DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and ATM2

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	NP_001078755.1	Gene:	ATM2 / 835516	AraportID:	AT5G54280	Length:	1220	Species:	Arabidopsis thaliana

Alignment Length:	931	Identity:	337/931 - (36%)
Similarity:	512/931 - (54%)	Gaps:	81/931 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RIQVRDDDGDEVWLAPERRIKA-------MHASSVQGVEDMISLGDLHEAGILRNLLIRYKENLI 92
            :||....|...|.|:....:|.       .:...::||||:|.|..|:|..:|.||.:||.:::|
plant   178 KIQSTSADTSLVMLSTANVVKVSTEELFPANPDILEGVEDLIQLSYLNEPSVLYNLRVRYLQDVI 242

  Fly    93 YTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGE 157
            |:..|.:|:||||::.:.||..|.|..|:::.:.  .||::|:.|.||..|.|..::|.::||||
plant   243 YSKAGPVLIAVNPFKNVEIYGNDVISAYQKKVMD--APHVYAVADAAYDEMMREEKNQSLIISGE 305

  Fly   158 SGAGKTESTKLILQYLAAISGKHSWIEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSAN 222
            |||||||:.|..:|||||:.|....:|.:||:...||||||||||.||.|||||||.|:|||||.
plant   306 SGAGKTETAKFAMQYLAALGGGSCGVEYEILKTTCILEAFGNAKTSRNANSSRFGKLIEIHFSAM 370

  Fly   223 GVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITC 287
            |.|.|||:|.:||||||:|...:.||:||:||.:.||.|...|.||.|..|::|.||:..:.:|.
plant   371 GKICGAKLETFLLEKSRVVQLFNGERSYHIFYELCAGASPILKERLKLKTASEYTYLSQSDCLTI 435

  Fly   288 EGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVER 352
            .|.|||.:|..:..|..::....:.......||||:|..||:.::.|  ||.:..|:.....|..
plant   436 AGVDDAQKFHKLLEAFDIVQIPKEHQERAFALLAAVLWLGNVSFRVT--DNENHVEVVADEAVAN 498

  Fly   353 VAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIF 417
            .|.|:|...:.|:..|:.|.|.|..:.:...|:..|:.|:||...|.||..:|..:|.:||.|:.
plant   499 AAMLMGCNTEELMVVLSTRKLQAGTDCIAKKLTLRQATDMRDGIAKFIYANLFDWLVEQINIALE 563

  Fly   418 KPRGTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIE 482
            ..:..:..:|.:|||:|||:|..|||||||||||||.|||.|.:|:||||||||..:.|:|..:|
plant   564 VGKSRTGRSISILDIYGFESFKNNSFEQFCINYANERLQQHFNRHLFKLEQEEYEEDGIDWTKVE 628

  Fly   483 FVDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHKTHGSHKNYLKP----KSDINTSF 543
            |||||:.||||..|.:.:::|:|||:.|||.||.|...||       |.:||.    |.:...:|
plant   629 FVDNQECLDLIEKKPIGLLSLLDEESNFPKATDLTFANKL-------KQHLKTNSCFKGERGRAF 686

  Fly   544 GLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAETRK-------RT 601
            .:||:||.|.|||.|||:||||....||::|:|....:.|: :|:  .:|..:::|       ..
plant   687 RVNHYAGEVLYDTNGFLEKNRDPLPADLINLLSSCDCQLLK-LFS--TKMRGKSQKPLMLSDSTN 748

  Fly   602 PTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGY 666
            .|:.|:|:..|..||..|.:..|.||||||||..:.|.:::..|..:|||..|::|.:||.|:||
plant   749 QTVGTKFKGQLFKLMNKLENTSPHFIRCIKPNSKQLPRVYEEDLVLQQLRCCGVLEVVRISRSGY 813

  Fly   667 PIRHGFREFVERYRFLIPGVPPAHRTDCQAATS--RICAVVLGKSD-----YQLGHTKVFLKDAH 724
            |.|...:||..||.||:        :|.:.|..  .:...||.:.|     ||:|:||::|:...
plant   814 PTRLTHQEFAGRYGFLL--------SDKKVAQDPLSVSIAVLKQYDVHPEMYQVGYTKLYLRTGQ 870

  Fly   725 DLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRL 789
            ....|..|.:|| :.|:.||:..||.:.|..|..:|...:.:|.:.:|...|:.:..
plant   871 IGIFEDRRKKVL-QGIVGLQKHFRGHLSRAYFQNMRKVTLVLQSYIRGENARRLFDT-------- 926

  Fly   790 QALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRK---- 850
            :|...:..:|.........::.||:..||:|.|:.:..     ::.|..:|. :|.:..||
plant   927 EAKFHADSVSEASTDELSAVIHLQSAVRGWLARKHFNS-----MQRQKELRN-VATKSKRKAGRR 985

  Fly   851 ------LRLEHKQFAEV----LQLRKLEEQELLHRGNKHAREIAEQ--HYRDRLHELE-RREIQE 902
                  :.||..|....    ||.|.|:.:..|.:..:....:.||  .:.:|..|.: :.:..|
plant   986 ISEDKDIPLEQPQVQPTSMSDLQKRILKSEAALSQKEEENTALREQLRQFEERWSEYDIKMKSME 1050

  Fly   903 QLENRRRVEVNMNIINDAARK 923
            :...::...:.|::.  ||||
plant  1051 ETWQKQMSSLQMSLA--AARK 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	286/686 (42%)
		MYSc_Myo7	77..721	CDD:276832	276/661 (42%)
		MyTH4	<1138..1245	CDD:214535
		B41	1251..1467	CDD:214604
		FERM_B-lobe	1355..1439	CDD:271216
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
ATM2	NP_001078755.1	MYSc	208..879	CDD:214580	286/692 (41%)
ATM2	NP_001078755.1	MYSc_Myo8	227..867	CDD:276834	276/661 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8405
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810