DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfIIS and SPOCD1

DIOPT Version :9

Sequence 1:	NP_001260457.1	Gene:	TfIIS / 34883	FlyBaseID:	FBgn0010422	Length:	313	Species:	Drosophila melanogaster
Sequence 2:	NP_653170.3	Gene:	SPOCD1 / 90853	HGNCID:	26338	Length:	1216	Species:	Homo sapiens

Alignment Length:	213	Identity:	50/213 - (23%)
Similarity:	89/213 - (41%)	Gaps:	33/213 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 AKTLIKNWKRFLASPAPTTPNNSSAKEGSSNNSSASKSTSAAKSSSSISGKDKSSSSSSSKDKEK 133
            |:.|.:..:..:..||.......|...|::.:............|.|::..|.||..:.|    :
Human   516 AQRLRRKKRPMVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPRSGSLALGDPSSDPACS----Q 576

  Fly   134 KGSTSSSQTSFPSG----------------GMTDAVRIKCREMLATALKIGEVPEGCGEP----- 177
            .|...:.:.|.|..                |:...|....:|:|.|.|:  |:|    :|
Human   577 SGPMEAEEDSLPEQPEDSAQLQQEKPSLYIGVRGTVVRSMQEVLWTRLR--ELP----DPVLSEE 635

  Fly   178 --EEMAAELEDAIYSEFNNTDMKYKNRIRSRVANLKDPKNPGLRGNFMCGAVTAKQLAKMTPEEM 240
              |.:||.:|.|::.....|:.:||.:.||.:.||:||:|..|....:.|.||...|.:|:..::
Human   636 VVEGIAAGIEAALWDLTQGTNGRYKTKYRSLLFNLRDPRNLDLFLKVVHGDVTPYDLVRMSSMQL 700

  Fly   241 ASDEMKKLREKFVKEAIN 258
            |..|:.:.|::..|..:|
Human   701 APQELARWRDQEEKRGLN 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIS	NP_001260457.1	TFSII	5..313	CDD:273592	50/213 (23%)
		TFS2N	7..82	CDD:197766	2/12 (17%)
		TFIIS_M	151..257	CDD:284835	33/112 (29%)
		Zn-ribbon_TFIIS	266..312	CDD:259796
SPOCD1	NP_653170.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..74
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..216
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..325
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..462
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..601		15/88 (17%)
		TFIIS_M	608..717	CDD:284835	33/114 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	823..850
		SPOC	867..965	CDD:285043
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1140
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1176..1216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910