DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and Myh10

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:XP_006534552.1 Gene:Myh10 / 77579 MGIID:1930780 Length:2007 Species:Mus musculus


Alignment Length:2217 Identity:558/2217 - (25%)
Similarity:932/2217 - (42%) Gaps:509/2217 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 TRGDY-----IWIEPASGREFDVAIGARVVSAEGRRIQVRDDDGDEVW--LAPERR--------I 54
            |:.|:     :|| |:....|:.|             .::::.||||.  ||...:        |
Mouse    26 TQADWTAKKLVWI-PSERHGFEAA-------------SIKEERGDEVMVELAENGKKAMVNKDDI 76

  Fly    55 KAMHASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKL 119
            :.|:......||||..|..|:||.:|.||..||...|||||:|...|.:|||:.||||:.:.|::
Mouse    77 QKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEM 141

  Fly   120 YKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSW-- 182
            |:.:|..|:||||:||.::||..|.:.|:||.|:.:|||||||||:||.::||||.::..|..  
Mouse   142 YRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRK 206

  Fly   183 -----------------IEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKI 230
                             :|:|:|:||||||:||||||::|||||||||:|.|:|...|.|.||.|
Mouse   207 DHNIPQESPKPVKPQGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANI 271

  Fly   231 EQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAE 295
            |.|||||||.|.|...||.:|:||.:|:|.....||.|.|....:|::|:.| .|...|:.|...
Mouse   272 ETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNG-YIPIPGQQDKDN 335

  Fly   296 FSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLP 360
            |.:...||.::.||.:||..::|:::::|..|||.:|..  .|.|...:||:...:::..|||:.
Mouse   336 FQETMEAMHIMGFSHEEILSMLKVVSSVLQFGNISFKKE--RNTDQASMPENTVAQKLCHLLGMN 398

  Fly   361 IQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRN 425
            :.....|:....:....:.|....:::|:....:|..|..|.|:|..:|.:||.|:.:.:....:
Mouse   399 VMEFTRAILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGAS 463

  Fly   426 AIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDA 489
            .||:|||.|||.|:.|||||.||||.||.|||.|...:|.||||||..|.|.|..|:| :|.|..
Mouse   464 FIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPC 528

  Fly   490 LDLIAIKQLN---IMALIDEEARFPKGTDQTMLAKLHKTHGSHKNYLKP-----KSDINTSFGLN 546
            :|||. :..|   ::||:|||..|||.||:|.:.||.:..|||..:.||     |:|    |.:.
Mouse   529 IDLIE-RPANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKAD----FCII 588

  Fly   547 HFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIE------------------- 592
            |:||.|.|....:|.||.|..:.::..|:.||:::|:.:::..:|:                   
Mouse   589 HYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDEIQTIQRASFYDSVSGLHEPPV 653

  Fly   593 ----------------MGA--ETRK-RTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKP 638
                            .|:  :|:| ...|:...:::||..||.||.:..|.|:|||.||..|:.
Mouse   654 DRIVGLDQVTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRA 718

  Fly   639 MMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP-GVPPAHRTDCQAATSRIC 702
            ...|..|...|||.:|::|.|||.|.|:|.|..|:||.:||..|.| .:|.......||....|.
Mouse   719 GKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIR 783

  Fly   703 AVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLR---AAAI 764
            |:.|..:.|::|.:|:|.:......||:|||..:|..|:..|...||::.|:.|.:.:   :|..
Mouse   784 ALELDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALK 848

  Fly   765 TVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRG------HIVGLQAHARGYLVRR 823
            .:||....|.:.:.::..|| :.:::.|::   ::.:...|:.      .:...|....|.|...
Mouse   849 VLQRNCAAYLKLRHWQWWRV-FTKVKPLLQ---VTRQEEELQAKDEELLKVKEKQTKVEGELEEM 909

  Fly   824 EYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLR------KLEEQELLHRGNKHARE 882
            |..|:...      ..:.::|    .:|:.|.:.|||..::|      |.|.:|:||  :..:| 
Mouse   910 ERKHQQLL------EEKNILA----EQLQAETELFAEAEEMRARLAAKKQELEEILH--DLESR- 961

  Fly   883 IAEQHYRDRLHELERREIQ-------EQLEN----RRRVEVNMNIINDAARKQEEPV-----DDG 931
            :.|:..|:::.:.|::::|       |||:.    |:::::.........:|.||.|     .:.
Mouse   962 VEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEVLLLEDQNS 1026

  Fly   932 KLV---EAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQ 993
            |.:   :.|.|.:.:.||..     ..|.....:|...:| .|:.:|:.:.....:|:.:..:.:
Mouse  1027 KFIKEKKLMEDRIAECSSQL-----AEEEEKAKNLAKIRN-KQEVMISDLEERLKKEEKTRQELE 1085

  Fly   994 KFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQA--LWITILR----FTGDMPEPKYHTMD 1052
            |              ||:.|......|..|..:|.||.  |.:.:.:    ..|.:......|:.
Mouse  1086 K--------------AKRKLDGETTDLQDQIAELQAQVDELKVQLTKKEEELQGALARGDDETLH 1136

  Fly  1053 RMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDV 1117
            :.:...|              ::|.| ||:..|..|.   :..::.|:|    ..|:|..|.|::
Mouse  1137 KNNALKV--------------ARELQ-AQIAELQEDF---ESEKASRNK----AEKQKRDLSEEL 1179

  Fly  1118 RRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNN------PL 1176
            .....:.|.|.|:..:..:.|.....|...       |:..|.||         |.|      .:
Mouse  1180 EALKTELEDTLDTTAAQQELRTKREQEVAE-------LKKALEDE---------TKNHEAQIQDM 1228

  Fly  1177 KSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLEL 1241
            :..||.....|         ||:.                    |:.||...|..:|:  ..|| 
Mouse  1229 RQRHATALEEL---------SEQL--------------------EQAKRFKANLEKNK--QGLE- 1261

  Fly  1242 QATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSD---KISLKDQFGFSLYIALFDKVSS 1303
               ...|.:...:..:    :.:.|:|....::|..|:.:   |:|..|:    |.:.|.:|.:.
Mouse  1262 ---TDNKELACEVKVL----QQVKAESEHKRKKLDAQVQELHAKVSEGDR----LRVELAEKANK 1315

  Fly  1304 LGSGGDHVMDAISQCE----QYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVV 1364
            |.:..|:|...:.:.|    ::||:....|.    :|...:|:.   .|.|..::..:...:|: 
Mouse  1316 LQNELDNVSTLLEEAEKKGIKFAKDAAGLES----QLQDTQELL---QEETRQKLNLSSRIRQL- 1372

  Fly  1365 RGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALV- 1428
                        ||:...:..||. .|.....::|:....|.:.:.|     ..|.::.....: 
Mouse  1373 ------------EEEKNSLQEQQE-EEEEARKNLEKQVLALQSQLAD-----TKKKVDDDLGTIE 1419

  Fly  1429 -LQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVY 1492
             |:..||......:....:::|.:::|.|          .|..:|   .|.:....:.|:     
Mouse  1420 SLEEAKKKLLKDVEALSQRLEEKVLAYDK----------LEKTKN---RLQQELDDLTVD----- 1466

  Fly  1493 VVDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLK 1557
             :|.|.|::..|          :|..|.|.|..:      ||....:..||: ||..     ..:
Mouse  1467 -LDHQRQIVSNL----------EKKQKKFDQLLA------EEKGISARYAEE-RDRA-----EAE 1508

  Fly  1558 KRSKYVIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGDFPAETV 1622
            .|.|...||...||..:.......|:.                        ...|.|.|      
Mouse  1509 AREKETKALSLARALEEALEAKEEFER------------------------QNKQLRAD------ 1543

  Fly  1623 YVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPR-DRPHTLMEYALDHFRLPPKRTMSK 1686
              :..|.....|:..  |:.|....:|        |:|.: :...|.:|...|..:         
Mouse  1544 --MEDLMSSKDDVGK--NVHELEKSKR--------ALEQQVEEMRTQLEELEDELQ--------- 1587

  Fly  1687 TLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSK---------- 1741
             .|..:|...|:   :...:||...|.||:::|..||   ....:||.:.:|.::          
Mouse  1588 -ATEDAKLRLEV---NMQAMKAQFERDLQTRDEQNEE---KKRLLLKQVRELEAELEDERKQRAL 1645

  Fly  1742 ----RPRMGNEITDHIFDGPLKHEI-----LRDEIYCQLMK---QLTDNRNRMSEERGWELMWLA 1794
                :.:|..::.|      |:.:|     .|||:..||.|   |:.|.:..:.|.|.     ..
Mouse  1646 AVASKKKMEIDLKD------LEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA-----SR 1699

  Fly  1795 TGLFACSQ--------------GLLKELLLFLRTRRHPISQ-------------------DSMHR 1826
            ..:||.|:              .|.:||....|.|||...:                   |...|
Mouse  1700 DEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIANSASGKSALLDEKRR 1764

  Fly  1827 LQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLR 1891
            |:..|...:.:....|..:|.:..:    |.|.....||... |:.:...|....:|..|:|..:
Mouse  1765 LEARIAQLEEELEEEQSNMELLNDR----FRKTTLQVDTLNT-ELAAERSAAQKSDNARQQLERQ 1824

  Fly  1892 TSEGFSLFVKIAD----------KVISVPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFF 1946
            ..|   |..|:.:          ..||..|..     :..|.:.:::....|..||.........
Mouse  1825 NKE---LKAKLQELEGAVKSKFKATISALEAK-----IGQLEEQLEQEAKERAAANKLVRRTEKK 1881

  Fly  1947 MKKLWTNTVPGKDRNADLIFHYHQELPKLLRGYHKCSR--EEAAKLAALVFRVRFGENKQELQAI 2009
            :|:::.. |..:.|:||   .|.:::.|......:..|  |||.:.|     .|...::::||  
Mouse  1882 LKEIFMQ-VEDERRHAD---QYKEQMEKANARMKQLKRQLEEAEEEA-----TRANASRRKLQ-- 1935

  Fly  2010 PQMLREL 2016
                |||
Mouse  1936 ----REL 1938

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 280/735 (38%)
MYSc_Myo7 77..721 CDD:276832 270/710 (38%)
MyTH4 <1138..1245 CDD:214535 20/112 (18%)
B41 1251..1467 CDD:214604 37/224 (17%)
FERM_B-lobe 1355..1439 CDD:271216 13/85 (15%)
FERM_C1_MyoVII 1461..1559 CDD:270019 18/97 (19%)
SH3 1560..1624 CDD:302595 9/63 (14%)
MyTH4 1701..1849 CDD:214535 41/202 (20%)
B41 1856..2068 CDD:214604 37/173 (21%)
FERM_M 1966..2068 CDD:278785 13/53 (25%)
FERM_C2_MyoVII 2064..2159 CDD:270020
Myh10XP_006534552.1 Myosin_N 33..72 CDD:397036 11/52 (21%)
MYSc_Myh10 99..802 CDD:276952 270/710 (38%)
Myosin_tail_1 879..1959 CDD:396244 247/1338 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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