DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and myh9b

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:XP_001920098.4 Gene:myh9b / 561431 ZFINID:ZDB-GENE-030131-998 Length:1698 Species:Danio rerio


Alignment Length:2114 Identity:509/2114 - (24%)
Similarity:859/2114 - (40%) Gaps:563/2114 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 IWIEPASGREFDVAI-----GARVV---SAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVE 66
            :|: |:....|:...     |..||   :..|::|:|..||           |:.|:......||
Zfish    30 VWV-PSERLGFEAGSLKEEHGDEVVVELADSGKKIRVNKDD-----------IQKMNPPKFSKVE 82

  Fly    67 DMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPH 131
            ||..|..|:||.:|.||..||...|||||:|...|.:|||:.||||:.:.:.:||.:|..|:|||
Zfish    83 DMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVDMYKGKKRHEMPPH 147

  Fly   132 IFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSW-------------I 183
            |:||.|.||..|.:.|:||.|:.:|||||||||:||.::||||.::..|..             :
Zfish   148 IYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKTKKDQSSSVLSHGEL 212

  Fly   184 EQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSER 248
            |:|:|:|||||||||||||::|||||||||:|.|:|..||.|.||.||.|||||||.:.|...||
Zfish   213 EKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEER 277

  Fly   249 NYHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEI 313
            .:|:||.:|.|:....:|.|.|.....|::|:.|| :|..|:.|...:.:...||:::.||::|.
Zfish   278 TFHMFYYMLTGVGDKLRSELCLEGYNKYRFLSNGN-VTIPGQQDRDMYVETVEAMRIMGFSEEEH 341

  Fly   314 WEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGE 378
            ..::::::::|..||:.:|..  .:.|...:|:....::|..|:|:.:.....|:....:....:
Zfish   342 VGLLRVISSVLQLGNMSFKKE--RHSDQASMPDDTAAQKVCHLMGMNVTDFTRAILSPRIKVGRD 404

  Fly   379 TVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSF 443
            .|....:::|:....:|..|..|.|||..:|.:||.|:.|.:....:.||:|||.|||.|:.|||
Zfish   405 YVQKAQTQEQAEFAVEALAKATYERMFRWLVMRINKALDKTKRQGASFIGILDIAGFEIFELNSF 469

  Fly   444 EQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLI--AIKQLNIMALID 505
            ||.||||.||.|||.|...:|.||||||..|.|.|..|:| :|.|..:|||  ......|:||:|
Zfish   470 EQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWSFIDFGLDLQPCIDLIEKPASPPGILALLD 534

  Fly   506 EEARFPKGTDQTMLAKLHKTHGSHKNYLKPKS-DINTSFGLNHFAGVVFYDTRGFLDKNRDTFSP 569
            ||..|||.||::.:.|:.:..|:|..:.|||. .....|.:.|:||.|.|....:|.||.|..:.
Zfish   535 EECWFPKATDKSFVEKVLQEQGTHPKFHKPKKLKDEADFCIIHYAGKVDYKADEWLMKNMDPLND 599

  Fly   570 DLLHLVSQSTNKFLRQIFAQDIEM--------------GA-ETRK-RTPTLSTQFRKSLDALMKT 618
            ::..|::|||::|:.::: :|::.              || :||| ...|:...:::.|..||.|
Zfish   600 NVATLLNQSTDRFVSELW-KDVDRIVGLDKVAGMSELPGAFKTRKGMFRTVGQLYKEQLSKLMAT 663

  Fly   619 LSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLI 683
            |.:..|.|:|||.||..||....|..|...|||.:|::|.|||.|.|:|.|..|:||.:||..|.
Zfish   664 LRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILT 728

  Fly   684 P-GVPPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSI 747
            | .:|.......||....|.|:.|..:.|::|.:|||.:......||:|||..:|..|:..|...
Zfish   729 PNSIPKGFMDGKQACMLMIRALELDPNLYRIGQSKVFFRAGVLAHLEEERDMKITDVIINFQAWC 793

  Fly   748 RGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGL 812
            ||:|.|:.|.:                             |.|.|...||              :
Zfish   794 RGYVARKAFAK-----------------------------RQQQLTAMRV--------------I 815

  Fly   813 QAHARGYLVRREYGHKMWAVIKIQSHVRRMIAM-RRYRKLRLEHKQFAEVLQLRKLEEQELLHRG 876
            |.:...||..|.     |...::.:.|:.::.: |:..:::.:.::.::|.:.:::.||:|:.  
Zfish   816 QRNCAAYLKLRN-----WQWWRLFTKVKPLLQVSRQEEEMQAKEEELSKVREKQQVAEQQLVE-- 873

  Fly   877 NKHAREIAEQHYRDRLHELERREIQEQLENRRRVEVNMNIINDA--------ARKQEEPVDDGKL 933
                .|:.:|..     ..|:..:||||      :..|::..:|        |:|||       |
Zfish   874 ----MEVKQQQL-----NAEKMALQEQL------QAEMDLCAEADEMRNRLVAKKQE-------L 916

  Fly   934 VEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAAT 998
            .|.:.|.                                    ...:.|:||             
Zfish   917 EEILHDL------------------------------------EARVEEEEE------------- 932

  Fly   999 YFQGNVNH-QYAKKALKHPLLPLHTQGD--QLAAQALWITILRFTGDMPEPKYHTMDRMDTTSVM 1060
                ..|| |..||.::..:..|..|.|  :.|.|.|                    :::..::.
Zfish   933 ----RANHLQAEKKKMQQNIADLEQQLDEEEAARQKL--------------------QLEKVTME 973

  Fly  1061 SKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDD- 1124
            :|:..|            |.::|.||                     .:.|||.::  ::|.:: 
Zfish   974 AKLKKT------------EEEVMVLD---------------------DQNNKLSKE--KKLMEER 1003

  Fly  1125 --EYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILL 1187
              |:|.:..:   :...:.:|:|                              ||:.|       
Zfish  1004 IAEFTTNLAE---EEEKSKSLQK------------------------------LKNKH------- 1028

  Fly  1188 SLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIML 1252
                             .|.|.:        .|:||:|.             |.|..:.:|    
Zfish  1029 -----------------EAMITD--------LEDRLRRE-------------EKQRQELEK---- 1051

  Fly  1253 PITFMDGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQ 1317
                   |.:.|..||        .:|.|:|:       .|...:.:..:.|....:.:.:|:::
Zfish  1052 -------NRRKLEGDS--------TELHDQIA-------ELQAQIAELKAQLAKKEEELQEALAR 1094

  Fly  1318 CEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLAM 1382
            .|    |:.||:..|..::   :|:     |....::..:|..::..| .|..::|.|..|:|..
Zfish  1095 IE----EEAAQKNLAQKKI---REL-----ESQLSELQEDLELERAAR-TKAEKHRRDLGEELEA 1146

  Fly  1383 I-----------AAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSY 1436
            :           ||||   |..|....|              ::.:.||:|..|           
Zfish  1147 LKTELEDTLDSTAAQQ---ELRTKRETE--------------VAQLKKALEEDA----------- 1183

  Fly  1437 YVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVDDQEQVL 1501
                     |:.|.:::..:.|....|....|...    .:.:|.|          .|:..:|.|
Zfish  1184 ---------KVHEQVMAEIRQKHSQAFDELNEQLE----QVKRNKV----------SVEKSKQAL 1225

  Fly  1502 LELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIAL 1566
                        ..:.|::..:..:|...:||....:......:::|.|...:..::|.:....|
Zfish  1226 ------------ESERNELQIELQTLMQGKGESEHRRKKAEAQLQELQVKHTESERQRIELAERL 1278

  Fly  1567 QDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKP 1631
            ...:|..|..:.|         |.|.. |:|:..:..|                     .|:...
Zfish  1279 TKMQAELDNVNTL---------LSDAE-GKSIKASKDC---------------------STVESQ 1312

  Fly  1632 PQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKR-------TMSKTLT 1689
            .||:..:...|     .|..:|.|....:..|..|:|.|...:...  .||       ||...|.
Zfish  1313 LQDVQEVLQEE-----TRQKLALNTRLRQLEDEQHSLREQLEEEEE--AKRNLEKQIGTMQAQLV 1370

  Fly  1690 LSSKRSE------ELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNE 1748
            ...|:.|      |....||..::    |.|::..:..:|...||       ..|...:.|:..|
Zfish  1371 DMKKKMEQESGSLECAEESRKRVQ----RDLEAVSQRLDERNAAF-------DKLDKTKTRLQQE 1424

  Fly  1749 ITDHIFDGPLKHEIL-----RDEIYCQLMKQLTDNRNRMSEERG---WELMWLATGLFACSQGL- 1804
            :.|.:.|.....:|:     :.:.:.|::.:......|.:|||.   .|.....|.:.|.::.| 
Zfish  1425 LDDMLVDQDHLRQIVSNLEKKQKKFDQMLAEEKSISARYAEERDRAEAEAREKETRMLALARELE 1489

  Fly  1805 ----LKELL----LFLRTRRHPI--SQD----SMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQI 1855
                :||.|    ..||.....:  |:|    |:|.|:|:.|..:::....:.::|.::      
Zfish  1490 TLTDMKEELDRTNKLLRAEMEDLVSSKDDVGKSVHDLEKSKRAMEQQLEEMKTQLEELE------ 1548

  Fly  1856 FHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEGFSLFVKIADKVISVPEGDFFFDFVR 1920
             .::...:|.....||:.......:..::..|..|...:...|..::.:..:.:.:.        
Zfish  1549 -DELQATEDAKLRLEVNMQAMKAQYERDLQGRDELGEEKKRQLLKQVREMEMELEDE-------- 1604

  Fly  1921 HLTDWIKKARPIRDGANPQFTYQVFFMKKLWTNTVPGKDRNADLIFHYHQELPKLLRGYH--KCS 1983
                  :|.|.:...|..:....:..::.........:|.....:.....::..|||...  :.|
Zfish  1605 ------RKQRTLAMAARKKMELDLKELEAAIDQANKNRDEALKQLKKVQAQMKDLLRELEDTRLS 1663

  Fly  1984 REEAAKLAALVFRVRFGENKQELQAIPQMLRELI 2017
            |||.           ..::|:..:.:..|..|:|
Zfish  1664 REEI-----------LAQSKENEKKVKSMEAEMI 1686

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 278/702 (40%)
MYSc_Myo7 77..721 CDD:276832 268/677 (40%)
MyTH4 <1138..1245 CDD:214535 13/106 (12%)
B41 1251..1467 CDD:214604 39/226 (17%)
FERM_B-lobe 1355..1439 CDD:271216 18/94 (19%)
FERM_C1_MyoVII 1461..1559 CDD:270019 13/97 (13%)
SH3 1560..1624 CDD:302595 9/63 (14%)
MyTH4 1701..1849 CDD:214535 35/170 (21%)
B41 1856..2068 CDD:214604 21/164 (13%)
FERM_M 1966..2068 CDD:278785 11/54 (20%)
FERM_C2_MyoVII 2064..2159 CDD:270020
myh9bXP_001920098.4 Myosin_N 28..66 CDD:280832 8/36 (22%)
Myosin_head 81..767 CDD:278492 275/689 (40%)
Motor_domain 93..767 CDD:277568 268/677 (40%)
KASH_CCD 937..1120 CDD:291334 52/353 (15%)
Sec1 <943..>1076 CDD:301618 40/291 (14%)
Dor1 1018..>1175 CDD:302817 45/287 (16%)
Filament 1034..1341 CDD:278467 76/465 (16%)
Rab5-bind 1306..1606 CDD:286404 61/359 (17%)
GrpE 1532..>1640 CDD:295646 11/128 (9%)
GBP_C <1596..1689 CDD:303769 15/116 (13%)
coiled coil 1660..1669 CDD:293879 4/19 (21%)
coiled coil 1678..1689 CDD:293879 3/9 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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