Protein Alignment ck and Myo3a

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_680779.4
• Gene: Myo3a / 667663
• MGIID: 2183924
• Length: 1613
• Species: Mus musculus
• Alignment Length: 1326
• Identity: 395/1326 - (29%)
• Similarity: 596/1326 - (44%)
• Gaps: 315/1326 - (23%)

  Fly    60 SSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERK 124
            ||::.|:|:.:|..|.|..:..:|...|..:.||.|.|.||:|:||:|.|.||:....:||...|
Mouse   335 SSLKDVDDLATLDVLDENTVSEHLEKCYSRDQIYIYVGDILIALNPFQSLGIYSTKLSRLYIGAK 399

  Fly   125 IGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGK--HSWIEQQI 187
            ....||||||:.|..|..|..|..|||||||||||||||||..|::|.|..: ||  :..::::|
Mouse   400 RTANPPHIFAMADLGYQSMVTYNADQCIVISGESGAGKTESAHLLVQQLTVL-GKANNRTLQEKI 463

  Fly   188 LEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHV 252
            |:.|.::||||||.||.||||||||||:::.|:::|.:.||:|.:|||||||::.|...|:|:|:
Mouse   464 LQMNNLVEAFGNACTIINDNSSRFGKYLEMKFTSSGAVVGAQISEYLLEKSRVIHQAIGEKNFHI 528

  Fly   253 FYCILAGLSADEKSRLDLGMAADYK---YLTGGNSITCEGRDD----AAEFSDIRSAMKVLLFSD 310
            ||.|.|||:  ||.:|.|....:.|   ||...|..|.:...:    .:::..|....||:.|:.
Mouse   529 FYYIYAGLA--EKKKLALYKLPENKPPRYLQNDNLRTVQDMMNNSFYKSQYELIEQCFKVIGFTM 591

  Fly   311 QEIWEIIKLLAALLHCGNIKYKATVVD-NLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLF 374
            :::..:..:|||:|:.|||::.:...: .:|.:.|..|..:|..|.||.:....|.:|||...:.
Mouse   592 EQLGSVYSVLAAILNVGNIEFSSVATEYQMDKSYICNHTALENSASLLCIQADELQEALTSHCVV 656

  Fly   375 AHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAI---FKPRGTSRNAIGVLDIFGFE 436
            ..|||::...:.:::.|||||..|.:|||:|..||..||:.:   ..|.|.....||:|||||||
Mouse   657 TRGETIIRPNTVEKAADVRDAMAKTLYGRLFSWIVNCINSLLKHDTSPSGDEELNIGILDIFGFE 721

  Fly   437 NFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIM 501
            ||.:|||||.|||.|||.:|.:|.||:|..||.||.:|.::.:.||:.||:..||:...|.:.::
Mouse   722 NFKRNSFEQLCINIANEQIQYYFNQHVFAWEQNEYLNEDVDARVIEYEDNRPLLDMFLQKPMGLL 786

  Fly   502 ALIDEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDT 566
            :|:|||:||||.||||::.|......| :.:.:||. :..|||::|:||.|.|...|||.|||||
Mouse   787 SLLDEESRFPKATDQTLIEKFEDNLKS-QYFWRPKR-MELSFGIHHYAGKVLYSASGFLAKNRDT 849

  Fly   567 FSPDLLHLVSQSTNKFLRQIF------------------------------------AQDIEMGA 595
            |..|::.|:..|.|..:||:.                                    .:|:...|
Mouse   850 FPTDIVLLLRSSENSVIRQLVNHPLTKTGNLPLSKTKNIVNYQMWNSEKSTNLTKGETRDVTCHA 914

  Fly   596 --ETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMET 658
              .|..:|.|:|:.||.||..|:..:...||.|:||||||..::...:|:.....|||.:|::||
Mouse   915 CETTNVKTQTVSSYFRYSLMDLLSKMVVGQPHFVRCIKPNNERQARKYDKEKVLLQLRCTGILET 979

  Fly   659 IRIRRAGYPIRHGFREFVERYRFLI------PGVPPAHRTDCQAATSRICAVVL---GKSDYQLG 714
            .||||.||..|..|..|::||..|.      |.|.|           ..||.:|   |..::.||
Mouse   980 ARIRRLGYSHRILFANFIKRYYILCYKSSEEPPVSP-----------DTCAAILEKAGLDNWALG 1033

  Fly   715 HTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRY 779
            .||||||..|...|...| :..|.|::::|.|:|.::..||:..|               |:||
Mouse  1034 KTKVFLKYYHVEQLNLMR-KEATNKLVLIQASVRAFLGARRYQEL---------------QQKR- 1081

  Fly   780 RNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIA 844
                                      :...|.:|:.||.:|:|: :|       |..|:|:....
Mouse  1082 --------------------------KSSAVIIQSAARRHLLRK-HG-------KETSNVKSAAG 1112

  Fly   845 MRRYRKLRLEHKQFAEVLQLRKLEEQELLHRGNKHAREIAEQHYRDRLHELERREIQEQLENRRR 909
                |.:|.:.::|                            .|:..........:::|.||
Mouse  1113 ----RSIRAKDQEF----------------------------DYKKNFETKRESFVKKQTEN--- 1142

  Fly   910 VEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSV--FNDLPHAQ----N 968
             .|..|..|.:....:|.              |.:...||.....:.|:|  .|...|.|    |
Mouse  1143 -AVPTNESNTSTPNNKES--------------PSAGKTAPFRAESKATNVESNNRRYHTQKKMSN 1192

  Fly   969 VNQDDIIAPIHISEDE-----------EDLSEFK-----------FQKFAATYFQGNVNHQYAKK 1011
            |..:.....::|.||.           :||.|.:           .|.:...|.:|: |.:.:|.
Mouse  1193 VYAEGQNQELYIVEDTWAEVSPRQKYVQDLEESRKMRKEEKGDAVIQSYCQWYTEGS-NFEESKA 1256

  Fly  1012 ALKHPLLPLHTQGDQLAAQALWIT---ILRFTGD---MPEPKYHTMDRMDTTSVMSKVTATLGRN 1070
            .    .|......::.:...||:|   .||.|.|   ..:..|...|..:....:|.||
Mouse  1257 T----CLEGRETWERTSCPGLWLTEEIYLRKTLDPTLSQKSVYQNADGKEKEHKVSVVT------ 1311

  Fly  1071 FIRSKEFQEAQLMGLDPD----AFLKQK-----PRS-IRHKLVSL-----TLKRKNKLGEDVRRR 1120
                   |.|.|..|:.|    .||.::     |:: ..||.||:     :.|:|.:||:|   |
Mouse  1312 -------QNAPLGNLERDYHLLGFLGEEDTGPVPQAQEEHKAVSIHSKYQSSKKKQQLGKD---R 1366

  Fly  1121 L----------------------------------------QDDEYTADSYQSW---LQSRPTSN 1142
            |                                        :.|...|...::|   :.||..|.
Mouse  1367 LAPPFKNQKILSSSTEVAKTTHNVYPCPTKQEGVHHSKMVDERDSKMASKKEAWDLAMFSRQISK 1431

  Fly  1143 LEKLHFIIG---HGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNYL 1204
            |.:.:||:.   :.|:.|:.....|..|.:....|...|:|                     .||
Mouse  1432 LSEEYFILQKNLNEIILAQQLKPFYLGIYRHKPINRHVSTH---------------------QYL 1475

  Fly  1205 RAFIR-EGPPGYAPYCEERLKRTFNN 1229
            ....: |.|....|....|..:|.||
Mouse  1476 SGVSKGEEPKILRPPRRPRKPKTLNN 1501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	273/703 (39%)
		MyTH4	<1138..1245	CDD:214535	21/96 (22%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612
		B41	1251..1467	CDD:214604
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myo3a	NP_680779.4	Protein Kinases, catalytic domain	2..287	CDD:473864
		MYSc_Myo3	352..1040	CDD:276830	273/703 (39%)
		MBD_Myo3a	1407..1454	CDD:439318	11/46 (24%)