DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and MYA1

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	NP_173201.2	Gene:	MYA1 / 838333	AraportID:	AT1G17580	Length:	1520	Species:	Arabidopsis thaliana

Alignment Length:	1499	Identity:	469/1499 - (31%)
Similarity:	720/1499 - (48%)	Gaps:	219/1499 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IVTRGDYIWIEPASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVED 67
            ::..|.::|:|.......|    ..|...:|..:.|:...|..| :......|...|.| .||:|
plant     5 VIIVGSHVWVEDPHLAWID----GEVTRIDGINVHVKTKKGKTV-VTNVYFPKDTEAPS-GGVDD 63

  Fly    68 MISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILP-IYTGDQIKLYKERKIGELPPH 131
            |..|..|||.|:||||..||:.|.||||||:||:||||:|.|| ||..|.::.||...:|||.||
plant    64 MTKLSYLHEPGVLRNLETRYELNEIYTYTGNILIAVNPFQRLPHIYETDMMEQYKGIALGELSPH 128

  Fly   132 IFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHS----WIEQQILEANP 192
            :|||||.||..|....::..|::||||||||||:||::::|||.:.|:..    .:|||:||:||
plant   129 VFAIGDAAYRAMINEGKNNSILVSGESGAGKTETTKMLMRYLAFLGGRSGVEGRTVEQQVLESNP 193

  Fly   193 ILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCIL 257
            :|||||||||:||:|||||||:::|.|..||.|.||.|..||||:||:...:..|||||.||.:.
plant   194 VLEAFGNAKTLRNNNSSRFGKFVEIQFDKNGRISGAAIRTYLLERSRVCQISDPERNYHCFYLLC 258

  Fly   258 AGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAA 322
            |....|.| :..|.....:.||...:....:|.|||:|:.:.|.||.|:..|::|...|.:::||
plant   259 AAPPEDIK-KYKLENPHKFHYLNQSSCYKLDGVDDASEYLETRRAMDVVGISNEEQEAIFRVVAA 322

  Fly   323 LLHCGNIKY------KATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVV 381
            :||.|||.:      .::|:.:.|:.   .|:|:  .|.||....|.|.|||.||.:....|.:.
plant   323 ILHLGNIDFGKGEEIDSSVIKDKDSR---SHLNM--AAELLMCNAQSLEDALIRRVMVTPEEIIT 382

  Fly   382 STLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFK-PRGTSRNAIGVLDIFGFENFDQNSFEQ 445
            .||..|.::..||...|.||..:|..||.||||:|.: ||  |::.||||||:|||:|..|||||
plant   383 RTLDPDNAIASRDTLAKTIYSHLFDWIVNKINTSIGQDPR--SKSIIGVLDIYGFESFKCNSFEQ 445

  Fly   446 FCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARF 510
            ||||:.||.|||.|.||:||:|||||..|.|.|.:|||:||||.|:||..|...|::|:||...|
plant   446 FCINFTNEKLQQHFNQHVFKMEQEEYTKEEIAWSYIEFIDNQDVLELIEKKPGGIISLLDEACMF 510

  Fly   511 PKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLV 575
            ||.|.:|...||.:|...|:.:.|||.. .|.|.::|:||.|.|.:..|:|||:|....:...|.
plant   511 PKSTHETFSQKLFQTFKEHERFAKPKLS-RTDFTISHYAGEVTYQSNHFIDKNKDYIVAEHQALF 574

  Fly   576 SQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMM 640
            :.|..||:..:|....|..:.:.|.: ::.::|::.|.:||::|:..:|.:|||||||.:.||.:
plant   575 TASNCKFVAGLFHALHEDSSRSSKFS-SIGSRFKQQLHSLMESLNGTEPHYIRCIKPNNVLKPGI 638

  Fly   641 FDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHRTDCQAATSRICAVV 705
            |:......|||..|::|.|||..||||.|..|.:|::|:..|.|.|...:..|..|     |.::
plant   639 FENFNVIHQLRCGGVLEAIRISCAGYPTRLAFYDFLDRFGLLAPEVLEGNYDDKVA-----CQMI 698

  Fly   706 LGK---SDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRF----------- 756
            |.|   :|||:|.||:||:......|:..|..||.....::||..|..:.|:.:
plant   699 LDKKSLTDYQIGKTKIFLRAGQMAELDARRAEVLGNAARVIQRQFRTCMARKNYRSIRNAAIVLQ 763

  Fly   757 --------------LRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVL--SHRFRHL 805
                          ||:.|||:.||:.::.|..||.:...|...:.||..:|:.:.  ..|.|..
plant   764 SFLRGEIARAVHKKLRIEAAALRVQKNFRRYVDRKSFVTTRSSTIVLQTGLRAMIARSEFRLRRQ 828

  Fly   806 RGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLR-KLEE 869
            |...:.||||.||......|.....|.|..|...|..:|.|..|.|::..:....:...: |||:
plant   829 RKAAIVLQAHWRGRQAFSYYTRLQKAAIVTQCAWRCRLARRELRMLKMAARDTGALKDAKNKLEQ 893

  Fly   870 --QEL---LHRGNKHAREIAEQHYRDRLHELERREI---QEQLENRR------------RVEVNM 914
              :||   ||         .|:..|..|.|.:.:|:   ||.|...|            ..|...
plant   894 RVEELSLRLH---------LEKRLRTDLEEAKVQEVAKLQEALHTMRLQLKETTAMVVKEQEAAR 949

  Fly   915 NIINDAARKQEEP--VDDGKLVEAMFDFLPDSSSDAPTPHG--GRETSVFNDLPHAQN---VNQD 972
            ..|.:|:...:||  |:|.:.::::       |::.....|  ..||...::..||..   |..:
plant   950 VAIEEASSVNKEPVVVEDTEKIDSL-------SNEIDRLKGLLSSETHKADEAQHAYQSALVQNE 1007

  Fly   973 DIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQALWITIL 1037
            ::...:..:..:.|..:...|:|....|    :.:...|.|:...|.:......||.:.. .||:
plant  1008 ELCKKLEEAGRKIDQLQDSVQRFQEKVF----SLESENKVLRQQTLTISPTTRALALRPK-TTII 1067

  Fly  1038 RFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIRSK--EFQEAQLMGLDPD-AFLKQKP---- 1095
            :.|     |:..|....:||.:....|....:..:..|  |.||..|..:..| .|.:.||
plant  1068 QRT-----PEKDTFSNGETTQLQEPETEDRPQKSLNQKQQENQELLLKSISEDIGFSEGKPVAAC 1127

  Fly  1096 ---------RSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIG 1151
                     ||...:..|:.    |::.|.:...::..| .:|....||.:..|. |..|...:.
plant  1128 LIYKCLIHWRSFEVERTSIF----NRIIETIASAIEMQE-NSDVLCYWLSNSATL-LMFLQRTLK 1186

  Fly  1152 HGIL-------RAELRDEIYCQICK------QLTNNPLKSSHARGWILLSL-CVGCFAPSEKFVN 1202
            .|..       |..:...::.::.:      |....|..:..|.|..|..| .|....|:..|..
plant  1187 AGATGSITTPRRRGMPSSLFGRVSQSFRGSPQSAGFPFMTGRAIGGGLDELRQVEAKYPALLFKQ 1251

  Fly  1203 YLRAFI------------REGPPGYAPYC------------EERLKRTFNNGTRNQP--PSWLEL 1241
            .|.||:            :|..|..|. |            :.|.:.|.||....:|  ..|..:
plant  1252 QLTAFLEKIYGMIRDKMKKEISPLLAS-CIQVPRTPRSGLVKGRSQNTQNNVVAPKPMIAHWQNI 1315

  Fly  1242 QATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKV----- 1301
                        :|.::|:.:|:.|:...:.  |.:::..:|     |.| :.:.||:.:
plant  1316 ------------VTCLNGHLRTMRANYVPSL--LISKVFGQI-----FSF-INVQLFNSLLLRRE 1360

  Fly  1302 SSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATN--LIYQQVV 1364
            ....|.|::|...:::.|::..:  |.|          :.:.:.|.|..|.:.|..  :|:|:..
plant  1361 CCSFSNGEYVKTGLAELEKWCHD--ATE----------EFVGSAWDELKHIRQAVGFLVIHQKPK 1413

  Fly  1365 RGVK 1368
            :.:|
plant  1414 KSLK 1417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	303/683 (44%)
		MYSc_Myo7	77..721	CDD:276832	293/658 (45%)
		MyTH4	<1138..1245	CDD:214535	27/146 (18%)
		B41	1251..1467	CDD:214604	23/125 (18%)
		FERM_B-lobe	1355..1439	CDD:271216	4/16 (25%)
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
MYA1	NP_173201.2	Myosin_N	9..47	CDD:397036	9/42 (21%)
		MYSc_Myo11	73..717	CDD:276835	293/658 (45%)
		IQ	850..872	CDD:197470	6/21 (29%)
		Smc	<867..>1114	CDD:224117	56/272 (21%)
		MyosinXI_CBD	1099..1486	CDD:271259	68/358 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	530	1.000	Domainoid score	I63
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8405
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810