DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and XIF

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	NP_001323600.1	Gene:	XIF / 817748	AraportID:	AT2G31900	Length:	1557	Species:	Arabidopsis thaliana

Alignment Length:	1613	Identity:	467/1613 - (28%)
Similarity:	742/1613 - (46%)	Gaps:	295/1613 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VIVTRGDYIWIEP-----ASGREFDV-AIGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHAS 60
            |.:|.|.::|:|.     .||...:: ...|::|:|.|:.:..              .|.:::..
plant     5 VNITLGSHVWVEDPELAWISGEVTEIKGTNAKIVTANGKTVVA--------------SISSIYPK 55

  Fly    61 SVQ----GVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILP-IYTGDQIKLY 120
            ..:    ||:||..|..|||.|:|.||..|:..|.||||||:||:||||:|.|| :|:...::.|
plant    56 DTEAPPAGVDDMTKLAYLHEPGVLHNLDCRFALNEIYTYTGNILIAVNPFQRLPHLYSVHMMEQY 120

  Fly   121 KERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSW--- 182
            |....|||.||:||:.|.:|..|....:.|.|::||||||||||:||::::|||.:.|:...
plant   121 KGAAFGELSPHLFAVADTSYRAMINEARSQSILVSGESGAGKTETTKMLMRYLAFMGGRSDTEGR 185

  Fly   183 -IEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHS 246
             :|||:||:||:|||||||||::|:|||||||:::|.|...|.|.||.|..||||:||:...:..
plant   186 SVEQQVLESNPVLEAFGNAKTVKNNNSSRFGKFVEIQFDKRGKISGAAIRTYLLERSRVCQVSDP 250

  Fly   247 ERNYHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQ 311
            |||||.|| :|.....:|..:..:|....:.||...|.......|||.|:.:.|:||.::....:
plant   251 ERNYHCFY-MLCAAPPEEAKKFKVGDPRTFHYLNQTNCYEVSNVDDAREYLETRNAMDIVGIGQE 314

  Fly   312 EIWEIIKLLAALLHCGNIKY-KATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFA 375
            ....|.:::||:||.||:.: |....|:....:.....:::..|.||....:.:.|:|.:|.:..
plant   315 AQDAIFRVVAAILHLGNVNFIKGEEADSSKLRDDKSRYHLQTAAELLMCNEKMMEDSLCKRVIVT 379

  Fly   376 HGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQ 440
            ....:...|..:.:...|||..|.:|.|:|..||.|||::|.:. ..:::.||||||:|||:|..
plant   380 PDGNITKPLDPESAASNRDALAKTVYSRLFDWIVDKINSSIGQD-PDAKSLIGVLDIYGFESFKI 443

  Fly   441 NSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALID 505
            |||||.|||..||.|||.|.||:||:|||||..|.|||.::|||||||.||||..|...|:||:|
plant   444 NSFEQLCINLTNEKLQQHFNQHVFKMEQEEYTREEINWSYVEFVDNQDVLDLIEKKPGGIIALLD 508

  Fly   506 EEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPD 570
            |...|||.|.:|...|:::|:..||.:.|||. ..|:|.:||:||.|.|....|||||:|....:
plant   509 EACMFPKSTHETFAQKMYQTYKGHKRFSKPKL-AQTAFTVNHYAGDVTYSAEQFLDKNKDYVVAE 572

  Fly   571 LLHLVSQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNEL 635
            ...|:..|...|:..:| ..:...|..:.:..::.|:|::.|.|||:||::.:|.:|||:|||.:
plant   573 HQALLDASKCSFVANLF-PPLPEDASKQSKFSSIGTRFKQQLQALMETLNTTEPHYIRCVKPNAV 636

  Fly   636 KKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHRTDCQAATSR 700
            .||.:|:......|||..|::|.|||..||||.:..|.||::|:..|...||..  :|.::|.:.
plant   637 LKPGIFENDNVLNQLRCGGVLEAIRISCAGYPTKRAFDEFLDRFVMLATDVPEG--SDEKSACAS 699

  Fly   701 ICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAIT 765
            ||. .:|...||:|.||:||:......|:..|..||.....::||.||.::.|:.||..:.|.|.
plant   700 ICN-KMGLKGYQIGKTKIFLRAGQMAELDARRTEVLAGATKLIQRQIRTYLTRKEFLGQKRATIY 763

  Fly   766 VQRFWKGYAQRKRYRNMR--VGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGH- 827
            :|:.|:....||.|:|||  ...:.:|..||:......:..|:.....:|...|....|.::.|
plant   764 MQKLWRAKLARKLYQNMRREAASICIQKNIRAHRARKNYTKLQASATVIQTGLRTMSARNKHRHR 828

  Fly   828 -KMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQL---RKLEEQELLHRGNKHAREI-AEQH 887
             :..|.|.||...||......|:|    ||:....||.   .|:..:||.:. ...|||. |.:.
plant   829 RRTKAAIIIQREWRRHQVHEAYKK----HKKATLALQCLWRAKVARKELKNL-RMAARETGALKE 888

  Fly   888 YRDRLH----------ELERREIQEQLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLP 942
            .:|:|.          |||:.: :..||:.:..|: ..:.|:....||      ||.||....:.
plant   889 AKDKLEKRVEELTWRLELEKNQ-KADLEDAKAQEI-AKLQNNLTELQE------KLDEAYAAIIR 945

  Fly   943 DSSS------DAPTPHGGRETSVFNDLPHAQN-----VNQDDIIAPIHISEDEEDLSEFKFQKFA 996
            |..:      .||        .:..::|...|     :|..:....:.:::.:..:.||:.:.||
plant   946 DKEAAKLAIEQAP--------PIIKEVPVVDNTQLELLNSQNNELEVEVAKLKGKIKEFEVKCFA 1002

  Fly   997 ------ATYFQGN------VNHQYAKKALKHPLLPLHTQGDQLAAQALWI-TILRFTGDMPEPKY 1048
                  |:..:..      |..|...:.|...|..|.::...|..|||.. |.:...|::...|
plant  1003 LENDSRASVTEAEDAKSKAVEFQEIIERLHTNLSNLESENQVLRQQALAASTSVEEIGELNSLK- 1066

  Fly  1049 HTMDRMDTTSVMSKVTATLGR----------------------NFIRSKEFQEAQLMGLDPDAFL 1091
                  |..:::.....||.|                      |..::||.|..:    :|
plant  1067 ------DKVAILESENETLRRQTESAEKTMPPARVFASEKNLENEHQTKEIQATK----EP---- 1117

  Fly  1092 KQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQS---WL-----------QSRPTSN 1142
             :.|.::..|..|||.:::.  ..:|..:...||...|:.:|   |:           ::..|:.
plant  1118 -RNPINVLAKQGSLTDRQQE--SHEVLMKCLTDERRFDNEKSVAAWIVYKALLQWRLFEAEKTNI 1179

  Fly  1143 LEKLHFIIGHGILRA--ELRDEIYCQICKQL-------------TNNPL----KSSHAR--GWIL 1186
            .:::...|...|.:.  :.|:..|.......             |||..    :||||.  |.::
plant  1180 FDRIVHKIRSSIEKGQDDTRELAYWLTTSSTLLYLLQSTLKFSNTNNAASRRNRSSHATLFGRLV 1244

  Fly  1187 LSL------------------------CVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTF 1227
            ..:                        .|....|:..|..:|.|::.:   .|. ...::||:..
plant  1245 QGMQPSSVGLETSSGYSGMAGIPNDQQMVEAKYPALLFKQHLAAYVEK---TYG-MIRDKLKKEI 1305

  Fly  1228 N----------NGTR-----------------NQPPSWLELQATKSKKPIMLPITFMDGNTKTLL 1265
            |          ..||                 .|..|:::.|...:|..          :|.|.:
plant  1306 NPLLNLCIHAPRPTRAKTLRDVTKSIHLTTIAKQQASYVQWQNIVNKLE----------HTLTFM 1360

  Fly  1266 ADS---ATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGA 1327
            |::   :...|:|.:|:...|::  |...||   |..:.....|.|:::...:.:.||:..:...
plant  1361 AENHVPSMITRKLFHQVFSYINV--QLFNSL---LLRRECCSVSNGEYLKMGLHELEQWCLKADD 1420

  Fly  1328 QERNAPW---RLFFRKEIFAPWHEPTH---DQVATN----LIYQQVVR-GVKFGEYRCDKEEDLA 1381
            :...:||   :...:..:|...|:.|.   |::|..    |...||.| |..|.:   ||
plant  1421 EATRSPWDELQHIRQAVMFLVSHQKTQKSLDEIAKEICPVLSIPQVYRIGTMFWD---DK----- 1477

  Fly  1382 MIAAQQYFIEYSTD-------MSMERLFT------LLPNFIPDFCLSGVDKAI 1421
                      |.|.       ..|.:|.|      ..|:|:.|     ||.:|
plant  1478 ----------YGTQGLSPEVINQMRKLMTEDSANMTYPSFLLD-----VDSSI 1515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	281/674 (42%)
		MYSc_Myo7	77..721	CDD:276832	271/649 (42%)
		MyTH4	<1138..1245	CDD:214535	27/178 (15%)
		B41	1251..1467	CDD:214604	41/198 (21%)
		FERM_B-lobe	1355..1439	CDD:271216	20/85 (24%)
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
XIF	NP_001323600.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	530	1.000	Domainoid score	I63
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8405
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810