DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and myo15ab

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:XP_021331574.1 Gene:myo15ab / 570113 ZFINID:ZDB-GENE-090312-149 Length:4355 Species:Danio rerio


Alignment Length:2746 Identity:670/2746 - (24%)
Similarity:1043/2746 - (37%) Gaps:943/2746 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 VRDDDGDE--VWLAPERRIKAMHASSVQ------GVEDMISLGDLHEAGILRNLLIRYKENLIYT 94
            |.|.:|:.  .|......|:::...|.:      |.|||..:..|.|..:|.||.||:.:.||||
Zfish  1926 VPDREGEPRGTWYDKMYSIRSLPTVSYRVKRKGDGTEDMTQMEQLTEPAVLINLKIRFDQELIYT 1990

  Fly    95 YTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESG 159
            |.|||||:|||||:..||..|.:..|:...:.:.|||:|||.:.||..|...:|:|||:||||||
Zfish  1991 YIGSILVSVNPYQLFNIYGTDMVLQYEGHAMADNPPHLFAIANVAYTTMMDIKQNQCIIISGESG 2055

  Fly   160 AGKTESTKLILQYLAAISGKHSWIEQ-QILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANG 223
            :||||:|||:|:||.||..|.:..:| :||||.|:||:||||||:||||||||||:::| |...|
Zfish  2056 SGKTEATKLVLRYLTAIHHKRNITQQIEILEATPLLESFGNAKTVRNDNSSRFGKFVEI-FLEEG 2119

  Fly   224 VIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCE 288
            ||.||...||||||||||.|...|||||:||.:||||.:..|....|..|..|.||..|.:....
Zfish  2120 VISGAITSQYLLEKSRIVFQAKDERNYHIFYEMLAGLPSHTKRAFYLQEAETYYYLNQGGNCGIT 2184

  Fly   289 GRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERV 353
            |:||..:|..::|||.:|.||.::...|.::|:::||.||:.:.....:..:...:.....:..|
Zfish  2185 GKDDGEDFRRLQSAMDILHFSTEDQSSIFRVLSSILHLGNVFFHRVETEVQETAGVVSTQEIRAV 2249

  Fly   354 AGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFK 418
            |.||.:..:.|..|:|.:...|..|.:.:.||.:.:||.|||..|.:|..:|..:..:||..:: 
Zfish  2250 ADLLQISPEGLQKAITFKVTEAMREKIYTPLSVESAVDARDAVAKILYSLLFNWLTDRINGRVY- 2313

  Fly   419 PRGTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF 483
            ||..:. :|.:|||:|||:...|||||.|||||||.||.||.:.|||.|||||..|.|||:.:.|
Zfish  2314 PRNEAL-SISLLDIYGFESLVFNSFEQLCINYANETLQFFFSKIIFKQEQEEYIREQINWKELTF 2377

  Fly   484 VDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHF 548
            .|||..:|||:.|...::.::|:::.||:.||.|.|.|.|..||::..|.|||..: ..|.:.|:
Zfish  2378 TDNQACIDLISAKPHGLLRILDDQSCFPQATDNTFLQKCHYHHGNNPLYSKPKMPL-PEFTVYHY 2441

  Fly   549 AGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIEM-----GAETRKRT------- 601
            ||.|.|....|||||.|....::|.|..||.|:.:..:|.:..||     ||..|..|       
Zfish  2442 AGRVTYQVHKFLDKNFDQVRQEVLDLFMQSQNRTVSNLFIKHSEMLNQQKGAMNRSSTVTRRYQP 2506

  Fly   602 PTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGY 666
            .|::.:|::||..|:..:..|.|||:||||||..|:|.:||..|...||||||:::|||||:.||
Zfish  2507 STVAAKFQQSLQELLDKMERCNPFFVRCIKPNNNKEPGIFDPELVATQLRYSGILDTIRIRKEGY 2571

  Fly   667 PIRHGFREFVERYRFLIPGV---PPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFL 728
            |||..|.:|:.||:.|: |:   ||:...:|....:::|.:  .|.|||:|.:|:|||:.....|
Zfish  2572 PIRVPFHKFLNRYKALL-GMKKPPPSDGDNCVMMLTKLCPI--NKGDYQVGVSKLFLKEEVYQLL 2633

  Fly   729 EQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALI 793
            |.:||||:....|.|||.:|.:..||:||:.|.....:|...||:..|:|:..||:..:|.:|:|
Zfish  2634 ESKRDRVMHIAALTLQRYVRMFFARRKFLKFRLTMTHLQAHCKGFMARQRFLRMRINLIRHRAMI 2698

  Fly   794 RSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQF 858
              |::.:|.|::|                                                    
Zfish  2699 --RLIVNRKRYIR---------------------------------------------------- 2709

  Fly   859 AEVLQLRKLEEQELLHRGNKHAREIAEQHYRDRLHELERREIQEQLENRRRVEVNMNIINDAARK 923
            ..||..|:.||                          |||.::.:..:|..|.|...:|      
Zfish  2710 INVLLARRAEE--------------------------ERRRLELERISREVVNVTQLVI------ 2742

  Fly   924 QEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFND---LPHAQNVNQD-DIIAPIHISEDE 984
               |.:.|.|::|              ..||||.  .:|   |..|..:..| .:..|:      
Zfish  2743 ---PAELGGLLQA--------------TAGGRER--HSDCLALVQAPRIQTDPQLTLPL------ 2782

  Fly   985 EDLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQA--LWITILRFTGDMPEPK 1047
             |::.....|:..|:|: .:........|::.|..|.   |.|...|  ::|.||||.||     
Zfish  2783 -DINNHLMTKYIRTHFR-ELLFGMLTAPLENSLTRLE---DDLKQDAVDVFILILRFMGD----- 2837

  Fly  1048 YHTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNK 1112
                                                                   .:|...::|.
Zfish  2838 -------------------------------------------------------PNLNGAQENL 2847

  Fly  1113 LGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLK 1177
            .|                                ::||..|:....:||||..||..|:..|...
Zfish  2848 FG--------------------------------NYIIQRGLATPPIRDEILAQIANQVWRNENS 2880

  Fly  1178 SSHARGWILLSLCVGCFAPSEKFVNYLRAFIRE-GPPGYAPYCEERLKRTFN------NGTRNQP 1235
            .:..|||:|::.|:..||||||...||..|:.: ...|:...|:.:|.:...      ..:|..|
Zfish  2881 RNAERGWLLMAACLSSFAPSEKMEKYLLKFVSDYALNGFKALCQHKLLQAMQKSYLVPEASRTYP 2945

  Fly  1236 PSWLELQATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSDK--ISLKDQFGFSL----- 1293
            ||.||..||:.|..::|.:...||.:......|.|....|...:...  :|.:.::|:|:     
Zfish  2946 PSLLEWTATRKKAHMVLQVHCFDGVSFLCPVHSWTNGEGLAGDVLQHRGVSAESRWGWSVLMKEP 3010

  Fly  1294 ----------YI----------------------------------------------------- 1295
                      |:                                                     
Zfish  3011 AQWVELEGHDYVLDLVCDLELLPDFPKQKTYFIISTEDPSKARPNASISLFGSGFDEDEDGPLSY 3075

  Fly  1296 ---------------------------------------ALFDKVSS------------------ 1303
                                                   :|||.|.|                  
Zfish  3076 ANRMSAVPTNSLPISEGHYSLDSEPSYDATQRGMDRYLDSLFDPVLSDAAGDFDASVLSGRMKGG 3140

  Fly  1304 LGSGGD----------------------------------------------------------- 1309
            .|.|||                                                           
Zfish  3141 GGVGGDEAQHTAKVTPLAALQPGAVRVLPPMPPMPGSPIMPSLPAVPPVPVPDQQHAVLAQQQQT 3205

  Fly  1310 ----------------------------------------------------------------- 1309
                                                                             
Zfish  3206 ILNQQAVIMAQQMTMQAMAMVTSPVSSPPMSPLTSPPTSPPPTPYSTLPPSPYPAIPPSPYANIP 3270

  Fly  1310 ----------------------------------------------------------------- 1309
                                                                             
Zfish  3271 PSPYAPMSAYSSPPVTPTQTFASTPNYNASSETLKKKSSPPNTQPRSNTKTQATPSKGSLGKKQA 3335

  Fly  1310 -------------------------------------------------HVMDAISQCE------ 1319
                                                             ::.|.|.|.:      
Zfish  3336 PAAPIKLDSRPAKRHAPVAVTGPMRSTPAPGTEVVKYSVSNSEHIVPSHNIKDIIKQYQTPTPEP 3400

  Fly  1320 -----------------------QYAKEQ------------------------------------ 1325
                                   |..|.|                                    
Zfish  3401 APLKQKRDGKGFVKKKNPHDEAMQILKTQMDNPPPPQRHAPTPAAVSRDEGLKPTKSSKKKAPEP 3465

  Fly  1326 --------------------------GAQER----NAPWRLFFRKEIFAPWHEPTHDQVATNLIY 1360
                                      |.:|.    |.||:::.|||:|.|.....| .:..:||:
Zfish  3466 PLTLPPPVSRDLPVETESIQTPLHRSGTEEHYTYTNVPWKIYLRKEVFYPKDSWNH-LLVLDLIF 3529

  Fly  1361 QQVVRGVKFGE--YRCDKEEDLAMIAA-QQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIE 1422
            :|:|... |.|  .|..|||...|.:. .||.||.:||:..|                       
Zfish  3530 KQIVNDT-FTEACVRITKEERQKMKSLFAQYGIEPNTDVQDE----------------------- 3570

  Fly  1423 RWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVN 1487
                                   .:|:.:::.|:..|.:.|||.:.|..:.|..:.    ::||:
Zfish  3571 -----------------------SVKKTVIAAARESWEIYFSRLFPASGSVGTGVQ----VLAVS 3608

  Fly  1488 WTGVYVV---------DDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAE 1543
            .||:.::         .|..:||...|:.:|..|:....|.:   .|:|   ..|:....|..|.
Zfish  3609 HTGIKLLKTVKSSTAAPDYFRVLRPYSYLDILFVTIPSPNML---EFNL---MNEKLILFSAKAP 3667

  Fly  1544 DIRDLVVYFLDGLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLIIL-------EDESCGESVLNN 1601
            .|:.:|..|:..|||.|:||:|.:::  .::..|.|:|.|||:|.|       |.:|.|..|...
Zfish  3668 QIKQMVDLFISHLKKDSEYVVAERNF--ITEDRSLLNFHKGDIIRLQAMDGLEEGQSYGCVVKKK 3730

  Fly  1602 --------------GWCIGRCD-RSQERGDFPAETVYVLPT---LSKP------PQD-------- 1634
                          ||..|... ||   |.||.|.|..:..   |..|      |:|        
Zfish  3731 VIYLEELKRGTPDFGWRYGAVQGRS---GAFPMECVVPVAAPDFLGLPAERRDEPRDRQGRVAAS 3792

  Fly  1635 ---ILALFNIEEAHHGRRLSMASNG----GAVEPR-----DRPHTLMEYALDHFRLPPK------ 1681
               .||:.:...||. ...|:.|:|    |..|..     |..:.::|:|..:||....      
Zfish  3793 GAIALAVASTAAAHE-LDPSLESDGFGDFGDSEAEGNVVLDSQYNMVEFARKYFRTSDGSKSDSF 3856

  Fly  1682 RTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEE-----ACFAFAAILKYMGDLPSK 1741
            |..||. ...||...|:.:::::||       |:|..:|.:.     |...|.||:|:|||.|  
Zfish  3857 RDKSKK-GKGSKDPAEMVKFNKNPI-------LESLIDFTDPNMNRVASEIFLAIMKFMGDHP-- 3911

  Fly  1742 RPRMGNEITDHIFDGPLK----HEILRDEIYCQLMKQLTDNRNRMSE--ERGWELMWLATGLFAC 1800
               :..:....:....||    :.:::||.|||::||:|.|.:...:  ::||.|:::.|..:.|
Zfish  3912 ---LRGQSEQFVVCTFLKLTGEYGLMKDEAYCQVLKQITANTSSKPDSCQKGWRLLYILTAFYRC 3973

  Fly  1801 SQGLLKELLLFLR-------TRRHPISQDSMHRLQKTIRHGQRKYPPHQVEVEAI---QHKTTQI 1855
            |:.|...||.|||       ...|.|::.....|:||.:.|.|...|..:|::||   :....|:
Zfish  3974 SEVLKPFLLKFLRDVCRSPEVHFHGIAKTCEQNLRKTFQFGGRSVYPSSMELKAIMAGRSSKRQL 4038

  Fly  1856 FHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEG---FSLFVKIADKVISVPEGDFFFD 1917
            |   .||...:...::.:.:.|.|....:...::|:..|.   :::|:                 
Zfish  4039 F---LFPGGIERHLKIKTCSVALDVIEELCYEMALQRLEAMDEYTVFI----------------- 4083

  Fly  1918 FVRHLTDWIKKARPIR----------DGANPQFTYQVFFMKKLWTNTVPGK-DRNADLIFHYHQE 1971
                :|:..:..||:.          :.......|..:|.:.:|.:  |.| |....:..||:|.
Zfish  4084 ----VTNRGQNVRPLNKREYILDIATEAEQIDANYSFWFRRVIWAH--PLKFDNELCVTMHYNQV 4142

  Fly  1972 LPKLLRG------YHKCSRE---EAAKLAALVFRVRFGENKQELQAIPQM--LRELIPSDIMKIQ 2025
            ||..|:|      ..|.|.:   :.||||||..|.     |..|.. |.:  |.|.||.:|...|
Zfish  4143 LPDYLKGLLNIVPQGKISEQQFNQFAKLAALQHRA-----KDSLYT-PTIHELMEYIPVEIFGRQ 4201

  Fly  2026 STSEWKRSIVASYNQDGGMTSEDAKVAFLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHG 2090
            ...:|.:.:....:....:....|:..||.:|..:|.|||:||.::.::........::|:|::|
Zfish  4202 IPQQWMQLVAQHVHAVQSLNPHQARSQFLGLVCAFPMFGSSFFYIQSSSNNTISAPCILAVNQNG 4266

  Fly  2091 VSLIHPVTKDILVTHPFTRISNW-----SSGNT--YFHMTIGNLVRGSKLLCETSLGYKMDDLLT 2148
            :..:|..|.::.|.....::.:.     |:|::  |..:.||:|........:...|.::..::.
Zfish  4267 LHFLHKDTHEVQVKVQLKQVQSAHTQRPSAGSSYPYVDVLIGDLTNHRVTQLQLEQGLELCRVIA 4331

  Fly  2149 SYISLMLTNMNKNRTI 2164
            .:|..||:...|..|:
Zfish  4332 MHIENMLSVREKRLTL 4347

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 300/684 (44%)
MYSc_Myo7 77..721 CDD:276832 290/659 (44%)
MyTH4 <1138..1245 CDD:214535 35/113 (31%)
B41 1251..1467 CDD:214604 60/678 (9%)
FERM_B-lobe 1355..1439 CDD:271216 18/86 (21%)
FERM_C1_MyoVII 1461..1559 CDD:270019 26/106 (25%)
SH3 1560..1624 CDD:302595 26/85 (31%)
MyTH4 1701..1849 CDD:214535 48/168 (29%)
B41 1856..2068 CDD:214604 51/236 (22%)
FERM_M 1966..2068 CDD:278785 34/112 (30%)
FERM_C2_MyoVII 2064..2159 CDD:270020 20/101 (20%)
myo15abXP_021331574.1 Atrophin-1 <546..799 CDD:331285
Atrophin-1 <719..1317 CDD:331285
FtsK <1119..>1705 CDD:332908
Motor_domain 1974..2626 CDD:328930 290/658 (44%)
MyTH4 2808..2955 CDD:214535 51/241 (21%)
SH3 3686..3765 CDD:327375 25/83 (30%)
MyTH4 3875..4028 CDD:214535 46/164 (28%)
FERM_B-lobe 4137..4234 CDD:271216 29/102 (28%)
FERM_C_MyoXV 4240..4341 CDD:270022 20/100 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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