Protein Alignment ck and myo9b

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: XP_005171391.2
• Gene: myo9b / 560956
• ZFINID: ZDB-GENE-030131-938
• Length: 1974
• Species: Danio rerio
• Alignment Length: 1550
• Identity: 401/1550 - (25%)
• Similarity: 638/1550 - (41%)
• Gaps: 469/1550 - (30%)

  Fly    34 RRIQVRDDDGDEVWLAPERRI--KAMH---ASSV------QGV-------------EDMISLGDL 74
            |:.|::....|..:.|.:...  ::||   .|||      ||:             :|:.:|.||
Zfish    92 RKAQLKHPQSDGYFFALQEGSYDRSMHYDIMSSVRREKVAQGLVTRGFVSQQPQEYDDLCNLPDL 156

  Fly    75 HEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNA 139
            .|..||..|..|:.:..|||:..:||:||||::.||||....:|:|:...:|:|.||:|||.|.|
Zfish   157 TEESILETLRHRFHKQKIYTFASNILIAVNPFKFLPIYNPRYVKMYENHTLGKLEPHVFAIADAA 221

  Fly   140 YAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAIS--GKHSWIEQQILEANPILEAFGNAKT 202
            :..|...|.:||||||||||:|||:||..::..|.|:|  |..|.:|:.||.|.|:|||||||||
Zfish   222 FHTMMNKRVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYTSGVERTILGAGPVLEAFGNAKT 286

  Fly   203 IRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSR 267
            ..|:|||||||:|.:::..:||:.||.:|:|||||.|:||:..:||||||||.:|.|.|.:|:..
Zfish   287 AYNNNSSRFGKFIQVNYLESGVVRGAVVEKYLLEKCRLVSRGKTERNYHVFYYLLIGASEEERDE 351

  Fly   268 LDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYK 332
            ..|....||.||.....|:.:..:...||..:..||:::.|......:|..:|:|:|:.||:.||
Zfish   352 FKLLQPNDYHYLKEEMPISEDQAEMTHEFRRLHQAMEMVGFLPPTKKQIFSVLSAILYLGNVTYK 416

  Fly   333 ATVVDNLDATEI-PEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAF 396
            ...|.  :..:: |:|: :..::.||.:.::.|::|||.|......:.::...|.::::..||:.
Zfish   417 PKDVG--EGLKVGPDHV-LSALSDLLKVKVELLVEALTTRKAMTANDKLILPYSLNEAITARDSM 478

  Fly   397 VKGIYGRMFVHIVRKINTAIFKPRGTSRN----AIGVLDIFGFENFDQNSFEQFCINYANENLQQ 457
            .|.:|..:|..||.:||.|:...|....:    :||||||||||:|..|||||||||||||.||.
Zfish   479 AKSLYSALFDWIVLRINHALLNKRDLEDSVPCLSIGVLDIFGFEDFKTNSFEQFCINYANEQLQY 543

  Fly   458 FFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKL 522
            :..|.||.||||||..|.|.|..::|.||...:.|.:.|...:..|:|||:.||:.||.|:|.|.
Zfish   544 YCNQRIFTLEQEEYLAEGITWHTVDFPDNIGCISLFSKKPTGLFFLLDEESNFPQATDSTLLEKF 608

  Fly   523 HKTHGSHKNYLK-PKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQI 586
            .:.|..:..::: |..:  .:|.:.||||.|.|..:.|.:||.|...||::.|:..|...:|||:
Zfish   609 KQQHQDNPFFVQTPVRE--PAFVILHFAGKVKYQIKDFREKNTDHMRPDIVALLRSSECSYLRQL 671

  Fly   587 FA--------------------------------------------------------------- 588
            ..
Zfish   672 IGANPVAVFRWGILRATIRTLAVFNKAGRTWAEKHPDEIRRYSRRSFGESRRPSPTVPTIQRLKS 736

  Fly   589 -------------------QDI-------------------EMGAE------------------- 596
                               :||                   :.|.|
Zfish   737 QSRIDFSFDRSEEDPLEAFEDIFATFESKKELHAKVLRSLRQFGVEVPQKLRLSTNSSRKYRLFS 801

  Fly   597 ------------------------------------------TRKRTPTLSTQFRKSLDALMKTL 619
                                                      |:|:.|::|.||:.||..|::||
Zfish   802 QKNRPNKHKQLIPKNLIDSHSLKFIMALTQHNRVTRSLLHLHTKKKPPSISAQFQASLSKLLETL 866

  Fly   620 SSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP 684
            ...:|||:|||:.|..|:.|.||..|..:||||:||::|:||||:||..:..||||::::|.|:|
Zfish   867 RKAEPFFVRCIRSNGDKREMHFDDALVLQQLRYTGMLQTVRIRRSGYGAKFTFREFIDQFRVLLP 931

  Fly   685 GVPPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRG 749
            ......:.|   .|:.:..:.|..|.:|:|.||||||::....|::...:.:.|:|:||||..|.
Zfish   932 KEISTPQED---ITNLLTKMGLPGSSFQIGRTKVFLKESERQILQETLHKEVMRRIIILQRWFRA 993

  Fly   750 WVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQA 814
            .:.|:::||.|...||:||.|:
Zfish   994 CLMRKQYLRGRKGIITIQRSWR------------------------------------------- 1015

  Fly   815 HARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQ--LRKLEEQE------ 871
                 .||..|  :..|.|.||      ||.|:.|:...:.|..|:..|  |.|:||::
Zfish  1016 -----FVRETY--RCRAAIVIQ------IAWRKSRQRAEQEKLKAQAFQRDLNKIEEKKPSQPKP 1067

  Fly   872 --LLHRGNKHAREIAEQHYRDRLHELERREIQEQ----------LENRRRVEVNMNIINDAARKQ 924
              .|...::.|........|.:|:...:.:|..|          ::..|....|..::.:   |:
Zfish  1068 LPSLPNESRTAESKKTDEPRPQLNTDTKPKIPTQPTPGITKQLSVKEDRLGRSNRGMVGN---KE 1129

  Fly   925 EEPVDDGKLVEAMFDFLPDSSSDAPTPHG---GRETSVFNDLPHA---QNVNQDDIIAPIHISED 983
            ..|                |.|..|.|..   ....|.:||..||   |..|:.:     .::|.
Zfish  1130 RHP----------------SPSGLPRPVSLPLNMSQSAYNDSQHAVQLQRQNKSN-----RLTEK 1173

  Fly   984 EEDLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKY 1048
            .|...|    :.:.....||::.   .|...|..:.....|..|:..
Zfish  1174 PEKWKE----RSSDAARMGNIDE---IKPRSHEKIGFIKPGISLSLD------------------ 1213

  Fly  1049 HTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKL 1113
             .:.||.::.  |..:|:..||                 :..::.:.|          ||.|.:|
Zfish  1214 -NVSRMSSSE--SDSSASSSRN-----------------EVMVENRKR----------LKHKRRL 1248

  Fly  1114 GEDVRRRLQDDEYTADSYQSWL----QSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNN 1174
            ... |..|:.|:........|.    ...|.:..:.:..::...::::.:..:
Zfish  1249 ARP-RSGLKVDDLDLSDSAYWSFPLPPISPAAPNQSITQVVVEAVMQSSVESD------------ 1300

  Fly  1175 PLKSSHARGWILLSLCVGCF-----APSEKFV---------NYLRAFIREGPPGYAPYC------ 1219
                             |||     :|||:.:         .:|:.|.:...|......
Zfish  1301 -----------------GCFPFSNRSPSEEVIAPSITPERKGFLKFFKKRSTPQDGTITMVKTLA 1348

  Fly  1220 -EERL--------KRTFNNGT-----RNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSAT 1270
             :|.|        .||.|:||     ||                   |...:...|:|.:..:|:
Zfish  1349 EKEELASGNHSNSPRTKNSGTYPGAHRN-------------------PTIKISRATRTQVQWNAS 1394

  Fly  1271 TARE-------------LCNQLSD------KISLKDQFGFSLYIALFDKVSSLGS 1306
            ..||             |.||::|      ::|..::..|:......:.:.|:.|
Zfish  1395 LDREITDTNELRHLDEFLGNQMNDLSTRSKELSETEKIFFTATTQFRETIKSMYS 1449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	270/813 (33%)
		MyTH4	<1138..1245	CDD:214535	19/140 (14%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	13/76 (17%)
		B41	1251..1467	CDD:214604	13/74 (18%)
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020
myo9b	XP_005171391.2	None