DRSC/TRiP Functional Genomics Resources

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Protein Alignment ck and MYO5C

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_061198.2 Gene:MYO5C / 55930 HGNCID:7604 Length:1742 Species:Homo sapiens


Alignment Length:1492 Identity:461/1492 - (30%)
Similarity:691/1492 - (46%) Gaps:237/1492 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 IVTRGDYIWI----EPASGREF--DVAIGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASS 61
            :.|:.:.:||    |.....|.  |..:|.:|:     |:.:.|....:..:.||......:...
Human     6 LYTQYNRVWIPDPEEVWKSAEIAKDYRVGDKVL-----RLLLEDGTELDYSVNPESLPPLRNPDI 65

  Fly    62 VQGVEDMISLGDLHEAGILRNLLIRYKEN-LIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKI 125
            :.|..|:.:|..|||..:|.||.||:.|: |||||:|.||||:|||:.||||....|..|..:.:
Human    66 LVGENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNM 130

  Fly   126 GELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAI--SGKHSWIEQQIL 188
            |::.|||||:.:.||..|.|..::|.|::|||||||||.|.:..::|.|.:  ||.::.:|.::|
Human   131 GDMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSGSNAHVEDKVL 195

  Fly   189 EANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVF 253
            .:|||.||.|||||.|||||||||||.:|.|.....|.||.:..|||||||:|.|:.:|||||:|
Human   196 ASNPITEAVGNAKTTRNDNSSRFGKYTEISFDEQNQIIGANMSTYLLEKSRVVFQSENERNYHIF 260

  Fly   254 YCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIK 318
            |.:.|.....|...|.||.|.::.|...|.:...||.:|.||..:.:....:|.|.:....::.|
Human   261 YQLCASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVNDRAEMVETQKTFTLLGFKEDFQMDVFK 325

  Fly   319 LLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVST 383
            :|||:||.||::..|...:....:|...|:.|  ...||||....:...|..|.:....||||..
Human   326 ILAAILHLGNVQITAVGNERSSVSEDDSHLKV--FCELLGLESGRVAQWLCNRKIVTSSETVVKP 388

  Fly   384 LSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCI 448
            ::|.|:|:.|||..|.||..:|..||.:||.|: :..|.....||||||:|||.||.||||||||
Human   389 MTRPQAVNARDALAKKIYAHLFDFIVERINQAL-QFSGKQHTFIGVLDIYGFETFDVNSFEQFCI 452

  Fly   449 NYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKG 513
            |||||.|||.|..|:||||||||..|.|.|..|:|.|||..:|||..| :.|:.|:|||...|.|
Human   453 NYANEKLQQQFNMHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAK-MGILELLDEECLLPHG 516

  Fly   514 TDQTMLAKLHKTHGSHKNYL--KPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVS 576
            ||:..|.||:... .::|.|  ||:.. ||||.:.|||..|.|...|||:|||||....|:.::.
Human   517 TDENWLQKLYNNF-VNRNPLFEKPRMS-NTSFVIQHFADKVEYKCEGFLEKNRDTVYDMLVEILR 579

  Fly   577 QSTNKFLRQIFAQD------------IEMGAETRK------RTPTLSTQFRKSLDALMKTLSSCQ 623
            .|........|.::            ::...:..|      || |:.::||.||..||:||::..
Human   580 ASKFHLCANFFQENPTPPSPFGSMITVKSAKQVIKPNSKHFRT-TVGSKFRSSLYLLMETLNATT 643

  Fly   624 PFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPP 688
            |.::||||||:.|.|..||.....:|||..|::|||||....||.|..:.||..||..|:     
Human   644 PHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSRYGILM----- 703

  Fly   689 AHRTDCQAATS---RICAVVLGK-----SDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQR 745
               |..:.:.|   .:|.|||.:     :.||.|.||:|.:.....:||:.|...|.:..:::|:
Human   704 ---TKQELSFSDKKEVCKVVLHRLIQDSNQYQFGKTKIFFRAGQVAYLEKLRLDKLRQSCVMVQK 765

  Fly   746 SIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIV 810
            .:|||:.|::|||.|.||:.:|::::|                 |..:|..:.:...:.....|:
Human   766 HMRGWLQRKKFLRERRAALIIQQYFRG-----------------QQTVRKAITAVALKEAWAAII 813

  Fly   811 GLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQELLHR 875
             :|.|.||||||..|.....|.|.:|::.|..:|.|||||:..|||  |.:||            
Human   814 -IQKHCRGYLVRSLYQLIRMATITMQAYSRGFLARRRYRKMLEEHK--AVILQ------------ 863

  Fly   876 GNKHAREIAEQHYRDRLHELERREIQEQLENRRRVEVNMNIINDAARKQEEPVDDGK----LVEA 936
              |:||.           .|.||..|    :.||..:|:.:.....|.|::..|..|    |||.
Human   864 --KYARA-----------WLARRRFQ----SIRRFVLNIQLTYRVQRLQKKLEDQNKENHGLVEK 911

  Fly   937 MFDFLPDSSSD-------------APTPHGGRE-------TSVFNDLPHAQNVN-----QDDIIA 976
            :.......:.|             |.|.....|       .:|...|...|..|     |.:.| 
Human   912 LTSLAALRAGDVEKIQKLEAELEKAATHRRNYEEKGKRYRDAVEEKLAKLQKHNSELETQKEQI- 975

  Fly   977 PIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQALWITILRFTG 1041
            .:.:.|..|:|.| |........|. :|..:..::.|......|.||..:...|:|...|.....
Human   976 QLKLQEKTEELKE-KMDNLTKQLFD-DVQKEERQRMLLEKSFELKTQDYEKQIQSLKEEIKALKD 1038

  Fly  1042 D------MPEPKYHTMDRMDT-TSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIR 1099
            :      :.|.::.|.|.:.. .:.:||...|:..   ..||.:..|...:|.:..::.:.|.:|
Human  1039 EKMQLQHLVEGEHVTSDGLKAEVARLSKQVKTISE---FEKEIELLQAQKIDVEKHVQSQKREMR 1100

  Fly  1100 HKLVSLTLKRKNKLG-EDVRRRL--QDDEYTADSYQSW------------LQSRPTS-------N 1142
            .|:..:|.:...... ||||.||  :|.|:..:..:.|            |:|...|       .
Human  1101 EKMSEITKQLLESYDIEDVRSRLSVEDLEHLNEDGELWFAYEGLKKATRVLESHFQSQKDCYEKE 1165

  Fly  1143 LEKLHFIIGH---------GILRAE--LRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAP 1196
            :|.|:|.:.|         .:.|.|  :.:.|..::.:..:.|.:.....:.          .:.
Human  1166 IEALNFKVVHLSQEINHLQKLFREENDINESIRHEVTRLTSENMMIPDFKQQ----------ISE 1220

  Fly  1197 SEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQA--------TKSKKPIMLP 1253
            .||....|...:.|    .|...:.:|:...|...|:|.....:.:|        ||.|:.::..
Human  1221 LEKQKQDLEIRLNE----QAEKMKGKLEELSNQLHRSQEEEGTQRKALEAQNEIHTKEKEKLIDK 1281

  Fly  1254 ITFMDGNTKTLLADSATTARELCN-------------QLSDKISLKDQFGFSLYIALFDKVSSLG 1305
            |..|...:..|.....|.:...||             .|.:::.:||:    :...|.|:|.:|.
Human  1282 IQEMQEASDHLKKQFETESEVKCNFRQEASRLTLENRDLEEELDMKDR----VIKKLQDQVKTLS 1342

  Fly  1306 SGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGV 1367
            .       .|.:........|.:|...  .|.:::|..|        ::..|||.....|||
Human  1343 K-------TIGKANDVHSSSGPKEYLG--MLQYKREDEA--------KLIQNLILDLKPRGV 1387

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 293/699 (42%)
MYSc_Myo7 77..721 CDD:276832 285/674 (42%)
MyTH4 <1138..1245 CDD:214535 19/132 (14%)
B41 1251..1467 CDD:214604 25/130 (19%)
FERM_B-lobe 1355..1439 CDD:271216 6/13 (46%)
FERM_C1_MyoVII 1461..1559 CDD:270019
SH3 1560..1624 CDD:302595
MyTH4 1701..1849 CDD:214535
B41 1856..2068 CDD:214604
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
MYO5CNP_061198.2 Myosin_N 12..48 CDD:280832 9/40 (23%)
MYSc 62..752 CDD:214580 293/704 (42%)
MYSc_Myo5 81..741 CDD:276831 285/674 (42%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 632..654 11/21 (52%)
IQ 810..828 CDD:197470 9/18 (50%)
COG1340 890..1150 CDD:224259 54/265 (20%)
P-loop_NTPase <910..>1163 CDD:304359 51/258 (20%)
GBP_C <927..1030 CDD:303769 21/105 (20%)
coiled coil 997..1010 CDD:293879 2/13 (15%)
coiled coil 1019..1030 CDD:293879 3/10 (30%)
Rab5-bind 1020..1345 CDD:286404 64/352 (18%)
DUF3585 1160..1326 CDD:304905 28/179 (16%)
Myo5c_CBD 1369..1736 CDD:271260 8/27 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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