DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and Myh7b

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	XP_017174700.1	Gene:	Myh7b / 668940	MGIID:	3710243	Length:	1947	Species:	Mus musculus

Alignment Length:	2156	Identity:	547/2156 - (25%)
Similarity:	878/2156 - (40%)	Gaps:	528/2156 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IWIEPASGREFDVAIGARV-VSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVEDMISLGD 73
            :|:..    |.|..:.|.| ..|.|.::.|...| .:|....|..::.|:......:|||..:..
Mouse    35 VWVPD----EQDAYVEAEVKTEATGGKVTVETKD-QKVLTVRETEMQPMNPPRFDLLEDMAMMTH 94

  Fly    74 LHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDN 138
            |:||.:|.||..||...:||||:|...|.:|||:.||:||...:..||.::..|.||||:|:.||
Mouse    95 LNEAAVLHNLRQRYARWMIYTYSGLFCVTINPYKWLPVYTAAVVAAYKGKRRSEAPPHIYAVADN 159

  Fly   139 AYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAIS------GKHS---------WIEQQIL 188
            ||..|.|.|::|.::|:||||||||.:||.::||.|.::      ||.:         .:|.||:
Mouse   160 AYNDMLRNRENQSMLITGESGAGKTVNTKRVIQYFAIVAALGDGPGKKAQFLATKTGGTLEDQII 224

  Fly   189 EANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVF 253
            ||||.:||||||||:||||||||||:|.|||...|.:..|.|:.|||||||::.|...||.|||:
Mouse   225 EANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPTGKLASADIDSYLLEKSRVIFQLPGERGYHVY 289

  Fly   254 YCILAGLSADEKSRLDLGM-AADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEII 317
            |.||:|...:.:..|.|.| ..||.:.:.|.: |.:..||..|......||.:|.||..|.....
Mouse   290 YQILSGKKPELQDMLLLSMNPYDYHFCSQGVT-TVDNMDDGEELIATDHAMDILGFSVDEKCACY 353

  Fly   318 KLLAALLHCGNIKYKATVVD---NLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGET 379
            |::.||||.||:|:|....:   ..|.||     :.::.|.|:|:....|:..|....:....|.
Mouse   354 KIVGALLHFGNMKFKQKQREEQAEADGTE-----SADKAAYLMGVSSGDLLKGLLHPRVRVGNEY 413

  Fly   380 VVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFK--PRGTSRNAIGVLDIFGFENFDQNS 442
            |....|.:|.|....|..|..|.|:|..:|.:||..:..  ||   :..||||||.|||.|:.||
Mouse   414 VTKGQSVEQVVFAVGALAKATYDRLFRWLVSRINQTLDTKLPR---QFFIGVLDIAGFEIFEFNS 475

  Fly   443 FEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMALIDE 506
            |||.|||:.||.|||||.||:|.||||||..|.|:|..|:| :|.|..:|||. |.|.|:::::|
Mouse   476 FEQLCINFTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDFGLDLQPCIDLIE-KPLGILSILEE 539

  Fly   507 EARFPKGTDQTMLAKLHKTH-GSHKNYLKPKSD----INTSFGLNHFAGVVFYDTRGFLDKNRDT 566
            |..|||.:|.:..|||:..| |...|:.:|:.|    ....|.:.|:||||.|...|:|:||:|.
Mouse   540 ECMFPKASDASFRAKLYDNHSGKSPNFQQPRPDKKRKYQAHFEVVHYAGVVPYSIVGWLEKNKDP 604

  Fly   567 FSPDLLHLVSQSTNKFLRQIF--------AQDIEMGA-ETRKRT---PTLSTQFRKSLDALMKTL 619
            .:..::.:..:|.|:.|..::        .:..:.|. |.||:.   .|:|...:::|:.||..|
Mouse   605 LNETVVPIFQKSQNRLLATLYENYAGSCSTEPPKSGVKEKRKKAASFQTVSQLHKENLNKLMTNL 669

  Fly   620 SSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP 684
            .:.||.|:|||.|||.|.|.:.|..|...|||.:|::|.|||.|.|:|.|..:.:|.:|||.|.|
Mouse   670 RATQPHFVRCIVPNENKTPGVMDSFLVLHQLRCNGVLEGIRICRQGFPNRLLYADFRQRYRILNP 734

  Fly   685 -GVPPAHRTDCQAATSRICAVVLGKSD-----YQLGHTKVFLKDAHDLFLEQERDRVLTRKILIL 743
             .:|.....|.:.||.::    ||..|     ||.||||||.|......||:.||:.|.:.:.:|
Mouse   735 SAIPDDTFVDSRKATEKL----LGSLDIDHTQYQFGHTKVFFKAGLLGILEELRDQRLAKVLTLL 795

  Fly   744 QRSIRGWVYRRRFLRL---RAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHL 805
            |...||.:.|..:.|:   |.|..|:|...:.:...|.:..|:: :.:::.|:||.........|
Mouse   796 QARSRGRLMRLEYQRMLGGRDALFTIQWNIRAFNAVKNWSWMKL-FFKMKPLLRSAQAEEELAAL 859

  Fly   806 RGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQ 870
            |..:.||    ||.|...|                   |.|                  ::|||.
Mouse   860 RAELRGL----RGALATAE-------------------AKR------------------QELEET 883

  Fly   871 ELLHRGNKHAREIAEQHYRDRLHELERR----------------EIQEQLENRRRVEVNMNIIND 919
            ::.....|:...:..|..:|.|.:.|.|                |:.|:||:..  |||.::
Mouse   884 QVSVTQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEAKVKELSERLEDEE--EVNADL--- 943

  Fly   920 AARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDE 984
            |||:::               |.|..           |.:..|:        ||:...:..:|.|
Mouse   944 AARRRK---------------LEDEC-----------TELKKDI--------DDLELTLAKAEKE 974

  Fly   985 EDLSEFKFQKFA---ATYFQGNVNHQYAKKAL----KHPLLPLHTQGDQLAAQA-LWITILRFTG 1041
            :..:|.|.:...   |...:..|.....||||    :..|..|..:.|:::|.| ..|.:.:...
Mouse   975 KQATENKVKNLTEEMAALDEAVVRLTKEKKALQEAHQQALGDLQAEEDRVSALAKAKIRLEQQVE 1039

  Fly  1042 DM-----PEPKYHTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHK 1101
            |:     .|.|.    ||||.....|:...|       |..||...........|::|.:....:
Mouse  1040 DLECSLEQEKKL----RMDTERAKRKLEGDL-------KLTQETVTDTTQDKQQLEEKLKKKDSE 1093

  Fly  1102 LVSLTLKRKNK--LGEDVRRRLQDDEYTADSYQSWLQSR--PTSNLEKLHFIIGHGILRAELRDE 1162
            |..|.|:.:::  :|..:::::::.:..|:..:..|::.  ..:.:||         .|||...|
Mouse  1094 LSQLNLRVEDEQLVGVQLQKKIKELQARAEELEEELEAERAARARVEK---------QRAEAARE 1149

  Fly  1163 IYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTF 1227
            :. ::.::|......|:..|        .||..             ||...|       ||:|..
Mouse  1150 LE-ELSERLEEAGGASAGQR--------EGCRK-------------REAELG-------RLRREL 1185

  Fly  1228 NNGT-----------RNQPPSWLEL------------QATKSKKPIMLPITFMDGNTKTLLADSA 1269
            ....           |.|..|..||            :..|.|..:.:.:..:..:.:| ||...
Mouse  1186 EEAVLRHEATVAALRRKQADSAAELSEQVDSLQRIRQKLEKEKSELRMEVDDLGASVET-LARGK 1249

  Fly  1270 TTARELCNQLSDKIS----------------------LKDQFGFSLYIALFDK---VSSLGSGGD 1309
            .:|.:||....|::|                      |:.:.| .|...|.:|   :|.|..|..
Mouse  1250 ASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTENG-ELGRLLEEKESMISQLSRGKT 1313

  Fly  1310 ------------------------HVMDAI-SQC----EQYAKEQGAQ--------ERN---APW 1334
                                    |.:.|: ..|    ||:.:|..||        :.|   |.|
Mouse  1314 SAAQSLEELRRQLEEESKAKGALAHAVQALRHDCDLLREQHEEESEAQAELQRLLSKANAEVAQW 1378

  Fly  1335 RLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSME 1399
            |..:..:......|....:....|..|:...||:....:|...|...:....:     |.|:::|
Mouse  1379 RSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTE-----SEDVTLE 1438

  Fly  1400 RLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVS--------YAK 1456
                             :::|....|||    .||..:::..:...:.:|:.:.        .|:
Mouse  1439 -----------------LERATSAAAAL----DKKQRHLERALEERRRQEEEMQRELEAAQREAR 1482

  Fly  1457 YKWPLLFS---------RFYEAYRNSGPNLPK--NDVIIAVNWTGVYVVD--------DQEQVLL 1502
            .....||.         ...|..:....||.:  :|:...|:.:|..:.:        :.|:..|
Mouse  1483 GLGTELFRLRHSHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKAKKALEGEKSEL 1547

  Fly  1503 ELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQ 1567
            :.:..|.......:..|.......||.|:.|.....:...|:..:|       .:...:.|.:||
Mouse  1548 QAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECTNL-------RRNHQRAVESLQ 1605

  Fly  1568 -----DYRAPSDGTSFLSFFKGDLIILE-------------------------DESCGESVLNNG 1602
                 :.||.::........:|||..||                         :|..|.
Mouse  1606 ASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQAMEAQAATRLLQAQLKEEQAGR------ 1664

  Fly  1603 WCIGRCDRSQ-------ERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLS--------- 1651
                  |..|       |:|........:   |:...:::.|.  :|:....|||:
Mouse  1665 ------DEEQRLAAELREQGQALERRAAL---LAAELEELRAA--LEQGERSRRLAEQELLEATE 1718

  Fly  1652 -----MASNGGAVEPRDRPHTLMEYALDHF----------RLPPKRTMSKTLTLSSKRSEELWRY 1701
                 .:.|.|.:..:.:    :|..|...          |...:....|.:|.::..:||| :.
Mouse  1719 RLNLLHSQNTGLLNQKKK----LEVDLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEEL-KK 1778

  Fly  1702 SRDP------IKAPL---LRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGP 1757
            .:|.      :|..|   :|:||::.|.||:|  |.....|.:..|.:|...:..|:     |..
Mouse  1779 EQDTSAHLERMKKTLEQTVRELQARLEEAEQA--ALRGGKKQVQKLEAKVRELEAEL-----DAE 1836

  Fly  1758 LKHEILRDEIYCQLMKQLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLRTRRHPIS-- 1820
            .|.       :.:.:|.:..:..|                       :|||:......|..::
Mouse  1837 QKK-------HAEALKGVRKHERR-----------------------VKELVYQTEEDRKNLARM 1871

  Fly  1821 QDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQI--FHKVYFPDDTDEAFEVDSSTRAKDFCNN 1883
            ||.:.:||..::..:|::.      ||.|..:|.:  :.|.        ..|:|.:....|....
Mouse  1872 QDLVDKLQSKVKSYKRQFE------EAEQQASTNLAKYRKA--------QHELDDAEERADMAET 1922

  Fly  1884 ISQRLSLRTSE 1894
            .:.:|..|:.:
Mouse  1923 QANKLRARSRD 1933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	288/713 (40%)
		MYSc_Myo7	77..721	CDD:276832	280/688 (41%)
		MyTH4	<1138..1245	CDD:214535	22/131 (17%)
		B41	1251..1467	CDD:214604	48/297 (16%)
		FERM_B-lobe	1355..1439	CDD:271216	15/83 (18%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	18/116 (16%)
		SH3	1560..1624	CDD:302595	16/100 (16%)
		MyTH4	1701..1849	CDD:214535	30/158 (19%)
		B41	1856..2068	CDD:214604	6/39 (15%)
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myh7b	XP_017174700.1	Myosin_N	32..71	CDD:367160	10/40 (25%)
		MYSc_Myh7b	98..773	CDD:276953	280/688 (41%)
		Myosin_tail_1	853..1930	CDD:366712	228/1313 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910