DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and myo5c

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:XP_691143.2 Gene:myo5c / 562676 ZFINID:ZDB-GENE-131127-196 Length:1746 Species:Danio rerio


Alignment Length:2073 Identity:544/2073 - (26%)
Similarity:869/2073 - (41%) Gaps:487/2073 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 IVTRGDYIWIEPAS--GREFDVAIGARVVSAEGRRIQVRDDDGDEVW--------LAPERRIKAM 57
            :.|:.:.:||..|.  .:..::....:...:|   ::::.:||.|:.        |.|.|     
Zfish     6 LYTKYNRVWIPDAEHVWKSAEILTDFKPGDSE---LELQLEDGTELHYPLEGGEKLPPLR----- 62

  Fly    58 HASSVQGVEDMISLGDLHEAGILRNLLIRYKEN-LIYTYTGSILVAVNPYQILPIYTGDQIKLYK 121
            :...:.|..|:.:|..|||..:|.||.:|:.|: :||||.|.||||||||:.||||....|..|.
Zfish    63 NPDILVGENDLTALSYLHEPAVLHNLKVRFVESKIIYTYCGIILVAVNPYKQLPIYGDAVIHAYS 127

  Fly   122 ERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAI--SGKHSWIE 184
            .:.:|:|.|||||:.:.||..|.|..::|.|::|||||||||.|.:..::|.|.:  ||..:.:|
Zfish   128 GQNMGDLDPHIFAVAEEAYKQMARNNKNQSIIVSGESGAGKTVSARYAMRYFAMVSKSGSKTRVE 192

  Fly   185 QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERN 249
            .::|.:|||.||.|||||.|||||||||||.:|.|.....|.||.:..|||||||:|.|:.:|||
Zfish   193 DKVLASNPITEAIGNAKTTRNDNSSRFGKYTEISFDKRYQIIGANMRTYLLEKSRVVFQSENERN 257

  Fly   250 YHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIW 314
            ||:||.:.|..:..|...|.|..|..:.|...|..|..||.||.|:.::.|....:|...:....
Zfish   258 YHIFYQMCACANQPEFKGLRLLGAEKFNYTRLGGEIEIEGVDDRADMAETRRTFNLLGLKENFQT 322

  Fly   315 EIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGET 379
            ::.|:|||:||.||:..||...:.........|:.:  ...|:|:..:.:...|..|.:....||
Zfish   323 DVFKVLAAILHLGNVIIKAKDPEKSFIGSRDPHLAI--FCDLMGVSTENMSRWLCHRRIVLSTET 385

  Fly   380 VVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFE 444
            ||....|:::|:.|||..|.||..:|..::.|||.|:..| |...:.||||||:|||.|:.||||
Zfish   386 VVKPQPRERAVNARDALAKHIYAHLFNWVIHKINHALMVP-GKQHSFIGVLDIYGFETFEINSFE 449

  Fly   445 QFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEAR 509
            |||||||||.|||.|..|:||||||||..|.|.|..|:|.|||..:|||..| :.|:.|:|||..
Zfish   450 QFCINYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAK-MGILDLLDEECL 513

  Fly   510 FPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHL 574
            ||:|||:..|.||:...||...:.||:.. |.||.:.|||..|.|..:|||:|||||...:|:.:
Zfish   514 FPQGTDKNWLQKLYNFLGSKPLFEKPRLS-NDSFMIQHFADKVEYQCKGFLEKNRDTLYEELVDI 577

  Fly   575 VSQSTNKFLRQIF-AQDIEMGAETRKRTP--------------TLSTQFRKSLDALMKTLSSCQP 624
            :..|....|...| .::.:.|.:..|.||              |:..:||.||..||:||::..|
Zfish   578 MRASQFALLAGFFKEEEADSGHKIIKVTPAQPRVKASNKQLRSTVGDKFRSSLYLLMETLNATTP 642

  Fly   625 FFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP----- 684
            .::|||||||.|.|..:|.....:|||..|::|||||....||.|..:.||..||..|:.     
Zfish   643 HYVRCIKPNEEKLPFEYDSRRVVQQLRACGVLETIRISAQSYPSRWTYVEFYSRYSILMSQSELK 707

  Fly   685 -GVPPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIR 748
             |   ..:..|:....|:   :...:.|:.|.||:|.:.....:||:.|...|....:.:|:.:|
Zfish   708 LG---EKKQTCRTVLQRL---IPDSNQYKFGRTKIFFRAGQVAYLEKLRLDHLRAACVTIQKHVR 766

  Fly   749 GWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQ 813
            ||..||.||.:|.||:.:|.:.:|..|                 ||..|.:...:.....|| :|
Zfish   767 GWRQRRSFLNIRQAALIIQLYVRGKKQ-----------------IRCTVTAQALKQGWAAIV-IQ 813

  Fly   814 AHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQELLHRGNK 878
            .|.||:||||.|...:.|.:.||:..|..:|.:||:|:..|||    .|.|:|.....|:.|..:
Zfish   814 RHCRGFLVRRIYQLVLRAAVTIQAFTRGWMARKRYKKMVAEHK----ALVLQKYARAWLVRRRFQ 874

  Fly   879 HAREI---AEQHYRDRLHELERREIQEQLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDF 940
            ..|.:   .:..|  |:.:|.::..::..||...:|...::.|..|:..|:       ::|:...
Zfish   875 TMRRLVINVQLSY--RVQQLRKKVEEQNKENCGLMEKLTSLSNARAQGLEK-------IQALEAE 930

  Fly   941 LPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHI-SEDEEDLSEFKFQKFAATYFQGNV 1004
            |            |:.|:..:.|......|.::....|.: ..|:|.|.|               
Zfish   931 L------------GKLTNEMSALVQRAKTNSEEANQAIDVLQNDKEKLVE--------------- 968

  Fly  1005 NHQYAKKALKHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGR 1069
                ..|||:..|..               |.::......:.|...|:.::....:.||..   .
Zfish   969 ----ENKALERKLKD---------------TTVQMQDQFEDVKRKLMEDLEREERLRKVAE---H 1011

  Fly  1070 NFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSW 1134
            |....||..:.:::.      :|::.|.:|.:.:.|    :.::.|||:...:            
Zfish  1012 NSELQKEDSDKEIVA------IKEENRRLREERIRL----QTQVEEDVKTNTE------------ 1054

  Fly  1135 LQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEK 1199
            ||       |::..:..|..:..:||.||          |.|:...|..                
Zfish  1055 LQ-------EQMLQLTKHVKVIPDLRKEI----------NNLQIQRAEA---------------- 1086

  Fly  1200 FVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTL 1264
                                 |:..|..|            ||| ::|..::         |:.|
Zfish  1087 ---------------------EKTLRAQN------------LQA-RAKMNLI---------TRQL 1108

  Fly  1265 LADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQE 1329
            |.|:  |.::|..:|:::.|..:..|..| |..||.:                 |:.||....|.
Zfish  1109 LGDA--TEQDLIQRLNEEASDNNDDGADL-ITAFDGM-----------------ERAAKVMETQL 1153

  Fly  1330 RNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYST 1394
            |.               .:..|:.....||::        .|:...:.|.|..:..::..|..|.
Zfish  1154 RE---------------QKDAHESQLEALIFK--------NEHLSKENEQLQALFQEKSDINQSI 1195

  Fly  1395 DMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIAPL--KIKE--DIVSYA 1455
            ...:.|| |.....||:.        .::.:.|....::....::|:.|.:  |:||  ..:..|
Zfish  1196 GQEVTRL-TAENMVIPEL--------KQQVSELNRHKHELESQLQDQTAEMSAKLKELSSALHLA 1251

  Fly  1456 KYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFPEITAVSSQKTNKV 1520
            ..:......|..|....|.....:.|..|:       .:.::.|.|.:....|     ||..|.:
Zfish  1252 VEEEQSQRRRLQEELTESQRRREETDRQIS-------ELQEENQQLKKAQITE-----SQAKNTL 1304

  Fly  1521 FTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRA---------PSDGT 1576
            ..:|   |.:..|...|:  ...|::|.::      |:....:.|||.:.|         |.:..
Zfish  1305 RLET---SRLTAENMDFE--EQLDMKDRLI------KRLQDQIKALQTHAAANQKAAPAVPKEYL 1358

  Fly  1577 SFLSFFKGD------LIILEDESCGESV--------------------LNNGWCIGRC------- 1608
            ..|.:.|.|      ::|||.:..|..|                    ||:|..: :|       
Zfish  1359 GMLEYKKEDEGRLIRILILELKPRGVGVNMIPGLAAHLLFMCVRHADYLNDGNKL-KCLMNNIIT 1422

  Fly  1609 ------DRSQERGD----FPAETVYVLPTLSK------------PPQDILALFNIEEAHHGRRLS 1651
                  ...||..:    :.:.|.:.|..|.:            |.|:...|.|.:.:.|.:.||
Zfish  1423 AVKEVITEHQENFELLSFWLSNTYHFLNCLKQYSGEEEFMKHNTPRQNKNCLKNFDLSEHRQILS 1487

  Fly  1652 MASNGGAVEPRDRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQS 1716
            ..    |:....:..::||.||....:|..........:||             :|...|||..|
Zfish  1488 DL----AINIYHQFISVMEDALFPMIIPGMLEHESLQGISS-------------MKPTGLRKRSS 1535

  Fly  1717 K------EEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIY------- 1768
            .      :....|| |:.::||:.:....|...:.|.|       ..|:.:|:|...|       
Zfish  1536 SVFEDGGDSSTSEA-FSVSSILQKLSTFNSSMCQQGME-------PQLQGQIVRQLFYLIGSSSV 1592

  Fly  1769 -CQLMKQLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIR 1832
             |.|::     ::..|..:|.::        .|:...|:|.|    ..:..:|.::|..|.    
Zfish  1593 NCILLR-----KDLCSCRKGMQI--------RCNISYLEEWL----REKDLLSSNAMETLG---- 1636

  Fly  1833 HGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEGFS 1897
                  |..|:......:|||.           ::|.|:      |..|:.:|.          .
Zfish  1637 ------PLSQIAWLLQVNKTTD-----------EDAAEI------KQRCSELSA----------V 1668

  Fly  1898 LFVKIADKVISVPEGDFFFDFVRHLT-DWIKKARPI---RDGA-----NPQFTYQVFF 1946
            ..|||.:....:.      ||.:.:. .:::|.:.:   |:|:     :.|:.:||.|
Zfish  1669 QIVKILNSYTPID------DFEKRVAPSFVRKVQALLQEREGSSQLMMDSQYRFQVTF 1720

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 286/692 (41%)
MYSc_Myo7 77..721 CDD:276832 278/667 (42%)
MyTH4 <1138..1245 CDD:214535 15/106 (14%)
B41 1251..1467 CDD:214604 39/219 (18%)
FERM_B-lobe 1355..1439 CDD:271216 13/83 (16%)
FERM_C1_MyoVII 1461..1559 CDD:270019 18/97 (19%)
SH3 1560..1624 CDD:302595 20/115 (17%)
MyTH4 1701..1849 CDD:214535 30/161 (19%)
B41 1856..2068 CDD:214604 17/100 (17%)
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
myo5cXP_691143.2 MYSc 63..750 CDD:214580 286/697 (41%)
MYSc_Myo5 82..739 CDD:276831 278/667 (42%)
IQ 808..826 CDD:197470 10/18 (56%)
IQ 830..849 CDD:197470 6/18 (33%)
Laminin_I 1068..1314 CDD:283627 65/381 (17%)
GBP_C <1176..1291 CDD:303769 22/130 (17%)
coiled coil 1280..1291 CDD:293879 2/17 (12%)
Myo5c_CBD 1366..1740 CDD:271260 80/441 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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