DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and Myo28B1

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	NP_723294.1	Gene:	Myo28B1 / 53515	FlyBaseID:	FBgn0040299	Length:	2122	Species:	Drosophila melanogaster

Alignment Length:	2231	Identity:	991/2231 - (44%)
Similarity:	1372/2231 - (61%)	Gaps:	209/2231 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RGDYIWIEPA-SGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVEDMI 69
            :|:|:|::|. :..||.|..|||:|..|..:..|.||...:.|:.....:||||.:|.:.|||||
  Fly     9 KGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGDVLKAMHITSQEDVEDMI 73

  Fly    70 SLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFA 134
            :||||.|..|||||..||.:.||||||||:|||:||||||||||..:|:||:.:.:.||||||||
  Fly    74 TLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPHIFA 138

  Fly   135 IGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSWIEQQILEANPILEAFGN 199
            |.|||:..::|.:::||:|||||||||||||||||||||||||||||||||||:|||||:|||||
  Fly   139 ISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSWIEQQIIEANPIMEAFGN 203

  Fly   200 AKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADE 264
            |||:||||||||||||:|.|:..|.|:||:|:||||||||||.|:..|||||:|||:|||||..|
  Fly   204 AKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLSTAE 268

  Fly   265 KSRLDL--GMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCG 327
            :.||.|  ...:.|.||..|...|..||.||.:|:|||:|||||.|..:|:|.|:.||||:||.|
  Fly   269 RERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAILHLG 333

  Fly   328 NIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDV 392
            |:::.||.|.||...||.:..|::|||.|||:||..|..|||:||:|.|||.|.::||::.:::.
  Fly   334 NLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAAIEG 398

  Fly   393 RDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQ 457
            ||||||.:|..:||.|||:||..|.|......|:|||||||||||||.|||||.|||||||||||
  Fly   399 RDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSFEQLCINYANENLQQ 463

  Fly   458 FFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKL 522
            |||.||||:||:||.:|.||||||||.|||..||||.:|.:|:|:|||||::||||||||:|.||
  Fly   464 FFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQTLLEKL 528

  Fly   523 HKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIF 587
            |..||:...|:|.|:...:.||:.|:||||.|:..|||:||||:||.||..||.:||||:|..||
  Fly   529 HVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIF 593

  Fly   588 AQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRY 652
            ..  ||..:|.|:.|||..:||.|||.||:|||...|:|||||||||.|:|..||:.||.|||||
  Fly   594 PH--EMPMDTAKKQPTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRY 656

  Fly   653 SGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHRTDCQAATSRICAVVL-GKSDYQLGHT 716
            ||||||.|||||||||||.:|.||||||.|:|.|.|..:.||:....:||.|.| ..||.|.|.|
  Fly   657 SGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKLARQICEVALPADSDRQYGKT 721

  Fly   717 KVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRN 781
            |:||:|..|..||.:|.:::.:.|:.:||.||..::||...|.|.|.|||||:|:|..||::|:.
  Fly   722 KLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQV 786

  Fly   782 MRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMR 846
            ||.|:.||.|.|.::.|:.:|..:|...:.|||.:||||||:::             .::::..|
  Fly   787 MRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRGYLVRKDF-------------QKKLLERR 838

  Fly   847 RYRKLRLEHKQFAEVLQLRKLEEQELLHRGNKHAREIAEQHYRDRLHELERREIQEQ---LENRR 908
            :..:|:.|     |:|:|.|::|.|.|.|    .:::.||..|::..:.|:|..:||   .|...
  Fly   839 KQNQLKKE-----ELLKLAKMKEAEELLR----LQQLKEQKEREQREQQEKRLQEEQRLKAEAAA 894

  Fly   909 RVEVNMNIINDAAR----KQEEP------------------------------------------ 927
            |..:.|..:....|    |||.|
  Fly   895 RNALAMAAVQQKRRTKPVKQEAPKAPTLQARNSLPPPPTTLIVAAPLPTRPASAVTRINTIPESP 959

  Fly   928 ----VDDGK-LVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEEDL 987
                |:..| :|:.:|.||.|....|              |....|::..|.|.......:..|.
  Fly   960 GTIDVESSKQMVDDVFRFLNDEPDAA--------------LRKLNNISSGDTIRLPKSVPNNIDT 1010

  Fly   988 SEFKFQKFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQALWITILRFTGDMPE----PKY 1048
            |:|.:.|:|||||.|....|:.:|.||..||......|::|::|:|:|||||.||:|:    |..
  Fly  1011 SDFSYLKYAATYFGGGATAQHERKPLKKSLLKHEHPIDEMASKAIWLTILRFMGDLPDVVSSPTL 1075

  Fly  1049 HTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKL 1113
            |..|..:..|.::.:..|       |..::        |..|::|..|.|...|.|
  Fly  1076 HVFDNENLMSDLASLLNT-------SDSYK--------PRLFVRQSQRRIPKPLAS--------- 1116

  Fly  1114 GEDVRRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKS 1178
            ||         :...:.||.|| :.|||:|||:||||||||::..|||||..||||||..||.:|
  Fly  1117 GE---------KEAQEFYQHWL-NVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNPSRS 1171

  Fly  1179 SHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPG-YAPYCEERLKRTFNNGTRNQPPSWLELQ 1242
            |::|||:|||||:.||.||::|..:||:|:::|... .|....:||:||..||.|.||||..||.
  Fly  1172 SYSRGWLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSLQRLERTLVNGPRCQPPSLFELH 1236

  Fly  1243 ATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSG 1307
            |.:.:.|:.|.|..|||..:.|..|:|:||||..|||...:.|.|.|||.|.::|..|:..||:|
  Fly  1237 AIRGRHPLRLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGAG 1301

  Fly  1308 GDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEY 1372
            .:||:||||:|||       ::.:|||:|:.|||:||.|::|:.|..||.|||:|::.|:|.|||
  Fly  1302 QEHVLDAISECEQ-------RQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKCGEY 1359

  Fly  1373 RCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPN----FIPDFCLSGVDKAIERWAALVLQAYK 1433
            ||..|:|:||:.|...|:||...    .:..|.|:    |:|...|:..::|||.|:.|:...|:
  Fly  1360 RCRSEKDIAMVCALACFVEYGPG----EILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYE 1420

  Fly  1434 KSYYVKDK------IAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVY 1492
            ||.|||::      .|..:.||||..:|...||:..||.:|..|..||.|..:::::.:|..|::
  Fly  1421 KSSYVKEEQNDLLLEAQKRAKEDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLF 1485

  Fly  1493 VVDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLK 1557
            ::|:.||||....|.|:..|..:..:|:...||     :...|..|..:|:|..:::.|.||.|:
  Fly  1486 LIDETEQVLASCCFSEVLKVHVESDDKLHVMTF-----QHVNFVLQCSSAQDANEVINYMLDNLR 1545

  Fly  1558 KRSKYVIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVL--NNGWCIGRCDRSQERGDFPAE 1620
            :||.|.:|| |.....|....|....||||..|....|..::  |...|...|...| .|.|.|.
  Fly  1546 QRSSYGVAL-DPVVEGDLEDCLVLNPGDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQ-WGQFLAG 1608

  Fly  1621 TVYVLPTLSKPP---QDILALFNIEE-------AHHGRRLSMASNGGAVEPRDRPHTLMEYALDH 1675
            .|.||.||:||.   ||||.....:|       |::.||              |.|.:.:.|..|
  Fly  1609 NVRVLATLTKPSEKLQDILREGRFQEPPKPTPRANYSRR--------------RQHNISQLAESH 1659

  Fly  1676 FRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPS 1740
            ||.|          |.|.:: .|.::|.:|:|||||:.:.......::|......|||||||:..
  Fly  1660 FREP----------LDSDKA-PLSKFSPEPLKAPLLKAVVKVPPLFQQALVMHHHILKYMGDIAR 1713

  Fly  1741 KRPRMGNEITDHIFDGPLKHEILRDEIYCQLMKQLTDNRNRMSEERGWELMWLATGLFACSQGLL 1805
            ....:.   ||.||...|:|.:|.||:||||||||:||.:..||:|||:|::|||||.|.|..::
  Fly  1714 SNLPVN---TDLIFQPALQHPLLCDELYCQLMKQLSDNPSSESEKRGWDLLYLATGLVAPSVLVM 1775

  Fly  1806 KELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFE 1870
            :||::.||.|...::...:.||::::..||||..||.:|||.||.:...|:||:||||||.||||
  Fly  1776 RELIILLRMRADALADACLKRLKRSLAQGQRKKAPHLIEVEGIQQRCLHIYHKIYFPDDTVEAFE 1840

  Fly  1871 VDSSTRAKDFCNNISQRLSLRTSEGFSLFVKIADKVISVPEGDFFFDFVRHLTDWIKKARPIRDG 1935
            ::|.||..:...:|:|||.|::..|:|:|:|..|:|.::||.:|.|||:..|..|:::.|.||..
  Fly  1841 IESHTRGAELIADIAQRLELKSPVGYSIFLKTGDRVYAMPEEEFVFDFITQLIYWLRQQRTIRSI 1905

  Fly  1936 ANPQFTYQVFFMKKLWTNTVPGKDRNADLIFHYHQELPKLLRGYHKCSREEAAKLAALVFRVRFG 2000
            ::.|  ||:.||:|||.|..||:|.|.|:||.|.|||.|.|:||:....|:|::||.||:.   .
  Fly  1906 SDGQ--YQLHFMRKLWLNNHPGEDLNGDMIFSYPQELHKYLKGYYPIDCEQASRLAILVYS---A 1965

  Fly  2001 ENKQELQAIPQMLRELIPSDIMKIQSTSEWKRSIVASYNQDGGMTSEDAKVAFLKIVYRWPTFGS 2065
            ::...||.:|::|..|||.|::.:|:.:||::.|:...::| .:|.:.||:.||:.:..:..|||
  Fly  1966 DHDVSLQRLPEVLTRLIPEDLIPLQTVAEWRQQILPKVHRD-HLTEDHAKILFLQELSHFACFGS 2029

  Fly  2066 AFFEVKQTTEPNYPEMLLIAINKHGVSLIHPVTKDILVTHPFTRISNWSSGNTYFHMTIGNLVRG 2130
            .||.|||..:...||.||||||..|..::.|.||:||.::.::::..||||..:||:..||::..
  Fly  2030 TFFVVKQQNDDALPETLLIAINSTGFHMLDPTTKEILRSYEYSQLGIWSSGKNHFHIRFGNMIGA 2094

  Fly  2131 SKLLCETSLGYKMDDLLTSYI 2151
            |||||.|:.||||||||.||:
  Fly  2095 SKLLCSTTQGYKMDDLLASYV 2115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	420/671 (63%)
		MYSc_Myo7	77..721	CDD:276832	405/646 (63%)
		MyTH4	<1138..1245	CDD:214535	61/107 (57%)
		B41	1251..1467	CDD:214604	94/225 (42%)
		FERM_B-lobe	1355..1439	CDD:271216	35/87 (40%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	28/97 (29%)
		SH3	1560..1624	CDD:302595	21/65 (32%)
		MyTH4	1701..1849	CDD:214535	63/147 (43%)
		B41	1856..2068	CDD:214604	88/211 (42%)
		FERM_M	1966..2068	CDD:278785	36/101 (36%)
		FERM_C2_MyoVII	2064..2159	CDD:270020	45/88 (51%)
Myo28B1	NP_723294.1	MYSc	62..737	CDD:214580	422/676 (62%)
		MYSc_Myo7	81..726	CDD:276832	405/646 (63%)
		IQ	765..785	CDD:197470	11/19 (58%)
		DUF4355	827..>887	CDD:290964	18/81 (22%)
		MyTH4	1031..1239	CDD:295320	97/241 (40%)
		B41	1248..1429	CDD:214604	83/191 (43%)
		FERM_N	1248..>1288	CDD:286467	19/39 (49%)
		FERM_B-lobe	1342..1429	CDD:271216	37/90 (41%)
		PH-like	1454..1547	CDD:302622	28/97 (29%)
		MyTH4	1674..1819	CDD:214535	63/147 (43%)
		B41	1827..2032	CDD:214604	88/210 (42%)
		FERM_N	1829..>1877	CDD:286467	23/47 (49%)
		FERM_M	1936..2032	CDD:278785	35/99 (35%)
		FERM_C2_MyoVII	2028..2121	CDD:270020	45/88 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466267
Domainoid	1	1.000	530	1.000	Domainoid score	I63
eggNOG	1	0.900	-	-		E2759_KOG4229
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1958
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1389at50557
OrthoFinder	1	1.000	-	-		FOG0001409
OrthoInspector	1	1.000	-	-		mtm8405
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	P	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.700