DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and myo7bb

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:XP_021322875.1 Gene:myo7bb / 566034 ZFINID:ZDB-GENE-070912-482 Length:2189 Species:Danio rerio


Alignment Length:2277 Identity:1009/2277 - (44%)
Similarity:1431/2277 - (62%) Gaps:225/2277 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MVIVTRGDYIWIEPASGREFDVAIGARV-VSAEGRRIQVRDDDGDEVWLAPE---RRIKAMHASS 61
            ||::.:||::|||.:.|    |.||..| :|..|:...: ||:|.|..: ||   ..:|.||.:|
Zfish     1 MVMLKKGDHVWIESSIG----VPIGGYVKISGSGQYCLI-DDEGKEHSI-PEGDRAALKPMHPTS 59

  Fly    62 VQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIG 126
            |:||:|||.||||.|||:||||.:|:|:.:||||.||:|||:|||::|||||.||::.|..||:|
Zfish    60 VEGVDDMICLGDLSEAGLLRNLFLRHKQGIIYTYIGSVLVAMNPYEMLPIYTADQVQQYHGRKLG 124

  Fly   127 ELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSWIEQQILEAN 191
            |||||||||.|:.|.:|:|.:::||.:||||||||||||||||||:|||:||:||||||||::||
Zfish   125 ELPPHIFAIADSCYFNMRRNKRNQCCIISGESGAGKTESTKLILQFLAAVSGQHSWIEQQIIQAN 189

  Fly   192 PILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCI 256
            |||||||||||||||||||||||::|.|:..||||||.:|||||||||:..|...|||||:|||:
Zfish   190 PILEAFGNAKTIRNDNSSRFGKYVEIFFNKAGVIEGAHMEQYLLEKSRVCHQALQERNYHIFYCM 254

  Fly   257 LAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLA 321
            |||:.:|.|..|.||.|:::.|||.|:.:||:|||||.||:.||||:|||.|:|::.|||.||||
Zfish   255 LAGMQSDHKKTLSLGDASEFNYLTEGDCLTCDGRDDADEFARIRSALKVLTFTDRDCWEIFKLLA 319

  Fly   322 ALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSR 386
            |:||.|||.:::|:::|:|:.::....:...:|.||.:....|..:||.|:...:.|.|...||.
Zfish   320 AILHMGNIDFQSTIMNNMDSCDVLSSSHFSVIAKLLEVDDAALDKSLTHRSFMTNREMVTKPLSS 384

  Fly   387 DQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPR----GTSRNAIGVLDIFGFENFDQNSFEQFC 447
            :|:.|:||||.|.:|||:||.:..|||:||.||:    ..:|.:||:|||||||||.||||||.|
Zfish   385 EQATDIRDAFAKALYGRLFVWMFTKINSAIHKPQTDEPSYTRQSIGLLDIFGFENFPQNSFEQLC 449

  Fly   448 INYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPK 512
            ||:|||:||||||:|:|||||:||..|.|:|:.|.|.|||..|||:|:|.|||:||||||:.|||
Zfish   450 INFANEHLQQFFVRHVFKLEQDEYTKEGISWKRIAFNDNQKTLDLLALKPLNILALIDEESHFPK 514

  Fly   513 GTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQ 577
            |||.|||.||.:.|..:|.|:..:.|....||:.||||:|:||..|||:|||||.|.|:|.|:.:
Zfish   515 GTDATMLNKLSQEHKGNKLYISSRGDHRIHFGVQHFAGLVYYDCEGFLEKNRDTVSMDILELIRK 579

  Fly   578 STNKFLRQIFAQDIEMGA----------------------ETRKRTPTLSTQFRKSLDALMKTLS 620
            |:||.|:|||.::|.:.:                      |:|::..|||.|||:|||:|||.||
Zfish   580 SSNKLLKQIFEKEINVNSVKNSNKMNKAVMTPKNSLRQVNESRRQISTLSGQFRQSLDSLMKALS 644

  Fly   621 SCQPFFIRCIKPNELKKPM-----------------------------MFDRGLCCRQLRYSGMM 656
            .||||||||.|||:.|.||                             :|:|.||.:|||||||:
Zfish   645 LCQPFFIRCFKPNDKKLPMVSIHFNITYILSSCEDAFKMTFSLYFPHQVFNRELCMQQLRYSGML 709

  Fly   657 ETIRIRRAGYPIRHGFREFVERYRFLI------PGVPPAHRTDCQAATSRICAVVLGKSDYQLGH 715
            ||||||:.||||||.|::|:.|||.|:      |...||.:  |.||..|  .::..:.|:::|.
Zfish   710 ETIRIRKLGYPIRHTFKDFLHRYRALLKSIDCDPNTEPAAK--CCAAICR--TLIKDEEDWKIGK 770

  Fly   716 TKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYR 780
            |||||:..||.:||.||.:.|.||.||:||.:.....|:.|:..|.||:.:|:.|:||.:::.:.
Zfish   771 TKVFLRGHHDTYLELERAQELYRKALIIQRVMLAHKDRKNFINKRKAALVLQKNWRGYKEKRDFC 835

  Fly   781 NMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAM 845
            .::.|:.||||.:|||.|...:...|...:.||...||.|.|:|...|..|||.:|:..|.::|.
Zfish   836 TVKQGFARLQAKVRSRKLHEEYMRRRAAAIVLQTQTRGLLARKELKSKKEAVILLQAQTRGLLAR 900

  Fly   846 RRYRKLRLEHKQFAEVLQLRKLEEQELLHRGNKHAREIAEQHYRDRLHELERREIQEQLENRRRV 910
            :                .|::::.:|.|....|.|:|:|....:.||.||.|:.           
Zfish   901 K----------------SLKRMKSEEFLTAQEKQAQELAALELQQRLEELLRKN----------- 938

  Fly   911 EVNMNIINDAARKQEEPVDDGKLVEAMFDFLPD--SSSDAPTPHGGR------------------ 955
                   .:.|:.|..  :|.::||.:|:|||.  :..:.|.|.|..                  
Zfish   939 -------EETAKSQNN--EDEEMVENIFNFLPTAIAGQEGPAPEGFEEFEAEPAKLEEVELIESP 994

  Fly   956 --ETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKALKHPLL 1018
              ||.|.: :|.:...:|      :...|:||:..||.|.|||:.:|||...|.|.::.|:.|||
Zfish   995 VVETKVMS-IPESSEDHQ------VKEEEEEEEDDEFSFSKFASLHFQGASTHSYIQQRLRQPLL 1052

  Fly  1019 PLHTQGDQLAAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLM 1083
            ....:||.||...:|..||||.||:||||...:..|     ...:...||:...|    :.:.|:
Zfish  1053 YHEDEGDTLACLTVWWIILRFMGDLPEPKQERVSAM-----ADPIQRNLGQRQAR----RLSNLV 1108

  Fly  1084 GLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSWLQS----------- 1137
            ||| ..||::|            :|::...|:.....:.::| ..:..:|.:::           
Zfish  1109 GLD-QKFLRKK------------MKQQKGGGKRKHSAIPEEE-PEEEPKSQMEAVQEEQVVLFGE 1159

  Fly  1138 -----RPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPS 1197
                 ||.:.|||||.|:|:.|:|.::|||||||||||||.|..:.|..|||||||:|:|.|:|:
Zfish  1160 GPTFDRPMTPLEKLHIIVGYAIVRPDIRDEIYCQICKQLTGNKNRKSVNRGWILLSICLGIFSPT 1224

  Fly  1198 EKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTK 1262
            |:...||::|||.||..|:.||.|||:||..||.||:||.|:|||:.::|.||.:.:..|||...
Zfish  1225 ERLTKYLQSFIRCGPSEYSAYCAERLRRTLANGERNEPPCWVELQSVENKNPIGVAVGLMDGRNI 1289

  Fly  1263 TLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGA 1327
            :|..|||:|:.|:|..:|...:|:|.||||||.|:::|:.|||||..|::||:|.|||..|.||.
Zfish  1290 SLTVDSASTSAEVCTAISQNTNLQDSFGFSLYAAMYEKMWSLGSGSQHILDAVSMCEQEEKRQGR 1354

  Fly  1328 QERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEY 1392
            :|::|||||:||||||.|||:.:.||::|.|||:|::.|:|.|||..|||:|...:||:.|::::
Zfish  1355 EEQHAPWRLYFRKEIFTPWHDCSSDQISTELIYRQIIHGLKNGEYLSDKEDDYVQLAAKHYYVQH 1419

  Fly  1393 STDMSMERLFTLLPNFIPDFCLSGV---DKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSY 1454
            .::.|:|    :....:.| |::..   :|::.:...||..|:.:..|:.......|:|.:.|.|
Zfish  1420 GSESSLE----IAQKIVRD-CMNMTIIENKSLVKLVQLVNSAHTQGPYINTNTPVYKVKSETVEY 1479

  Fly  1455 AKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFPEIT---AVSSQK 1516
            |:.|||:.||:.|||...|||::|::..::.|||.||:..|:.|...|:||:||::   .||..:
Zfish  1480 AQQKWPIHFSKLYEAQVISGPSVPQDQFVVVVNWKGVFFQDETEGEFLQLSYPEVSRIEIVSEDR 1544

  Fly  1517 TNKVFTQT-----FSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAPSDGT 1576
            :..:...|     :.|..|:|:|..          :||..|:.|||:||.|.:|:||.....|.|
Zfish  1545 SGGLVCLTTPKGMYELKIVKGKELV----------ELVNMFISGLKERSMYAVAIQDLSRQEDPT 1599

  Fly  1577 SFLSFFKGD-LIILEDESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFN 1640
             .||:.:|| |.|::|   ||..|..||...|.:|:.:.|....:.:.:||.|::|.::.|.|.|
Zfish  1600 -LLSYRRGDVLYIIKD---GEYSLEEGWIKARNERTSQTGAVSLDAIQILPMLTRPTEETLNLLN 1660

  Fly  1641 IEEAHHGRRLSMASNGGAVEPRDRPH-TLMEYALDHFRLPPKRTMSKTLTLSSKR----SEELWR 1700
            :..|.....:.:......:......| ||.|::.|:||.|..         ..:|    .|:||.
Zfish  1661 LSPARRKSVMPVLPQKEELSTERVAHMTLKEFSFDYFRDPVN---------EGRRGKGGKEKLWA 1716

  Fly  1701 YSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRD 1765
            .|::|:|.||:|.||...|....|..:|.||||||||.|.|..|...::|:.||.....|..|||
Zfish  1717 NSKEPLKQPLIRNLQGNSELCHLASDSFTAILKYMGDYPVKHVRTPIDLTNQIFGPATAHVELRD 1781

  Fly  1766 EIYCQLMKQLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLRTR-RHPISQDSMHRLQK 1829
            |||||:|||:|:|||.:|.||||:|:||..|||..||.||:....||.:| |.|::...:.|:|.
Zfish  1782 EIYCQIMKQMTNNRNGLSMERGWQLLWLCCGLFPPSQLLLRHAQRFLESRPREPLASACLQRMQA 1846

  Fly  1830 TIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSE 1894
            .:....||.|||||||:|||:.:|||||||:||:||.|.|||.::||.||.|.||::.|.|.:.|
Zfish  1847 MLSIEGRKLPPHQVEVDAIQNNSTQIFHKVHFPNDTSEIFEVTTTTRIKDLCRNIAKDLRLSSPE 1911

  Fly  1895 GFSLFVKIADKVISVPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFFMKKLWTNTVPGKD 1959
            |:|||||.:.||.|:...::|||.:|.|||..||.:.:|:.......|.|.||:|||.|.:||||
Zfish  1912 GYSLFVKTSTKVESMNSEEYFFDNLRQLTDVTKKGKKVREATPTIVPYLVLFMRKLWFNVIPGKD 1976

  Fly  1960 RNADLIFHYHQELPKLLRGYHKCSREEAAKLAALVFRVRFGENKQELQAIPQMLRELIPSDIMKI 2024
            ..|||:||:.|||||.|||||..|:|:...|..|:||.|...:|.:...||:||:||:|:|..||
Zfish  1977 ITADLMFHFPQELPKYLRGYHSVSKEDMIALGGLLFRTRVDADKSQFVMIPRMLKELVPADQQKI 2041

  Fly  2025 QSTSEWKRSIVASYNQDGGMTSEDAKVAFLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKH 2089
            .:..:||:.|:.|||:..||:.::||:.|||.|..|||||.||||||||:|.|||.:::|:|:|.
Zfish  2042 MTAEDWKKHIINSYNKQAGMSVDEAKLQFLKTVSPWPTFGCAFFEVKQTSEKNYPSVIMISISKQ 2106

  Fly  2090 GVSLIHPVTKDILVTHPFTRISNWSSGNTYFHMTIGNLVRGSKLLCETSLGYKMDDLLTSYISLM 2154
            |:|||:..||::|..|.|::|::||||:|||||||||||:|:.||||||.|||:.|||:||.:|.
Zfish  2107 GISLINSKTKEVLAAHLFSKITSWSSGSTYFHMTIGNLVQGNTLLCETSQGYKISDLLSSYKNLY 2171

  Fly  2155 LT 2156
            ::
Zfish  2172 VS 2173

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 397/729 (54%)
MYSc_Myo7 77..721 CDD:276832 381/704 (54%)
MyTH4 <1138..1245 CDD:214535 63/106 (59%)
B41 1251..1467 CDD:214604 89/218 (41%)
FERM_B-lobe 1355..1439 CDD:271216 26/86 (30%)
FERM_C1_MyoVII 1461..1559 CDD:270019 34/105 (32%)
SH3 1560..1624 CDD:302595 22/64 (34%)
MyTH4 1701..1849 CDD:214535 73/148 (49%)
B41 1856..2068 CDD:214604 106/211 (50%)
FERM_M 1966..2068 CDD:278785 50/101 (50%)
FERM_C2_MyoVII 2064..2159 CDD:270020 57/93 (61%)
myo7bbXP_021322875.1 MYSc_Myo7 75..776 CDD:276832 381/704 (54%)
ERM 855..>997 CDD:330563 39/177 (22%)
MyTH4 1176..1270 CDD:307090 55/93 (59%)
B41 1279..1492 CDD:214604 89/217 (41%)
PH-like 1486..1582 CDD:327399 34/105 (32%)
SH3 1583..1635 CDD:327375 21/55 (38%)
MyTH4 1718..1866 CDD:214535 73/147 (50%)
B41 1873..2085 CDD:214604 106/211 (50%)
FERM_C2_MyoVII 2081..2176 CDD:270020 57/93 (61%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D21221at33208
OrthoFinder 1 1.000 - - FOG0001409
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.720

Return to query results.
Submit another query.