DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and MYO10

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_036466.2 Gene:MYO10 / 4651 HGNCID:7593 Length:2058 Species:Homo sapiens


Alignment Length:2384 Identity:637/2384 - (26%)
Similarity:1025/2384 - (42%) Gaps:581/2384 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 TRGDYIWIEPASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPE-----RRIKAMHASSVQG 64
            |.|..:|:. .:|:.|...:.:   .|||  |.|...|..:|:...:     :::.|||.::.:|
Human     6 TEGTRVWLR-ENGQHFPSTVNS---CAEG--IVVFRTDYGQVFTYKQSTITHQKVTAMHPTNEEG 64

  Fly    65 VEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQ-ILPIYTGDQIKLYKERKIGEL 128
            |:||.||.:||...|:.||..|||.|.||||.||||.:||||| |..:|....::.|..|.:|||
Human    65 VDDMASLTELHGGSIMYNLFQRYKRNQIYTYIGSILASVNPYQPIAGLYEPATMEQYSRRHLGEL 129

  Fly   129 PPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAIS---------GKHSWIE 184
            |||||||.:..|..:.:...:|||:|||||||||||||||||::|:.||         .|.|.:|
Human   130 PPHIFAIANECYRCLWKRHDNQCILISGESGAGKTESTKLILKFLSVISQQSLELSLKEKTSCVE 194

  Fly   185 QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERN 249
            :.|||::||:||||||||:.|:|||||||::.::....|.|:|.:|..|||||:|:|.||..|||
Human   195 RAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNIQGGRIVDYLLEKNRVVRQNPGERN 259

  Fly   250 YHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIW 314
            ||:||.:||||..:|:....|....:|.||.....:..:...|...|.::.:||.|:.||.:|:.
Human   260 YHIFYALLAGLEHEEREEFYLSTPENYHYLNQSGCVEDKTISDQESFREVITAMDVMQFSKEEVR 324

  Fly   315 EIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGET 379
            |:.:|||.:||.|||::...     ...::.....:.|.|.||||....|.||||:|::|..||.
Human   325 EVSRLLAGILHLGNIEFITA-----GGAQVSFKTALGRSAELLGLDPTQLTDALTQRSMFLRGEE 384

  Fly   380 VVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAI-----FKPRGTSRNAIGVLDIFGFENFD 439
            :::.|:..|:||.||:....:|...|..:::|||:.|     ||       :||:|||||||||:
Human   385 ILTPLNVQQAVDSRDSLAMALYACCFEWVIKKINSRIKGNEDFK-------SIGILDIFGFENFE 442

  Fly   440 QNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALI 504
            .|.||||.||||||.||::|.:|||.|||.||:.|.:.|:.|:::||.:.||||. |:|.::|||
Human   443 VNHFEQFNINYANEKLQEYFNKHIFSLEQLEYSREGLVWEDIDWIDNGECLDLIE-KKLGLLALI 506

  Fly   505 DEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSP 569
            :||:.||:.||.|:|.|||..|.::..|:||:..:| :||:.|:||.|.||.||.|:||||||..
Human   507 NEESHFPQATDSTLLEKLHSQHANNHFYVKPRVAVN-NFGVKHYAGEVQYDVRGILEKNRDTFRD 570

  Fly   570 DLLHLVSQSTNKFLRQIFA-------QD-IEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFF 626
            |||:|:.:|...|:..:|.       || ::.|::.|:  ||:|:||:.||.:||.||||..|||
Human   571 DLLNLLRESRFDFIYDLFEHVSSRNNQDTLKCGSKHRR--PTVSSQFKDSLHSLMATLSSSNPFF 633

  Fly   627 IRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP--GVPPA 689
            :||||||..|.|..||:.:...|||||||:||:|||:|||.:|..|::|.:||:.|:.  .:|..
Human   634 VRCIKPNMQKMPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRNLALPED 698

  Fly   690 HRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDR---------------VLTRK 739
            .|..|   ||.:.......|::|||.|||||:::.:..||:.|:.               .|.||
Human   699 VRGKC---TSLLQLYDASNSEWQLGKTKVFLRESLEQKLEKRREEEVSHAAMVIRAHVLGFLARK 760

  Fly   740 --------ILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNM-------------- 782
                    ::|:|::.|.::.|||||.|:.|||..|:..:|...|:.||.:              
Human   761 QYRKVLYCVVIIQKNYRAFLLRRRFLHLKKAAIVFQKQLRGQIARRVYRQLLAEKREQEEKKKQE 825

  Fly   783 RVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRR 847
            .....:.:...|.|....|...||..             :.|...|...:..:|...:.....|.
Human   826 EEEKKKREEEERERERERREAELRAQ-------------QEEETRKQQELEALQKSQKEAELTRE 877

  Fly   848 YRKLRLEHKQFAEVLQLRK-------LEEQELLHRGNKHAREIAEQHYRD--RLHELERREIQEQ 903
            ..|.: |:||..|:|:|.|       ::||:.|.......:::.|:..::  ||.|...|..||.
Human   878 LEKQK-ENKQVEEILRLEKEIEDLQRMKEQQELSLTEASLQKLQERRDQELRRLEEEACRAAQEF 941

  Fly   904 LENR---------RRVEVNMNI------------------INDAARKQEEPVDDGKLVEAMFDFL 941
            ||:.         |.:|.::::                  .|.:....||.||:|      |:..
Human   942 LESLNFDEIDECVRNIERSLSVGSEFSSELAESACEEKPNFNFSQPYPEEEVDEG------FEAD 1000

  Fly   942 PDSSSDAPTP----HGGRETSVF--NDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAATYF 1000
            .|:..|:|.|    |..:.||..  :|....::...:|.:.|...|.|...|.....|...:.:.
Human  1001 DDAFKDSPNPSEHGHSDQRTSGIRTSDDSSEEDPYMNDTVVPTSPSADSTVLLAPSVQDSGSLHN 1065

  Fly  1001 QGNVNHQYAKKALKHPLLPLHTQGDQLAAQALWITILRFTGDMPEP--KY-HTMDRMDTTSVMSK 1062
            ..:....|.        :|.:                  .||:|.|  .| :..|..:..::.|.
Human  1066 SSSGESTYC--------MPQN------------------AGDLPSPDGDYDYDQDDYEDGAITSG 1104

  Fly  1063 VTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLG------EDVRRRL 1121
            .:.|...::  ..::        .||              ...::...|..|      |..:...
Human  1105 SSVTFSNSY--GSQW--------SPD--------------YRCSVGTYNSSGAYRFSSEGAQSSF 1145

  Fly  1122 QDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQL--------TNNPLKS 1178
            :|.|...|       ||..:: ::|.:          .||.:|.  |..|        ....|.:
Human  1146 EDSEEDFD-------SRFDTD-DELSY----------RRDSVYS--CVTLPYFHSFLYMKGGLMN 1190

  Fly  1179 SHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTF----NNGT-----RNQ 1234
            |..|.|        |....|.|: :.|:            .:|.||:.:    ..|:     ||.
Human  1191 SWKRRW--------CVLKDETFL-WFRS------------KQEALKQGWLHKKGGGSSTLSRRNW 1234

  Fly  1235 PPSWLELQATKSKKPIMLPITFMDGNTKTLLADS--ATTARELCNQLSDKISLKDQFGFSLYIA- 1296
            ...|..|:.:|        :.:.:.:::..|..:  ..||:|:.:..:      .:.|..:.:| 
Human  1235 KKRWFVLRQSK--------LMYFENDSEEKLKGTVEVRTAKEIIDNTT------KENGIDIIMAD 1285

  Fly  1297 -LFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIY 1360
             .|..::............:||... :.:|..||                    .||:.|..   
Human  1286 RTFHLIAESPEDASQWFSVLSQVHA-STDQEIQE--------------------MHDEQANP--- 1326

  Fly  1361 QQVVRGVKFG--EYRC-----DKEEDLAMIAAQQYF-IEYSTDMSMERLFTLLPNFIPDFCLSGV 1417
            |..|..:..|  :..|     |:.....:|.|.:.. ....|...|....|||.....|..:.|.
Human  1327 QNAVGTLDVGLIDSVCASDSPDRPNSFVIITANRVLHCNADTPEEMHHWITLLQRSKGDTRVEGQ 1391

  Fly  1418 DKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDV 1482
            :..:..|       ..|......|::.||:|:        :|.:|.....:.|::|..|..|...
Human  1392 EFIVRGW-------LHKEVKNSPKMSSLKLKK--------RWFVLTHNSLDYYKSSEKNALKLGT 1441

  Fly  1483 IIAVNWTGVYVVDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRD 1547
            ::..:...  ||...|::..|..:..:|....:...:::|:.                       
Human  1442 LVLNSLCS--VVPPDEKIFKETGYWNVTVYGRKHCYRLYTKL----------------------- 1481

  Fly  1548 LVVYFLDGLKKRSKYVIALQ---DYRAPSDGTSFLSFFKGDLIILED--ESCGESVLNNGWCIGR 1607
                    |.:.:::..|:|   |.:||.|..:        ..:::|  |:|..|.:        
Human  1482 --------LNEATRWSSAIQNVTDTKAPIDTPT--------QQLIQDIKENCLNSDV-------- 1522

  Fly  1608 CDRSQERGDFPAETVYVL--PTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLME 1670
            .::..:|......|.:.|  |.|..|..||             .|::..:.|..       ||.:
Human  1523 VEQIYKRNPILRYTHHPLHSPLLPLPYGDI-------------NLNLLKDKGYT-------TLQD 1567

  Fly  1671 YALDHFR-LPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKY 1734
            .|:..|. |....:||                  |||  |:::                 .||:.
Human  1568 EAIKIFNSLQQLESMS------------------DPI--PIIQ-----------------GILQT 1595

  Fly  1735 MGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYCQLMKQL--TDNRNRMSEERGWELMWLATGL 1797
            ..||   ||                   ||||:||||:||.  ..:...:.....|:::...:..
Human  1596 GHDL---RP-------------------LRDELYCQLIKQTNKVPHPGSVGNLYSWQILTCLSCT 1638

  Fly  1798 FACSQGLLKELLLFLRTRRHPISQDSMHR--------LQKTIRHGQRKYPPHQVEVEAIQHKTTQ 1854
            |..|:|:||.|...|:..|.......|.:        |:||   ..|::.|.:.|:||:.|: .:
Human  1639 FLPSRGILKYLKFHLKRIREQFPGSEMEKYALFTYESLKKT---KCREFVPSRDEIEALIHR-QE 1699

  Fly  1855 IFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEG-FSLFVKIADKVISVPEGDFFFDF 1918
            :...||..........::|.|.|.:....:.:.|::..|.. |:|                 |::
Human  1700 MTSTVYCHGGGSCKITINSHTTAGEVVEKLIRGLAMEDSRNMFAL-----------------FEY 1747

  Fly  1919 VRHLTDWIKKARPIRD--------------GANP-QFTYQVFFMKKLWTNTVPGKDRNADLIFHY 1968
            ..|:...|:....:.|              |..| :|.::::..  |.|:.|| || :.:..|.:
Human  1748 NGHVDKAIESRTVVADVLAKFEKLAATSEVGDLPWKFYFKLYCF--LDTDNVP-KD-SVEFAFMF 1808

  Fly  1969 HQELPKLLRGYHKCSREEAAKLAALVFRVRFGE--------------NKQELQA-IPQMLRELIP 2018
            .|....::.|:|....|....||||..:...|:              :.|.|:| |.|..:...|
Human  1809 EQAHEAVIHGHHPAPEENLQVLAALRLQYLQGDYTLHAAIPPLEEVYSLQRLKARISQSTKTFTP 1873

  Fly  2019 SDIMKIQSTS---------------------------EW--------KRSIVASYNQDGGMTSED 2048
            .:.::.:.||                           .|        :.||:..:.:..||..|.
Human  1874 CERLEKRRTSFLEGTLRRSFRTGSVVRQKVEEEQMLDMWIKEEVSSARASIIDKWRKFQGMNQEQ 1938

  Fly  2049 AKVAFLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSLIHPVTKDILVTHPFTRISNW 2113
            |...::.::..||.:||..|:| :..|..:|:.|.:.::...||:........|....:..|.::
Human  1939 AMAKYMALIKEWPGYGSTLFDV-ECKEGGFPQELWLGVSADAVSVYKRGEGRPLEVFQYEHILSF 2002

  Fly  2114 SS--GNTYFHMTIGNLVRGSKLLCETSLGYKMDDLLTSYISLML 2155
            .:  .|||     ..:|...:||.|||....:..|:.:|||:::
Human  2003 GAPLANTY-----KIVVDERELLFETSEVVDVAKLMKAYISMIV 2041

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 319/693 (46%)
MYSc_Myo7 77..721 CDD:276832 308/668 (46%)
MyTH4 <1138..1245 CDD:214535 23/123 (19%)
B41 1251..1467 CDD:214604 37/227 (16%)
FERM_B-lobe 1355..1439 CDD:271216 17/91 (19%)
FERM_C1_MyoVII 1461..1559 CDD:270019 12/97 (12%)
SH3 1560..1624 CDD:302595 12/68 (18%)
MyTH4 1701..1849 CDD:214535 38/157 (24%)
B41 1856..2068 CDD:214604 51/277 (18%)
FERM_M 1966..2068 CDD:278785 29/151 (19%)
FERM_C2_MyoVII 2064..2159 CDD:270020 24/94 (26%)
MYO10NP_036466.2 MYSc 58..739 CDD:214580 320/699 (46%)
MYSc_Myo10 77..727 CDD:276840 308/668 (46%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 619..641 15/21 (71%)
SAH. /evidence=ECO:0000250|UniProtKB:F8VQB6, ECO:0000250|UniProtKB:P79114 815..908 19/106 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 819..840 1/20 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 847..866 4/31 (13%)
Mediates antiparallel dimerization. /evidence=ECO:0000269|PubMed:23012428 883..933 13/49 (27%)
MYO10_CC 883..933 CDD:293340 13/49 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1090 27/157 (17%)
PH-like 1181..>1223 CDD:302622 11/62 (18%)
PH2_MyoX 1215..1316 CDD:270108 17/115 (15%)
PH 1215..1308 CDD:278594 15/106 (14%)
PH3_MyoX-like 1381..1506 CDD:270109 27/172 (16%)
PH 1396..1495 CDD:278594 21/146 (14%)
MyTH4 1549..1695 CDD:214535 49/227 (22%)
B41 1704..1958 CDD:214604 51/274 (19%)
UBQ 1705..>1753 CDD:294102 10/64 (16%)
FERM_M 1796..1958 CDD:278785 33/163 (20%)
FERM_C_MyoX 1954..2042 CDD:270023 24/94 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

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