DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and MYO3A

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_059129.3 Gene:MYO3A / 53904 HGNCID:7601 Length:1616 Species:Homo sapiens


Alignment Length:1368 Identity:395/1368 - (28%)
Similarity:634/1368 - (46%) Gaps:305/1368 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 SSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERK 124
            |:::.|:|:.:|..|.|..:...|...|..:.||.|.|.||:|:||:|.|.:|:....|||...|
Human   335 SNLKDVDDLATLEILDENTVSEQLEKCYSRDQIYVYVGDILIALNPFQSLGLYSTKHSKLYIGSK 399

  Fly   125 IGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGK--HSWIEQQI 187
            ....||||||:.|..|..|..|..||||||||||||||||:..|::|.|..: ||  :..::::|
Human   400 RTASPPHIFAMADLGYQSMITYNSDQCIVISGESGAGKTENAHLLVQQLTVL-GKANNRTLQEKI 463

  Fly   188 LEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHV 252
            |:.|.::||||||.||.||||||||||:::.|:::|.:.||:|.:|||||||::.|...|:|:|:
Human   464 LQVNNLVEAFGNACTIINDNSSRFGKYLEMKFTSSGAVVGAQISEYLLEKSRVIHQAIGEKNFHI 528

  Fly   253 FYCILAGLSADEKSRLDLGMAADYK--------YLTGGNSITCEGRDD----AAEFSDIRSAMKV 305
            ||.|.|||:  ||.:|     |.||        ||...:..|.:...:    .:::..|....||
Human   529 FYYIYAGLA--EKKKL-----AHYKLPENKPPRYLQNDHLRTVQDIMNNSFYKSQYELIEQCFKV 586

  Fly   306 LLFSDQEIWEIIKLLAALLHCGNIKYKATVVDN-LDATEIPEHINVERVAGLLGLPIQPLIDALT 369
            :.|:.:::..|..:|||:|:.|||::.:...:: :|.:.|..|..:|..|.||.:....|.:|||
Human   587 IGFTMEQLGSIYSILAAILNVGNIEFSSVATEHQIDKSHISNHTALENCASLLCIRADELQEALT 651

  Fly   370 RRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRN----AIGVL 430
            ...:...|||::...:.:::.|||||..|.:|||:|..||..||:.:......|.|    :||:|
Human   652 SHCVVTRGETIIRPNTVEKATDVRDAMAKTLYGRLFSWIVNCINSLLKHDSSPSGNGDELSIGIL 716

  Fly   431 DIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAI 495
            ||||||||.:|||||.|||.|||.:|.::.||:|..||.||.:|.::.:.||:.||...||:...
Human   717 DIFGFENFKKNSFEQLCINIANEQIQYYYNQHVFAWEQNEYLNEDVDARVIEYEDNWPLLDMFLQ 781

  Fly   496 KQLNIMALIDEEARFPKGTDQTMLAKLHKTHGSHKN--YLKPKSDINTSFGLNHFAGVVFYDTRG 558
            |.:.:::|:|||:||||.||||::.|.   .|:.|:  :.:||. :..|||::|:||.|.|:..|
Human   782 KPMGLLSLLDEESRFPKATDQTLVEKF---EGNLKSQYFWRPKR-MELSFGIHHYAGKVLYNASG 842

  Fly   559 FLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDI-------------------------------E 592
            ||.|||||...|::.|:..|.|..:||:....:                               :
Human   843 FLAKNRDTLPTDIVLLLRSSDNSVIRQLVNHPLTKTGNLPHSKTKNVINYQMRTSEKLINLAKGD 907

  Fly   593 MGAETR-------KRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQL 650
            .|..||       .:|.|:::.||.||..|:..:...||.|:||||||..::...:|:.....||
Human   908 TGEATRHARETTNMKTQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNSERQARKYDKEKVLLQL 972

  Fly   651 RYSGMMETIRIRRAGYPIRHGFREFVERYRFLI------PGVPPAHRTDCQAATSRICAVVL--- 706
            ||:|::||.||||.|:..|..|..|::||..|.      |.:.|           ..||.:|   
Human   973 RYTGILETARIRRLGFSHRILFANFIKRYYLLCYKSSEEPRMSP-----------DTCATILEKA 1026

  Fly   707 GKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRL----RAAAITVQ 767
            |..::.||.||||||..|...|...|...:. |::::|..:|.::..||:.::    :.:||.:|
Human  1027 GLDNWALGKTKVFLKYYHVEQLNLMRKEAID-KLILIQACVRAFLCSRRYQKIQEKRKESAIIIQ 1090

  Fly   768 RFWKGYAQRKR---------------------------YRNMRVGYMRLQALIRSRVLSHRFRHL 805
            ...:|:..||:                           :.|.|..:::.||   ...:|...|.:
Human  1091 SAARGHLVRKQRKEIVDMKNTAVTTIQTSDQEFDYKKNFENTRESFVKKQA---ENAISANERFI 1152

  Fly   806 -----RGHIV---------------GLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRK 850
                 :|.:.               .::::.|.|...::..:.....:|.:.::.......:.:.
Human  1153 SAPNNKGSVSVVKTSTFKPEEETTNAVESNNRVYQTPKKMNNVYEEEVKQEFYLVGPEVSPKQKS 1217

  Fly   851 LRLEHKQFAEVLQLRKLEEQELLHRGNKHAREIAEQHYRD-RLHELERREIQEQ--------LEN 906
            :    |...|...|||:|::|.:.: :.:.|...|::..: :...|||:.|.|:        .||
Human  1218 V----KDLEENSNLRKVEKEEAMIQ-SYYQRYTEERNCEESKAAYLERKAISERPSYPVPWLAEN 1277

  Fly   907 ----RRRVEVNM---NIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLP 964
                ::.:|..:   :|..:|...::|     |....:....|..|.:.     ||     ..|.
Human  1278 ETSFKKTLEPTLSQRSIYQNANSMEKE-----KKTSVVTQRAPICSQEE-----GR-----GRLR 1327

  Fly   965 HAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKK----ALKHPLLPLHTQGD 1025
            | :.|.:.. :.|:..:::|||    |...|..:.::|....|..:|    :.||          
Human  1328 H-ETVKERQ-VEPVTQAQEEED----KAAVFIQSKYRGYKRRQQLRKDKMSSFKH---------- 1376

  Fly  1026 QLAAQALWIT---ILRFTGDM-PEPKYH-------TMDRMDTTSVMSKVTATLGRNFIRSKEFQE 1079
                |.:..|   :.|.|.:: ..|..|       ..|..|:.:...:....|.   |.||    
Human  1377 ----QRIVTTPTEVARNTHNLYSYPTKHEEINNIKKKDNKDSKATSEREACGLA---IFSK---- 1430

  Fly  1080 AQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNK---LG----EDVRRRLQDDEYTADSYQSWLQS 1137
             |:..|..:.|:.||      ||..:.|.::.|   ||    :.:.||:        |.|..|..
Human  1431 -QISKLSEEYFILQK------KLNEMILSQQLKSLYLGVSHHKPINRRV--------SSQQCLSG 1480

  Fly  1138 ----------RPTSNLEK----------LHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHAR 1182
                      ||.....|          .::.:.|..::.|.|             .|.|.|..:
Human  1481 VCKGEEPKILRPPRRPRKPKTLNNPEDSTYYYLLHKSIQEEKR-------------RPRKDSQGK 1532

  Fly  1183 GWILLSLCVGCFAPSEKFVNYLRAFI--REGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATK 1245
               ||.|        |.|  |.:.|:  |.||..::|...||           :|...|:.|..|
Human  1533 ---LLDL--------EDF--YYKEFLPSRSGPKEHSPSLRER-----------RPQQELQNQCIK 1573

  Fly  1246 SKK 1248
            :.:
Human  1574 ANE 1576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 279/736 (38%)
MYSc_Myo7 77..721 CDD:276832 270/711 (38%)
MyTH4 <1138..1245 CDD:214535 25/118 (21%)
B41 1251..1467 CDD:214604
FERM_B-lobe 1355..1439 CDD:271216
FERM_C1_MyoVII 1461..1559 CDD:270019
SH3 1560..1624 CDD:302595
MyTH4 1701..1849 CDD:214535
B41 1856..2068 CDD:214604
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
MYO3ANP_059129.3 STKc_myosinIIIA_N 2..287 CDD:132969
S_TKc 21..287 CDD:214567
MYSc 337..1053 CDD:214580 279/738 (38%)
MYSc_Myo3 352..1041 CDD:276830 270/711 (38%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 934..956 10/21 (48%)
Interaction with MORN4. /evidence=ECO:0000269|PubMed:25822849 1401..1479 21/99 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1545..1567 7/32 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1581..1616
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.