Protein Alignment ck and myo5c

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: XP_691143.2
• Gene: myo5c / 562676
• ZFINID: ZDB-GENE-131127-196
• Length: 1746
• Species: Danio rerio
• Alignment Length: 2073
• Identity: 544/2073 - (26%)
• Similarity: 869/2073 - (41%)
• Gaps: 487/2073 - (23%)

  Fly     3 IVTRGDYIWIEPAS--GREFDVAIGARVVSAEGRRIQVRDDDGDEVW--------LAPERRIKAM 57
            :.|:.:.:||..|.  .:..::....:...:|   ::::.:||.|:.        |.|.|
Zfish     6 LYTKYNRVWIPDAEHVWKSAEILTDFKPGDSE---LELQLEDGTELHYPLEGGEKLPPLR----- 62

  Fly    58 HASSVQGVEDMISLGDLHEAGILRNLLIRYKEN-LIYTYTGSILVAVNPYQILPIYTGDQIKLYK 121
            :...:.|..|:.:|..|||..:|.||.:|:.|: :||||.|.||||||||:.||||....|..|.
Zfish    63 NPDILVGENDLTALSYLHEPAVLHNLKVRFVESKIIYTYCGIILVAVNPYKQLPIYGDAVIHAYS 127

  Fly   122 ERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAI--SGKHSWIE 184
            .:.:|:|.|||||:.:.||..|.|..::|.|::|||||||||.|.:..::|.|.:  ||..:.:|
Zfish   128 GQNMGDLDPHIFAVAEEAYKQMARNNKNQSIIVSGESGAGKTVSARYAMRYFAMVSKSGSKTRVE 192

  Fly   185 QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERN 249
            .::|.:|||.||.|||||.|||||||||||.:|.|.....|.||.:..|||||||:|.|:.:|||
Zfish   193 DKVLASNPITEAIGNAKTTRNDNSSRFGKYTEISFDKRYQIIGANMRTYLLEKSRVVFQSENERN 257

  Fly   250 YHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIW 314
            ||:||.:.|..:..|...|.|..|..:.|...|..|..||.||.|:.::.|....:|...:....
Zfish   258 YHIFYQMCACANQPEFKGLRLLGAEKFNYTRLGGEIEIEGVDDRADMAETRRTFNLLGLKENFQT 322

  Fly   315 EIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGET 379
            ::.|:|||:||.||:..||...:.........|:.:  ...|:|:..:.:...|..|.:....||
Zfish   323 DVFKVLAAILHLGNVIIKAKDPEKSFIGSRDPHLAI--FCDLMGVSTENMSRWLCHRRIVLSTET 385

  Fly   380 VVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFE 444
            ||....|:::|:.|||..|.||..:|..::.|||.|:..| |...:.||||||:|||.|:.||||
Zfish   386 VVKPQPRERAVNARDALAKHIYAHLFNWVIHKINHALMVP-GKQHSFIGVLDIYGFETFEINSFE 449

  Fly   445 QFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEAR 509
            |||||||||.|||.|..|:||||||||..|.|.|..|:|.|||..:|||..| :.|:.|:|||..
Zfish   450 QFCINYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAK-MGILDLLDEECL 513

  Fly   510 FPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHL 574
            ||:|||:..|.||:...||...:.||:.. |.||.:.|||..|.|..:|||:|||||...:|:.:
Zfish   514 FPQGTDKNWLQKLYNFLGSKPLFEKPRLS-NDSFMIQHFADKVEYQCKGFLEKNRDTLYEELVDI 577

  Fly   575 VSQSTNKFLRQIF-AQDIEMGAETRKRTP--------------TLSTQFRKSLDALMKTLSSCQP 624
            :..|....|...| .::.:.|.:..|.||              |:..:||.||..||:||::..|
Zfish   578 MRASQFALLAGFFKEEEADSGHKIIKVTPAQPRVKASNKQLRSTVGDKFRSSLYLLMETLNATTP 642

  Fly   625 FFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP----- 684
            .::|||||||.|.|..:|.....:|||..|::|||||....||.|..:.||..||..|:.
Zfish   643 HYVRCIKPNEEKLPFEYDSRRVVQQLRACGVLETIRISAQSYPSRWTYVEFYSRYSILMSQSELK 707

  Fly   685 -GVPPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIR 748
             |   ..:..|:....|:   :...:.|:.|.||:|.:.....:||:.|...|....:.:|:.:|
Zfish   708 LG---EKKQTCRTVLQRL---IPDSNQYKFGRTKIFFRAGQVAYLEKLRLDHLRAACVTIQKHVR 766

  Fly   749 GWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQ 813
            ||..||.||.:|.||:.:|.:.:|..|                 ||..|.:...:.....|| :|
Zfish   767 GWRQRRSFLNIRQAALIIQLYVRGKKQ-----------------IRCTVTAQALKQGWAAIV-IQ 813

  Fly   814 AHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQELLHRGNK 878
            .|.||:||||.|...:.|.:.||:..|..:|.:||:|:..|||    .|.|:|.....|:.|..:
Zfish   814 RHCRGFLVRRIYQLVLRAAVTIQAFTRGWMARKRYKKMVAEHK----ALVLQKYARAWLVRRRFQ 874

  Fly   879 HAREI---AEQHYRDRLHELERREIQEQLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDF 940
            ..|.:   .:..|  |:.:|.::..::..||...:|...::.|..|:..|:       ::|:...
Zfish   875 TMRRLVINVQLSY--RVQQLRKKVEEQNKENCGLMEKLTSLSNARAQGLEK-------IQALEAE 930

  Fly   941 LPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHI-SEDEEDLSEFKFQKFAATYFQGNV 1004
            |            |:.|:..:.|......|.::....|.: ..|:|.|.|
Zfish   931 L------------GKLTNEMSALVQRAKTNSEEANQAIDVLQNDKEKLVE--------------- 968

  Fly  1005 NHQYAKKALKHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGR 1069
                ..|||:..|..               |.::......:.|...|:.::....:.||..   .
Zfish   969 ----ENKALERKLKD---------------TTVQMQDQFEDVKRKLMEDLEREERLRKVAE---H 1011

  Fly  1070 NFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSW 1134
            |....||..:.:::.      :|::.|.:|.:.:.|    :.::.|||:...:
Zfish  1012 NSELQKEDSDKEIVA------IKEENRRLREERIRL----QTQVEEDVKTNTE------------ 1054

  Fly  1135 LQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEK 1199
            ||       |::..:..|..:..:||.||          |.|:...|..
Zfish  1055 LQ-------EQMLQLTKHVKVIPDLRKEI----------NNLQIQRAEA---------------- 1086

  Fly  1200 FVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTL 1264
                                 |:..|..|            ||| ::|..::         |:.|
Zfish  1087 ---------------------EKTLRAQN------------LQA-RAKMNLI---------TRQL 1108

  Fly  1265 LADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQE 1329
            |.|:  |.::|..:|:::.|..:..|..| |..||.:                 |:.||....|.
Zfish  1109 LGDA--TEQDLIQRLNEEASDNNDDGADL-ITAFDGM-----------------ERAAKVMETQL 1153

  Fly  1330 RNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYST 1394
            |.               .:..|:.....||::        .|:...:.|.|..:..::..|..|.
Zfish  1154 RE---------------QKDAHESQLEALIFK--------NEHLSKENEQLQALFQEKSDINQSI 1195

  Fly  1395 DMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIAPL--KIKE--DIVSYA 1455
            ...:.|| |.....||:.        .::.:.|....::....::|:.|.:  |:||  ..:..|
Zfish  1196 GQEVTRL-TAENMVIPEL--------KQQVSELNRHKHELESQLQDQTAEMSAKLKELSSALHLA 1251

  Fly  1456 KYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFPEITAVSSQKTNKV 1520
            ..:......|..|....|.....:.|..|:       .:.::.|.|.:....|     ||..|.:
Zfish  1252 VEEEQSQRRRLQEELTESQRRREETDRQIS-------ELQEENQQLKKAQITE-----SQAKNTL 1304

  Fly  1521 FTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRA---------PSDGT 1576
            ..:|   |.:..|...|:  ...|::|.::      |:....:.|||.:.|         |.:..
Zfish  1305 RLET---SRLTAENMDFE--EQLDMKDRLI------KRLQDQIKALQTHAAANQKAAPAVPKEYL 1358

  Fly  1577 SFLSFFKGD------LIILEDESCGESV--------------------LNNGWCIGRC------- 1608
            ..|.:.|.|      ::|||.:..|..|                    ||:|..: :|
Zfish  1359 GMLEYKKEDEGRLIRILILELKPRGVGVNMIPGLAAHLLFMCVRHADYLNDGNKL-KCLMNNIIT 1422

  Fly  1609 ------DRSQERGD----FPAETVYVLPTLSK------------PPQDILALFNIEEAHHGRRLS 1651
                  ...||..:    :.:.|.:.|..|.:            |.|:...|.|.:.:.|.:.||
Zfish  1423 AVKEVITEHQENFELLSFWLSNTYHFLNCLKQYSGEEEFMKHNTPRQNKNCLKNFDLSEHRQILS 1487

  Fly  1652 MASNGGAVEPRDRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQS 1716
            ..    |:....:..::||.||....:|..........:||             :|...|||..|
Zfish  1488 DL----AINIYHQFISVMEDALFPMIIPGMLEHESLQGISS-------------MKPTGLRKRSS 1535

  Fly  1717 K------EEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIY------- 1768
            .      :....|| |:.::||:.:....|...:.|.|       ..|:.:|:|...|
Zfish  1536 SVFEDGGDSSTSEA-FSVSSILQKLSTFNSSMCQQGME-------PQLQGQIVRQLFYLIGSSSV 1592

  Fly  1769 -CQLMKQLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIR 1832
             |.|::     ::..|..:|.::        .|:...|:|.|    ..:..:|.::|..|.
Zfish  1593 NCILLR-----KDLCSCRKGMQI--------RCNISYLEEWL----REKDLLSSNAMETLG---- 1636

  Fly  1833 HGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEGFS 1897
                  |..|:......:|||.           ::|.|:      |..|:.:|.          .
Zfish  1637 ------PLSQIAWLLQVNKTTD-----------EDAAEI------KQRCSELSA----------V 1668

  Fly  1898 LFVKIADKVISVPEGDFFFDFVRHLT-DWIKKARPI---RDGA-----NPQFTYQVFF 1946
            ..|||.:....:.      ||.:.:. .:::|.:.:   |:|:     :.|:.:||.|
Zfish  1669 QIVKILNSYTPID------DFEKRVAPSFVRKVQALLQEREGSSQLMMDSQYRFQVTF 1720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	278/667 (42%)
		MyTH4	<1138..1245	CDD:214535	15/106 (14%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	18/97 (19%)
		B41	1251..1467	CDD:214604	39/219 (18%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	18/97 (19%)
		SH3	1560..1624	CDD:473055	20/115 (17%)
		MyTH4	1701..1849	CDD:214535	30/161 (19%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	17/102 (17%)
		B41	1856..2068	CDD:214604	17/100 (17%)
		FERM_C2_MyoVII	2064..2159	CDD:270020
myo5c	XP_691143.2	COG5022	12..1333	CDD:227355	456/1592 (29%)
		MYSc_Myo5	82..739	CDD:276831	278/667 (42%)
		Myo5c_CBD	1366..1740	CDD:271260	80/441 (18%)