DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfIIS and LOC498453

DIOPT Version :9

Sequence 1:	NP_001260457.1	Gene:	TfIIS / 34883	FlyBaseID:	FBgn0010422	Length:	313	Species:	Drosophila melanogaster
Sequence 2:	XP_006251782.1	Gene:	LOC498453 / 498453	RGDID:	1591965	Length:	301	Species:	Rattus norvegicus

Alignment Length:	317	Identity:	163/317 - (51%)
Similarity:	215/317 - (67%)	Gaps:	22/317 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VEEEVFRIQKKMSKMA--SDGTGQDQALDLLKALQTLNINLDILTKTRIGMTVNELRKSSKDDEV 65
            :|:||.||.|||.||.  .:..|   ||||||.|:.:.:.|::|..|||||:||.:||.|.|:||
  Rat     1 MEDEVVRIAKKMDKMVQKKNAAG---ALDLLKELKNIPMTLELLQSTRIGMSVNAIRKQSTDEEV 62

  Fly    66 IALAKTLIKNWKRFLASPAPTTPNNSSAKEGSSNNSSASKSTSAAKSSSSISGKDKSSSSSS-SK 129
            .:|||:|||:||:.|..|:            :..:|...|...|..|.:|...:::|||||. |.
  Rat    63 TSLAKSLIKSWKKLLDGPS------------TDKDSEEKKKEPAISSQNSPEAREESSSSSHVSS 115

  Fly   130 DKEKKGSTSSSQTSFPSGGMT-DAVRIKCREMLATALKIGE--VPEGCGEPEEMAAELEDAIYSE 191
            .|::..:..:..:|||....| |:||:|||||||.||:.|:  |..|..| ||:.:::|:|||.|
  Rat   116 RKDETNARDTYVSSFPRAPSTSDSVRLKCREMLAAALRTGDDYVAIGADE-EELGSQIEEAIYQE 179

  Fly   192 FNNTDMKYKNRIRSRVANLKDPKNPGLRGNFMCGAVTAKQLAKMTPEEMASDEMKKLREKFVKEA 256
            ..|||||||||:|||::||||.|||.||.|.:||.:.....|:||.|||||||:|::|:...|||
  Rat   180 IRNTDMKYKNRVRSRISNLKDAKNPNLRKNVLCGNIPPDLFARMTAEEMASDELKEMRKNLTKEA 244

  Fly   257 INDAQLATVQGTKTDLLKCAKCKKRNCTYNQLQTRSADEPMTTFVMCNECGNRWKFC 313
            |.:.|:|...||:|||..|.||||:||||.|:|||||||||||||:|||||||||||
  Rat   245 IREHQMAKTGGTQTDLFTCGKCKKKNCTYTQVQTRSADEPMTTFVVCNECGNRWKFC 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIS	NP_001260457.1	TFSII	5..313	CDD:273592	160/313 (51%)
		TFS2N	7..82	CDD:197766	40/76 (53%)
		TFIIS_M	151..257	CDD:284835	61/107 (57%)
		Zn-ribbon_TFIIS	266..312	CDD:259796	36/45 (80%)
LOC498453	XP_006251782.1	TFSII	4..301	CDD:273592	160/312 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5176
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	306	1.000	Inparanoid score	I2550
OMA	1	1.010	-	-		QHG53988
OrthoDB	1	1.010	-	-		D1579101at2759
OrthoFinder	1	1.000	-	-		FOG0001112
OrthoInspector	1	1.000	-	-		otm45396
orthoMCL	1	0.900	-	-		OOG6_101177
Panther	1	1.100	-	-	LDO	PTHR11477
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X770
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980