DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and MYO9B

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_004136.2 Gene:MYO9B / 4650 HGNCID:7609 Length:2157 Species:Homo sapiens


Alignment Length:2148 Identity:541/2148 - (25%)
Similarity:837/2148 - (38%) Gaps:685/2148 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 IQVRDDDGDEVWLAPERRIKAMHASSV-----------QGV--------EDMISLGDLHEAGILR 81
            :|.|:.||         .||.:|...|           :|:        :|:.:|.:|.|..:|:
Human   109 LQERNADG---------TIKYVHMQLVAQATATRRLVERGLLPRQQADFDDLCNLPELTEGNLLK 164

  Fly    82 NLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMKRY 146
            ||..|:.:..||||.||||||:||::.||||....:|:|:.:::|:|.||:||:.|.||..|.|.
Human   165 NLKHRFLQQKIYTYAGSILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFALADVAYYTMLRK 229

  Fly   147 RQDQCIVISGESGAGKTESTKLILQYLAAIS--GKHSWIEQQILEANPILEAFGNAKTIRNDNSS 209
            |.:||||||||||:|||:||..::..|.|:|  |..|.:|:.||.|.|:|||||||||..|:|||
Human   230 RVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASGVERTILGAGPVLEAFGNAKTAHNNNSS 294

  Fly   210 RFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAA 274
            ||||:|.:.:..:|::.||.:|:|||||||:|||...||||||||.:|.|:|.:|:....|....
Human   295 RFGKFIQVSYLESGIVRGAVVEKYLLEKSRLVSQEKDERNYHVFYYLLLGVSEEERQEFQLKQPE 359

  Fly   275 DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVVDNL 339
            ||.||...|....:|.|...:|..::.||:::.|......:|..:|:|:|:.||:.||.......
Human   360 DYFYLNQHNLKIEDGEDLKHDFERLKQAMEMVGFLPATKKQIFAVLSAILYLGNVTYKKRATGRE 424

  Fly   340 DATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRM 404
            :..|:.....::.::.||.:..:.|::.||:|......:.::...|..:::..||:..|.:|..:
Human   425 EGLEVGPPEVLDTLSQLLKVKREILVEVLTKRKTVTVNDKLILPYSLSEAITARDSMAKSLYSAL 489

  Fly   405 FVHIVRKINTAIFKPR----GTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFK 465
            |..||.:||.|:...:    ..|..:||||||||||:|::|||||||||||||.||.:|.|||||
Human   490 FDWIVLRINHALLNKKDVEEAVSCLSIGVLDIFGFEDFERNSFEQFCINYANEQLQYYFNQHIFK 554

  Fly   466 LEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHKTHGSHK 530
            ||||||..|.|.|.:|.:.||...:.||:.|...:..|:|||:.||..|.||:|||..:.|..:|
Human   555 LEQEEYQGEGITWHNIGYTDNVGCIHLISKKPTGLFYLLDEESNFPHATSQTLLAKFKQQHEDNK 619

  Fly   531 NYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQD----- 590
            .:|.... :..:|.:.||||.|.|..:.|.:||.|...||::.|:..|.:.::|::...|     
Human   620 YFLGTPV-MEPAFIIQHFAGKVKYQIKDFREKNMDYMRPDIVALLRGSDSSYVRELIGMDPVAVF 683

  Fly   591 -------------------------------------------IEMGAET--------------- 597
                                                       :..||.|               
Human   684 RWAVLRAAIRAMAVLREAGRLRAERAEKAAGMSSPGAQSHPEELPRGASTPSEKLYRDLHNQMIK 748

  Fly   598 ----------------------------------------------------------------- 597
                                                                             
Human   749 SIKGLPWQGEDPRSLLQSLSRLQKPRAFILKSKGIKQKQIIPKNLLDSKSLKLIISMTLHDRTTK 813

  Fly   598 -------RKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGM 655
                   :|:.|::|.||:.||:.|::.|...:|||||||:.|..||.:.||..|..:||||:||
Human   814 SLLHLHKKKKPPSISAQFQTSLNKLLEALGKAEPFFIRCIRSNAEKKELCFDDELVLQQLRYTGM 878

  Fly   656 METIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHRTDCQAATSRICAVV----LGKSDYQLGHT 716
            :||:||||:||..::.|::|.|:::.|:|       .|.|.....|..::    :.|.:||:|.|
Human   879 LETVRIRRSGYSAKYTFQDFTEQFQVLLP-------KDAQPCREVISTLLEKMKIDKRNYQIGKT 936

  Fly   717 KVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRN 781
            |||||:.....|::...|.:.||||:||...|..:.||.||:::.||:|:|..|:.|..|:    
Human   937 KVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRHFLQMKRAAVTIQACWRSYRVRR---- 997

  Fly   782 MRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMR 846
                     ||.|::.           .|.|||..|||..|:.|.|:..::|::||..|..:..:
Human   998 ---------ALERTQA-----------AVYLQASWRGYWQRKLYRHQKQSIIRLQSLCRGHLQRK 1042

  Fly   847 RYRKLRLEHKQFAEVLQLRKLEE----------------QELLHRG------------------- 876
            .:.:: :..||.||..:...||.                |::..:|                   
Human  1043 SFSQM-ISEKQKAEEKEREALEAARAGAEEGGQGQAAGGQQVAEQGPEPAEDGGHLASEPEVQPS 1106

  Fly   877 --------------------------------------------------------NKHAREIAE 885
                                                                    |||.:...|
Human  1107 DRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRGLEHVKFQNKHIQSCKE 1171

  Fly   886 QHYRDRLHELERREIQEQ----LENRR--RVEVNMNIINDAAR--KQEEPVDD------GKLVEA 936
            :   ..|.|..||..|||    ||:::  |.:..:.::...|.  .|::|.:.      ||:.|.
Human  1172 E---SALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEE 1233

  Fly   937 MFDFLPDSSSDAPTPHGG---RETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLS---------E 989
            ....||..|     |..|   |.||:..|    ..|:..   ||....|..||.|         |
Human  1234 TEKTLPSGS-----PRPGQLERPTSLALD----SRVSPP---APGSAPETPEDKSKPCGSPRVQE 1286

  Fly   990 FKFQKFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQALWITIL----------RFTGDMP 1044
            .......:|..|..::.:....|::      ..:|.:|.|.|....:|          |.||...
Human  1287 KPDSPGGSTQIQRYLDAERLASAVE------LWRGKKLVAAASPSAMLSQSLDLSDRHRATGAAL 1345

  Fly  1045 EPKYHTMDRMD--TTSVMSKVTATLG----------------RNFIRSKEFQEAQLM---GLDPD 1088
            .|   |.:|..  :||.:||:..:|.                :..::.|:..:|..:   ||.|.
Human  1346 TP---TEERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDAGLSPG 1407

  Fly  1089 AFLKQK---PRSIRHK-----------------------LVSLTLK------------------- 1108
            :.:..|   .|...||                       |.:.|:|                   
Human  1408 SQVDSKSTFKRLFLHKTKDKKYSLEGAEELENAVSGHVVLEATTMKKGLEAPSGQQHRHAAGEKR 1472

  Fly  1109 --------RKN---KLG---------EDVRRRLQD-------DEYTADSYQSWLQSRPT------ 1140
                    :||   |:|         |.|.|::.:       ||:..:.... |:|:.|      
Human  1473 TKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLDEFLLNKIND-LRSQKTPIESLF 1536

  Fly  1141 --------SNLEKLHFIIGHGILRAELRD--EIYCQICKQL-TNNPLKSSHARGWILLSLCVGCF 1194
                    ||: |..:.:.:|.:....:|  |.|..:...| |....|.::    ::|:|     
Human  1537 IEATEKFRSNI-KTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQKDTN----LVLNL----- 1591

  Fly  1195 APSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDG 1259
                 |.:.|..|.|    ||               |:|......:.:|.|.|:.....:...:|
Human  1592 -----FQSLLDEFTR----GY---------------TKNDFEPVKQSKAQKKKRKQERAVQEHNG 1632

  Fly  1260 NTKTLLADSATTARELCNQLSDKISLKDQ------------------------------------ 1288
            :   :.|....:..:.|.|....|.|.|:                                    
Human  1633 H---VFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVE 1694

  Fly  1289 ---FGFSLYIALFDKVS---SLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKE------ 1341
               ||..:.....||.|   .|....:||.......|...::.||..|....|...:.:      
Human  1695 PGHFGVCVDSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKL 1759

  Fly  1342 ----------IFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDM 1396
                      :...|.....:.:.|...|...:|.|:..|    |:|.||.|.|....:..:...
Human  1760 ENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPE----KQEQLAAIYAVLEHLPEANHN 1820

  Fly  1397 SMERLF------TLLPN------------FIPDF--CLSGVDK--------AIERWAALVLQAYK 1433
            |:|||.      .||.:            |.|..  |....|.        .|.....::::...
Human  1821 SLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQM 1885

  Fly  1434 KSYYVK-DKIAPLKIKEDI----VSYAKYK--WPLL--FSRFYEAYRNSGPNLPKNDVIIAVNWT 1489
            :.|.|| ::|:.|:..|.|    :|..:..  |||.  ||..||...|..|....          
Human  1886 RKYKVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRD---------- 1940

  Fly  1490 GVYVVDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLD 1554
               :.:::.:||||   .|.......:..::..:  .:.:::.|:        |||    .|.|.
Human  1941 ---IQEEELEVLLE---EEAAGGDEDREKEILIE--RIQSIKEEK--------EDI----TYRLP 1985

  Fly  1555 GLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGD--- 1616
            .|..|.            ||..:..|         |..:..||:|..     |..|....|.   
Human  1986 ELDPRG------------SDEENLDS---------ETSASTESLLEE-----RAGRGASEGPPAP 2024

  Fly  1617 -FP---AETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDHFR 1677
             .|   |.|...|||::.||:              ||.|.........||..|  :|..|  :.:
Human  2025 ALPCPGAPTPSPLPTVAAPPR--------------RRPSSFVTVRVKTPRRTP--IMPTA--NIK 2071

  Fly  1678 LPP 1680
            |||
Human  2072 LPP 2074

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 284/821 (35%)
MYSc_Myo7 77..721 CDD:276832 276/788 (35%)
MyTH4 <1138..1245 CDD:214535 22/123 (18%)
B41 1251..1467 CDD:214604 56/310 (18%)
FERM_B-lobe 1355..1439 CDD:271216 23/111 (21%)
FERM_C1_MyoVII 1461..1559 CDD:270019 19/99 (19%)
SH3 1560..1624 CDD:302595 13/70 (19%)
MyTH4 1701..1849 CDD:214535
B41 1856..2068 CDD:214604
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
MYO9BNP_004136.2 Myosin_IXb_RA 7..112 CDD:176374 1/2 (50%)
MYSc 141..950 CDD:214580 283/816 (35%)
MYSc_Myo9 160..941 CDD:276836 276/788 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 709..734 2/24 (8%)
Actin-binding. /evidence=ECO:0000305 844..855 7/10 (70%)
Neck or regulatory domain. /evidence=ECO:0000305 940..1044 39/127 (31%)
IQ 978..999 CDD:197470 7/33 (21%)
IQ 1000..1022 CDD:197470 9/32 (28%)
Tail. /evidence=ECO:0000305 1045..2157 213/1171 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1046..1298 46/267 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1320..1410 19/92 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1455..1484 1/28 (4%)
C1 1633..1681 CDD:237996 6/50 (12%)
RhoGAP_myosin_IXB 1698..1883 CDD:239872 36/188 (19%)
Interaction with RHOA. /evidence=ECO:0000269|PubMed:26529257 1739..1744 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1980..2157 34/143 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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