DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfIIS and BYE1

DIOPT Version :9

Sequence 1:	NP_001260457.1	Gene:	TfIIS / 34883	FlyBaseID:	FBgn0010422	Length:	313	Species:	Drosophila melanogaster
Sequence 2:	NP_012921.3	Gene:	BYE1 / 853865	SGDID:	S000001488	Length:	594	Species:	Saccharomyces cerevisiae

Alignment Length:	238	Identity:	56/238 - (23%)
Similarity:	92/238 - (38%)	Gaps:	58/238 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 FLASPAPTTPNNS--SAK---------EGSSNNSSASKSTSAAKSSSSISGKDKSSSSSSSKD-- 130
            ||...:|.....|  |||         :.|:.:...:||..||||.::.:.........|.|:
Yeast   172 FLDEESPRKRKRSPDSAKGIHIKSKQVKKSNGSKKRNKSIDAAKSDTAENEMPTRKDFESEKEHK 236

  Fly   131 ----KEKKGSTSSSQTSFPSGGMTDAVRIKCREMLATALKIGEVPEG---CGEPEEMAAELEDAI 188
                .||..||..|:...|.               ....|:.|:|:|   ....:|.|..||:.:
Yeast   237 LRYNAEKMFSTLFSKFIVPE---------------TIEAKLYELPDGKDVISISQEFAHNLEEEL 286

  Fly   189 YS-----EFNNTDMKYKNRIRSRVANLKDPKNPGLRGNFMCGAVTAKQLAKMTPEEMASDEMKKL 248
            |.     ||...|..|..::||..:||||.||..|:.:.:.|.:...:|..|...|:|:.::::.
Yeast   287 YKACLNVEFGTLDKIYTEKVRSLYSNLKDKKNLELKAHVVEGKLPLNKLVNMNASELANPDLQEF 351

  Fly   249 REK------------------FVKEAINDAQLATVQGTKTDLL 273
            :||                  :||....|..:..:...:.|:|
Yeast   352 KEKRDKIILENFIVEVPDKPMYVKTHKGDELIEDIAEPQEDIL 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIS	NP_001260457.1	TFSII	5..313	CDD:273592	56/238 (24%)
		TFS2N	7..82	CDD:197766	2/2 (100%)
		TFIIS_M	151..257	CDD:284835	31/131 (24%)
		Zn-ribbon_TFIIS	266..312	CDD:259796	2/8 (25%)
BYE1	NP_012921.3	PHD_Bye1p_SIZ1_like	74..131	CDD:277045
		TFS2M	235..354	CDD:128786	33/133 (25%)
		SPOC	434..589	CDD:400205
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I2908
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001112
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11477
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010