DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and Myh13

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_001074719.1 Gene:Myh13 / 544791 MGIID:1339967 Length:1938 Species:Mus musculus


Alignment Length:2093 Identity:529/2093 - (25%)
Similarity:879/2093 - (41%) Gaps:444/2093 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 ASGREFD------------VAIGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVED 67
            |..|.||            :.:...:.|.|..::.|:..|..|:.|..: ::..|:......:||
Mouse    27 AQNRPFDSKKACFAVDDKEMYVKGMIQSRENDKVIVKTLDDRELTLNSD-QVFPMNPPKFDKIED 90

  Fly    68 MISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHI 132
            |..:..|||..:|.||..||...:||||:|...|.||||:.||:|..:.:..|:.:|..|.||||
Mouse    91 MAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHI 155

  Fly   133 FAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAIS-----------GK-HSWIEQ 185
            |:|.||||..|...|.:|.|:|:||||||||.:||.::||.|.|:           || ...:|.
Mouse   156 FSISDNAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKEQQPGKMQGTLED 220

  Fly   186 QILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNY 250
            ||::|||:|||||||||:||||||||||:|.|||.|.|.:..|.||.|||||||:..|..|||:|
Mouse   221 QIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVTFQLSSERSY 285

  Fly   251 HVFYCILAGLSADEKSRLDLGMAA----DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQ 311
            |:||.|   :|..:...:||.:.:    |:.:::.| .:|....||:.|.....:|:.:|.||.:
Mouse   286 HIFYQI---MSNKKPELIDLLLISTNPFDFPFVSQG-EVTVASIDDSEELLATDNAIDILGFSPE 346

  Fly   312 EIWEIIKLLAALLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTL 373
            |...|.||..|::|.||:|:|....:..   |.||:     .::...|:||....::..|....:
Mouse   347 EKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEV-----ADKAGYLMGLNSAEMLKGLCCPRV 406

  Fly   374 FAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAI--FKPRGTSRNAIGVLDIFGFE 436
            ....|.|....:..|..:...|..|.:|.:||:.:|.:||..:  .:||   :..||||||.|||
Mouse   407 KVGNEYVTKGQNVQQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPR---QYFIGVLDIAGFE 468

  Fly   437 NFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNI 500
            .||.||.||.|||:.||.|||||..|:|.||||||..|.|.|:.|:| :|....::||. |.:.|
Mouse   469 IFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIE-KPMGI 532

  Fly   501 MALIDEEARFPKGTDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRGFLD 561
            .::::||..|||.||.:...||:..| |...|:.||   |......|.|.|:||.|.|:..|:||
Mouse   533 FSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPTKGKAEAHFSLVHYAGTVDYNIAGWLD 597

  Fly   562 KNRDTFSPDLLHLVSQSTNKFLRQIF-------AQDIEMGAETRKRT----PTLSTQFRKSLDAL 615
            ||:|..:..::.|..:|:.|.|..:|       |.|...|.:..|:.    .|:|..||::|:.|
Mouse   598 KNKDPLNETVVGLYQKSSLKLLSFLFSNYAGAEAGDSAGGKKGGKKKGSSFQTVSAVFRENLNKL 662

  Fly   616 MKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYR 680
            |..|.|..|.|:||:.|||.|.|.:.|..|...|||.:|::|.|||.|.|:|.|..:.:|.:|||
Mouse   663 MTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYADFKQRYR 727

  Fly   681 FL-IPGVPPAHRTDCQAATSRIC-AVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILIL 743
            .| ...:|.....|.:.|:.::. ::.:.:..::.||||||.|......||:.||..|...:...
Mouse   728 ILNASAIPEGQFIDSKNASEKLLNSIDVDREQFRFGHTKVFFKAGLLGLLEEMRDEKLVTLMTRT 792

  Fly   744 QRSIRGWVYRRRFLRL---RAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRS-------RVL 798
            |...||::.|..|.::   |.:...:|...:.:...|.:..|.: :.:::.|::|       ..:
Mouse   793 QAVCRGYLMRVEFKKMMERRESIFCIQYNVRSFMNVKHWPWMNL-FFKIKPLLKSAEAEKEMATM 856

  Fly   799 SHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAV--------IKIQSHVRRMI-AMRRYR----- 849
            ...|...:..:      ||....|:|...||.::        :::||....:: |..|..     
Mouse   857 KEDFERAKEDL------ARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKS 915

  Fly   850 KLRLEHKQFAEVLQL-RKLEEQELLH-------------------------------RGNKHARE 882
            |::||    |:|.:| .:|||:|.::                               ...|||.|
Mouse   916 KIQLE----AKVKELNERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATE 976

  Fly   883 IAEQHYRDRLHELERREIQEQLENRRRVEVNMNIINDAARKQEEPVDDGKL-----VEAMFDFLP 942
            ...::..:.:..||....:...|.:...|.:...::|.  :.||...:|.:     :|...|.|.
Mouse   977 NKVKNLSEEMTALEETISKLTKEKKSLQEAHQQTLDDL--QVEEDKVNGLIKINVKLEQQTDDLE 1039

  Fly   943 DSSSDAPTPHGGRETSVFNDLPHAQ-------NVNQDDIIAPIHISEDEEDLSE-FKFQKFAATY 999
            .|..        :|..:..||...:       .::|:.|   :.:..|.:.|.| .|.::|..:.
Mouse  1040 GSLE--------QEKKLRADLERVKRKLEGDLKMSQESI---MDLENDTQQLEEKLKKKEFEMSQ 1093

  Fly  1000 FQGNV-NHQYAKKALKHPLLPLHTQGDQL-----AAQALWITILRFTGDMPEPKYHTMDRMDTTS 1058
            .|..: :.|.....|:..:..|..:.::|     |...:...|.:...|:........:|::..|
Mouse  1094 LQTRIDDEQVLSLQLQKKIKELQARTEELEEEIEAEHTVRAKIEKQRSDLARELEEISERLEEAS 1158

  Fly  1059 VMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQ--KPRSIRHKLVSLTLKRKN-----KLGED 1116
              ...:|.:..|..|..|||:           |::  :..:::|:..:.||::|:     :|||.
Mouse  1159 --GATSAQIEMNKKRESEFQK-----------LRRDLEEATLQHEATAATLRKKHADTVAELGEQ 1210

  Fly  1117 ------VRRRLQDD----EYTADSYQSWLQ--SRPTSNLEKLHFIIGHGILRAELRDEIYCQICK 1169
                  |:::|:.:    :...|...|.::  |:..||:|::...:.......:.:|:...|:..
Mouse  1211 IDNLQRVKQKLEKEKSELKMEIDDMASNIETVSKSKSNMERMCRSVEDQFNEIKAKDDQQTQLIH 1275

  Fly  1170 QLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQ 1234
            .|                              |..:|.::......:...||:            
Mouse  1276 DL------------------------------NMQKARLQTQNGELSHQVEEK------------ 1298

  Fly  1235 PPSWLELQATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFD 1299
              ..|..|.||||:.:          |:.|        .||..||.::...|:....:|      
Mouse  1299 --ESLVSQLTKSKQAL----------TQQL--------EELKRQLEEETKAKNALAHAL------ 1337

  Fly  1300 KVSSLGSGGDHVMDAISQCEQYAKEQ-----------GAQERNAPWRLFFRKEIFAPWH--EPTH 1351
                  ....|..|.:.  |||.:||           .|....|.||..:..:......  |...
Mouse  1338 ------QSSRHDCDLLR--EQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 1394

  Fly  1352 DQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTD---MSMERLFTLLPNFIPDFC 1413
            .::|..|  |:.....:....:|      |.:...:..::...|   :.:||..|.....  |..
Mouse  1395 KKLAQRL--QEAEENTEASNSKC------ASLEKTKQRLQGEVDDLMLDLERANTACATL--DKK 1449

  Fly  1414 LSGVDKAIERW-------AALVLQAYKKSYYVKDKIAPLK-IKEDIVSYAKYKWPLLFSRFYEAY 1470
            ....||.:..|       .|.:..|.|:|..:..:|..:: ..|::|..            .|..
Mouse  1450 QRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTEIFKMRNAYEEVVDQ------------LETL 1502

  Fly  1471 RNSGPNLPK--NDVIIAVNWTGVYVVD--------DQEQVLLELSFPEITAVSSQKTNKVFTQTF 1525
            |....||.:  :|:...:..||..:.:        :||:..|:.:..|:......:.:|:.....
Mouse  1503 RRENKNLQEEISDLTEQIAETGKNLQEVEKTKKQVEQEKSDLQAALEEVEGSLEHEESKILRVQL 1567

  Fly  1526 SLSTVRGE---EFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQ-----DYRAPSDGTSFLSFF 1582
            .||.|:.|   :.|.:....|.|:          :...:.|.|:|     :.|:.:|........
Mouse  1568 ELSQVKSELDRKVTEKDEEIEQIK----------RNSQRAVEAMQSVLDAEIRSRNDALRLKKKM 1622

  Fly  1583 KGDLIILEDESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHG 1647
            :|||..:|.:            :...:|.      .|||...|.|:....:|  :..::::|.. 
Mouse  1623 EGDLNEMEIQ------------LSHANRQ------VAETQKHLRTVQGQLKD--SQLHLDDAQR- 1666

  Fly  1648 RRLSMASNGGAVEPR---DRPHTLMEYALDHFRLP------PKRTMSKTLTLSSKRSEELWRY-- 1701
                  ||....|..   :|.:.|::..|:..::.      .:|...:.|..||.|.:.|...  
Mouse  1667 ------SNEDLKEQLAIVERRNGLLQEELEEMKVALEQTERTRRLSEQELLDSSDRVQLLHSQNT 1725

  Fly  1702 ----SRDPIKAPL----------LRKLQSKEEFAEEA---CFAFAAILKYMGDLPSKRPRMGNEI 1749
                ::..::|.|          :::.::.||.|::|   ....|..||...|..:...||...:
Mouse  1726 SLINTKKKLEADLAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1790

  Fly  1750 TDHIFDGPLKHEILRDEIYCQL-----MKQLTDNRNRMSE---------ERGWELMWLATGLFAC 1800
            ...:.|  |:|.:...|   ||     .||:.....|:.|         :||.|.:         
Mouse  1791 EQTVKD--LQHRLDEAE---QLALKGGKKQIQKLEARVRELESELDAEQKRGAEAL--------- 1841

  Fly  1801 SQGL------LKELLLFLRTRRHPI--SQDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQIFH 1857
             :|.      :||:.......|..|  .||.:.:||..::..:|     |.| ||.:...||:..
Mouse  1842 -KGAHKYERKVKEMTYQAEEDRKNILRLQDLVDKLQAKVKSYKR-----QAE-EAEEQANTQLSR 1899

  Fly  1858 KVYFPDDTDEAFE 1870
            ......:.:||.|
Mouse  1900 CRRVQHELEEAEE 1912

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 280/707 (40%)
MYSc_Myo7 77..721 CDD:276832 271/682 (40%)
MyTH4 <1138..1245 CDD:214535 12/106 (11%)
B41 1251..1467 CDD:214604 40/239 (17%)
FERM_B-lobe 1355..1439 CDD:271216 17/93 (18%)
FERM_C1_MyoVII 1461..1559 CDD:270019 19/110 (17%)
SH3 1560..1624 CDD:302595 13/68 (19%)
MyTH4 1701..1849 CDD:214535 39/188 (21%)
B41 1856..2068 CDD:214604 3/15 (20%)
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
Myh13NP_001074719.1 Myosin_N 36..73 CDD:280832 5/36 (14%)
Myosin_head 88..770 CDD:278492 277/694 (40%)
MYSc_Myh13 100..770 CDD:276887 271/682 (40%)
Myosin_tail_1 850..1927 CDD:279860 224/1255 (18%)
DUF342 <1506..1582 CDD:302792 14/75 (19%)
TMPIT 1744..>1837 CDD:285135 20/97 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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