DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and MYO9A

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:XP_011519915.1 Gene:MYO9A / 4649 HGNCID:7608 Length:2638 Species:Homo sapiens


Alignment Length:2552 Identity:605/2552 - (23%)
Similarity:999/2552 - (39%) Gaps:720/2552 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 VSAEGRRIQVRDDDGD--------EVWL-APERRIKAMHASSV-----QGVEDMISLGDLHEAGI 79
            :|.|..|..:|:.:.|        :.|| ..|.|.:.|....:     :..:|:.||.||:|..:
Human    98 LSGEDYRFLLREKNLDGSIHYGSLQSWLRVTEERRRMMERGFLPQPQQKDFDDLCSLPDLNEKTL 162

  Fly    80 LRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMK 144
            |.||..|:|...||||.||||:.:||::.||||....:|:|...::|:|.|||:|:.|.||..|.
Human   163 LENLRNRFKHEKIYTYVGSILIVINPFKFLPIYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAML 227

  Fly   145 RYRQDQCIVISGESGAGKTESTKLILQYLAAIS--GKHSWIEQQILEANPILEAFGNAKTIRNDN 207
            :.:::||||||||||:|||:||..::.:|.|:|  |..|.:||.||.|.|:|||||||||..|:|
Human   228 QRKKNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAGPVLEAFGNAKTAHNNN 292

  Fly   208 SSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGM 272
            ||||||:|.:::...|.:.||.:|:|||||||:|.|.|:||||||||.:|||.|.||:|...|..
Human   293 SSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLAGASEDERSAFHLKQ 357

  Fly   273 AADYKYLTGGNSIT------------------C---EGRDDAAEFSDIRSAMKVLLFSDQEIWEI 316
            ..:|.||   |.||                  |   ||.|...:|..::.||:::.|..:...:|
Human   358 PEEYHYL---NQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQI 419

  Fly   317 IKLLAALLHCGNIKYKATVV--DNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGET 379
            ..||:|:||.|||.||....  |::|... ||.:.:  |:.||.:..:.|.:||..|.....||.
Human   420 FSLLSAILHLGNICYKKKTYRDDSIDICN-PEVLPI--VSELLEVKEEMLFEALVTRKTVTVGEK 481

  Fly   380 VVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRN----AIGVLDIFGFENFDQ 440
            ::......::|.||::..|.:|..:|..||.:||.|:...:....|    :||||||||||:::.
Human   482 LILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEHNTKTLSIGVLDIFGFEDYEN 546

  Fly   441 NSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALID 505
            |||||||||:|||.||.:|.|||||||||||..|.|:|.:|:::||...::||:.|...::.|:|
Human   547 NSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLISKKPTGLLHLLD 611

  Fly   506 EEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPD 570
            ||:.||:.|:||:|.|....| ...:|::..:.:..:|.:.|:||.|.|..:.|.:||.|...||
Human   612 EESNFPQATNQTLLDKFKHQH-EDNSYIEFPAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPD 675

  Fly   571 LLHLVSQSTNKF-----------------LRQIFAQ----------------------------- 589
            ::.|:..|.|.|                 ||..|..                             
Human   676 IVALLRSSKNAFISGMIGIDPVAVFRWAILRAFFRAMVAFREAGKRNIHRKTGHDDTAPCAILKS 740

  Fly   590 --------------------------------------------------------DIEMGAET- 597
                                                                    ||.....| 
Human   741 MDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNALNEKNQHDTFDIAWNGRTG 805

  Fly   598 ----------------------------------------------------------------- 597
                                                                             
Human   806 IRQSRLSSGTSLLDKDGIFANSTSSKLLERAHGILTRNKNFKSKPALPKHLLEVNSLKHLTRLTL 870

  Fly   598 -------------RKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQ 649
                         :|:.|::|.||:.||..||:||...:|:|::||:.|..|.|:.|...|..||
Human   871 QDRITKSLLHLHKKKKPPSISAQFQASLSKLMETLGQAEPYFVKCIRSNAEKLPLRFSDVLVLRQ 935

  Fly   650 LRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP-GVPPAHRTDCQAATSRICAVVLGKSDYQL 713
            |||:||:||:|||::||..::.|::||..:..|:| .:.|: :.:.|....:|   .|...:||:
Human   936 LRYTGMLETVRIRQSGYSSKYSFQDFVSHFHVLLPRNIIPS-KFNIQDFFRKI---NLNPDNYQV 996

  Fly   714 GHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKR 778
            |.|.||||:.....|:....:.:.|:|::|||..|..:.|:.||.||.|::.:||||:.|..:|:
Human   997 GKTMVFLKEQERQHLQDLLHQEVLRRIILLQRWFRVLLCRQHFLHLRQASVIIQRFWRNYLNQKQ 1061

  Fly   779 YRN---------MRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRR----------- 823
            .|:         |......|||..|:.:...|:..||...:.:|...|.|..||           
Human  1062 VRDAAVQKDAFVMASAAALLQASWRAHLERQRYLELRAAAIVIQQKWRDYYRRRHMAAICIQARW 1126

  Fly   824 -------EYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLE-EQELLHRGNKHA 880
                   .|..:...:|.:||..|...|.:|::.|:.:        :||:.: |..|::.....:
Human  1127 KAYRESKRYQEQRKKIILLQSTCRGFRARQRFKALKEQ--------RLRETKPEVGLVNIKGYGS 1183

  Fly   881 REI--------AEQHYRDRLHELERREIQEQLE-NRRRVEVNMNIINDAARKQEEPVDDGKLVEA 936
            .||        .:..:.:|:..:|  |.:..:| ||...|.:::.:.::..||:|.......|:.
Human  1184 LEIQGSDPSGWEDCSFDNRIKAIE--ECKSVIESNRISRESSVDCLKESPNKQQERAQSQSGVDL 1246

  Fly   937 MFDFL----PDSSSDAPTPHGGR-----------ETSVFN-DLPHAQNVNQDDIIAPIHISEDEE 985
            ..|.|    |.|..|......||           |.::|: :|...:::..   |:|   |||..
Human  1247 QEDVLVRERPRSLEDLHQKKVGRAKRESRRMRELEQAIFSLELLKVRSLGG---ISP---SEDRR 1305

  Fly   986 DLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLPL-HTQGDQLAAQALWITILRFTGDM--PEPK 1047
            ..:|...:...:.  :|..:.:.::.:|:  ||.. .:|..:|.      :::...||:  |.||
Human  1306 WSTELVPEGLQSP--RGTPDSESSQGSLE--LLSYEESQKSKLE------SVISDEGDLQFPSPK 1360

  Fly  1048 YHTMDRMDT-TSVMSKVTATLGRNFIRSKEFQEAQLMGLD--------PDAFLKQKPRSIRHKLV 1103
            ..:..:.|: .:.:|....|.....::....:|..:...:        .|:|:.....:..:...
Human  1361 ISSSPKFDSRDNALSASNETSSAEHLKDGTMKEMVVCSSESITCKPQLKDSFISNSLPTFFYIPQ 1425

  Fly  1104 SLTLKRKNKLGEDVRR-RLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQI 1167
            ...||..::|...::| :|.::|.||....:...:|.|   .:.|         ...:|:|...:
Human  1426 QDPLKTNSQLDTSIQRNKLLENEDTAGEALTLDINRET---RRYH---------CSGKDQIVPSL 1478

  Fly  1168 CKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTR 1232
            ..:.:|..||......             :||                    |||.|:......:
Human  1479 NTESSNPVLKKLEKLN-------------TEK--------------------EERQKQLQQQNEK 1510

  Fly  1233 ------NQPPSWLELQATKSK---KP-----IMLPITFMD----GNTKTLLADSATTARELCNQL 1279
                  .|....||.:....|   ||     ::.|.::..    ....:||:.:.:...|| |.|
Human  1511 EMMEQIRQQTDILEKERKAFKTIEKPRIGECLVAPSSYQSKQRVERPSSLLSLNTSNKGEL-NVL 1574

  Fly  1280 SDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFA 1344
            . .:||||       .||..|.||    ..|:                ..::.|..:||.:: .:
Human  1575 G-SLSLKD-------AALAQKDSS----SAHL----------------PPKDRPVTVFFERK-GS 1610

  Fly  1345 PWHEPTHDQVA-TNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNF 1408
            |....|..::: |:.:..|:....|....|..|.|.   ....|.:...|.|:|.|      .|.
Human  1611 PCQSSTVKELSKTDRMGTQLNVACKLSNNRISKREH---FRPTQSYSHNSDDLSRE------GNA 1666

  Fly  1409 IPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIA-PLKIKEDIVSYAKYKWPLLFSRFYEAYRN 1472
            .|.|                       :..||.:: ||..|                   ||..:
Human  1667 RPIF-----------------------FTPKDNMSIPLVSK-------------------EALNS 1689

  Fly  1473 SGPNLPKNDVIIAVNWTGVYVV--DDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEF 1535
            ..|.|.|.|   ...|..|.:.  ..:|||          |..:.|......:|.|....||...
Human  1690 KNPQLHKED---EPAWKPVKLAGPGQREQV----------ARPAHKKKARMARTRSDFLTRGTFA 1741

  Fly  1536 TFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAPSDGTS-----------FLSFFKGDLIIL 1589
            ..:....||..|.::..|..|.:.|...:.    .|||.|.:           |.|        :
Human  1742 DGEGDTEEDDYDDIIEPLLSLDQASHCELG----PAPSLGQASHSDSEMTSQRFSS--------V 1794

  Fly  1590 EDESCGESVLNNG-------------------------WCIGRCDRSQERGDFPAETVYVLPTLS 1629
            ::::.....::.|                         |..|:      :|:  .:|..|.||..
Human  1795 DEQAKLHKTMSQGEITKLAVRQKASDSDIRPQRAKMRFWAKGK------QGE--KKTTRVKPTTQ 1851

  Fly  1630 KPPQDILALFNIEEAHHGRRLSMASNGGAVEPR-----DRPHTLMEYALDHFRLPPKRTMSKTLT 1689
            .....:.|..::..||     .......|..|.     :.|.:..:...::....||....:::.
Human  1852 SEVSPLFAGTDVIPAH-----QFPDELAAYHPTPPLSPELPGSCRKEFKENKEPSPKAKRKRSVK 1911

  Fly  1690 LSSKRSEEL-WRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHI 1753
            :|:...:.: |:.....|.|. :..|:|.:||          :||.:.||.::..:. :.:.|.:
Human  1912 ISNVALDSMHWQNDSVQIIAS-VSDLKSMDEF----------LLKKVNDLDNEDSKK-DTLVDVV 1964

  Fly  1754 FDGPLKH-------------------EILRDEIYCQLMKQLTDNRNRMSEE----RGWELMWLAT 1795
            |...||.                   .|...::|. |.:|:.:...|:.:.    .....:|:.|
Human  1965 FKKALKEFRQNIFSFYSSALAMDDGKSIRYKDLYA-LFEQILEKTMRLEQRDSLGESPVRVWVNT 2028

  Fly  1796 GLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVE------VEAIQH---- 1850
                 .:..|.|.:...:|     |..:..::.||.|..:||.....||      .:|.|:    
Human  2029 -----FKVFLDEYMNEFKT-----SDCTATKVPKTERKKRRKKETDLVEEHNGHIFKATQYSIPT 2083

  Fly  1851 -------------------------------KTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNI 1884
                                           |||....|.|.|:.:...|.|:            
Human  2084 YCEYCSSLIWIMDRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVE------------ 2136

  Fly  1885 SQRLSLRTSEGFSLFVKIADKVISVPE-GDFFFDFVRHLTDWIKKARPIRDGA------------ 1936
               ||..|||..::.: :.:|:|:..| ...:.:.:...:....|.:.:|.|.            
Human  2137 ---LSRLTSEDRTVPL-VVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLDDY 2197

  Fly  1937 NPQFTYQVFFMKKLWTNTVPGKDRNADLIFHYH---------QELPKLLRGYH----KCSREEAA 1988
            |......||   |.|...:|    |..:.|..:         ||..:.:||.:    :.||....
Human  2198 NIHVIASVF---KQWLRDLP----NPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSRTHLN 2255

  Fly  1989 KLAALVF---RVRFGENKQELQAIPQMLRELIPSDIMKIQSTSEWKRSIVASYNQDGGMTSEDAK 2050
            .|..|:|   |:...|:...:.|  ..|..:....|::...|::..:|:     ||...|:...:
Human  2256 TLERLIFHLVRIALQEDTNRMSA--NALAIVFAPCILRCPDTTDPLQSV-----QDISKTTTCVE 2313

  Fly  2051 VAFLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSLIHPVTKDILVTHPFTRIS-NWS 2114
            :..::.:.::..      .:|..:...:.|...    |..:|||....|.:|:...|..|: |..
Human  2314 LIVVEQMNKYKA------RLKDISSLEFAENKA----KTRLSLIRRSMKPVLIAVRFMNITRNSV 2368

  Fly  2115 SGNTYFHMTIGNLVRGS 2131
            ||.       |.:.||:
Human  2369 SGK-------GRIRRGN 2378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 293/879 (33%)
MYSc_Myo7 77..721 CDD:276832 284/854 (33%)
MyTH4 <1138..1245 CDD:214535 17/112 (15%)
B41 1251..1467 CDD:214604 41/221 (19%)
FERM_B-lobe 1355..1439 CDD:271216 14/84 (17%)
FERM_C1_MyoVII 1461..1559 CDD:270019 22/99 (22%)
SH3 1560..1624 CDD:302595 12/99 (12%)
MyTH4 1701..1849 CDD:214535 33/176 (19%)
B41 1856..2068 CDD:214604 43/240 (18%)
FERM_M 1966..2068 CDD:278785 20/117 (17%)
FERM_C2_MyoVII 2064..2159 CDD:270020 16/69 (23%)
MYO9AXP_011519915.1 UBQ 6..110 CDD:294102 4/11 (36%)
MYSc 143..1014 CDD:214580 293/881 (33%)
MYSc_Myo9 160..1004 CDD:276836 284/854 (33%)
C1 2072..2120 CDD:237996 5/47 (11%)
RhoGAP_myosin_IX 2133..2318 CDD:239842 40/214 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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