Protein Alignment ck and MYO3A

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_059129.3
• Gene: MYO3A / 53904
• HGNCID: 7601
• Length: 1616
• Species: Homo sapiens
• Alignment Length: 1366
• Identity: 394/1366 - (28%)
• Similarity: 635/1366 - (46%)
• Gaps: 301/1366 - (22%)

  Fly    60 SSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERK 124
            |:::.|:|:.:|..|.|..:...|...|..:.||.|.|.||:|:||:|.|.:|:....|||...|
Human   335 SNLKDVDDLATLEILDENTVSEQLEKCYSRDQIYVYVGDILIALNPFQSLGLYSTKHSKLYIGSK 399

  Fly   125 IGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGK--HSWIEQQI 187
            ....||||||:.|..|..|..|..||||||||||||||||:..|::|.|..: ||  :..::::|
Human   400 RTASPPHIFAMADLGYQSMITYNSDQCIVISGESGAGKTENAHLLVQQLTVL-GKANNRTLQEKI 463

  Fly   188 LEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHV 252
            |:.|.::||||||.||.||||||||||:::.|:::|.:.||:|.:|||||||::.|...|:|:|:
Human   464 LQVNNLVEAFGNACTIINDNSSRFGKYLEMKFTSSGAVVGAQISEYLLEKSRVIHQAIGEKNFHI 528

  Fly   253 FYCILAGLSADEKSRLDLGMAADYK--------YLTGGNSITCEGRDD----AAEFSDIRSAMKV 305
            ||.|.|||:  ||.:|     |.||        ||...:..|.:...:    .:::..|....||
Human   529 FYYIYAGLA--EKKKL-----AHYKLPENKPPRYLQNDHLRTVQDIMNNSFYKSQYELIEQCFKV 586

  Fly   306 LLFSDQEIWEIIKLLAALLHCGNIKYKATVVDN-LDATEIPEHINVERVAGLLGLPIQPLIDALT 369
            :.|:.:::..|..:|||:|:.|||::.:...:: :|.:.|..|..:|..|.||.:....|.:|||
Human   587 IGFTMEQLGSIYSILAAILNVGNIEFSSVATEHQIDKSHISNHTALENCASLLCIRADELQEALT 651

  Fly   370 RRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRN----AIGVL 430
            ...:...|||::...:.:::.|||||..|.:|||:|..||..||:.:......|.|    :||:|
Human   652 SHCVVTRGETIIRPNTVEKATDVRDAMAKTLYGRLFSWIVNCINSLLKHDSSPSGNGDELSIGIL 716

  Fly   431 DIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAI 495
            ||||||||.:|||||.|||.|||.:|.::.||:|..||.||.:|.::.:.||:.||...||:...
Human   717 DIFGFENFKKNSFEQLCINIANEQIQYYYNQHVFAWEQNEYLNEDVDARVIEYEDNWPLLDMFLQ 781

  Fly   496 KQLNIMALIDEEARFPKGTDQTMLAKLHKTHGSHKN--YLKPKSDINTSFGLNHFAGVVFYDTRG 558
            |.:.:::|:|||:||||.||||::.|.   .|:.|:  :.:||. :..|||::|:||.|.|:..|
Human   782 KPMGLLSLLDEESRFPKATDQTLVEKF---EGNLKSQYFWRPKR-MELSFGIHHYAGKVLYNASG 842

  Fly   559 FLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDI-------------------------------E 592
            ||.|||||...|::.|:..|.|..:||:....:                               :
Human   843 FLAKNRDTLPTDIVLLLRSSDNSVIRQLVNHPLTKTGNLPHSKTKNVINYQMRTSEKLINLAKGD 907

  Fly   593 MGAETR-------KRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQL 650
            .|..||       .:|.|:::.||.||..|:..:...||.|:||||||..::...:|:.....||
Human   908 TGEATRHARETTNMKTQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNSERQARKYDKEKVLLQL 972

  Fly   651 RYSGMMETIRIRRAGYPIRHGFREFVERYRFLI------PGVPPAHRTDCQAATSRICAVVL--- 706
            ||:|::||.||||.|:..|..|..|::||..|.      |.:.|           ..||.:|
Human   973 RYTGILETARIRRLGFSHRILFANFIKRYYLLCYKSSEEPRMSP-----------DTCATILEKA 1026

  Fly   707 GKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRL----RAAAITVQ 767
            |..::.||.||||||..|...|...|...:. |::::|..:|.::..||:.::    :.:||.:|
Human  1027 GLDNWALGKTKVFLKYYHVEQLNLMRKEAID-KLILIQACVRAFLCSRRYQKIQEKRKESAIIIQ 1090

  Fly   768 RFWKGYAQRKR---------------------------YRNMRVGYMRLQALIRSRVLSHRFRHL 805
            ...:|:..||:                           :.|.|..:::.||   ...:|...|.:
Human  1091 SAARGHLVRKQRKEIVDMKNTAVTTIQTSDQEFDYKKNFENTRESFVKKQA---ENAISANERFI 1152

  Fly   806 -----RGHIV---------------GLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRK 850
                 :|.:.               .::::.|.|...::..:.....:|.:.::.......:.:.
Human  1153 SAPNNKGSVSVVKTSTFKPEEETTNAVESNNRVYQTPKKMNNVYEEEVKQEFYLVGPEVSPKQKS 1217

  Fly   851 LRLEHKQFAEVLQLRKLEEQELLHRGNKHAREIAEQHYRD-RLHELERREIQEQ--------LEN 906
            :    |...|...|||:|::|.:.: :.:.|...|::..: :...|||:.|.|:        .||
Human  1218 V----KDLEENSNLRKVEKEEAMIQ-SYYQRYTEERNCEESKAAYLERKAISERPSYPVPWLAEN 1277

  Fly   907 ----RRRVEVNM---NIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLP 964
                ::.:|..:   :|..:|...::|     |....:....|..|.:.     ||     ..|.
Human  1278 ETSFKKTLEPTLSQRSIYQNANSMEKE-----KKTSVVTQRAPICSQEE-----GR-----GRLR 1327

  Fly   965 HAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKK----ALKHP-LLPLHTQG 1024
            | :.|.:.. :.|:..:::|||    |...|..:.::|....|..:|    :.||. ::...|:
Human  1328 H-ETVKERQ-VEPVTQAQEEED----KAAVFIQSKYRGYKRRQQLRKDKMSSFKHQRIVTTPTE- 1385

  Fly  1025 DQLAAQALWITILRFTGDM-PEPKYH-------TMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQ 1081
                       :.|.|.:: ..|..|       ..|..|:.:...:....|.   |.||     |
Human  1386 -----------VARNTHNLYSYPTKHEEINNIKKKDNKDSKATSEREACGLA---IFSK-----Q 1431

  Fly  1082 LMGLDPDAFLKQKPRSIRHKLVSLTLKRKNK---LG----EDVRRRLQDDEYTADSYQSWLQS-- 1137
            :..|..:.|:.||      ||..:.|.::.|   ||    :.:.||:        |.|..|..
Human  1432 ISKLSEEYFILQK------KLNEMILSQQLKSLYLGVSHHKPINRRV--------SSQQCLSGVC 1482

  Fly  1138 --------RPTSNLEK----------LHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGW 1184
                    ||.....|          .::.:.|..::.|.|             .|.|.|..:
Human  1483 KGEEPKILRPPRRPRKPKTLNNPEDSTYYYLLHKSIQEEKR-------------RPRKDSQGK-- 1532

  Fly  1185 ILLSLCVGCFAPSEKFVNYLRAFI--REGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSK 1247
             ||.|        |.|  |.:.|:  |.||..::|...||           :|...|:.|..|:.
Human  1533 -LLDL--------EDF--YYKEFLPSRSGPKEHSPSLRER-----------RPQQELQNQCIKAN 1575

  Fly  1248 K 1248
            :
Human  1576 E 1576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	270/711 (38%)
		MyTH4	<1138..1245	CDD:214535	25/118 (21%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	394/1366 (29%)
		B41	1251..1467	CDD:214604
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020
MYO3A	NP_059129.3	STKc_myosinIIIA_N	2..287	CDD:132969
		MYSc_Myo3	352..1041	CDD:276830	270/711 (38%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	934..956		10/21 (48%)
		Interaction with MORN4. /evidence=ECO:0000269|PubMed:25822849	1401..1479		21/99 (21%)
		MBD_Myo3a	1409..1456	CDD:439318	14/60 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1545..1567		7/32 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1581..1616