DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and myo3b

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	XP_001920287.4	Gene:	myo3b / 564573	ZFINID:	ZDB-GENE-070706-2	Length:	1307	Species:	Danio rerio

Alignment Length:	843	Identity:	307/843 - (36%)
Similarity:	463/843 - (54%)	Gaps:	119/843 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 EDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPP 130
            :|:::|..|.|..|:.:|..||::..||||.|.||:|:||:|.|.||:....|||...|....||
Zfish   358 DDLVNLELLDEETIIAHLQKRYQDLQIYTYVGDILIALNPFQNLSIYSPQFSKLYHGMKRSTNPP 422

  Fly   131 HIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGK--HSWIEQQILEANPI 193
            ||||..|.||..|....:||||:||||||||||||..||:|:|..: ||  :..:.::||:.||:
Zfish   423 HIFATADAAYQSMVTLCKDQCIIISGESGAGKTESAHLIVQHLTFL-GKANNRTLREKILQVNPL 486

  Fly   194 LEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILA 258
            :||||||.|..||||||||||:::.|:..|.:.||||.:|||||||::.|...|:|:|:||.|.|
Zfish   487 VEAFGNACTAINDNSSRFGKYLEMKFTPTGAVMGAKISEYLLEKSRVIKQATGEKNFHIFYYIYA 551

  Fly   259 GLSADEKSRLDLGMAADYKY--LTGGNSITC----------EGRDDAAEFSDIRSAMKVLLFSDQ 311
            ||...:..|       .||.  .|....|.|          ..:....:|..|:...:::.|:::
Zfish   552 GLYHQDNLR-------KYKLPNKTAPRYIDCVNGKVMQDIISSKLYKEQFDAIQDCFRIIGFTEE 609

  Fly   312 EIWEIIKLLAALLHCGNIKY-KATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFA 375
            |:..:.::|||:|:.|||:: .|:.....|.:|:|....::..|.||.:..:.|.:|||...:..
Zfish   610 EVNSVYRILAAILNTGNIEFASASSQHQSDKSEVPNSEALDNAAALLSIGSEELQEALTSHCVVT 674

  Fly   376 HGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKP-----RGTSRNAIGVLDIFGF 435
            .|||::.|.:.|::.|||||..|.:|||:|..||.:|| |:.:|     ...|...:|:||||||
Zfish   675 RGETIIRTNTVDKATDVRDAMSKALYGRLFSWIVNRIN-ALLQPDTNICAAESGMNVGILDIFGF 738

  Fly   436 ENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNI 500
            |||.:|||||.|||.|||.:|.:|.||||.|||.||..|.::...:|:.||:..||:...|.:.:
Zfish   739 ENFKKNSFEQLCINIANEQIQFYFNQHIFALEQIEYQSEGVDVSLVEYEDNRPILDMFLQKPMGL 803

  Fly   501 MALIDEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRD 565
            ::|:|||:|||:.||||::.|. :.:..:|.:..||. :...||:.|:||.|.|:..|||:||||
Zfish   804 LSLLDEESRFPQATDQTLVDKF-QDNLRNKYFWIPKR-VELCFGIQHYAGQVLYNVSGFLEKNRD 866

  Fly   566 TFSPDLLHLVSQSTNKFLRQIFAQDI--------------------------------------- 591
            |...|::.::..|.|:.|:|:|:..:
Zfish   867 TLPADIVVVLRTSENRLLQQLFSSPLTKTGNLATSRARVTAASRSLPPQLNSGRNKSPKYLLKVD 931

  Fly   592 --EM----GAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQL 650
              ||    ...|..|..|:::.||.||..|:..:....|.|:||||||:.::.:.|::.....||
Zfish   932 TMEMMRHPEETTNMRRQTVASYFRYSLMDLLSKMVVGTPHFVRCIKPNDDRQALRFNKERVMVQL 996

  Fly   651 RYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHRTDCQAATSRICAVVL---GKSDY- 711
            ||:|::||:.|||.||..|...:|||.||.:|      |.|.......|:..|:::   .|.||
Zfish   997 RYTGILETVNIRRQGYSHRILIQEFVNRYYYL------AFRAHQMPEGSKENAIIILQKAKLDYW 1055

  Fly   712 QLGHTKVFLKDAH----DLFLEQERDRVLTRKILILQRSIRGWV----YRRRFLRLRAAAITVQR 768
            .:|:||||||..|    :|.|     |.:..:::::|...:||:    |||...:.|..|:.:|.
Zfish  1056 VVGNTKVFLKYYHVEQLNLML-----REVIARVVLMQAYTKGWLGARRYRREREKRRNGAVVIQS 1115

  Fly   769 FWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGH-KMW 830
            .|:|:..|:..:           ||:        |......|.:|:..|||.||::|.. :.|
Zfish  1116 AWRGHVARQNLK-----------LIK--------REREQAAVQIQSVYRGYRVRKDYKQSRQW 1159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	282/739 (38%)
		MYSc_Myo7	77..721	CDD:276832	273/712 (38%)
		MyTH4	<1138..1245	CDD:214535
		B41	1251..1467	CDD:214604
		FERM_B-lobe	1355..1439	CDD:271216
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
myo3b	XP_001920287.4	PKc_like	13..310	CDD:304357
		S_TKc	36..309	CDD:214567
		MYSc	358..1072	CDD:214580	280/730 (38%)
		MYSc_Myo3	369..1065	CDD:276830	273/712 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810