Protein Alignment ck and Myh10

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: XP_017453033.1
• Gene: Myh10 / 79433
• RGDID: 71000
• Length: 2007
• Species: Rattus norvegicus
• Alignment Length: 2225
• Identity: 559/2225 - (25%)
• Similarity: 934/2225 - (41%)
• Gaps: 525/2225 - (23%)

  Fly     5 TRGDY-----IWIEPASGREFDVAIGARVVSAEGRRIQVRDDDGDEVW--LAPERR--------I 54
            |:.|:     :|| |:....|:.|             .::::.||||.  ||...:        |
  Rat    26 TQADWTAKKLVWI-PSERHGFEAA-------------SIKEERGDEVMVELAENGKKAMVNKDDI 76

  Fly    55 KAMHASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKL 119
            :.|:......||||..|..|:||.:|.||..||...|||||:|...|.:|||:.||||:.:.|::
  Rat    77 QKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEM 141

  Fly   120 YKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSW-- 182
            |:.:|..|:||||:||.::||..|.:.|:||.|:.:|||||||||:||.::||||.::..|..
  Rat   142 YRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRK 206

  Fly   183 -----------------IEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKI 230
                             :|:|:|:||||||:||||||::|||||||||:|.|:|...|.|.||.|
  Rat   207 DHNIPQESPKPVKPQGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANI 271

  Fly   231 EQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAE 295
            |.|||||||.|.|...||.:|:||.:|:|.....||.|.|....:|::|:.| .|...|:.|...
  Rat   272 ETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNG-YIPIPGQQDKDN 335

  Fly   296 FSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLP 360
            |.:...||.::.||.:||..::|:::::|..|||.:|..  .|.|...:||:...:::..|||:.
  Rat   336 FQETMEAMHIMGFSHEEILSMLKVVSSVLQFGNISFKKE--RNTDQASMPENTVAQKLCHLLGMN 398

  Fly   361 IQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRN 425
            :.....|:....:....:.|....:::|:....:|..|..|.|:|..:|.:||.|:.:.:....:
  Rat   399 VMEFTRAILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGAS 463

  Fly   426 AIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDA 489
            .||:|||.|||.|:.|||||.||||.||.|||.|...:|.||||||..|.|.|..|:| :|.|..
  Rat   464 FIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPC 528

  Fly   490 LDLIAIKQLN---IMALIDEEARFPKGTDQTMLAKLHKTHGSHKNYLKP-----KSDINTSFGLN 546
            :|||. :..|   ::||:|||..|||.||:|.:.||.:..|||..:.||     |:|    |.:.
  Rat   529 IDLIE-RPANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKAD----FCII 588

  Fly   547 HFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIE------------------- 592
            |:||.|.|....:|.||.|..:.::..|:.||:::|:.:::..:|:
  Rat   589 HYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDEIQNIQRASFYDSVSGLHEPPV 653

  Fly   593 ----------------MGA--ETRK-RTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKP 638
                            .|:  :|:| ...|:...:::||..||.||.:..|.|:|||.||..|:.
  Rat   654 DRIVGLDQVTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRA 718

  Fly   639 MMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP-GVPPAHRTDCQAATSRIC 702
            ...|..|...|||.:|::|.|||.|.|:|.|..|:||.:||..|.| .:|.......||....|.
  Rat   719 GKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIR 783

  Fly   703 AVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLR---AAAI 764
            |:.|..:.|::|.:|:|.:......||:|||..:|..|:..|...||::.|:.|.:.:   :|..
  Rat   784 ALELDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALK 848

  Fly   765 TVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRG------HIVGLQAHARGYLVRR 823
            .:||....|.:.:.::..|| :.:::.|::   ::.:...|:.      .:...|....|.|...
  Rat   849 VLQRNCAAYLKLRHWQWWRV-FTKVKPLLQ---VTRQEEELQAKDEELLKVKEKQTKVEGELEEM 909

  Fly   824 EYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLR------KLEEQELLHRGNKHARE 882
            |..|:...      ..:.::|    .:|:.|.:.|||..::|      |.|.:|:||  :..:|
  Rat   910 ERKHQQLL------EEKNILA----EQLQAETELFAEAEEMRARLAAKKQELEEILH--DLESR- 961

  Fly   883 IAEQHYRDRLHELERREIQ-------EQLEN----RRRVEVNMNIINDAARKQEEPV-----DDG 931
            :.|:..|:::.:.|::::|       |||:.    |:::::.........:|.||.|     .:.
  Rat   962 VEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEVLLLEDQNS 1026

  Fly   932 KLV---EAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQ 993
            |.:   :.|.|.:.:.||..     ..|.....:|...:| .|:.:|:.:.....:|:.:..:.:
  Rat  1027 KFIKEKKLMEDRIAECSSQL-----AEEEEKAKNLAKIRN-KQEVMISDLEERLKKEEKTRQELE 1085

  Fly   994 KFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQA--LWITILR----FTGDMPEPKYHTMD 1052
            |              ||:.|......|..|..:|.||.  |.:.:.:    ..|.:......|:.
  Rat  1086 K--------------AKRKLDGETTDLQDQIAELQAQVDELKVQLTKKEEELQGALARGDDETLH 1136

  Fly  1053 RMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDV 1117
            :.:...|              ::|.| ||:..|..|.   :..::.|:|    ..|:|..|.|::
  Rat  1137 KNNALKV--------------ARELQ-AQIAELQEDF---ESEKASRNK----AEKQKRDLSEEL 1179

  Fly  1118 RRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNN------PL 1176
            .....:.|.|.|:..:..:.|.....|...       |:..|.||         |.|      .:
  Rat  1180 EALKTELEDTLDTTAAQQELRTKREQEVAE-------LKKALEDE---------TKNHEAQIQDM 1228

  Fly  1177 KSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLEL 1241
            :..||.....|         ||:.                    |:.||...|..:|:  ..||
  Rat  1229 RQRHATALEEL---------SEQL--------------------EQAKRFKANLEKNK--QGLE- 1261

  Fly  1242 QATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSD---KISLKDQFGFSLYIALFDKVSS 1303
               ...|.:...:..:    :.:.|:|....::|..|:.:   |:|..|:    |.:.|.:|.:.
  Rat  1262 ---TDNKELACEVKVL----QQVKAESEHKRKKLDAQVQELHAKVSEGDR----LRVELAEKANK 1315

  Fly  1304 LGSGGDHVMDAISQCE----QYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVV 1364
            |.:..|:|...:.:.|    ::||:....|.    :|...:|:.   .|.|..::..:...:|:
  Rat  1316 LQNELDNVSTLLEEAEKKGMKFAKDAAGLES----QLQDTQELL---QEETRQKLNLSSRIRQL- 1372

  Fly  1365 RGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDF---------CLSGVDKA 1420
                        ||:...:..||. .|.....::|:....|.:.:.|.         .:.|:::|
  Rat  1373 ------------EEEKNSLQEQQE-EEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIEGLEEA 1424

  Fly  1421 IERWAALVLQAYKKSYYVKD-KIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVII 1484
                         |...:|| :....:::|.:::|.|          .|..:|   .|.:....:
  Rat  1425 -------------KKKLLKDVEALSQRLEEKVLAYDK----------LEKTKN---RLQQELDDL 1463

  Fly  1485 AVNWTGVYVVDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLV 1549
            .|:      :|.|.|::..|          :|..|.|.|..:      ||....:..||: ||..
  Rat  1464 TVD------LDHQRQIVSNL----------EKKQKKFDQLLA------EEKGISARYAEE-RDRA 1505

  Fly  1550 VYFLDGLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQER 1614
                 ..:.|.|...||...||..:.......|:.                        ...|.|
  Rat  1506 -----EAEAREKETKALSLARALEEALEAKEEFER------------------------QNKQLR 1541

  Fly  1615 GDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPR-DRPHTLMEYALDHFRL 1678
            .|        :..|.....|:..  |:.|....:|        |:|.: :...|.:|...|..:
  Rat  1542 AD--------MEDLMSSKDDVGK--NVHELEKSKR--------ALEQQVEEMRTQLEELEDELQ- 1587

  Fly  1679 PPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSK-- 1741
                     .|..:|...|:   :...:||...|.||:::|..||   ....:||.:.:|.::
  Rat  1588 ---------ATEDAKLRLEV---NMQAMKAQFERDLQTRDEQNEE---KKRLLLKQVRELEAELE 1637

  Fly  1742 ------------RPRMGNEITDHIFDGPLKHEI-----LRDEIYCQLMK---QLTDNRNRMSEER 1786
                        :.:|..::.|      |:.:|     .|||:..||.|   |:.|.:..:.|.|
  Rat  1638 DERKQRALAVASKKKMEIDLKD------LEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEAR 1696

  Fly  1787 GWELMWLATGLFACSQ--------------GLLKELLLFLRTRRHPISQ---------------- 1821
            .     ....:||.|:              .|.:||....|.|||...:
  Rat  1697 A-----SRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIANSASGKS 1756

  Fly  1822 ---DSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNN 1883
               |...||:..|...:.:....|..:|.:..:    |.|.....||... |:.:...|....:|
  Rat  1757 ALLDEKRRLEARIAQLEEELEEEQSNMELLNDR----FRKTTLQVDTLNT-ELAAERSAAQKSDN 1816

  Fly  1884 ISQRLSLRTSEGFSLFVKIAD----------KVISVPEGDFFFDFVRHLTDWIKKARPIRDGANP 1938
            ..|:|..:..|   |..|:.:          ..||..|..     :..|.:.:::....|..||.
  Rat  1817 ARQQLERQNKE---LKAKLQELEGAVKSKFKATISALEAK-----IGQLEEQLEQEAKERAAANK 1873

  Fly  1939 QFTYQVFFMKKLWTNTVPGKDRNADLIFHYHQELPKLLRGYHKCSR--EEAAKLAALVFRVRFGE 2001
            ........:|:::.. |..:.|:||   .|.:::.|......:..|  |||.:.|     .|...
  Rat  1874 LVRRTEKKLKEIFMQ-VEDERRHAD---QYKEQMEKANARMKQLKRQLEEAEEEA-----TRANA 1929

  Fly  2002 NKQELQAIPQMLREL 2016
            ::::||      |||
  Rat  1930 SRRKLQ------REL 1938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	270/710 (38%)
		MyTH4	<1138..1245	CDD:214535	20/112 (18%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	19/104 (18%)
		B41	1251..1467	CDD:214604	38/232 (16%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	18/97 (19%)
		SH3	1560..1624	CDD:473055	9/63 (14%)
		MyTH4	1701..1849	CDD:214535	41/202 (20%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	20/106 (19%)
		B41	1856..2068	CDD:214604	37/173 (21%)
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myh10	XP_017453033.1	Myosin_N	31..76	CDD:460670	11/58 (19%)
		MYSc_Myh10	99..802	CDD:276952	270/710 (38%)
		Myosin_tail_1	879..1959	CDD:460256	248/1346 (18%)