Protein Alignment ck and myo5ab

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: XP_009296049.3
• Gene: myo5ab / 565267
• ZFINID: ZDB-GENE-050411-72
• Length: 1800
• Species: Danio rerio
• Alignment Length: 1691
• Identity: 471/1691 - (27%)
• Similarity: 746/1691 - (44%)
• Gaps: 398/1691 - (23%)

  Fly    64 GVEDMISLGDLHEAGILRNLLIRYKEN-LIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGE 127
            |..|:.:|..|||..:|.||.:|:.:: |||||.|.||||:|||:.||||..|.|..|..:.:|:
Zfish    70 GENDLTALSYLHEPAVLHNLRVRFTDSKLIYTYCGIILVAINPYESLPIYGSDIINAYSGQNMGD 134

  Fly   128 LPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAI--SGKHSWIEQQILEA 190
            :.|||||:.:.||..|.|..::|.|::|||||||||.|.|..::|.|.:  |...:.:|:::|.:
Zfish   135 MDPHIFAVSEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVSESSDDASVEEKVLAS 199

  Fly   191 NPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYC 255
            |||:||||||||.||||||||||||:|.|.....|.||.:..|||||||:|.|...|||||:||.
Zfish   200 NPIMEAFGNAKTTRNDNSSRFGKYIEIGFDRKHHIIGANMRTYLLEKSRVVFQASEERNYHIFYQ 264

  Fly   256 ILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLL 320
            :.|.....|...|.||.|.|:.|...|.|....|.:|..|....|.|..:|..::.....:.::|
Zfish   265 LCACAHLPEFKPLKLGSADDFPYTNQGGSPVIVGVNDLKEMQATRKAFSLLGITEAHQMGLFQIL 329

  Fly   321 AALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLS 385
            :|:||.||::.|.....:...::  |:.:::....|..:..:.:...|..:.|....||:...::
Zfish   330 SAILHLGNVEVKERGSSSCSISD--ENGHLDMFCDLTEVSNESMAHWLCHKKLKTATETLNKPVT 392

  Fly   386 RDQSVDVRDAFVKGIYGRMFVHIVRKINTAI---FKPRGTSRNAIGVLDIFGFENFDQNSFEQFC 447
            |.::|:.|||..|.||.::|..||.::|.|:   .||    .:.||||||:|||.|:.|||||||
Zfish   393 RLEAVNGRDALAKHIYAKLFSWIVSQVNKALSTSSKP----HSFIGVLDIYGFETFELNSFEQFC 453

  Fly   448 INYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPK 512
            ||||||.|||.|..|:||||||||..|.|.|..|:|.|||..::||..| :.::.|:|||...||
Zfish   454 INYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIEAK-MGLLDLLDEECTMPK 517

  Fly   513 GTDQTMLAKLHKTH---GSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHL 574
            |:|.:...||:.||   .||  :.||:.. |.:|.:.|||..|.|...|||:||:||.:.:.:::
Zfish   518 GSDDSWAQKLYNTHLKKSSH--FEKPRMS-NKAFIILHFADKVEYQCDGFLEKNKDTVNEEQINV 579

  Fly   575 VSQSTNKFLRQIFAQDIE---------------MGAET---RKRTPTLSTQFRKSLDALMKTLSS 621
            :..|....|.::| ||.|               .|..|   |:...::..|||.||..||:||::
Zfish   580 LKASKFSLLLELF-QDEESPAAPNTTASSGRAKFGRSTQSFREHKKSVGLQFRNSLHLLMETLNA 643

  Fly   622 CQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLI--P 684
            ..|.::||||||::|.|.|.|.....:|||..|::|||||..||:|.|..::||..||:.|:  .
Zfish   644 TTPHYVRCIKPNDVKAPFMMDPHRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYQVLMTKK 708

  Fly   685 GVPPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRG 749
            .:....:..||:...|:   |..|..||.|.||:|.:.....:||:.|...|....:.:|::||.
Zfish   709 EILLDRKLTCQSVLERL---VQNKDKYQFGKTKIFFRAGQVAYLEKLRADKLRTACIHIQKTIRC 770

  Fly   750 WVYRRRFLRLRAAAITVQRFWKG-------------------------YAQRKRYRNMRVGYMRL 789
            |:.|:::||:|.||||:|::.:|                         :|.|::|...:...:.:
Zfish   771 WLARKKYLRIRQAAITLQKYTRGHQARCLCKTLRRTRAAVVFQKNTRMWAARRQYLRQKTAAVLI 835

  Fly   790 QALIRSRVLSHRFRHL--RGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLR 852
            |.::|.......::.|  ....:.:|...||:|.|..|.....||:.:|..||||:|.|..:||:
Zfish   836 QRILRGYTARLEYKRLVCEHKALLIQRWVRGFLARWRYRRIKRAVVYLQCCVRRMLARRELKKLK 900

  Fly   853 LEHKQFA-----------EVLQL-RKLEEQELLHRGNKHAREIAEQ------H---YRDRLH--- 893
            :|.:...           :::|| |||:||   |:.|   ||::||      |   ..::||
Zfish   901 IEARSVEHYKKLNYGMENKIMQLQRKLDEQ---HKEN---RELSEQIGAIESHSVVELEKLHVQL 959

  Fly   894 --------ELERRE-----IQEQLE-NRRRVEVNMNIINDAARK----QEEPVDDGKLVEAMFDF 940
                    |...||     :||:|| .||.:|.|..::.:...|    :.|..:..:|::.....
Zfish   960 KTLQEAEEEARHREDLVTSLQEELELVRRELEKNKEMVVELNEKNTMLKSEKEEMNRLIQEQEQQ 1024

  Fly   941 LPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVN 1005
            :.:.|                      .|..:|:...:....:||   .|::|.....:.:  :.
Zfish  1025 IREKS----------------------EVTNEDVTENLQTQLNEE---RFRYQNLLTEHLK--LE 1062

  Fly  1006 HQYAKKALKHPLLPLHTQGD----------------------------------QLAAQ-ALWIT 1035
            .:||....:.....:.|.||                                  |:||. :|.:.
Zfish  1063 ERYADLRSEKEAAEISTAGDSRADSGYSSSQSESIHSSMLTGSEVSSLEKEDAVQVAADVSLLLK 1127

  Fly  1036 ILRFTGDMPEPKYHTMDRMDTTS---VMSKV------TATLGRNFIRSKEFQEAQLMGLDPD-AF 1090
            :.|...::.:........|||..   |:.|.      ..|||    ..::::..:...|:.| ..
Zfish  1128 LQRRVAELEKENMDMQSEMDTKEEQLVLEKAKELEDCRKTLG----AERDYEALKRQELESDNKK 1188

  Fly  1091 LKQKPRSIRHKL---------------VSLTLKRKNKLGEDVRRRLQD----------------- 1123
            ||:..:.:|..|               .::.|::.|...|::..|.::
Zfish  1189 LKKDLQELRQSLSKGTGSKVTSPGGRAYNVILEQLNSTNEELEVRKEEVLILRSQLVSHEAFKHK 1253

  Fly  1124 ----DEYTADSYQS--------------W----------------LQSRPTSN---LEKLHFIIG 1151
                :..:.||.:|              |                ||::..|:   .|.|...:.
Zfish  1254 ELGTEGDSGDSSRSPTLDLTELNEDGELWMAYESLKETNRILVSQLQTQRESHEKETESLRAELQ 1318

  Fly  1152 HGILRAELRDEIYCQICKQLTNNPLKSSH-ARGWILLSL-------------CVGCFAPSEKFVN 1202
            |  |:|||..:      :|:.:..|:..| ||  |..||             .:......:|.|.
Zfish  1319 H--LKAELDQQ------QQMLSQSLELPHDAR--IQASLQHEISRLTQQNMDLLEQMGKQDKMVR 1373

  Fly  1203 --------YLRAFIREGPPGYAPYCEE----------------RLKRTFNN--GTRNQPPSWLEL 1241
                    |::.|   |.|....:.:.                |.:|.|..  ..|.:..:.|..
Zfish  1374 KLKKQLKIYMKKF---GEPEGVHFEQSSPENMLAESGRTVSIVRKERDFQGMLEYRREDENKLFK 1435

  Fly  1242 QATKSKKPIMLPITFMDGNTKTLL------ADSATTARELCNQLSDKI-SLKDQFGFSLYIALFD 1299
            ......||..:.:..:.|....:|      ||.|.....:...|:..| |:|
Zfish  1436 TLITDLKPRGVAVNLVPGLPAYILFMCLRHADYANDDLRVSTLLNTSINSIK------------- 1487

  Fly  1300 KVSSLGSGGDHVMDAIS----------QC-EQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQ 1353
              ::|...||  .::||          .| :||:.|:|..:.|.|.:   .:.....:....:.|
Zfish  1488 --NTLKKRGD--FESISFWLANTCRFLHCLKQYSGEEGYSKHNTPRQ---NEHCLTNFDLSEYRQ 1545

  Fly  1354 VATNL---IYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYST--------------------- 1394
            |.::|   ||||::|.:          |::.........:|..|
Zfish  1546 VLSDLAIQIYQQLIRVI----------ENILQPMIAPAMLEQETIQGVMGVKPTGMRKRTSSFHE 1600

  Fly  1395 --DMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIA--PLKIKEDIVSYA 1455
              ..|:|.:...|..|.......|.|      |.:|.|..|:.:||...:.  .|.:::|:.|::
Zfish  1601 ENSHSLESILKQLDGFYFTLLQHGND------AEVVRQVIKQQFYVICSVTLNNLLLRKDMCSWS 1659

  Fly  1456 K 1456
            |
Zfish  1660 K 1660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	275/672 (41%)
		MyTH4	<1138..1245	CDD:214535	27/149 (18%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	22/115 (19%)
		B41	1251..1467	CDD:214604	48/252 (19%)
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020
myo5ab	XP_009296049.3	None