DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and myo9b

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	XP_005171391.1	Gene:	myo9b / 560956	ZFINID:	ZDB-GENE-030131-938	Length:	1974	Species:	Danio rerio

Alignment Length:	1532	Identity:	403/1532 - (26%)
Similarity:	621/1532 - (40%)	Gaps:	493/1532 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 RRIQVRDDDGDEVWLAPERRI--KAMH---ASSV------QGV-------------EDMISLGDL 74
            |:.|::....|..:.|.:...  ::||   .|||      ||:             :|:.:|.||
Zfish    92 RKAQLKHPQSDGYFFALQEGSYDRSMHYDIMSSVRREKVAQGLVTRGFVSQQPQEYDDLCNLPDL 156

  Fly    75 HEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNA 139
            .|..||..|..|:.:..|||:..:||:||||::.||||....:|:|:...:|:|.||:|||.|.|
Zfish   157 TEESILETLRHRFHKQKIYTFASNILIAVNPFKFLPIYNPRYVKMYENHTLGKLEPHVFAIADAA 221

  Fly   140 YAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAIS--GKHSWIEQQILEANPILEAFGNAKT 202
            :..|...|.:||||||||||:|||:||..::..|.|:|  |..|.:|:.||.|.|:|||||||||
Zfish   222 FHTMMNKRVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYTSGVERTILGAGPVLEAFGNAKT 286

  Fly   203 IRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSR 267
            ..|:|||||||:|.:::..:||:.||.:|:|||||.|:||:..:||||||||.:|.|.|.:|:..
Zfish   287 AYNNNSSRFGKFIQVNYLESGVVRGAVVEKYLLEKCRLVSRGKTERNYHVFYYLLIGASEEERDE 351

  Fly   268 LDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYK 332
            ..|....||.||.....|:.:..:...||..:..||:::.|......:|..:|:|:|:.||:.||
Zfish   352 FKLLQPNDYHYLKEEMPISEDQAEMTHEFRRLHQAMEMVGFLPPTKKQIFSVLSAILYLGNVTYK 416

  Fly   333 ATVVDNLDATEI-PEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAF 396
            ...|.  :..:: |:|: :..::.||.:.::.|::|||.|......:.::...|.::::..||:.
Zfish   417 PKDVG--EGLKVGPDHV-LSALSDLLKVKVELLVEALTTRKAMTANDKLILPYSLNEAITARDSM 478

  Fly   397 VKGIYGRMFVHIVRKINTAIFKPRGTSRN----AIGVLDIFGFENFDQNSFEQFCINYANENLQQ 457
            .|.:|..:|..||.:||.|:...|....:    :||||||||||:|..|||||||||||||.||.
Zfish   479 AKSLYSALFDWIVLRINHALLNKRDLEDSVPCLSIGVLDIFGFEDFKTNSFEQFCINYANEQLQY 543

  Fly   458 FFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKL 522
            :..|.||.||||||..|.|.|..::|.||...:.|.:.|...:..|:|||:.||:.||.|:|.|.
Zfish   544 YCNQRIFTLEQEEYLAEGITWHTVDFPDNIGCISLFSKKPTGLFFLLDEESNFPQATDSTLLEKF 608

  Fly   523 HKTHGSHKNYLK-PKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQI 586
            .:.|..:..::: |..:  .:|.:.||||.|.|..:.|.:||.|...||::.|:..|...:|||:
Zfish   609 KQQHQDNPFFVQTPVRE--PAFVILHFAGKVKYQIKDFREKNTDHMRPDIVALLRSSECSYLRQL 671

  Fly   587 FA--------------------------------------------------------------- 588
            ..
Zfish   672 IGANPVAVFRWGILRATIRTLAVFNKAGRTWAEKHPDEIRRYSRRSFGESRRPSPTVPTIQRLKS 736

  Fly   589 -------------------QDI-------------------EMGAE------------------- 596
                               :||                   :.|.|
Zfish   737 QSRIDFSFDRSEEDPLEAFEDIFATFESKKELHAKVLRSLRQFGVEVPQKLRLSTNSSRKYRLFS 801

  Fly   597 ------------------------------------------TRKRTPTLSTQFRKSLDALMKTL 619
                                                      |:|:.|::|.||:.||..|::||
Zfish   802 QKNRPNKHKQLIPKNLIDSHSLKFIMALTQHNRVTRSLLHLHTKKKPPSISAQFQASLSKLLETL 866

  Fly   620 SSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP 684
            ...:|||:|||:.|..|:.|.||..|..:||||:||::|:||||:||..:..||||::::|.|:|
Zfish   867 RKAEPFFVRCIRSNGDKREMHFDDALVLQQLRYTGMLQTVRIRRSGYGAKFTFREFIDQFRVLLP 931

  Fly   685 GVPPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRG 749
            ......:.|   .|:.:..:.|..|.:|:|.||||||::....|::...:.:.|:|:||||..|.
Zfish   932 KEISTPQED---ITNLLTKMGLPGSSFQIGQTKVFLKESERQILQETLHKEVMRRIIILQRWFRA 993

  Fly   750 WVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQA 814
            .:.|:::||.|...||:||.|       ||
Zfish   994 CLMRKQYLRGRKGIITIQRSW-------RY----------------------------------- 1016

  Fly   815 HARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQ--LRKLEE-------- 869
                  ||..|  :..|.|.||      ||.|:.|:...:.|..|:..|  |.|:||
Zfish  1017 ------VRETY--RCRAAIVIQ------IAWRKSRQRAEQEKLKAQAFQRDLNKIEEKKPSQPKP 1067

  Fly   870 ----------------------------------------------QELLHRGNKHAREIAEQH- 887
                                                          ::.|.|.|:......|:|
Zfish  1068 LPSLPNESRTAESKKTDEPRPQLNTDTKPKIPTQPTPGITKQLSVKEDRLGRSNRGMVGNKERHP 1132

  Fly   888 -------------------YRDRLH--ELERREIQEQL--------------------------- 904
                               |.|..|  :|:|:....:|
Zfish  1133 SPSGLPRPVSLPLNMSQSAYNDSQHTVQLQRQNKSNRLTEKPEKWKERSSDAARMGNIDEIKPRS 1197

  Fly   905 ---------------------------------------ENRRRVEVNMNIINDAARKQEEPVDD 930
                                                   |||:|::....:   |..:....|||
Zfish  1198 HEKIGFLKPGISLSLDNVSRMSSSESDSSASSSRNEVMVENRKRLKHKRRL---ARPRSGLKVDD 1259

  Fly   931 GKLVE-AMFDF-LPDSSSDAPTP-------HGGRETSVFND--LPHAQNVNQDDIIAPIHISEDE 984
            ..|.: |.:.| ||..|..||..       ....::||.:|  .|.:.....:::|||   |...
Zfish  1260 LDLSDSAYWSFPLPPISPAAPNQSITQVVVEAVMQSSVESDGCFPFSNRSPSEEVIAP---SITP 1321

  Fly   985 EDLSEFKFQKFAATYFQGNV---------------NHQYAKK---------ALKHPLLPLHTQGD 1025
            |.....||.|..:|...|.:               ||..:.:         |.::|.:.:   ..
Zfish  1322 ERKGFLKFFKKRSTPQDGTITMVKTLAEKEELASGNHSNSPRTKNSGTYPGAHRNPTIKI---SR 1383

  Fly  1026 QLAAQALWITILRFTGDMPEPKYHTMDRMDT-TSVMSKVTATLGRNF----IRSKEFQEAQLMGL 1085
            ....|..|..              ::||..| |:.:..:...||...    .||||..|.:.:..
Zfish  1384 ATRTQVQWNA--------------SLDREITDTNELRHLDEFLGNQMNDLSTRSKELSETEKIFF 1434

  Fly  1086 DPDAFLKQKPR--------SIRHK-LVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSWLQSRPTS 1141
            ......::..:        ||.:| |:|...|:.:.|..  :::..:.....:.:||.|.
Zfish  1435 TATTQFRETIKSMYSISNPSIGYKVLMSGYQKKVDSLAG--KKKASEVPLVVNLFQSVLD----- 1492

  Fly  1142 NLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKS 1178
                       |.:|.||: .|..:.||....|..||
Zfish  1493 -----------GFIRGELK-RIDAEPCKVKERNRRKS 1517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	279/851 (33%)
		MYSc_Myo7	77..721	CDD:276832	270/813 (33%)
		MyTH4	<1138..1245	CDD:214535	10/41 (24%)
		B41	1251..1467	CDD:214604
		FERM_B-lobe	1355..1439	CDD:271216
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
myo9b	XP_005171391.1	UBQ	13..110	CDD:294102	4/17 (24%)
		MYSc	147..974	CDD:214580	278/834 (33%)
		MYSc_Myo9	159..965	CDD:276836	270/813 (33%)
		C1	1529..1577	CDD:237996
		RhoGAP	1593..1778	CDD:295372
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810