DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfIIS and med26

DIOPT Version :9

Sequence 1:	NP_001260457.1	Gene:	TfIIS / 34883	FlyBaseID:	FBgn0010422	Length:	313	Species:	Drosophila melanogaster
Sequence 2:	NP_001016996.1	Gene:	med26 / 549750	XenbaseID:	XB-GENE-1001802	Length:	597	Species:	Xenopus tropicalis

Alignment Length:	259	Identity:	59/259 - (22%)
Similarity:	100/259 - (38%)	Gaps:	59/259 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LDLLKALQTLNINLDILTKTRIGMTVNELRKSSKDDEVIALAKTLIKNWKRFLASPAPTTPNN-- 90
            |:::.:|:...|..:.|.:||:|..:|::||.:.::|:...||.|::||::.:   .|.|.|.
Frog    32 LEVISSLEKYPITKEALEETRLGKLINDVRKKTSNEELAKRAKKLLRNWQKLI---EPVTQNEQL 93

  Fly    91 --------SSAKEGSSNNSSASKSTSAAKSSSSISG-KDKSSSSSSSKDKEKKGSTSSSQTSFPS 146
                    .||..|.|:|..|..:.:.......|.| ||::....:...|..|.:....:.....
Frog    94 VRGISNLPGSANGGGSHNCKAEPTPTTLLGGKPIQGLKDRNDIQRAHSPKADKTTNRKRKGEHRD 158

  Fly   147 GGMTDAVRIKCREMLATALKIGEVPEGCGEPEEMAAELEDAIYSEFNNTDMKYKNRI-RSRVANL 210
            ||::                   .|....:|..   ||       |.|:.....|.| .|...||
Frog   159 GGLS-------------------TPGHVSKPNH---EL-------FQNSSPPPTNGIGGSPPENL 194

  Fly   211 KDPKNPGLRGNFMCGAVTAKQLAKMTPEEMASDEMKKLREKFVKEAINDAQLATVQGTKTDLLK 274
            ..|.:.||:.|            ::.|.|  :|:..|:....|:...|...|.....| :.|||
Frog   195 PSPLDGGLQSN------------RLEPAE--NDKHGKIPVNAVRPHTNSPGLVKHPST-SSLLK 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIS	NP_001260457.1	TFSII	5..313	CDD:273592	59/259 (23%)
		TFS2N	7..82	CDD:197766	16/53 (30%)
		TFIIS_M	151..257	CDD:284835	20/106 (19%)
		Zn-ribbon_TFIIS	266..312	CDD:259796	4/9 (44%)
med26	NP_001016996.1	TFIIS_I	14..85	CDD:238107	16/55 (29%)
		Med26_M	178..414	CDD:374027	20/81 (25%)
		Med26_C	419..595	CDD:374026
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910