK------AEDASADDAAGDHHFRKPANDITSQLEINFGDL 340

  Fly   376 GGPGGFGGRGGRGGPRPGGFGGGPRSEGGNRDGGNREGGRDNREGGNRGPRDGQQHNNEGGGSSA 440
            |.||     .||||||                     |||                   ||..:|
Zfish   341 GRPG-----RGRGGPR---------------------GGR-------------------GGRGAA 360

  Fly   441 QNQRPPIDRRGPGNNQNNNQNSGPGPNKRFERQQNTAPKVNDERQFPTLA 490
            ...|||.:||               |:|   ....:.|.|:|...||.||
Zfish   361 AATRPPRERR---------------PDK---VGGVSVPNVDDPEAFPALA 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vig	NP_523572.1	HABP4_PAI-RBP1	217..319	CDD:282609	49/102 (48%)
serbp1a	XP_009300781.1	IHABP4_N	5..95	CDD:292792	31/127 (24%)
serbp1a	XP_009300781.1	HABP4_PAI-RBP1	191..293	CDD:282609	49/102 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580737
Domainoid	1	1.000	97	1.000	Domainoid score	I7158
eggNOG	1	0.900	-	-		E1_KOG2945
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	156	1.000	Inparanoid score	I4255
OMA	1	1.010	-	-		QHG48663
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002116
OrthoInspector	1	1.000	-	-		mtm6592
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12299
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5307
SonicParanoid	1	1.000	-	-		X1570
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.980