DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and XIJ

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	NP_001319790.1	Gene:	XIJ / 824985	AraportID:	AT3G58160	Length:	1242	Species:	Arabidopsis thaliana

Alignment Length:	1190	Identity:	391/1190 - (32%)
Similarity:	613/1190 - (51%)	Gaps:	144/1190 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YIWIEPASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPERRI--KAMHASSVQGVEDMISL 71
            ::|:|.......|    ..|::.:|...:::.:||.:| :|...|:  |...|.| :|||||..|
plant    10 HVWVEDPERAWID----GVVLNIKGEEAEIKTNDGRDV-IANLSRLYPKDTEAPS-EGVEDMTRL 68

  Fly    72 GDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILP-IYTGDQIKLYKERKIGELPPHIFAI 135
            ..|||..:|.||..||:.|.||||||:||:||||:|.|| :|..:.::.|||....||.||:|||
plant    69 SYLHEPAVLDNLATRYELNEIYTYTGNILIAVNPFQGLPHLYDAEVMEKYKEAYFKELNPHVFAI 133

  Fly   136 GDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLA------AISGKHSWIEQQILEANPIL 194
            |..||..|....:::||::|||||:||||:||::::|||      |:.|:  .:|.|:||:||:|
plant   134 GGIAYREMINEGRNKCILVSGESGSGKTETTKMLMRYLAYFGGHTAVEGR--TVENQVLESNPVL 196

  Fly   195 EAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAG 259
            ||||||||::|:|||||||:::|.|...|.|.||.|..||||:||:...:..|||||.|| :|..
plant   197 EAFGNAKTVKNNNSSRFGKFVEIQFDDVGRISGAAIRTYLLERSRVCQVSDPERNYHCFY-LLCA 260

  Fly   260 LSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALL 324
            ...::..|..||....::||...:....:|.:||.|:...|.||.|:..|::|...|.:::|::|
plant   261 APPEDVERFKLGDPKSFRYLNQSSCYKLDGVNDAEEYLATRRAMDVVGISEKEQDAIFRVVASIL 325

  Fly   325 HCGNIKY-KATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQ 388
            |.|||:: |....|:....:.....:::..:.||......|.|||.:|.:....|.:..:|....
plant   326 HLGNIEFSKGEDADSSSVKDEQSMFHLQMTSELLMCDPHSLEDALCKRMMVTPEEVIKRSLDPLG 390

  Fly   389 SVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCINYANE 453
            :...||...|.||.|:|..:|.|||.:|.:. ..||..||||||:|||:|..||||||||||.||
plant   391 AAVSRDGLAKTIYSRLFDWLVNKINISIGQD-SHSRRLIGVLDIYGFESFKTNSFEQFCINYTNE 454

  Fly   454 NLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTM 518
            .|||.|.||:||:||.||..|.|:|.::|||||:|.:|||..|...|:||:||....||.|.:|.
plant   455 KLQQHFNQHVFKMEQGEYQKEEIDWSYVEFVDNKDVVDLIEKKPGGIIALLDEACMLPKSTPETF 519

  Fly   519 LAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFL 583
            ..||:.|...||.::|||. ..:.|.|.|:||.|.|.:..|||||:|....:...|::.|...|:
plant   520 SEKLYHTFKDHKRFMKPKL-TRSDFTLVHYAGDVQYQSDQFLDKNKDYVVAEHQDLLNASKCSFV 583

  Fly   584 RQIFAQDIEMGAETRK-RTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCC 647
            ..:|.   .:..|:.| :..::..:|:..|..||:||:|.:|.:|||:|||.|.:|.:||.....
plant   584 SGLFP---PLPKESSKSKFSSIGARFKLQLQQLMETLNSTEPHYIRCVKPNNLLQPTVFDNANVL 645

  Fly   648 RQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHRTDCQAATSRICAVVL---GKS 709
            .|||..|::|.||::.||||....|.||:.|:..|.|.:   .:.:.:|..:  |..:|   |.:
plant   646 HQLRSGGVLEAIRVKCAGYPTNRTFIEFLNRFLILAPEI---LKGEYEAEVA--CKWILEKKGLT 705

  Fly   710 DYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYA 774
            .||:|.:||||:......|:..|.|||.....::|..:|..:.|.||:.:|.|::.:|..|:|..
plant   706 GYQIGKSKVFLRAGQMAELDAHRTRVLGESARMIQGQVRTRLTRERFVLMRRASVNIQANWRGNI 770

  Fly   775 QRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHV 839
            .||..:.||    |.:|.|:                 :|.:.|..:.:::||....:.:.:||.|
plant   771 ARKISKEMR----REEAAIK-----------------IQKNLRRQIAKKDYGKTKSSALTLQSGV 814

  Fly   840 RRMIAMRRYR---------KLRLEHKQFAEVLQLRKLEEQELLHRGNKHAR----EIAEQHYRDR 891
            |.|.|...:|         .::...:.::.:...:||:...||.:.|...|    ::.:....||
plant   815 RTMAARHEFRYKLTTRAATVIQAYWRGYSAISDYKKLKRVSLLCKSNLRGRIARKQLGQSKQADR 879

  Fly   892 LHELERREIQEQLENRRRVEVNMNII------NDA----ARK------QEEPVDDGKLVEAMFDF 940
            ..|.| :|.:.:|.||....|:|:.:      :||    .||      .|:.:|...::.:
plant   880 KEETE-KERKVELSNRAEEAVDMSFVLHSEQSDDAESGHGRKAKLSIESEDGLDKSSVLHS---- 939

  Fly   941 LPDSSSDAPTPH------------GGRETSVFNDLPHAQN----VNQDDIIAPIHI----SEDEE 985
              :.|.|....|            |..:.|...::.|.:.    :..:|.|...::    ..|:|
plant   940 --EQSDDEELGHERKTKLSIESEDGHSDQSDDEEIEHERKTKHCIQAEDGIEKSYVMHSDQSDDE 1002

  Fly   986 DLSEFKFQKFAATYFQG----NVNH--QYAKKALKHPLLPLHTQGDQLAAQALWITILRFTGDMP 1044
            ::...:..|.:.....|    .|.|  |...:.:.|.....|....:...|..::|       ..
plant  1003 EIGHKRKTKHSIQAEDGIEKSFVVHSDQSDDEEIGHERKTKHAIQVEDGIQKSFVT-------CS 1060

  Fly  1045 EPKYHTMDRMDTTSVMSKVTATLGRNFIRSKEFQ----EAQLMGLDPDAFLKQKPRSIRHKLVSL 1105
            |..|:|.      ||:|::|:.     ||..|.:    |.:::    .|.|:.:.:  |..:...
plant  1061 EKPYNTF------SVVSQITSP-----IRDTEIESLTAEVEML----KALLQVEKQ--RADISER 1108

  Fly  1106 TLKRKNKLGEDVRRRLQDDE 1125
            ......:|||..|:||::.|
plant  1109 KCAEARELGERRRKRLEETE 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	284/680 (42%)
		MYSc_Myo7	77..721	CDD:276832	273/655 (42%)
		MyTH4	<1138..1245	CDD:214535
		B41	1251..1467	CDD:214604
		FERM_B-lobe	1355..1439	CDD:271216
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
XIJ	NP_001319790.1	Myosin_N	9..46	CDD:397036	8/40 (20%)
		MYSc_Myo11	74..717	CDD:276835	273/655 (42%)
		IQ	829..849	CDD:197470	0/19 (0%)
		DUF460	<1081..>1142	CDD:421465	12/54 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	530	1.000	Domainoid score	I63
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8405
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810