DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfIIS and Med26

DIOPT Version :9

Sequence 1:	NP_001260457.1	Gene:	TfIIS / 34883	FlyBaseID:	FBgn0010422	Length:	313	Species:	Drosophila melanogaster
Sequence 2:	XP_038950406.1	Gene:	Med26 / 306328	RGDID:	1309524	Length:	609	Species:	Rattus norvegicus

Alignment Length:	228	Identity:	50/228 - (21%)
Similarity:	94/228 - (41%)	Gaps:	61/228 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LDLLKALQTLNINLDILTKTRIGMTVNELRKSSKDDEVIALAKTLIKNWKRFLASPAPTTPNNSS 92
            |:::.:|:...|..:.|.:||:|..:|::||.:|::|:...||.|:::|::.:   .|...|..:
  Rat    53 LEVISSLERYPITKEALEETRLGKLINDVRKKTKNEELAKRAKRLLRSWQKLI---EPVHQNEVA 114

  Fly    93 AK-----EGSSNN-----------SSASKSTSAAKSSSSIS----------------GKDKSSSS 125
            .:     .||:|.           :.|.||....|:.:.|.                |..:....
  Rat   115 LRALAGAAGSANGGAHNCRPELGVAGAPKSIHDLKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGH 179

  Fly   126 SSSKDKEKKGSTS---SSQTSFPSGGMTDAVRIKCREMLATALKIGEVPEGCGE--PEEMAAELE 185
            .....|..|||..   .:.:..|:.|::.:     .|.|.:.|      :|.|.  |:....||.
  Rat   180 PGPPHKVSKGSPDPLVPNASPLPTNGISGS-----PESLPSPL------DGSGHLGPDGSRLELS 233

  Fly   186 DAIYSEFNNTDMKYKNRIRSRVANLKDPKNPGL 218
            :   :|.::|.:.. |.:|.|      |.:|||
  Rat   234 E---NEKHSTKIPV-NAVRPR------PSSPGL 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIS	NP_001260457.1	TFSII	5..313	CDD:273592	50/228 (22%)
		TFS2N	7..82	CDD:197766	16/53 (30%)
		TFIIS_M	151..257	CDD:284835	17/70 (24%)
		Zn-ribbon_TFIIS	266..312	CDD:259796
Med26	XP_038950406.1	TFS2N	47..107	CDD:197766	16/56 (29%)
		Med26_M	199..426	CDD:406186	19/79 (24%)
		Med26_C	428..607	CDD:406185
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900