DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and XIB

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	NP_171912.2	Gene:	XIB / 839246	AraportID:	AT1G04160	Length:	1500	Species:	Arabidopsis thaliana

Alignment Length:	1095	Identity:	381/1095 - (34%)
Similarity:	578/1095 - (52%)	Gaps:	127/1095 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GDYIWIEPASGREFD---VAIGA---RVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGV 65
            |.::|:|.......|   |.|..   :|:.|.|:::.|:|.:     :.|    |.:.|.: .||
plant    10 GSHVWVEDPDEAWLDGEVVEINGDQIKVLCASGKQVVVKDSN-----IYP----KDVEAPA-SGV 64

  Fly    66 EDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILP-IYTGDQIKLYKERKIGELP 129
            |||..|..|||.|:|:||..||..|.|||||||||:||||::.|| :|:...:..||...:|||.
plant    65 EDMTRLAYLHEPGVLQNLQSRYDINEIYTYTGSILIAVNPFRRLPHLYSSHMMTQYKGASLGELS 129

  Fly   130 PHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHS-----WIEQQILE 189
            ||.||:.|.||..|......|.|::||||||||||||||:::|||.:.|:.:     .:||::||
plant   130 PHPFAVADAAYRQMVNEGVSQSILVSGESGAGKTESTKLLMRYLAFMGGRGAATEGRTVEQKVLE 194

  Fly   190 ANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFY 254
            :||:|||||||||::|:|||||||:::|.|..:|.|.||.|..||||:||:...:..|||||.||
plant   195 SNPVLEAFGNAKTVKNNNSSRFGKFVEIQFDQSGRISGAAIRTYLLERSRVCQVSDPERNYHCFY 259

  Fly   255 CILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKL 319
            .:.|....|.| :..||....|.||.....|..:..:||.|:...:.||.|:..|.:|...|.::
plant   260 MLCAAPEEDAK-KFKLGDPKIYHYLNQSKCIQLDAMNDAEEYHATKKAMDVVGISSEEQDAIFRV 323

  Fly   320 LAALLHCGNIKY-KATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVST 383
            :|::||.|||:: |.|.:|:....:.....:::..|.||....:.|.|:|.:|.:....||:..|
plant   324 VASILHLGNIEFAKGTEIDSSIPRDEKSWFHLKTAAELLMCNEKSLEDSLCKRIMATRDETITKT 388

  Fly   384 LSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCI 448
            |..:.::..|||..|.:|.|:|..:|.||||:|.:. ..|:..||||||:|||:|..||||||||
plant   389 LDPEAALLSRDALAKVMYSRLFDWLVEKINTSIGQD-PDSKYLIGVLDIYGFESFKTNSFEQFCI 452

  Fly   449 NYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKG 513
            |..||.|||.|.||:||:|||||..|.|||.:||||||||.||||..|...|:||:||...||:.
plant   453 NLTNEKLQQHFNQHVFKMEQEEYKKEEINWSYIEFVDNQDILDLIEKKPGGIIALLDEACMFPRS 517

  Fly   514 TDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQS 578
            |.:|...||::|:.:||.:.|||. ..:.|.:.|:||.|.|.|..|||||:|....:...|::.|
plant   518 THETFAQKLYQTYKNHKRFTKPKL-ARSDFTICHYAGDVTYQTELFLDKNKDYVIAEHQALLNAS 581

  Fly   579 TNKFLRQIF---AQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMM 640
            |..|:..:|   :.|     ..:.:..::.|:|::.|.:|::.|::.:|.:|||||||.|.||.:
plant   582 TCSFVANLFPPVSDD-----SKQSKFSSIGTRFKQQLVSLLEILNTTEPHYIRCIKPNNLLKPGI 641

  Fly   641 FDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHRTDCQAATSRICAVV 705
            |:.....:|||..|:||.|||..||||.|..|.||:.|:..:.|.|     .|..:.....|..:
plant   642 FENQNVLQQLRCGGVMEAIRISCAGYPTRKHFDEFLNRFGIIAPQV-----LDKNSNEPAACKKL 701

  Fly   706 LGKS---DYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQ 767
            |.|:   .||:|.:||||:......|:..|..:|.|...|:||.:|.::.::.|::||.:|..:|
plant   702 LDKAGLEGYQIGKSKVFLRAGQMADLDTRRTEILGRSASIIQRKVRSYLAQKTFIQLRISATQIQ 766

  Fly   768 RFWKGYAQRKRYRNMR--VGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRRE--YGHK 828
            ...:||..|..|..||  ...:::|..:|..:....:..|....:.:||..||.:.|:|  ...:
plant   767 AVCRGYLARSIYEGMRREAAALKIQRDLRKFLARKAYTELFSATILIQAGMRGMVSRKELCLRRQ 831

  Fly   829 MWAVIKIQSHVRRMIAMRRYRKL-------------RLEHKQFAEVLQLRKLEEQELLHRGNKHA 880
            ..|...||:..|..:|...||||             ::..|:... |::...|...|....||..
plant   832 TKAATIIQTRCRVYLARLHYRKLKKAAITTQCAWRGKVARKELKN-LKMAARETGALQEAKNKLE 895

  Fly   881 REIAEQHYRDRLHELERREIQ--------------EQLENR-RRVEVNMNIINDAARK------- 923
            :::.|..:|.:|.:..|.:::              |:::|: :..|..:....:||:.
plant   896 KQVEELTWRLQLEKRMRTDLEEAKKQENAKYESSLEEIQNKFKETEALLIKEREAAKTVSEVLPI 960

  Fly   924 -QEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIH----ISED 983
             :|.||.|.:|:|.:.:                |......:..:..:..|:....:|    ||:|
plant   961 IKEVPVVDQELMEKLTN----------------ENEKLKGMVSSLEIKIDETAKELHETARISQD 1009

  Fly   984 ----------------------EEDLSEFKFQKFAATYFQGNVNHQYAKKALKHP 1016
                                  ||.:|:.:.:|  ....|..:.:...|....||
plant  1010 RLKQALAAESKVAKLKTAMQRLEEKISDMETEK--QIMLQQTILNTPVKSVAGHP 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	296/681 (43%)
		MYSc_Myo7	77..721	CDD:276832	285/656 (43%)
		MyTH4	<1138..1245	CDD:214535
		B41	1251..1467	CDD:214604
		FERM_B-lobe	1355..1439	CDD:271216
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
XIB	NP_171912.2	Myosin_N	11..48	CDD:280832	8/36 (22%)
		MYSc	57..731	CDD:214580	297/687 (43%)
		MYSc_Myo11	76..720	CDD:276835	285/656 (43%)
		IQ	830..852	CDD:197470	5/21 (24%)
		Tropomyosin	877..1053	CDD:278679	31/193 (16%)
		MyosinXI_CBD	1097..1470	CDD:271259
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	530	1.000	Domainoid score	I63
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8405
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810