DRSC/TRiP Functional Genomics Resources

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Protein Alignment ck and myo15aa

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:XP_021330383.1 Gene:myo15aa / 560592 ZFINID:ZDB-GENE-080425-2 Length:2394 Species:Danio rerio


Alignment Length:2676 Identity:665/2676 - (24%)
Similarity:1031/2676 - (38%) Gaps:908/2676 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 GVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGEL 128
            |||||..|.:|||..:|.||..|::.||||||.|||||:||||::..||..|.:..:|...:||.
Zfish    20 GVEDMTQLEELHEGAVLLNLKKRFERNLIYTYIGSILVSVNPYKMFNIYGTDMVLQHKGHALGEN 84

  Fly   129 PPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSWIEQQILEANPI 193
            |||:|||.:.:|..|...:::|||:||||||:||||:|||:|:|||||..|.: |.||||||.|:
Zfish    85 PPHLFAIANASYTKMMDAKENQCIIISGESGSGKTETTKLVLRYLAAIHHKQN-ITQQILEATPL 148

  Fly   194 LEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILA 258
            ||:||||||:|||||||||||::| |...|||.||...||||||||||.|...|||||:||.:||
Zfish   149 LESFGNAKTVRNDNSSRFGKYMEI-FMEEGVISGAITSQYLLEKSRIVFQAKDERNYHIFYEMLA 212

  Fly   259 GLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAAL 323
            ||.:.:|....|..|..|.||..|......|:.|..:|..:.|||::|.||.::...|.::|:::
Zfish   213 GLPSQQKQSFYLQDAETYYYLNQGGDCVIVGKSDGEDFRRLLSAMEILHFSAEDQSGIFRVLSSI 277

  Fly   324 LHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQ 388
            ||.||:.::....::.:...:.....:..||.||.:..:.|..::|.:......|.:.:.|:.:.
Zfish   278 LHLGNVFFERYETESQEVASVVSAQEIRVVAELLQISPEGLQKSITFKVTETMREKIYTPLTVES 342

  Fly   389 SVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCINYANE 453
            ::|.|||..|.:|..:|..:..:||..:: ||..:. :|.:|||:|||:...|||||.|||||||
Zfish   343 AIDARDAVAKILYSLLFSWLTDRINKQVY-PRNEAL-SISILDIYGFEDLTFNSFEQLCINYANE 405

  Fly   454 NLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTM 518
            .||.||.:.|||.||:|||.|.|.|:.:.|.|||..:||||.|...|:.::|:::.||:.||.|.
Zfish   406 YLQFFFNRVIFKEEQDEYNREQIIWEEVPFSDNQACIDLIAAKPHGILRILDDQSGFPQATDHTF 470

  Fly   519 LAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFL 583
            |.|.|..||::..|.|||..: ..|.:.|:||.|.|....|||||.|....|:|.|..||.||.:
Zfish   471 LQKCHYHHGNNPLYSKPKMPL-PEFTIKHYAGKVSYQVHKFLDKNYDQVRQDVLDLFIQSKNKMV 534

  Fly   584 RQIF--------AQDIEMGAET----RKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELK 636
            ..:|        .|..::|..:    |.:..|::.:|::||..|::.:....|:|:||||||:.|
Zfish   535 AYLFMNYAEALNQQRSQIGKNSTVTRRHQASTVAAKFQQSLLELIEKMERANPYFVRCIKPNQNK 599

  Fly   637 KPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGV---PPAHRTDCQAAT 698
            :|.:||..|...||.|||::||:||||.|||||..|..|:.||:.|: |:   |||:..:|....
Zfish   600 EPAVFDMELVSAQLCYSGILETVRIRREGYPIRMPFDVFLFRYKSLL-GLKQPPPANGENCVIML 663

  Fly   699 SRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAA 763
            .::|.|..|.  :|:|.||:|:|:.....||.:||||                       ...||
Zfish   664 RKLCPVRPGA--FQVGVTKLFMKEEIYFLLESKRDRV-----------------------RHVAA 703

  Fly   764 ITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHK 828
            :|:||:.:.:..||||...|:                       .|:.||||.||:|.|:.|...
Zfish   704 LTLQRYTRMFFVRKRYTAFRM-----------------------KIIRLQAHCRGFLTRKRYVKM 745

  Fly   829 MWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQELLHRGNKHAREIAEQHYRDRLH 893
            ..:::|.:|.|...:..:||.:||.|.:        ||.||                        
Zfish   746 RVSLVKFRSLVHMYVDRKRYIRLRYEAR--------RKAEE------------------------ 778

  Fly   894 ELERREIQEQLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETS 958
              |:|.|:.:|..|..|.|...:|         |.:.|.|::|              ..||||  
Zfish   779 --EQRRIEMELSKREVVNVTHLVI---------PAELGALLQA--------------AAGGRE-- 816

  Fly   959 VFND---LPHAQNVN-QDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKALKHPL-L 1018
            :.:|   |..|..|. :..:..|:       |::.:...|....:|:     :.....|..|| .
Zfish   817 LHSDCLALVQAPTVQVETQLTLPL-------DINNYTISKLVQIHFK-----EPKFGMLTAPLKT 869

  Fly  1019 PLHTQGDQLAAQAL--WITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQ 1081
            ||....|.|..:||  ::.||||.||                                       
Zfish   870 PLTHVDDDLTHEALDVFVMILRFMGD--------------------------------------- 895

  Fly  1082 LMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKL 1146
                         |.        |...::|..|                                
Zfish   896 -------------PH--------LNGAQENLFG-------------------------------- 907

  Fly  1147 HFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIRE- 1210
            ::||..|:....|||||.|||..|:..||...:..|||:||..|:..||||.|...||..|:.: 
Zfish   908 NYIIQKGLTNLNLRDEILCQIANQVWRNPNPDNSERGWLLLLACLSAFAPSAKVEKYLLKFVSDH 972

  Fly  1211 -----GPPGYAPYCEERLKRTFNNGT-RNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSA 1269
                 ...|.....:...|..:...| |..|.|.||..|.:.|..::|.:...||.:......|.
Zfish   973 AYNEFKAVGQHKLIQAMQKSLYGPETARTYPLSLLEWTANRKKANMVLQVHCFDGTSFLCPVHSW 1037

  Fly  1270 TTARELCNQL------------------------------------------------------- 1279
            |:..||...:                                                       
Zfish  1038 TSGEELAGDILQHRGVTEAWKGCSVIMKEHGQWAELAGHDYVMDLIADMELMRNFPKQKSYFIIS 1102

  Fly  1280 --------------------------------------------------SDKISLKDQFGFSLY 1294
                                                              ||......|.|...|
Zfish  1103 AESPTRTRPNAGLALFGSGFDSDDDSSLLLPQTMLSSSLPDSDGYYSHAESDFSEAPTQKGMDRY 1167

  Fly  1295 I-ALFDKVSSLGSG--------------------------------------------------- 1307
            : :|||.|.|.|:|                                                   
Zfish  1168 LDSLFDPVLSDGNGDFEKSSSMSSRMKGAGGIGGENGDLEKPPSGRPYPPGLQPGAVPVLPVMGG 1232

  Fly  1308 ----------------------------------------------------------------- 1307
                                                                             
Zfish  1233 TMMPPIPMPAMPSVPHAQASAAVPSVPPMPAMPSMPAMPAMLPLPALPNVPPMPDMSGVDPAVLA 1297

  Fly  1308 ----------------------------------------------------------------- 1307
                                                                             
Zfish  1298 QHQQAIINQQAIILAQQMTMQAMALQQQMYNSVHHPHSELLPAARSSQYSPTKQDIGPVSYKPAP 1362

  Fly  1308 ---------------------GDHVMDAISQCE-------------QY----------------- 1321
                                 |:.|...:|..|             ||                 
Zfish  1363 VSPPQKSSQRHYSPPRREPPPGEVVRATVSNTEYLEPSHNIKDIIKQYQTNPVKPAEIPRREAKV 1427

  Fly  1322 --------------AKEQGA---QER--------------------------------------- 1330
                          .|:|.:   |:|                                       
Zfish  1428 FSKKPDPHDEAMMILKDQMSAPPQQRKKTYTPVPPSSSGKEFSYDGGPMKPVKSITTKRSPPVPA 1492

  Fly  1331 --------------------------------------NAPWRLFFRKEIFAPWHEPTHDQVATN 1357
                                                  |.||:::.|||:|.|.....|..: .:
Zfish  1493 VSQRFPAPAPVSRDLPVEDENIQTQLHKRSSEEHYTYTNVPWKIYLRKEVFYPKDSFNHPLI-LD 1556

  Fly  1358 LIYQQVVRGVKFGE--YRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKA 1420
            |:::|:|... |.|  .|...||...|   :..|.|:|.|.|..                     
Zfish  1557 LLFKQIVHDT-FSEACIRITTEERQKM---KSIFAEHSIDASAT--------------------- 1596

  Fly  1421 IERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIA 1485
                             ::|:    .:|:.:|..||..|.:.|||.:.|..:.|..:.    :::
Zfish  1597 -----------------IQDE----NVKKKVVVAAKDTWDIYFSRLFPASGSVGTGVQ----VLS 1636

  Fly  1486 VNWTGV---------YVVDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPN 1541
            |:..|:         .|..|..:||...|:.:|..|:....|.:   .|:|:   .|:....|..
Zfish  1637 VSHRGIKLLKMVRSSAVAPDYFRVLRPYSYTDIMFVTIPSKNML---EFNLN---NEKLILFSAK 1695

  Fly  1542 AEDIRDLVVYFLDGLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLIILED--------------- 1591
            |..::.::.||:..|||.|.||:|:::|  .:|..:.|||.|||:|.|:.               
Zfish  1696 APQVKTMIDYFITELKKDSDYVVAVRNY--ITDDRTLLSFHKGDIIRLQKMEGLDAGQYYGCIVK 1758

  Fly  1592 ------ESCGESVLNNGWCIGRC-DRSQERGDFPAETV--YVLPTLSKPPQD------------- 1634
                  |.......:.||..|.. .||   |.||.|.|  ...|.....|.|             
Zfish  1759 KKVILLEELKRDTPDFGWKFGAIHGRS---GVFPVEFVQPVAAPDFINIPVDKKEEPKNKQGRVA 1820

  Fly  1635 -----ILALFNIEEAHH-GRRLSMA------------SNGGAVEPR---DRPHTLMEYALDHFRL 1678
                 .:|:.:...||. .|.:.:|            |....::.|   |..:.::|:|..:||.
Zfish  1821 ASAAVAVAVGSAAAAHELDRTIEVASPVSEYTEAYTDSTDMDIDERILQDVQYNMVEFAKKYFRG 1885

  Fly  1679 PPKRTMSKTLTLSSKRSE------ELWRYSRDPIKAPLLRKLQSKEEFAEE-----ACFAFAAIL 1732
            ..::....:....||:|:      |:.::|:.||:..|:       ||.:|     |...|.||:
Zfish  1886 AQRKNGGDSYKKKSKKSKEPRDPSEMVKFSKSPIQESLI-------EFTDENLNKVAAEIFLAIM 1943

  Fly  1733 KYMGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYCQLMKQLTDNRNRMSE--ERGWELMWLAT 1795
            |:|||.|.| .:...::...|.....::.::|||.|||:::|:|.|.:..:|  :|||.|:::.|
Zfish  1944 KFMGDYPMK-GQAEQDVISTILRLSGEYGLMRDEAYCQVLRQITGNTSSKTESCQRGWRLLYIFT 2007

  Fly  1796 GLFACSQGLLKELLLFLR-------TRRHPISQDSMHRLQKTIRHGQRKYPPHQVEVEAI---QH 1850
            ..:.||:.|...||.:|:       .....|::.....|:||.::|.|...|:.:|::|:   :.
Zfish  2008 AYYKCSEVLKPYLLKYLQDVCASPGVHFQGIAKACEQNLRKTFQYGGRIEHPNGMELKAMLAGRS 2072

  Fly  1851 KTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEG---FSLFVKIADKVISVPEG 1912
            ...|:|   ..|...:...::.:.:.|.|....:...:.|...|.   :::||            
Zfish  2073 SKRQLF---LLPGGIERHLKIKTCSVALDAIEELCYEMGLHKLEALDEYAVFV------------ 2122

  Fly  1913 DFFFDFVRHLTDWIKKARPIR----------DGANPQFTYQVFFMKKLWTNTVPGK-DRNADLIF 1966
                     :|:..:..||:.          :..:....|.::|.:.:||.  |.| |....:..
Zfish  2123 ---------VTNRGQNVRPLNKREYILDITTEAEHVDSNYSLWFRRVIWTQ--PLKFDNELGVTM 2176

  Fly  1967 HYHQELPKLLRG------YHKCSR---EEAAKLAALVFRVRFGENKQELQAIPQMLRELIPSDIM 2022
            ||:|..|..|:|      ..|.|.   ::.||||||..|.:   :...|..|.: ::|.||:.:.
Zfish  2177 HYNQVYPDYLKGLLTVLPQGKASEQQLQQVAKLAALQHRAK---DSLYLPTIHE-VQEYIPTQLS 2237

  Fly  2023 KIQSTSEWKRSIVASYNQDGGMTSEDAKVAFLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAIN 2087
            .:|...:|.........|...::...||..||.:|..:|.|||:||.:..::........::|:|
Zfish  2238 GLQRAQQWLNMATQHMQQVQPLSPHQAKAQFLGLVSAFPMFGSSFFYILSSSNSAVDTPCVLAVN 2302

  Fly  2088 KHGVSLIHPVTKDILVTHPF-----TRISNWSSGNTYFHMTI--GNLV--RGSKLLCETSL---- 2139
            ::|::.:...|.:.:|..|.     ||....::|::|.::.|  |:|:  |.::|..|.||    
Zfish  2303 QNGLNFLSKETHEPMVKFPLKEVQSTRTQRPTAGSSYPYVEIMLGDLMSQRITQLQLEQSLELCR 2367

  Fly  2140 --GYKMDDLLT 2148
              ...|::||:
Zfish  2368 VVAMHMENLLS 2378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 299/683 (44%)
MYSc_Myo7 77..721 CDD:276832 287/658 (44%)
MyTH4 <1138..1245 CDD:214535 37/113 (33%)
B41 1251..1467 CDD:214604 61/649 (9%)
FERM_B-lobe 1355..1439 CDD:271216 14/85 (16%)
FERM_C1_MyoVII 1461..1559 CDD:270019 24/106 (23%)
SH3 1560..1624 CDD:302595 25/87 (29%)
MyTH4 1701..1849 CDD:214535 48/164 (29%)
B41 1856..2068 CDD:214604 50/234 (21%)
FERM_M 1966..2068 CDD:278785 32/110 (29%)
FERM_C2_MyoVII 2064..2159 CDD:270020 25/100 (25%)
myo15aaXP_021330383.1 Motor_domain 34..684 CDD:328930 287/657 (44%)
IQ 723..742 CDD:279006 10/41 (24%)
MyTH4 866..1013 CDD:214535 55/238 (23%)
Atrophin-1 <1205..1505 CDD:331285 10/299 (3%)
SH3_MYO15A 1716..1795 CDD:213000 24/83 (29%)
MyTH4 1914..2068 CDD:214535 48/161 (30%)
FERM_B-lobe 2176..2273 CDD:271216 27/100 (27%)
FERM_C_MyoXV 2279..2380 CDD:270022 25/100 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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