Protein Alignment ck and MYO1

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_011888.1
• Gene: MYO1 / 856418
• SGDID: S000001065
• Length: 1928
• Species: Saccharomyces cerevisiae
• Alignment Length: 2178
• Identity: 556/2178 - (25%)
• Similarity: 890/2178 - (40%)
• Gaps: 572/2178 - (26%)

  Fly    16 SGREFDVAIGARVVSAE-GRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVEDMISLGDLHEAGI 79
            :|:|..:.|...:.|.| ...:|||..|           :..::.|:...||:|..|..|:|..:
Yeast    38 TGQEEQIGIVHPLDSTEVSNLVQVRISD-----------VFPVNPSTFDKVENMSELTHLNEPSV 91

  Fly    80 LRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLY--KERKIG----------ELPPHI 132
            |.||..||..:|||||:|..|||:|||..|.:|:.|.|.||  |..::.          :|||||
Yeast    92 LYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHNKHNRLSKSRLDENSHEKLPPHI 156

  Fly   133 FAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAI-SGKHSWI------------E 184
            |||.:.||.::....:||.|:::|||||||||:||.||||||:| ||..|.|            |
Yeast   157 FAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASITSGSPSNIAPVSGSSIVESFE 221

  Fly   185 QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERN 249
            .:||::|||||:||||:|:||:|||||||:|.|.|:.:|:|.||.||.|||||||||.||..|||
Yeast   222 MKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIEWYLLEKSRIVHQNSKERN 286

  Fly   250 YHVFYCILAGLSADEKSRLDLGM--AADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQE 312
            ||:||.:|:||...|...|.|..  ..|||.|:..|.....|.:|...|.::.||:.::.||..:
Yeast   287 YHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNSNQDIIPGINDVENFKELLSALNIIGFSKDQ 351

  Fly   313 IWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHG 377
            |..|.:::|.:|..|||::   |.|..:......  :|..:...||:..:....|:.|....|..
Yeast   352 IRWIFQVVAIILLIGNIEF---VSDRAEQASFKN--DVSAICSNLGVDEKDFQTAILRPRSKAGK 411

  Fly   378 ETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNS 442
            |.|..:.:..|:..:.:|..:.:|.|:|.:||..||..:.....| .|.||:|||.|||.|:.||
Yeast   412 EWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMINKNLDHGSAT-LNYIGLLDIAGFEIFENNS 475

  Fly   443 FEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIK--QLNIMALI 504
            |||.||||.||.|||||..|:|.|||.||..|.|.|.:|:: .|.|..:|||..|  ...::.|:
Yeast   476 FEQLCINYTNEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQLTIDLIESKGPPTGVLPLL 540

  Fly   505 DEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSP 569
            ||||..||.||::..:||..|...:.:..| :|.:...|.|.|:||.|.|...|:|.||:|..:.
Yeast   541 DEEAVLPKSTDESFYSKLISTWDQNSSKFK-RSRLKNGFILKHYAGDVEYTVEGWLSKNKDPLND 604

  Fly   570 DLLHLVSQSTNKFLRQIFAQDIEMGA-----------ETRK--RTPTL---STQFRKSLDALMKT 618
            :||.|:|.|.|..:.::|..:.|..:           |.:|  ||.|.   |::.|:....|:..
Yeast   605 NLLSLLSSSQNDIISKLFQPEGEKSSSAGVEANISNQEVKKSARTSTFKTTSSRHREQQITLLNQ 669

  Fly   619 LSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLI 683
            |:|..|.|:|||.||.:||...|:|.|...|||.:|::|.||:.|.|||.|..|:||.:|||.|.
Yeast   670 LASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLEGIRLAREGYPNRIAFQEFFQRYRILY 734

  Fly   684 P--GVPPAHRTDCQAATSRIC-----AVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKIL 741
            |  .......:..:|:|.:.|     ::.|....|::|:||:|.|......||:::|..|...::
Yeast   735 PENSTTTTFSSKLKASTKQNCEFLLTSLQLDTKVYKIGNTKLFFKAGVLADLEKQKDVKLNNIMI 799

  Fly   742 ILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLR 806
            .|..:|||:..|:.        ||                     ..||.|.::||:.:.||
Yeast   800 KLTATIRGYTVRKE--------IT---------------------YHLQKLKKTRVIGNTFR--- 832

  Fly   807 GHIVGLQAHARGYLVRREYGHKMW--AVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEE 869
                         |..|......|  ..|:|:..:.....|.|.:|       |.|.:...|.:.
Yeast   833 -------------LYNRLVKEDPWFNLFIRIKPLLTSSNDMTRTKK-------FNEQINKLKNDL 877

  Fly   870 QELLHRGNKHAREIAEQHYRDRLHELERRE--IQEQLENRRRVEVNMNIINDAARKQEEPVDDGK 932
            ||:     :..::..|:..:..::|||..:  :.::.||.|:.|..:|.:..::...::..||
Yeast   878 QEM-----ESKKKFLEEKNQKTVNELENTQDLLNQEKENLRKNESLLNRVKTSSETLQKQFDD-- 935

  Fly   933 LVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAA 997
            ||         |..|..:    ||     .|..|||:                   |...||...
Yeast   936 LV---------SEKDEIS----RE-----KLEVAQNL-------------------EEAHQKIQG 963

  Fly   998 TYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSK 1062
              .|..:..:.|      .|..||::.::|..|     |.....|:.:       ...:.|::.:
Yeast   964 --LQETIREREA------TLEKLHSKNNELIKQ-----ISDLNCDISK-------EQSSQSLIKE 1008

  Fly  1063 VTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYT 1127
            ....|.....|.|:...::          :::.:|...||.|..        ||:..:|...|..
Yeast  1009 SKLKLENEIKRLKDVINSK----------EEEIKSFNDKLSSSE--------EDLDIKLVTLEKN 1055

  Fly  1128 ADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVG 1192
            .:...|.|||..|.|              ::||.:
Yeast  1056 CNIAMSRLQSLVTEN--------------SDLRSK------------------------------ 1076

  Fly  1193 CFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFM 1257
                :|.|                    ::.|...||..:|:     |.:..|.|:.|
Yeast  1077 ----NENF--------------------KKEKAALNNQLKNK-----ESELLKMKEKI------- 1105

  Fly  1258 DGNTKTLLADSATTARELCNQLSD--KIS--LKD-QFGFSLYIALFDKVSSLGSGGDHVMDAISQ 1317
            |.:.|.|    ||.:::..:.:|:  ||:  ||: :...:.|.:.:.|:.          :..|.
Yeast  1106 DNHKKEL----ATFSKQRDDAVSEHGKITAELKETRIQLTEYKSNYQKIK----------EEYSN 1156

  Fly  1318 CEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLAM 1382
            .::..|||..::||:             ..|..:|.....|            |.|..:|
Yeast  1157 FQRETKEQEQKKRNS-------------LVESLNDSKIKEL------------EARLSQE----- 1191

  Fly  1383 IAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIAPLKI 1447
            |:..||..:..:..|:|                          ..:....:.:.|..|   ||.
Yeast  1192 ISLNQYLNKRISGNSVE--------------------------TNISSTRRSTSYSDD---PLD- 1226

  Fly  1448 KEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFPEITAV 1512
            ||||:.    |:..|...|.|..||.     :|:            :::::.::..|.|.|....
Yeast  1227 KEDIIK----KYYDLQLAFTEITRNL-----ENE------------IEEKKNLISRLRFTETRLA 1270

  Fly  1513 SS-----------QKTNKVFTQ---TFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKK----- 1558
            ||           :|..|:...   :..|.::..|..........||..|::. :|.||:
Yeast  1271 SSSFEDQKIKAQMKKLKKLIQDMDPSIPLDSILNEPLDNCPDKESDINKLMLE-VDYLKRQLDIE 1334

  Fly  1559 -RSKY-----VIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRS------ 1611
             |:.|     :.||........|.|.||  ..|:..|:.|:..|.|           :|
Yeast  1335 TRAHYDAENAISALHSKFRKIQGESSLS--SSDIYKLKFEASEERV-----------KSLEDKLK 1386

  Fly  1612 ----QERGDFP-AETVYVLPTLSKPPQDI----LALFNIEEAHHGRRLSMASNGGAVEPRDRPHT 1667
                ::|.:.| .:.:....::||..::|    |..:.::|      :...|||
Yeast  1387 TMPLRDRTNLPVGDIIKNRDSISKYEEEIRYYKLENYKLQE------ILNESNG----------- 1434

  Fly  1668 LMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKL------QSKEEFAEEACF 1726
                .|....|..:::.||...|    ||:|.|..:|.......::|      |.|::|  |.|
Yeast  1435 ----KLSQLTLDLRQSKSKEALL----SEQLDRLQKDLESTERQKELLSSTIKQQKQQF--ENC- 1488

  Fly  1727 AFAAILKYMGDLPSKRPRMGNE--ITDHIFDGPLKHEILRDEIYCQLMKQLTD---NRNRMSEER 1786
                    |.||      .|||  :.:||      |.:.:.|...:.|..:.:   .:|:..|:.
Yeast  1489 --------MDDL------QGNELRLREHI------HALKQAEEDVKNMASIIEKLKTQNKQKEKL 1533

  Fly  1787 GWEL--------MWLATGLFACS-----QGLLKELLLFLRTRRHPISQ-----DSMHRLQKTIRH 1833
            .||.        |.|...|....     :.:|.:.|..|:.|...:..     |.::||::.:..
Yeast  1534 IWEREMERNDSDMQLQETLLELKRVQDVKKILSDDLAHLKERLSAVEDRSQYTDEINRLKEELNC 1598

  Fly  1834 GQRKYPPHQVEVEAIQHK----TTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSE 1894
            ..:.....:.|...:::|    |.....|:     :|...::|..|:..:..||....:||...|
Yeast  1599 SLKAETNLKKEFATLKYKLETSTNDSEAKI-----SDLLKQLDHYTKVVEMLNNEKDAISLAEKE 1658

  Fly  1895 GFSLF-------VKIADKVISVP------EGDFFFDFVRHLTDWIKKARPIRDGA-------NPQ 1939
            .:..:       ..:..|::|:.      |.|     :...||    |..|.:.|       |.:
Yeast  1659 LYQKYEALNTECESLKGKIVSLTKIKQELESD-----LNQKTD----ALQISNAALSSSTQKNKE 1714

  Fly  1940 FTYQVFFMKKLWTNTVPGKDRNADLIFHYHQELPKLLRGYHKCSREEAAKLAALVFRVRFGENKQ 2004
            .|.::.::::.....:....||.:|:    :.|.....||.....:|..|      .:...|..|
Yeast  1715 ITEKIKYLEETLQLQMEQNSRNGELV----KTLQASCNGYKDKFDDEKQK------NIDLYEENQ 1769

  Fly  2005 ELQAIPQMLRELIPSDIMKIQSTSE---WKRSI 2034
            .||.:...|:..:.:...::..|:|   |...|
Yeast  1770 TLQKLNTDLQLQLKNLHERLSDTTEKNAWLSKI 1802

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	281/696 (40%)
		MyTH4	<1138..1245	CDD:214535	11/106 (10%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	19/102 (19%)
		B41	1251..1467	CDD:214604	39/220 (18%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	21/117 (18%)
		SH3	1560..1624	CDD:473055	15/79 (19%)
		MyTH4	1701..1849	CDD:214535	33/176 (19%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	20/116 (17%)
		B41	1856..2068	CDD:214604	37/202 (18%)
		FERM_C2_MyoVII	2064..2159	CDD:270020
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	532/2051 (26%)
		Smc	1607..>1901	CDD:440809	40/220 (18%)