DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ck and PLEKHH3

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	XP_016880602.1	Gene:	PLEKHH3 / 79990	HGNCID:	26105	Length:	882	Species:	Homo sapiens

Alignment Length:	295	Identity:	73/295 - (24%)
Similarity:	120/295 - (40%)	Gaps:	60/295 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1153 GILRA-----ELRDEIYCQICKQLTNNPL---------KSSHARGWILLSLCVGC-FAPSEKFVN 1202
            |:|:.     .||||::.|:.|| |:.|.         ..:..|.|.||: |:.| |.|......
Human   378 GVLQTCRDLPALRDELFLQLAKQ-TSGPAGPPGLPATQDPAALRYWQLLT-CMSCTFRPGGAVRG 440

  Fly  1203 YLRAFIREGPPG--------YAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDG 1259
            :|...:......        ||.:..:.|.||..   |...||..|:.|...::.::..:.....
Human   441 HLLGHLERTEQALPDSELAEYARFIRKALGRTRG---RELVPSLAEISALSQRQELLCTVHCPGA 502

  Fly  1260 NTKTLLADSATTARELCNQLSDKISL-KDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAK 1323
            ....:..||.|||.|:..:|..::.| :.:..|:||.....:..:| :||..|.|.:::.|..|.
Human   503 GACAVAIDSHTTAGEVARELVGRLGLARSRNAFALYEQRGAQERAL-AGGTLVADVLTRFENLAA 566

  Fly  1324 EQGAQERNAP---WRLFFRKEIFAPWHEPTH------DQVATNLIYQQ----VVRGVKFGEYRCD 1375
            |:...| ::|   |||..|      .|.|.|      |......:::|    ::||      |..
Human   567 EEAGLE-DSPDSGWRLCLR------LHGPLHPEGLSPDGHELPFLFEQAHALLLRG------RPP 618

  Fly  1376 KEED----LAMIAAQQYFIEYSTDMSMERLFTLLP 1406
            ..:|    ||.:..|....::|..:.:.||..|||
Human   619 PPDDTLRALAALRLQSLQRDFSPRVPLPRLDRLLP 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580
		MYSc_Myo7	77..721	CDD:276832
		MyTH4	<1138..1245	CDD:214535	30/114 (26%)
		B41	1251..1467	CDD:214604	43/174 (25%)
		FERM_B-lobe	1355..1439	CDD:271216	14/60 (23%)
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
PLEKHH3	XP_016880602.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810