DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and myo9ab

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:XP_021326243.1 Gene:myo9ab / 562199 ZFINID:ZDB-GENE-080424-6 Length:2343 Species:Danio rerio


Alignment Length:2261 Identity:545/2261 - (24%)
Similarity:862/2261 - (38%) Gaps:715/2261 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 EGRRIQVRDDDGD--------EVWL--APERRIKAMHA-----SSVQGVEDMISLGDLHEAGILR 81
            |..|..:|:.:.|        ::||  ..|||......     .:.|.|.|:.||.||:|..:|.
Zfish   102 EDYRFLLREKNLDGSIHYGSLQMWLRVTEERRRMVERGLLPQPPAAQFVADLCSLPDLNEHTMLE 166

  Fly    82 NLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMKRY 146
            ||..|:::..||||.||||:||||::.||||....:|:|.:.::|:|.|||||:.|.||..|.:.
Zfish   167 NLRGRFRQENIYTYVGSILIAVNPFKFLPIYNPKYVKMYDKHRLGQLEPHIFAVADAAYHAMLQR 231

  Fly   147 RQDQCIVISGESGAGKTESTKLILQYLAAIS--GKHSWIEQQILEANPILEAFGNAKTIRNDNSS 209
            .::||||||||||:|||:||..::.:|.|:|  |..|.:||.||.|.|:|||||||||..|:|||
Zfish   232 HRNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAGPVLEAFGNAKTAHNNNSS 296

  Fly   210 RFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAA 274
            ||||:|.:::..:|.:.||.:|:|||||||:|.|.|:||||||||.:|||.|.||:|...|....
Zfish   297 RFGKFIQVNYQESGTVRGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLAGASEDERSXFHLLRPE 361

  Fly   275 DYKYLTGGNSIT-----------------C---EGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKL 319
            :|.||   |.||                 |   |..|...:|..::.||:::.|......:|..|
Zfish   362 EYHYL---NQITKSVHKQHWGNHCDTELDCFSVEAEDLKHDFERLQLAMEMVGFLPTTRKQIFSL 423

  Fly   320 LAALLHCGNIKYKATVV--DNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVS 382
            |:|:||.|||:||....  |::|... ||.:.:  |:.||.:..:.|.:|||.|.....||.::.
Zfish   424 LSAILHLGNIRYKKKTFRDDSIDICN-PEVLPI--VSELLEVKEEMLFEALTTRKTVTVGERLIV 485

  Fly   383 TLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNA----IGVLDIFGFENFDQNSF 443
            .....::..|||:..|.:|..:|..||.:.|.|:...:....:|    ||||||||||:::.|||
Zfish   486 PYKLAEAGTVRDSMAKSLYCALFDWIVFRTNHALLYNKDLEDSAKILSIGVLDIFGFEDYENNSF 550

  Fly   444 EQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEA 508
            ||||||:|||.||.:|.||:||||||||..|.|||..|:::||...::||:.|...::.|:|||.
Zfish   551 EQFCINFANETLQHYFNQHVFKLEQEEYRSEGINWHMIDYIDNTACINLISKKPTALLHLLDEEC 615

  Fly   509 RFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLH 573
            .||:.::||:|.|..:.|..:. |::..:.:..:|.:.|:||.|.|..:.|.:||.|...||::.
Zfish   616 NFPQASNQTLLDKFKRQHEGNA-YMEFPAVMEPAFIIRHYAGKVKYSVKDFREKNTDHLRPDIVS 679

  Fly   574 LVSQSTNKF-----------------LRQIF-------------------AQDIEM--------- 593
            |:..|...|                 :|..|                   ..|:.:         
Zfish   680 LLKSSRKAFICGLMGLDPVASFRWAVIRAFFRALVAFRHAGLQHRDNRSSGSDVHLQPQKSVDSF 744

  Fly   594 ----------------------------------------GAET--------------------- 597
                                                    ||.|                     
Zfish   745 SFLHHPVHQRSLEILQRCKDDRYNSCVSRRSPRTPLSDLQGANTFSSNGRGWRSERVSSFAHEDE 809

  Fly   598 --------------------------------------------------------------RKR 600
                                                                          :|:
Zfish   810 GIFVNSVNNRLLERAQGILMRNKNYKPKPSLPKHLLDVKSLKYLSSLTLHDRITKSLLHLHKKKK 874

  Fly   601 TPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAG 665
            .|::|.||..||:.||:||...:|:|::||:.|..|.|:.|:..|..|||||:||:||:|||::|
Zfish   875 PPSISAQFNVSLNKLMETLGQSEPYFVKCIRSNAEKLPLRFNDALVLRQLRYTGMLETVRIRQSG 939

  Fly   666 YPIRHGFREFVERYRFLIPGVPPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQ 730
            |.:::.|::|...:..|:|....|.:   ......:.:..|..|.||:|.:.|||.:.....|:.
Zfish   940 YSVKYSFKDFAHHFHVLLPAGFSASQ---MGIREFLRSADLEPSGYQVGRSMVFLHERLRQRLQD 1001

  Fly   731 ERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRS 795
            |..:.:.|:|:.||||.|....|:.|.|.|.||..:||:|:....:   .:..|..:.||     
Zfish  1002 ELHQEVLRRIVCLQRSFRTQRDRKHFCRQRRAARLIQRWWRSCISQ---ADGSVCALELQ----- 1058

  Fly   796 RVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMI--------------AMR 846
                      :|..:.|||..||:..||.|..:..||:.||...||::              ..|
Zfish  1059 ----------QGAALRLQAVWRGFRARRLYLQQRRAVLIIQRCWRRVLNTRNTAATLIQAVWRTR 1113

  Fly   847 RYRKLRLEHKQFAEVLQ-----------LRKLEEQEL-------------LHRGNKHAREIAE-- 885
            .:|:..|:.::.|..||           .|.|.||:.             ||:..:.|.::.|  
Zfish  1114 THRRSFLQQRRAAVTLQAACRGQQSRQRCRILREQQCREQSKHPSTVTKSLHQNTEEAEKLEEVW 1178

  Fly   886 -------------------QHYRD--RLHELER-------------------------------- 897
                               ::.|:  |..|||:                                
Zfish  1179 EKQTTDPPPKAVDDSTLKSRNKRESRRQRELEQATFSLELLKVRSGSNTEDAQIPPSKHHPPHQA 1243

  Fly   898 ----REIQEQLENR------------RRVEVNM------------------NIINDA-------- 920
                :|..|.|||.            ..:|||.                  :.||.|        
Zfish  1244 STDSQESFELLENEDSASAKLELSKSEPMEVNQTSPAASFKPHFYIPDEDGSPINSAPQTPNRAK 1308

  Fly   921 -------------ARKQEEPVDDGKLVEAMFDFLP----DSSSDA---PTPHGGRETSVFNDLPH 965
                         :.::|.|||...|.......:|    :|:||.   |.|....|.    |...
Zfish  1309 QIREKKESVVVIISMQKENPVDRSSLQTLEAQDVPLSNGESASDCSIIPEPRTNHEL----DTGS 1369

  Fly   966 AQNVNQDDIIAPIHISEDEEDLSEFKF---QKFAATYFQGNVNHQYAKKAL--KHPLLPLHTQGD 1025
            :.:|:...:...:..:...|:.||.|.   :||.:.....::....|..|.  |...|.......
Zfish  1370 SFSVSSKPLQLDLRSAASNEEPSEPKADVQKKFVSQSISISMKETAANVAFPPKRSRLTFSKSDK 1434

  Fly  1026 QLAAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGR---NFI-------------RS 1074
            .|..|...:.|.|..|      :.::...|.|....|..|.:.|   :|:             ..
Zfish  1435 DLVNQERSLAIQREAG------FRSLKNRDVTRAGCKKKARMARTRSDFLSRACSTEADCEEDED 1493

  Fly  1075 KEFQEAQLMGL------------------DPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRL 1121
            .|:::..::..                  |.:...:::.:.|:..:.|..|.:.:.|.:.:.   
Zfish  1494 DEYEDTPVLSCTRPPHSPSSPDIDCVFHSDSEMSSQKEQKRIQKTMSSGDLGKMDSLRKSMS--- 1555

  Fly  1122 QDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWIL 1186
            |.|.......:.|.:|:             ||..:...|                          
Zfish  1556 QTDSRVRGKMRFWSKSK-------------HGDKKISSR-------------------------- 1581

  Fly  1187 LSLCVGCFAPSEKFVNYLRAFIREGPPG---YAPYCEERLKRTFNNGTRNQPPSWLELQATKSKK 1248
                 |..|.||     |.....:.|||   :|...|.|     .:...|:.| .|.:.:.|.::
Zfish  1582 -----GRSADSE-----LTDRRNDSPPGSPEHAGVSERR-----RDSKENREP-MLGMMSMKRRR 1630

  Fly  1249 PIMLPITFMDG----NTKTLLADSATTARELCNQLSDKISLKD-------------------QF- 1289
            .:.:....::.    |....:..|....|.:.:.|..|||..|                   :| 
Zfish  1631 SLKISSVSLESTAWQNDALHILTSTADYRSMNDFLMKKISDLDAEDGQKDTAVDVVFKKALKEFR 1695

  Fly  1290 -----GFSLYIALFD----KVSSLGSGGDHVMDAISQCEQ------------------------- 1320
                 .:|..:|:.|    :...|.:..:|:::...:.||                         
Zfish  1696 LNIFNSYSTALAMDDGRSIRYKDLYALFEHILEKSMRLEQRDWSESPVKVWVNTFKVFLDEFMTE 1760

  Fly  1321 YAKEQGA-QERNAPWRLFFRKE-----------IF--APWHEPTHDQVATNLIYQQVVRGV-KFG 1370
            |....|. .:...|.|...||:           ||  ..:..||:.:..::||:......| |..
Zfish  1761 YKPMDGTISKAPKPERKKRRKKESDTVEEHMGHIFKSTQYSIPTYCEFCSSLIWMMDKACVCKLC 1825

  Fly  1371 EYRCDKEEDLAM-----------IAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERW 1424
            .|.|.|:..|.|           ::::|:.:|.|...|.||...|:...:.::        ||..
Zfish  1826 RYACHKKCCLRMTTKCSKKFDPELSSRQFGVELSRLTSDERSVPLVVEKLINY--------IEMH 1882

  Fly  1425 AALVLQAYKKSYYVKDKIAPLKIKED--------------IVSYAKYKW------PLLFSRFYEA 1469
            .......|:||... :||..||...|              :::....:|      ||:....||.
Zfish  1883 GLYTEGIYRKSGST-NKIKELKQGLDTDANSVNLDDYNIHVIASVLKQWLRDLPNPLMTFELYEE 1946

  Fly  1470 YRNSGPNLPKNDVIIAVNWTGVYVVDDQ---------EQV---LLELSFPEITAVSSQKTNKVFT 1522
            :..:.....|.:|:     .|||.:.||         |::   |:.:||.|       :||::..
Zfish  1947 FLRAMGLQDKREVV-----QGVYSIIDQLSRTHLNTLERLIFHLVRISFQE-------ETNRMSA 1999

  Fly  1523 Q----TFSLSTVRGEEFTFQSPNAEDIR------DLVVYFLDGLKKRSKYVIALQDY-------- 1569
            .    .|:...:|..:.|....:..||.      :|::     .::..||...|:|.        
Zfish  2000 NALAIVFAPCILRCPDTTDPLQSVRDISKTTACVELII-----CEQMRKYKARLKDINTLEFAEN 2059

  Fly  1570 RAPSDGTSFLSFFKGDLIILEDESCGESVLN-NGWCIG------------------RCDRSQERG 1615
            :|.|..|......|..||.:.......:|.: |....|                  |....:|..
Zfish  2060 KAKSRLTHIRRSMKPVLIAVRFIGISRTVTSPNAAKKGKSRARKSGHHTPSPPLSPRASEREEPV 2124

  Fly  1616 DFPAETVYVLPTLSKPPQDIL---------ALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEY 1671
            |..||     |.||:..|..:         .:.|:::........|.    |:|||         
Zfish  2125 DEGAE-----PVLSEQQQAAMQQEEKVLTQQIENLQKEKEELTYEML----ALEPR--------- 2171

  Fly  1672 ALDHFRLPPKRTM-----SKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSK 1717
            |.|...|..:.::     |:.|..|...:.:.|..|...:.|...||.:||
Zfish  2172 ASDDEMLESEASIGTADSSENLMESEGAASDPWEKSPGAVSASRWRKSESK 2222

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 290/864 (34%)
MYSc_Myo7 77..721 CDD:276832 280/839 (33%)
MyTH4 <1138..1245 CDD:214535 17/109 (16%)
B41 1251..1467 CDD:214604 55/319 (17%)
FERM_B-lobe 1355..1439 CDD:271216 21/95 (22%)
FERM_C1_MyoVII 1461..1559 CDD:270019 23/119 (19%)
SH3 1560..1624 CDD:302595 18/90 (20%)
MyTH4 1701..1849 CDD:214535 6/17 (35%)
B41 1856..2068 CDD:214604
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
myo9abXP_021326243.1 UBQ 7..111 CDD:320785 3/8 (38%)
MYSc_Myo9 163..991 CDD:276836 279/837 (33%)
C1 1793..1841 CDD:237996 13/47 (28%)
RhoGAP_myosin_IXA 1854..2039 CDD:239871 41/210 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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