Protein Alignment ck and myo10l1

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: XP_001924041.3
• Gene: myo10l1 / 566674
• ZFINID: ZDB-GENE-080425-1
• Length: 2041
• Species: Danio rerio
• Alignment Length: 2398
• Identity: 620/2398 - (25%)
• Similarity: 1000/2398 - (41%)
• Gaps: 607/2398 - (25%)

  Fly     7 GDYIWIEPASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWL----APERRIKAMHASSVQGVED 67
            |..:|:     ...|..:.:.|.|.....:.:..|.|:.|:|    ....::.|||.||:.||||
Zfish     8 GSRVWV-----NHKDQLLPSTVNSCGDGNLVLTTDYGEVVYLQQAEVNREKVSAMHQSSIDGVED 67

  Fly    68 MISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPY-QILPIYTGDQIKLYKERKIGELPPH 131
            |.:|.:||||.|:.||..||:::.|||..||||.||||| ||..:|....::||.:..:||||||
Zfish    68 MSTLAELHEAAIMHNLHQRYQKDNIYTNIGSILAAVNPYKQIKGLYDLSAVELYSQHHLGELPPH 132

  Fly   132 IFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAIS---------GKHSWIEQQI 187
            ||||.:..|..:.:....||::|||||||||||||||:||:|:.:|         .|.:.:||.|
Zfish   133 IFAIANECYRCLWKRHDSQCVLISGESGAGKTESTKLLLQFLSVMSQNSAGTPPTEKSTRVEQAI 197

  Fly   188 LEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHV 252
            ::::||:||||||||:.|:|||||||:|.:|||.:|.|:|..|..|||||:|:|.||..|||||:
Zfish   198 VQSSPIMEAFGNAKTVYNNNSSRFGKFIQLHFSQSGNIQGGCIVDYLLEKNRVVRQNPGERNYHI 262

  Fly   253 FYCILAGLSADEKSRLDLGMAAD-YKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEI 316
            ||.:|||.|..||....|..:.: :.||:....:.....||...|.|:..|:||:.|:::||.::
Zfish   263 FYALLAGASKSEKETYFLEDSPELFHYLSQSGCVKDRSLDDKKLFDDVMEALKVMEFTEEEIRDM 327

  Fly   317 IKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVV 381
            .|||:.:|..||:::.......:...::     |..|:.||||....|.:.||:|::...||.:.
Zfish   328 FKLLSGVLQLGNVEFMTAGGAQITTKQV-----VTNVSELLGLDCFQLSEVLTQRSMILRGEEIC 387

  Fly   382 STLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSR-NAIGVLDIFGFENFDQNSFEQ 445
            |.|:.:|::|.||:....:|.:.|..|:.:||..|   :|... .:||:|||||||||:.|.|||
Zfish   388 SPLTVEQAIDSRDSVAMALYSQCFSWIIMRINQKI---KGKDNFKSIGILDIFGFENFEVNRFEQ 449

  Fly   446 FCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARF 510
            |.||||||.||::|.:|||.|||.|||.|.|:|:.|:::||.:.||||. |:|.::||::||:||
Zfish   450 FNINYANEKLQEYFNKHIFSLEQLEYNREGIHWEAIDWMDNAECLDLIE-KKLGMLALVNEESRF 513

  Fly   511 PKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLV 575
            |||||.|:|.|||..|.::..|:||:. .:..||:.|:||.|.||.||.|:||||||..|:|:::
Zfish   514 PKGTDFTLLEKLHGRHSTNPYYVKPRL-ADHQFGIKHYAGEVLYDVRGILEKNRDTFRDDILNML 577

  Fly   576 SQSTNKFLRQIFAQ--------DIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKP 632
            ..|...|:..:|.|        .::||  |.::.||:|:|||.||.:||.|||...|||:|||||
Zfish   578 KDSRLDFIYDLFEQVSSRNNEETLKMG--TARKKPTVSSQFRDSLHSLMATLSVSNPFFVRCIKP 640

  Fly   633 NELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLI----PGVPPAHRTD 693
            |..|.|..||..:...|||||||:||::|||||:|:|..|::|..||:.::    .....::..|
Zfish   641 NMDKTPNKFDPEVVLNQLRYSGMLETVKIRRAGFPVRRTFKDFFTRYKIILKEKEKAAVASNGDD 705

  Fly   694 CQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLR 758
            .:.:|..:......|.::|.|.||||||:..:..||::||.|.::..||::..:..::.|:.|.:
Zfish   706 KKKSTDLLTIHDKTKKEWQFGKTKVFLKETLEQKLEKQRDEVRSKAGLIIRAYLLRYIARKDFKK 770

  Fly   759 LRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRR 823
            ...:.:|:|         |.||.                                     :|.||
Zfish   771 ALESIVTIQ---------KNYRT-------------------------------------HLYRR 789

  Fly   824 EYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQELLHRGNKHAR-EIAEQH 887
            .:..|..|.:.:|.|.|..:|....||||.|.|: .|..:.:|.||||....|::..: |..::.
Zfish   790 RFQRKRSAALVLQKHRRGQVARGVCRKLRDEKKK-REEEERKKKEEQEKKTEGDREKKNEEEDEA 853

  Fly   888 YRDRLHELERREIQEQLENRRRVEVNMNIINDAA-------------RKQEEPVDDGKL---VEA 936
            ...|..|.:.|:::|.|...|.:|:......|:.             |:..|.:...|.   |..
Zfish   854 ESPRTVEEDTRQMEEILRLEREIEILQKKREDSVSTLCESSKQELRLRRDAEVLRQKKAASRVAT 918

  Fly   937 MFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFK-------FQK 994
            .|..|.|:......|...::.:     ..:....::::....|..|:...|.||.       .|:
Zfish   919 EFLELLDTGGPEVIPGDPKQAA-----SRSATATEEEVDEGFHAEEECIPLPEFPPPAEGPVDQE 978

  Fly   995 FAAT-------YFQGNVNHQYAKKALK-------------HPLLPLHTQGDQ------------- 1026
            ..||       :.:|.|    |..|..             .|.||..|:.::
Zfish   979 ILATLPPPPAAFAEGTV----APSAPNVPPGAPPPPSPPPPPPLPGETKKEEGKPEEAKTDKEVD 1039

  Fly  1027 --------------LAAQALWITILRFTGDMPEPKYHT-------MDRMDTTSVMSKVTATLGRN 1070
                          .||::|        .|..||.|..       .|:.|.....|.:.||.|.:
Zfish  1040 GKKEGEDVDRTSRLTAAESL--------PDTEEPIYSVPGDGESDYDQDDLEDGQSSIAATDGEH 1096

  Fly  1071 FIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEY--TADSYQS 1133
            ..:|.....:|                                 |...|  ..|.|  :.|.:..
Zfish  1097 ARKSTCTNASQ---------------------------------ESYNR--SSDSYAESDDEHDG 1126

  Fly  1134 WLQSRPTSNLEKLHFIIGHG--------ILRA-----------ELRDEIYCQI-CKQLTNNPLKS 1178
            ::.:....:..|::.:.|:|        .::|           .|:||.:... .||   ..|||
Zfish  1127 YVDTDEEVSNGKVNILNGNGPPYFHSYLYMKAGLMIPWRRRWCVLKDETFMWFRSKQ---ESLKS 1188

  Fly  1179 SHARGWILLSLCVGCFAPSEKFVNY-LRAFI-REGPPGYAPY-CEERLKRTFNNGTRNQPPSWLE 1240
                || |.....|....|.:  |: :|.|: |:....|... .||:||.|            ::
Zfish  1189 ----GW-LYKKGGGLSTLSRR--NWKMRWFVLRDSKLMYFENDSEEKLKGT------------ID 1234

  Fly  1241 LQATKS-----KKPIMLPITFMDGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDK 1300
            ::|.|.     :|...|.|. .|..|..:.|:|.                :|..|:
Zfish  1235 IRAAKEIVDNHEKENALNIV-TDERTYQVFAESP----------------EDASGW--------- 1273

  Fly  1301 VSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVR 1365
                       ...:|:....:.||                :....||..:.:.|...:...::.
Zfish  1274 -----------FTMLSRVHNASPEQ----------------LLEMSHEQANPKNAVGTLDVGLID 1311

  Fly  1366 GVKFGEYRC-----DKEEDLAMIAAQQYFIEYSTDM--SMERLFTLLPNFIPDFCLSGVDKAIER 1423
            .|      |     |:.....:|.|.: .|..::|:  .|....:||.....|....|.:..:..
Zfish  1312 SV------CASDNPDRPNSFVIITANR-VIHCNSDLPEEMHHWISLLQKPKGDSKSDGQEFLVRG 1369

  Fly  1424 WAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNW 1488
            |....::|..||       :.||:|:        :|.:|.....:.|::|..|..|...::..:.
Zfish  1370 WLHKEMKAGAKS-------SALKLKK--------RWFVLTHNSLDYYKSSERNASKMGTLVLNSL 1419

  Fly  1489 TGVYVVDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFL 1553
            ..  ||..:|:...|..:..|.....:.:.:::|:.
Zfish  1420 CS--VVQPEEKKFKETGYWNIIVHGRKHSYRLYTKL----------------------------- 1453

  Fly  1554 DGLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGDFP 1618
              |.:..::|.|:|                             .|::|              ..|
Zfish  1454 --LNEAMRWVSAIQ-----------------------------GVIDN--------------KVP 1473

  Fly  1619 AETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKRT 1683
            .||         |.|.::.  :|:|        .:.|..|||...|.:.::
Zfish  1474 IET---------PTQQLIR--DIKE--------NSVNSEAVEQMYRRNPIL-------------- 1505

  Fly  1684 MSKTLTLSSKRSEELWRYSRDPIKAPL-----------LRKLQSKEEFAEEACFAFAAI--LKYM 1735
                            ||::.|:.:||           |||.:......:||...|.::  ::.:
Zfish  1506 ----------------RYTQHPLHSPLLPLPYGEVSDSLRKEKGYGSLQDEAVKIFNSLQEMEIV 1554

  Fly  1736 GDLPSKRPRMGNEITDHIFDGPLK--HEI--LRDEIYCQLMKQL--TDNRNRMSEERGWELMWLA 1794
            .|..:            |..|.|:  |::  ||||:||||:||.  ....|..:....|.|:...
Zfish  1555 SDPVA------------IIQGILQTCHDLRPLRDEVYCQLIKQTNHVPQPNSPANRAHWHLLTCM 1607

  Fly  1795 TGLFACSQGLLKELLLFLR--TRRHPISQDSMH------RLQKTIRHGQRKYPPHQVEVEAI--- 1848
            :..|..|:.:|:.|...|:  ..|:|.::...:      .|:||   ..|:|.|.|.|:.|:
Zfish  1608 SCTFLPSRAILRYLRFHLKRVRERYPGTEIEKYAHFIGESLKKT---KAREYVPSQEEIAALLIR 1669

  Fly  1849 QHKTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEG-FSLFV--KIADKVIS-- 1908
            |..||    .||..........::|.|.|.:....:.:.|::..|.. ||||.  |:..:.|.
Zfish  1670 QEMTT----TVYCHGGGSCKISINSHTTAGEVVEKLIRGLAMENSRNMFSLFEHNKVESRAIESR 1730

  Fly  1909 VPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFFMKKLWTNTVPGKDRNADLIFHYHQELP 1973
            |...|....|.| ||.        .:....:..::::|....:.:.........:..|.:.|...
Zfish  1731 VIVADVLAKFER-LTG--------SEEEEEEGPWRLYFKLYCFLDVESMPKEGVEFAFMFEQAHE 1786

  Fly  1974 KLLRGYHKCSREEAAKLAAL---------------------VFRVR---FGENKQELQAIP---- 2010
            .|:.|:.....|....||||                     |.|:|   |...|.....:|
Zfish  1787 SLISGHFPAPEETLQHLAALRLQYIHGDVARTPWSLSSVYPVGRLRTRIFQSTKAGGAGVPGAGM 1851

  Fly  2011 -----------------QMLRELIPSDIMKIQSTSE--------------WKRSIVASYNQDGGM 2044
                             ..||....:..:|.|...|              ...|::..:::..||
Zfish  1852 VGPGGHTLERRKTNFLDGTLRRSFKTGSLKKQRVEEEHMLEMFVKEEMSATLTSVLEKWSRLQGM 1916

  Fly  2045 TSEDAKVAFLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSLIHPVTKDILVTHPFTR 2109
            ....|.:.::.::..||.:||..|:| :..|..:|..|.:.::...||:........|.|..:..
Zfish  1917 PQHQAMLNYMTVIKEWPGYGSTLFDV-ECKEGGFPHDLWLGVSAENVSVYKRGEPKPLETFQYEH 1980

  Fly  2110 ISNWSSGNTYFHMTIGNLVRGSKLLCETSLGYKMDDLLTSYISLMLTNMNKNRTIRAN 2167
            |..:.:...   .|...:|...::..|||...::..::.:||::::.......:|.:|
Zfish  1981 IVFFGAPQP---STYKIIVDEREMFFETSQVGEITKIMKAYINMIVKKRCSIMSITSN 2035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	298/667 (45%)
		MyTH4	<1138..1245	CDD:214535	28/129 (22%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	11/97 (11%)
		B41	1251..1467	CDD:214604	35/222 (16%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	12/97 (12%)
		SH3	1560..1624	CDD:473055	8/63 (13%)
		MyTH4	1701..1849	CDD:214535	44/177 (25%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	20/101 (20%)
		B41	1856..2068	CDD:214604	48/275 (17%)
		FERM_C2_MyoVII	2064..2159	CDD:270020	19/94 (20%)
myo10l1	XP_001924041.3	SH3_19	7..58	CDD:465815	10/54 (19%)
		MYSc_Myo10	77..733	CDD:276840	298/667 (45%)
		MYO10_CC	861..911	CDD:465249	8/49 (16%)
		PH-like	1153..>1184	CDD:473070	6/33 (18%)
		PH2_MyoX	1187..1288	CDD:270108	31/172 (18%)
		PH3_MyoX-like	1353..1478	CDD:270109	30/224 (13%)
		MyTH4	1561..1665	CDD:459939	31/106 (29%)
		FERM_F1_Myosin-X	1669..1765	CDD:340726	23/108 (21%)
		B41	1676..1940	CDD:214604	48/272 (18%)
		FERM_C_MyoX	1936..2024	CDD:270023	19/91 (21%)