Protein Alignment ck and Myo1c

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_001401097.1
• Gene: Myo1c / 65261
• RGDID: 620443
• Length: 1063
• Species: Rattus norvegicus
• Alignment Length: 908
• Identity: 328/908 - (36%)
• Similarity: 500/908 - (55%)
• Gaps: 96/908 - (10%)

  Fly    56 AMHASSVQGVEDMISLGDL-HEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKL 119
            |:.|....||:|.:.|.:. .||..:.||..|::|||||||.|.:||:||||:.|.|||...::.
  Rat    39 ALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYTRQHMER 103

  Fly   120 YKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLA---AISGKHS 181
            |:.....|:|||:||:.|..|..::..|:||.::|||||||||||:||.:||:.|   ....:..
  Rat   104 YRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGG 168

  Fly   182 WIEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHS 246
            .:..::|::||:|||||||||:|||||||||||:|:.|...|...|..|..|||||||:|.|||.
  Rat   169 AVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHG 233

  Fly   247 ERNYHVFYCILAGLSADEKSRLDLGMAAD---YKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLF 308
            |||:||||.:|.|  .:|::...||:..:   |.||..|........:|.:::..:|.|:.|:.|
  Rat   234 ERNFHVFYQLLEG--GEEEALRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALSVIDF 296

  Fly   309 SDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTL 373
            ::.|:.:::.::|::||.|||.:.|   |.....::.....::.:..|||:....|.:|||.|.:
  Rat   297 TEDEVEDLLSIVASVLHLGNIHFAA---DEDSNAQVTTENQLKYLTRLLGVEGTTLREALTHRKI 358

  Fly   374 FAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIF-----KPRGTSRNAIGVLDIF 433
            .|.||.::|.|:.:|:...|||..|.:|.|.|..:|||||.::.     .|...|...:|:|||:
  Rat   359 IAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVRKINRSLASKDAESPSWRSTTVLGLLDIY 423

  Fly   434 GFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQL 498
            |||.|..||||||||||.||.|||.|::...|.|||||..|.|.|:.:::.:|:...||:..|..
  Rat   424 GFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFK 488

  Fly   499 NIMALIDEEARFP-KGTDQTMLAKLHKTHGSHKNYLKPK-SDINT-------SFGLNHFAGVVFY 554
            .|::::|||...| :.||.|.|.||..|...|.::|..| :|..|       .|.|.|:||.|.|
  Rat   489 GIISILDEECLRPGEATDLTFLEKLEDTIKHHPHFLTHKLADQKTRKSLDRGEFRLLHYAGEVTY 553

  Fly   555 DTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTL 619
            ...||||||.|....:|...:..|||..:.|.|.:. |:  ..:||..|::|||:.||..|::.|
  Rat   554 SVTGFLDKNNDLLFRNLKETMCSSTNPIMAQCFDKS-EL--SDKKRPETVATQFKMSLLQLVEIL 615

  Fly   620 SSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP 684
            .|.:|.:|||||||:.|:|..||..|...|::|.|:||.:|:||||:..|..:..|::||:.|.|
  Rat   616 RSKEPAYIRCIKPNDAKQPGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRKYEAFLQRYKSLCP 680

  Fly   685 GVPPAHRTDCQAATSR----ICAVV--LG--KSDYQLGHTKVFLKDAHDLF-----LEQERDRVL 736
            ...|..       |.|    :..:|  ||  ..:|::|.||:|::....||     ||..|..:.
  Rat   681 ETWPVW-------TGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDSLEVRRQSLA 738

  Fly   737 TRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHR 801
            |:    :|.:.||:.:|::|||::.:||.:|.:|:|...|::....:.....::.|||..:|.|.
  Rat   739 TK----IQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFILRHA 799

  Fly   802 FR---------HLRGHIVGLQAHARGYL--VRREYGHKM----W----AVIKIQSHVRRMIAMR- 846
            .|         |:|          ..:|  :||:....:    |    ..::..|.:.|.:.|:
  Rat   800 PRCPENAFFLDHVR----------TSFLLNLRRQLPRNVLDTSWPTPPPALREASELLRELCMKN 854

  Fly   847 ---RY-RKLRLEHKQFAEVLQLRKLEEQELLHRGNK--HAREIAEQHYRDRL--HELERREIQ 901
               :| |.:..|.||     ||::......:.:|.|  :.:.:.......||  .|:..|.:|
  Rat   855 MVWKYCRSISPEWKQ-----QLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTEEISPRVLQ 912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	273/671 (41%)
		MyTH4	<1138..1245	CDD:214535
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612
		B41	1251..1467	CDD:214604
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020
Myo1c	NP_001401097.1	MYSc_Myo1	62..718	CDD:276829	272/670 (41%)
		IQCG	751..781	CDD:467744	10/29 (34%)
		Myosin_TH1	874..1055	CDD:461801	7/39 (18%)