DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfIIS and TCEA1

DIOPT Version :9

Sequence 1:	NP_001260457.1	Gene:	TfIIS / 34883	FlyBaseID:	FBgn0010422	Length:	313	Species:	Drosophila melanogaster
Sequence 2:	NP_006747.1	Gene:	TCEA1 / 6917	HGNCID:	11612	Length:	301	Species:	Homo sapiens

Alignment Length:	317	Identity:	158/317 - (49%)
Similarity:	213/317 - (67%)	Gaps:	22/317 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VEEEVFRIQKKMSKMA--SDGTGQDQALDLLKALQTLNINLDILTKTRIGMTVNELRKSSKDDEV 65
            :|:||.|..|||.||.  .:..|   ||||||.|:.:.:.|::|..|||||:||.:||.|.|:||
Human     1 MEDEVVRFAKKMDKMVQKKNAAG---ALDLLKELKNIPMTLELLQSTRIGMSVNAIRKQSTDEEV 62

  Fly    66 IALAKTLIKNWKRFLASPAPTTPNNSSAKEGSSNNSSASKSTSAAKSSSSISGKDKSSSSSS-SK 129
            .:|||:|||:||:.|..|:            :..:....|...|..|.:|...:::|:||.: |.
Human    63 TSLAKSLIKSWKKLLDGPS------------TEKDLDEKKKEPAITSQNSPEAREESTSSGNVSN 115

  Fly   130 DKEKKGSTSSSQTSFPSGGMT-DAVRIKCREMLATALKIGE--VPEGCGEPEEMAAELEDAIYSE 191
            .|::..:..:..:|||....| |:||:|||||||.||:.|:  :..|..| ||:.:::|:|||.|
Human   116 RKDETNARDTYVSSFPRAPSTSDSVRLKCREMLAAALRTGDDYIAIGADE-EELGSQIEEAIYQE 179

  Fly   192 FNNTDMKYKNRIRSRVANLKDPKNPGLRGNFMCGAVTAKQLAKMTPEEMASDEMKKLREKFVKEA 256
            ..|||||||||:|||::||||.|||.||.|.:||.:.....|:||.|||||||:|::|:...|||
Human   180 IRNTDMKYKNRVRSRISNLKDAKNPNLRKNVLCGNIPPDLFARMTAEEMASDELKEMRKNLTKEA 244

  Fly   257 INDAQLATVQGTKTDLLKCAKCKKRNCTYNQLQTRSADEPMTTFVMCNECGNRWKFC 313
            |.:.|:|...||:|||..|.||||:||||.|:|||||||||||||:|||||||||||
Human   245 IREHQMAKTGGTQTDLFTCGKCKKKNCTYTQVQTRSADEPMTTFVVCNECGNRWKFC 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIS	NP_001260457.1	TFSII	5..313	CDD:273592	155/313 (50%)
		TFS2N	7..82	CDD:197766	39/76 (51%)
		TFIIS_M	151..257	CDD:284835	60/107 (56%)
		Zn-ribbon_TFIIS	266..312	CDD:259796	36/45 (80%)
TCEA1	NP_006747.1	TFSII	4..301	CDD:273592	155/312 (50%)
TCEA1	NP_006747.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..137		13/68 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5307
eggNOG	1	0.900	-	-		E1_COG1594
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	300	1.000	Inparanoid score	I2700
Isobase	1	0.950	-	0	Normalized mean entropy	S1233
OMA	1	1.010	-	-		QHG53988
OrthoDB	1	1.010	-	-		D1579101at2759
OrthoFinder	1	1.000	-	-		FOG0001112
OrthoInspector	1	1.000	-	-		otm41267
orthoMCL	1	0.900	-	-		OOG6_101177
Panther	1	1.100	-	-	LDO	PTHR11477
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2312
SonicParanoid	1	1.000	-	-		X770
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820