DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and MYO4

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	NP_009373.1	Gene:	MYO4 / 851204	SGDID:	S000000027	Length:	1471	Species:	Saccharomyces cerevisiae

Alignment Length:	1506	Identity:	442/1506 - (29%)
Similarity:	673/1506 - (44%)	Gaps:	308/1506 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VTRGDYIWIEPASGREFDVAIGARVVSAEGRRIQVR----DDDGDEVWLAPERRIKAMHASSVQG 64
            ||:.|:          |:......:...:|..:.:.    ::|.|...|...|     :...::.
Yeast    23 VTKNDF----------FEGTFHLELKLEDGETVSIETNSFENDDDHPTLPVLR-----NPPILES 72

  Fly    65 VEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPY-QILPIYTGDQIKLYKERKIGEL 128
            .:|:.:|..|:|..:|..:..||....||||:|.:|:|.||: ::..:|:.:.|:.|..::..||
Yeast    73 TDDLTTLSYLNEPAVLHAIKKRYMNGQIYTYSGIVLIAANPFDKVDHLYSREMIQNYSSKRKDEL 137

  Fly   129 PPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKH--------SWIEQ 185
            .||:|||.:.||..|...:.:|.:|:|||||||||.|.|.|::|.|::...:        |.||.
Yeast   138 EPHLFAIAEEAYRFMVHEKANQTVVVSGESGAGKTVSAKYIMRYFASVQESNNREGEVEMSQIES 202

  Fly   186 QILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNY 250
            |||..|||:||||||||.|||||||||||:.|.|..|..|.|:||..|||||||:|.|..:||||
Yeast   203 QILATNPIMEAFGNAKTTRNDNSSRFGKYLQILFDENTTIRGSKIRTYLLEKSRLVYQPETERNY 267

  Fly   251 HVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWE 315
            |:||.||.||....|..|.|....||.|...|......|.|:|.|:.....|:.::..:.:....
Yeast   268 HIFYQILEGLPEPVKQELHLSSPKDYHYTNQGGQPNIAGIDEAREYKITTDALSLVGINHETQLG 332

  Fly   316 IIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETV 380
            |.|:||.|||.|||:.|.|   ..||:...|..|::....|||:........:.::.:....|.:
Yeast   333 IFKILAGLLHIGNIEMKMT---RNDASLSSEEQNLQIACELLGIDPFNFAKWIVKKQIVTRSEKI 394

  Fly   381 VSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSR----NAIGVLDIFGFENFDQN 441
            |:.|:.:|::..||:..|.||..:|..:|..||..::.|....:    :.||:|||:|||:|::|
Yeast   395 VTNLNYNQALIARDSVAKFIYSTLFDWLVDNINKTLYDPELDQQDHVFSFIGILDIYGFEHFEKN 459

  Fly   442 SFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDE 506
            ||||||||||||.|||.|.||:||||||||..|.|.|..|||.|||..:|||..| |.|::|:||
Yeast   460 SFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFSDNQPCIDLIENK-LGILSLLDE 523

  Fly   507 EARFPKGTDQTMLAKLHKTHG---SHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFS 568
            |:|.|.|:|::..:||:....   |::.:.||:.. .|.|.::|:|..|.|:..||::||||:.|
Yeast   524 ESRLPSGSDESWASKLYSAFNKPPSNEVFSKPRFG-QTKFIVSHYAVDVEYEVEGFIEKNRDSVS 587

  Fly   569 PDLLHLVSQSTNKFLRQIF----------------AQDIEMGAETRKRTPTLSTQFRKSLDALMK 617
            ...|.:...:||...:||.                .:.|.:.|...::.|||.:.|:|||..||.
Yeast   588 LGHLDVFKATTNPIFKQILDNRELRSDDAPEEQNTEKKIMIPARLSQKKPTLGSMFKKSLGELMA 652

  Fly   618 TLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFL 682
            .::|....:|||||||..|||..||..:...|||..|::|||||..||:|.|..|.|||:|| ||
Yeast   653 IINSTNVHYIRCIKPNSEKKPWEFDNLMVLSQLRACGVLETIRISCAGFPSRWTFDEFVQRY-FL 716

  Fly   683 I------------PGVP-PAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDR 734
            :            |.:| .|....||   |.:.|.:...:.||:|:||:|.|.....|||:.|..
Yeast   717 LTDYSLWSGILYNPDLPKEAIVNFCQ---SILDATISDSAKYQIGNTKIFFKAGMLAFLEKLRTN 778

  Fly   735 VLTRKILILQRSIRGWVYRRRF--------------------------LRLRAAAI---TVQRFW 770
            .:....:|:|:.||...||.::                          |:.|||.:   .::..|
Yeast   779 KMNEICIIIQKKIRARYYRLQYLQTMESIKKCQSQIRSLLVRTRVDHELKTRAAILLQTNIRALW 843

  Fly   771 KGYAQRKRYRNMRVGYMRLQALIRSRVL----SHRFRHLRGHIVGLQAHARGYLVRREYGHKM-W 830
            |    |:.||......::||...:.:::    :.:|..:...|:      :.|:  |.||||. :
Yeast   844 K----REYYRAAIGQIIKLQCTCKRKLILDSVNRKFMLMAAVII------QSYI--RSYGHKTDY 896

  Fly   831 AVIK-----IQSHVRRMIAMRRY---------RKLR-----------LEHKQF----AEVL---- 862
            ..:|     :||.:|..:|.|||         |.:|           :|.|..    .|:|
Yeast   897 RTLKRSSILVQSAMRMQLARRRYIVLQKEVEERNIRASYGIGLLEEAIEFKNSFILNLEMLNDSY 961

  Fly   863 -QLRKLEEQELLHRGNKHAREIAE--QHYRDRLHELERREIQEQLENRRRVEVNMNIINDAARKQ 924
             :|.:|.:.:|.:..:|..:|...  ..|.|::.:|:..:          ||: ||.:|.....:
Yeast   962 TRLTQLLQGDLSNIPSKQRQEYETIVNGYNDKISKLKTLQ----------VEI-MNTLNKKNALK 1015

  Fly   925 EEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSE 989
            |.......|:::....|.....:.|:.......|:..:|...:||          |::|
Yeast  1016 ERKKKQSSLIQSHMQSLAAIKGNKPSRLSDEVKSMKQELAFIENV----------IAQD------ 1064

  Fly   990 FKFQKFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQAL---WITILRFTGDMPEPKYHTM 1051
                 |..|| ..|.|.:              .:|..:|.|.:   .:.::|.....|:.....|
Yeast  1065 -----FTTTY-SANKNDK--------------VKGLGIAGQQVKPKLVNVIRRESGNPDLLELLM 1109

  Fly  1052 D----RMDTTSVMSK---VTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKR 1109
            |    .::.|....|   ||...|.|.:.........:..|..:..|.|..:.|...|:::
Yeast  1110 DLNCYTLEVTEGYLKKVNVTEVNGDNVLGPIHVITTVVSSLVRNGLLIQSSKFISKVLLTV---- 1170

  Fly  1110 KNKLGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKL-HFIIGHGIL----RAELRDEIYCQICK 1169
                 |.:...|..|| |......||     |||.:| .|......|    ..:.:|::......
Yeast  1171 -----ESIVMSLPKDE-TMLGGIFWL-----SNLSRLPAFAANQKTLYEANGGDEKDKLTLIYLN 1224

  Fly  1170 QLTNNPLK--SSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTR 1232
            .|.|..||  ......|::            ||:.:..|.|..    :.....|:|   |.|
Yeast  1225 DLENETLKVFDKIYSTWLV------------KFMKHASAHIEI----FDMVLNEKL---FKN--- 1267

  Fly  1233 NQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIAL 1297
                                     .|:.|  .|...|...|.     |.:..|.|...|::..:
Yeast  1268 -------------------------SGDEK--FAKLFTFLNEF-----DAVLCKFQVVDSMHTKI 1300

  Fly  1298 F-DKVSSLGSGGDHVM---DAISQCEQYAKEQGAQ-ERNAPWRLFFRKEIFAPWHEPTHDQVATN 1357
            | |.:..|     :||   |.|::|.....:.|.: :||.        |....|.||..:.|..|
Yeast  1301 FNDTLKYL-----NVMLFNDLITKCPALNWKYGYEVDRNI--------ERLVSWFEPRIEDVRPN 1352

  Fly  1358 LIYQQVVRGVK 1368
            ||  |:::.||
Yeast  1353 LI--QIIQAVK 1361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	289/713 (41%)
		MYSc_Myo7	77..721	CDD:276832	281/688 (41%)
		MyTH4	<1138..1245	CDD:214535	20/113 (18%)
		B41	1251..1467	CDD:214604	31/123 (25%)
		FERM_B-lobe	1355..1439	CDD:271216	6/14 (43%)
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
MYO4	NP_009373.1	COG5022	2..1471	CDD:227355	442/1506 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810