Protein Alignment ck and myo10

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_001362203.1
• Gene: myo10 / 548806
• XenbaseID: XB-GENE-1018818
• Length: 2086
• Species: Xenopus tropicalis
• Alignment Length: 2377
• Identity: 614/2377 - (25%)
• Similarity: 1012/2377 - (42%)
• Gaps: 635/2377 - (26%)

  Fly    52 RRIKAMHASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILP-IYTGD 115
            :::.::|.:|..|||||.:|.||||..|:.||..||::|.||||.||||.:||||:::. :|..:
 Frog    52 QKVTSIHPTSADGVEDMAALSDLHEGSIMYNLFQRYQQNKIYTYIGSILASVNPYKMIAGLYDCN 116

  Fly   116 QIKLYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKH 180
            .::||....:||:||||||:....|..:.:...:||::|||||||||||||||||::|:|:| :|
 Frog   117 AVELYSRHHMGEIPPHIFAVASECYRCLWKRHDNQCVLISGESGAGKTESTKLILKFLSAMS-QH 180

  Fly   181 SW----------IEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLL 235
            |.          :||.|||::||:||||||||:.|:|||||||:|.::....|.|:|.:|..|||
 Frog   181 SLEISSKEKTASVEQAILESSPIMEAFGNAKTVYNNNSSRFGKFIQLNICQKGHIQGGRIVDYLL 245

  Fly   236 EKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIR 300
            ||:|:|.||..|||||:||.:|.|...:|:....|..|..|.||.....|..|...|...|.:::
 Frog   246 EKNRVVRQNPEERNYHIFYALLEGAGKEERDAFYLLQAEKYHYLNQSGCILDETISDHETFQEVK 310

  Fly   301 SAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLI 365
            :||:|:.||.:|:.||.:|||.:||.||:::...     ...:|.....:.|.:.||||..:.:.
 Frog   311 AAMEVMKFSREEVREIFRLLAGILHLGNMEFITA-----GGAQISSKTALGRASELLGLDSEQMA 370

  Fly   366 DALTRRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAI-----FKPRGTSRN 425
            :|||:|::...||.:.:.||.:|:||.||:....:|.:.|..::.|||:.|     ||
 Frog   371 EALTQRSMILRGEEISTPLSVEQAVDSRDSVAMALYSQCFAWVIMKINSRIKGKDDFK------- 428

  Fly   426 AIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDAL 490
            :||:|||||||||:.|.||||.||||||.||::|.:|||.|||.||:.|.:.|..|:::||.:.|
 Frog   429 SIGILDIFGFENFEVNRFEQFNINYANEKLQEYFNKHIFSLEQLEYSREGLAWNAIDWIDNGECL 493

  Fly   491 DLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYD 555
            |||. |:|.::|||:||:.||:.||.|:|.||||.|.::..|:||:..:: :||:.|:||.|.||
 Frog   494 DLIE-KKLGLLALINEESYFPQATDNTLLEKLHKQHANNHFYVKPRVAVH-NFGVKHYAGEVLYD 556

  Fly   556 TRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIF--------AQDIEMGAETRKRTPTLSTQFRKSL 612
            .||.|:||||||..|||:|:.:|:..|:..:|        .:.::.|.:.:|  ||:|.||:.||
 Frog   557 VRGTLEKNRDTFRDDLLNLLRESSLDFIYDLFEHVSSRNNQETLKSGNKHKK--PTVSLQFKDSL 619

  Fly   613 DALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVE 677
            .:||..||:..|||:||||||..|.|..||..:...|||||||:||:|||:||:|:|..|.:|..
 Frog   620 HSLMAKLSTSNPFFVRCIKPNIHKMPDQFDDTVVLNQLRYSGMLETVRIRKAGFPVRRLFNDFCF 684

  Fly   678 RYRFLIP--GVPPAHRTDCQAATSRICAVVLGKSD-----YQLGHTKVFLKDAHDLFLEQERD-- 733
            ||:.|:.  .:|...:..|:        |:|...|     :|:|.|||||:::.:..||::||
 Frog   685 RYKVLMKNLSLPEDMKGKCE--------VLLHLHDNTDTEWQIGKTKVFLRESLEHKLEKQRDIE 741

  Fly   734 -----------------RVLTRKIL----ILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRK 777
                             |...:|:|    ::|::.|.:::||:||||:.||:|.||..:|...|:
 Frog   742 VFKAALIIQAHIMGFVARKQYKKVLYCVVVIQKNYRAFLWRRKFLRLKKAAVTFQRQLRGQIARR 806

  Fly   778 RYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSH---- 838
            .|:.:|....|.:...|.:....|.:.........:...|   :|:|...|...:.:.:.|
 Frog   807 IYKQLREQKQREEEERRRKEEEERKKKEEEERRRREEEER---LRKEEERKKKEIEERERHRQEE 868

  Fly   839 ---------------VRRMIAMRRYRKL--RLEHKQFAEVLQLRKLEEQELLHRGNKHAREIAE- 885
                           :..|:..:.:.::  :.|:||..|:|:|.| |..:|..:..|....:.|
 Frog   869 ETLAKQAEEARKQQELAAMLEAQNHNEIDKQKENKQVEEILRLEK-EIDDLQRQKEKQELSLTEA 932

  Fly   886 -----QHYRD----RLHELERREIQEQLENR---------RRVEVNMNI---------------- 916
                 |..||    ||.|...|..||.||:.         :.:|:::::
 Frog   933 SLQRLQELRDNELKRLEEEACRAAQEFLESLNFDEIDECVKNIEMSLSVSDVFPELSNIPGVSST 997

  Fly   917 ---INDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTP--HGGRETSVFNDLPHAQNVNQDDIIA 976
               .|.:....||.||:|      |:...::..|:|.|  ||                :.|...:
 Frog   998 KPSFNFSQPYPEEEVDEG------FEADDEAFKDSPNPSEHG----------------HSDQRTS 1040

  Fly   977 PIHISED--EEDLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQALWITILRF 1039
            .|..|:|  |||           .|....|... .:.|..:.||.|    |:..|....:|....
 Frog  1041 GIRTSDDSSEED-----------PYMNYTVGGP-PQAATSNKLLSL----DENKANVKKLTSGES 1089

  Fly  1040 TGDMP-----EPKY------------HTMDRMDTTSVMSKVTATLGRNFIRSK-----EFQEAQL 1082
            |..:|     ||:.            :..|..:..::.|..:.|.. |.:.|:     .|.....
 Frog  1090 TYCVPENAPCEPQNPGSIIIPDGDYDYDHDDYEDGAITSGSSVTFS-NSVSSQWSPDYNFSLGTY 1153

  Fly  1083 MGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKLH 1147
            .|.....|..:..:|               ..||..... |..:..|...|:
 Frog  1154 NGSSAYRFSSEGAQS---------------SFEDSEEEF-DSRFDTDDELSY------------- 1189

  Fly  1148 FIIGHGILRAELRDEIYCQICKQL--------TNNPLKSSHARGWILLSLCVGCFAPSEKFVNYL 1204
                       .||.:|.  |..|        ....:.:|..:.|        |....|.|: :.
 Frog  1190 -----------RRDSVYS--CVSLPYFHSYLYMKGGMMNSWKKRW--------CVLKDETFL-WF 1232

  Fly  1205 RAFIREGPPGYAPYCEERLKRTF----NNGT-----RNQPPSWLELQATKSKKPIMLPITFMDGN 1260
            |:            .:|.||:.:    ..|:     ||....|..|:.:|        :.:.:.:
 Frog  1233 RS------------KQEALKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSK--------LMYFEND 1277

  Fly  1261 TKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQ 1325
            ::              ::....|.|:|.           |.....:|.::.:|.|.:...|....
 Frog  1278 SE--------------DRQKGTIELRDA-----------KEVIDNTGKENGIDIIMENRTYHLIA 1317

  Fly  1326 GAQERNAPWRLFFRKEIFAPWHEPT-------HDQVATNLIYQQVVRGVKFG--EYRC-----DK 1376
            .:.|..:.|     ..:.:..|..|       ||:.|..   |..|..:..|  :..|     |:
 Frog  1318 ESPEDASQW-----FSVMSQVHTSTEQEIREMHDEQANP---QNAVGTLDVGMIDSVCASDNPDR 1374

  Fly  1377 EEDLAMIAAQQYFIEYSTDM--SMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVK 1439
            .....:|.|.: .:..:||.  .|....|||.....|..:.|.:..:..|       ..|.....
 Frog  1375 PNSFVIITANR-VLHCNTDTPEEMHHWITLLQRSKGDTRVEGQEFIVRGW-------LHKEVKNS 1431

  Fly  1440 DKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLEL 1504
            .|::.||:|:        :|.:|.....:.|::|..:..|...::..:...  ||..:|::..|.
 Frog  1432 PKMSSLKLKK--------RWFVLTHNSLDYYKSSEKSAMKLGTLVLNSLCS--VVQPEEKIFKET 1486

  Fly  1505 SFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQ-- 1567
            .:..:|....:...:::|:.                               |.:.:::..|:|
 Frog  1487 GYWNVTVYGRKHCYRLYTKL-------------------------------LNEATRWSSAIQNV 1520

  Fly  1568 -DYRAPSDGTSFLSFFKGDLIILED--ESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLPTLS 1629
             |.:||.|..:        ..:::|  |:|..|.:                   .|.:|
 Frog  1521 IDTKAPIDTPT--------QQLIQDIKENCLNSEV-------------------VEQIY------ 1552

  Fly  1630 KPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKRTMSKTLTLSSKR 1694
                                                                            |
 Frog  1553 ----------------------------------------------------------------R 1553

  Fly  1695 SEELWRYSRDPIKAPL-----------LRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNE 1748
            ...:.||:..|:.:||           |.|.:......:||...|.: |:.:..|....|
 Frog  1554 RNPILRYTHHPLHSPLLPLPYGDINLNLLKEKGYTTLQDEAIKIFNS-LQQLESLSDPVP----- 1612

  Fly  1749 ITDHIFDGPLK--HEI--LRDEIYCQLMKQLTDNRNRMSEE------RGWELMWLATGLFACSQG 1803
                |..|.|:  |::  ||||:||||:||    .|::|..      ..|:::...:..|..|:.
 Frog  1613 ----IIQGILQTGHDLRPLRDELYCQLIKQ----TNKVSNPGCTGNLYHWQILTCLSCTFPPSRR 1669

  Fly  1804 LLKELLLFLRTRRHPISQDSMHR----LQKTIRHGQ-RKYPPHQVEVEAI---QHKTTQIF-H-- 1857
            ::|.|...|:..|.......|.:    :..:::..: |::.|.:.|:||:   |..||.:: |
 Frog  1670 IVKYLKFHLKRIREQYQGSEMEKYALFIYDSLKKSKCREFVPSRAEIEALISRQEVTTTVYCHGG 1734

  Fly  1858 ---KVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEG-FSLFV--KIADKVIS--VPEGDF 1914
               |:          .::|.|.|.:....:.:.|::..|.. |:||.  ...||.|.  ....|.
 Frog  1735 GACKI----------TINSHTTAGEVVEKLIRGLAMEDSRNMFALFEYNGTTDKAIESRTVVADV 1789

  Fly  1915 FFDFVRHLTDWIKKARPIRDGANP-QFTYQVFFMKKLWTNTVPGKDRNADLIFHYHQELPKLLRG 1978
                   |..:.|.|.....|..| :|.::::..  |.|..|| || :.:.:|.:.|....::.|
 Frog  1790 -------LAKFEKLAVSSEAGDKPWKFYFKLYCF--LDTEHVP-KD-SVEYVFMFEQAHEAVIHG 1843

  Fly  1979 YHKCSREEAAKLAALVFRVRFGENKQELQ-AIPQMLRELIP--------SDIMKIQSTSE----- 2029
            ::....|....||||  |:::.:....|. ::|:| .|..|        :...|:.||||
 Frog  1844 HYPAPEETLQILAAL--RLQYTQGDYSLHTSVPEM-EEFYPMQKLKARITQSTKVSSTSERCERK 1905

  Fly  2030 -------------------------------W--------KRSIVASYNQDGGMTSEDAKVAFLK 2055
                                           |        :.:|:..:.:..||.::.....::.
 Frog  1906 RSSFLEGTLRRSFRSGSVSKQRLEEEQMQEMWVKEEVLSTRTNIIDKWKRFQGMNTDQCMSKYMA 1970

  Fly  2056 IVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSLIHPVTKDILVTHPFTRISNWSS--GNT 2118
            ::..||::||.||:| :..|..:|:.|.:.:....||:........|....:..|.::.:  .||
 Frog  1971 LIKEWPSYGSTFFDV-ECKEGGFPQELWLGVCVEAVSVYKRGEGRPLEVFHYEHILSFGAPYANT 2034

  Fly  2119 YFHMTIGNLVRGSKLLCETSLGYKMDDLLTSYISLML 2155
            |     ..:|...:||.|||...::..|:.:|||:::
 Frog  2035 Y-----KIVVDERELLFETSAVVEIAKLMKAYISMIV 2066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	297/674 (44%)
		MyTH4	<1138..1245	CDD:214535	19/123 (15%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	10/97 (10%)
		B41	1251..1467	CDD:214604	38/231 (16%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	11/97 (11%)
		SH3	1560..1624	CDD:473055	11/68 (16%)
		MyTH4	1701..1849	CDD:214535	41/176 (23%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	20/108 (19%)
		B41	1856..2068	CDD:214604	53/276 (19%)
		FERM_C2_MyoVII	2064..2159	CDD:270020	25/94 (27%)
myo10	NP_001362203.1	SH3_19	7..58	CDD:465815	0/5 (0%)
		MYSc_Myo10	77..727	CDD:276840	297/674 (44%)
		IQ	744..763	CDD:459869	1/18 (6%)
		SMC_N	871..>976	CDD:481474	23/105 (22%)
		MYO10_CC	901..951	CDD:465249	16/50 (32%)
		PH-like	<1210..>1237	CDD:473070	6/47 (13%)
		PH2_MyoX	1240..1341	CDD:270108	19/138 (14%)
		PH3_MyoX-like	1406..1531	CDD:270109	26/172 (15%)
		MyTH4	1574..1720	CDD:214535	37/159 (23%)
		FERM_F1_Myosin-X	1722..1817	CDD:340726	23/113 (20%)
		B41	1729..1983	CDD:214604	53/277 (19%)
		FERM_C_MyoX	1979..2067	CDD:270023	25/94 (27%)