Protein Alignment ck and MYO2

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_014971.1
• Gene: MYO2 / 854504
• SGDID: S000005853
• Length: 1574
• Species: Saccharomyces cerevisiae
• Alignment Length: 1610
• Identity: 478/1610 - (29%)
• Similarity: 734/1610 - (45%)
• Gaps: 313/1610 - (19%)

  Fly    24 IGARVVSAE---GR---RIQVRDDD----------GDEVWLAPERRIKAMHASSVQGVEDMISLG 72
            |||.|:..|   |:   .:|:.||:          .|:....|..|    :...::..||:.||.
Yeast    19 IGAEVIKNEFNDGKYHLELQLEDDEIVSVDTKDLNNDKDQSLPLLR----NPPILEATEDLTSLS 79

  Fly    73 DLHEAGILRNLLIRYKENLIYTYTGSILVAVNPY-QILPIYTGDQIKLYKERKIGELPPHIFAIG 136
            .|:|..:|..:..||.:..||||:|.:|:|.||: ::..:||.|.|:.|..::.|||.||:|||.
Yeast    80 YLNEPAVLHAIKQRYSQLNIYTYSGIVLIATNPFDRVDQLYTQDMIQAYAGKRRGELEPHLFAIA 144

  Fly   137 DNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKH----------SWIEQQILEAN 191
            :.||..||..:|:|.||:|||||||||.|.|.|::|.|::..::          |..||:||..|
Yeast   145 EEAYRLMKNDKQNQTIVVSGESGAGKTVSAKYIMRYFASVEEENSATVQHQVEMSETEQKILATN 209

  Fly   192 PILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCI 256
            ||:||||||||.|||||||||||::|.|..:..|.||:|..||||:||:|.|...|||||:||.:
Yeast   210 PIMEAFGNAKTTRNDNSSRFGKYLEILFDKDTSIIGARIRTYLLERSRLVYQPPIERNYHIFYQL 274

  Fly   257 LAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLA 321
            :|||.|..|..|.|..|:||.|:..|......|.|||.|:.....|:.::..:.:...:|.|:||
Yeast   275 MAGLPAQTKEELHLTDASDYFYMNQGGDTKINGIDDAKEYKITVDALTLVGITKETQHQIFKILA 339

  Fly   322 ALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSR 386
            ||||.|||:.|.|   ..||:...:..|::....|||:........:|::.:....|.:||.|:.
Yeast   340 ALLHIGNIEIKKT---RNDASLSADEPNLKLACELLGIDAYNFAKWVTKKQIITRSEKIVSNLNY 401

  Fly   387 DQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSR--NAIGVLDIFGFENFDQNSFEQFCIN 449
            .|::..:|:..|.||..:|..:|..|||.:..|....:  :.||||||:|||:|::|||||||||
Yeast   402 SQALVAKDSVAKFIYSALFDWLVENINTVLCNPAVNDQISSFIGVLDIYGFEHFEKNSFEQFCIN 466

  Fly   450 YANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKGT 514
            ||||.|||.|.||:||||||||..|.|.|..|||.|||..:|||..| |.|::|:|||:|.|.|:
Yeast   467 YANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFNDNQPCIDLIENK-LGILSLLDEESRLPAGS 530

  Fly   515 DQTMLAKLHKT---HGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVS 576
            |::...||::|   ..::|.:.||:.. .|.|.::|:|..|.||..||::|||||.|...|.::.
Yeast   531 DESWTQKLYQTLDKSPTNKVFSKPRFG-QTKFIVSHYALDVAYDVEGFIEKNRDTVSDGHLEVLK 594

  Fly   577 QSTNKFLRQIF------------AQDIEM---GAE------TRKRTPTLSTQFRKSLDALMKTLS 620
            .|||:.|..|.            |:.:|:   |::      |..|.|||.:.|::||..||.|::
Yeast   595 ASTNETLINILEGLEKAAKKLEEAKKLELEQAGSKKPGPIRTVNRKPTLGSMFKQSLIELMNTIN 659

  Fly   621 SCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPG 685
            |....:|||||||..|:...||..:...|||..|::|||||..||:|.|..|.|||.||..|||
Yeast   660 STNVHYIRCIKPNADKEAWQFDNLMVLSQLRACGVLETIRISCAGFPSRWTFEEFVLRYYILIP- 723

  Fly   686 VPPAH-------------RTDCQAATSRIC-AVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVL 736
                |             ..|..:....|. |.|..||.||:|:||:|.|.....:||:.|...:
Yeast   724 ----HEQWDLIFKKKETTEEDIISVVKMILDATVKDKSKYQIGNTKIFFKAGMLAYLEKLRSNKM 784

  Fly   737 TRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRN-MRVGYMR-LQALIRSR-VL 798
            ...|:::|:.||...||:::|::..|...:|...||:..|:|..: |:|.... |||..|.. :.
Yeast   785 HNSIVMIQKKIRAKYYRKQYLQISQAIKYLQNNIKGFIIRQRVNDEMKVNCATLLQAAYRGHSIR 849

  Fly   799 SHRFRHLRGHIVGLQAHARGYLVRRE--YGHKMWAVIKIQSHV---------------------- 839
            ::.|..|| .|..||...|..|.:|:  ..|:..|.:.|||.|
Yeast   850 ANVFSVLR-TITNLQKKIRKELKQRQLKQEHEYNAAVTIQSKVRTFEPRSRFLRTKKDTVVVQSL 913

  Fly   840 -RRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQELLHRGNKHAREIAE-QHYRDRLHEL-----ER 897
             ||..|.|:.::|:.:.|....:.::....|.:::......|.::.| :...:|:.||     |.
Yeast   914 IRRRAAQRKLKQLKADAKSVNHLKEVSYKLENKVIELTQNLASKVKENKEMTERIKELQVQVEES 978

  Fly   898 REIQEQLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFND 962
            .::||.|||.:: |..::|.|..::..|..    |.:|........:..||             .
Yeast   979 AKLQETLENMKK-EHLIDIDNQKSKDMELQ----KTIENNLQSTEQTLKDA-------------Q 1025

  Fly   963 LPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQG-NVNHQYAKKALKHPLLPLHTQGDQ 1026
            |.....|.|.|.:.    .|.::.|.|.:..|.....:|. |.:.|...|:||..:..|.|
Yeast  1026 LELEDMVKQHDELK----EESKKQLEELEQTKKTLVEYQTLNGDLQNEVKSLKEEIARLQT---- 1082

  Fly  1027 LAAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSK-----VTATLGRNFIRSKEFQEAQLMGLD 1086
              |.:|...                    ||||:.:     |......|| .:...:.:.|...|
Yeast  1083 --AMSLGTV--------------------TTSVLPQTPLKDVMGGGASNF-NNMMLENSDLSPND 1124

  Fly  1087 PDAFLKQKPRSIRHKLVSLTLKRKN-----KLGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKL 1146
            .:...:..|.|..:.:.||::.|:|     ::.|::.|.|:|.|.        |....|..|.|.
Yeast  1125 LNLKSRSTPSSGNNHIDSLSVDRENGVNATQINEELYRLLEDTEI--------LNQEITEGLLKG 1181

  Fly  1147 HFIIGHGI-LRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIRE 1210
            ..:...|: ::...||.:|               .||..|::
Yeast  1182 FEVPDAGVAIQLSKRDVVY---------------PARILIIV----------------------- 1208

  Fly  1211 GPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPI-------MLPI-TFMDGNTKTLLA- 1266
                        |...:..|...|..|:|....|..:|.:       ::|. .|...|.:.|.:
Yeast  1209 ------------LSEMWRFGLTKQSESFLAQVLTTIQKVVTQLKGNDLIPSGVFWLANVRELYSF 1261

  Fly  1267 -----DSATTARELCNQLSDK---------ISLKDQF---GFSLYIALFDKVS------------ 1302
                 :|..|.....|.::|:         ..|||.|   .:::|.....|:.
Yeast  1262 VVFALNSILTEETFKNGMTDEEYKEYVSLVTELKDDFEALSYNIYNIWLKKLQKQLQKKAINAVV 1326

  Fly  1303 --------SLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLI 1359
                    |.|.....:....:..|:|..:......|:   :::..:.|...:|..|..|.|.|.
Yeast  1327 ISESLPGFSAGETSGFLNKIFANTEEYTMDDILTFFNS---IYWCMKSFHIENEVFHAVVTTLLN 1388

  Fly  1360 YQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIER- 1423
            |   |..:.|.|           :..::.|:.:...:.:....|.|..:.....|:...:.::.
Yeast  1389 Y---VDAICFNE-----------LIMKRNFLSWKRGLQLNYNVTRLEEWCKTHGLTDGTECLQHL 1439

  Fly  1424 -WAALVLQAYKKSYYVKD---------KIAPLKIKEDIVSY--AKYKWPL 1461
             ..|.:||..|  |.::|         .:.|.::::.|..|  |.|:.|:
Yeast  1440 IQTAKLLQVRK--YTIEDIDILRGICYSLTPAQLQKLISQYQVADYESPI 1487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	295/694 (43%)
		MyTH4	<1138..1245	CDD:214535	15/107 (14%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	20/143 (14%)
		B41	1251..1467	CDD:214604	45/263 (17%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	0/1 (0%)
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020
MYO2	NP_014971.1	COG5022	2..1567	CDD:227355	478/1610 (30%)