DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and ATM1

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	NP_001154628.2	Gene:	ATM1 / 821534	AraportID:	AT3G19960	Length:	1176	Species:	Arabidopsis thaliana

Alignment Length:	1028	Identity:	344/1028 - (33%)
Similarity:	535/1028 - (52%)	Gaps:	176/1028 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 WIEPASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVEDMISLGDLH 75
            ||:..:|   :..:| :::|..|....:...:|..:.:..|..:.| :...:.||:|::.|..|:
plant   118 WIQLPNG---NWELG-KILSTSGEESVISLPEGKVIKVISETLVPA-NPDILDGVDDLMQLSYLN 177

  Fly    76 EAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAY 140
            |..:|.||..||.:::|||..|.:||||||::.:|:|....|:.|  ||.....||::||.|.|.
plant   178 EPSVLYNLNYRYNQDMIYTKAGPVLVAVNPFKEVPLYGNRYIEAY--RKKSNESPHVYAIADTAI 240

  Fly   141 AHMKRYRQDQCIVI----------------SGESGAGKTESTKLILQYLAAISGKHSWIEQQILE 189
            ..|.|...:|.|:|                ||||||||||:.|:.:|||||:.| .|.||.:||:
plant   241 REMIRDEVNQSIIIRCICIHESMTYSISSSSGESGAGKTETAKIAMQYLAALGG-GSGIEYEILK 304

  Fly   190 ANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFY 254
            .||||||||||||:||||||||||.|:||||.:|.|.||:|:.:||||||:|.....||:||:||
plant   305 TNPILEAFGNAKTLRNDNSSRFGKLIEIHFSESGKISGAQIQTFLLEKSRVVQCAEGERSYHIFY 369

  Fly   255 CILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKL 319
            .:.||.|...:.:|:|..|.:||||...|..:..|.|||..|..::.|:.::..|.::...:..:
plant   370 QLCAGASPALREKLNLTSAHEYKYLGQSNCYSINGVDDAERFHTVKEALDIVHVSKEDQESVFAM 434

  Fly   320 LAALLHCGNIKYKATVVDNLDATE---------------------IPEHINVERVAGLLGLPIQP 363
            |||:|..||:.:  ||:||.:..|                     :..::.:..||.|:|..|..
plant   435 LAAVLWLGNVSF--TVIDNENHVEPVADESFLFHSLGSWCWKQECLLHNMCLSTVAKLIGCNINE 497

  Fly   364 LIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIG 428
            |...|::|.:....:|:|..|:..|::|.|||..|.||..:|..:|.:||.::...:..:..:|.
plant   498 LTLTLSKRNMRVRNDTIVQKLTLPQAIDARDALAKSIYSCLFDWLVEQINKSLAVGKRRTGRSIS 562

  Fly   429 VLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLI 493
            :|||:|||:||:|||||||||||||.|||.|.:|:||||||||..:.|:|..::|.|||:.|.|.
plant   563 ILDIYGFESFDKNSFEQFCINYANERLQQHFNRHLFKLEQEEYIQDGIDWTRVDFEDNQNCLSLF 627

  Fly   494 AIKQLNIMALIDEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKS----DINTSFGLNHFAGVVFY 554
            ..|.|.:::|:|||:.||.|||.|:..||       |.:|:..|    |....|.:.|:||.|.|
plant   628 EKKPLGLLSLLDEESTFPNGTDLTLANKL-------KQHLQSNSCFRGDKGKLFTVVHYAGEVTY 685

  Fly   555 DTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIEM--------------GAETRKRTPTLS 605
            :|.|||:||||....|.:.|:| |.:..|.|.||..:.:              ||::::.  :::
plant   686 ETTGFLEKNRDLLHSDSIQLLS-SCSCLLPQAFASSMLIQSEKPVVGPLYKAGGADSQRL--SVA 747

  Fly   606 TQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGY---- 666
            |:|:..|..||:.|.:..|.||||||||.::.|.::::||..:|||..|::|.  :.:..|
plant   748 TKFKSQLFQLMQRLGNTTPHFIRCIKPNNIQSPGVYEQGLVLQQLRCCGVLEV--LCKGPYKRFF 810

  Fly   667 --PIRHGFREFVERYRFLIPGVPPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLE 729
              .|.|.|.        ::|.:                        ||:|:||:|.:......||
plant   811 IIAILHQFN--------ILPEM------------------------YQVGYTKLFFRTGQIGVLE 843

  Fly   730 QERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGY---MRLQA 791
            ..|:|.| ..||.:|.|.||:..|.....|:.....:|.|.:|...||.:..:|..:   ..:|:
plant   844 DTRNRTL-HGILRVQSSFRGYQARCLLKELKRGISILQSFVRGEKIRKEFAELRRRHKAAATIQS 907

  Fly   792 LIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMW-------------AVIK--IQSHVRR 841
            .::|::...:::.:....|.:|:..||:||||..|...|             .::|  :.|.::|
plant   908 QVKSKIARIQYKGIADASVVIQSAIRGWLVRRCSGDIGWLKSGGAKTNELGEVLVKASVLSELQR 972

  Fly   842 MIAMRRYRKLRLEHKQFAEVLQLRKLEEQELLHRGNKHAREIAEQHYRDRLHELERR-----EI- 900
            .:..             ||.....|.||.::|.:        ..|.|.:|..|.|.:     ||
plant   973 RVLK-------------AEAALREKEEENDILQQ--------RLQQYENRWSEYETKMKSMEEIW 1016

  Fly   901 QEQLENRRRVEVNMNI------INDAARKQEEPVDDGKLVEAMFDFLPDSSSD 947
            |:|:   |.::.:::|      :.|:||..:..|:.....:.      ||||:
plant  1017 QKQM---RSLQSSLSIAKKSLAVEDSARNSDASVNASDATDW------DSSSN 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	278/729 (38%)
		MYSc_Myo7	77..721	CDD:276832	270/704 (38%)
		MyTH4	<1138..1245	CDD:214535
		B41	1251..1467	CDD:214604
		FERM_B-lobe	1355..1439	CDD:271216
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
ATM1	NP_001154628.2	MYSc	160..847	CDD:214580	278/735 (38%)
ATM1	NP_001154628.2	MYSc_Myo8	179..835	CDD:276834	270/704 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8405
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810