Protein Alignment ck and MYO9A

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: XP_011519915.1
• Gene: MYO9A / 4649
• HGNCID: 7608
• Length: 2638
• Species: Homo sapiens
• Alignment Length: 2562
• Identity: 606/2562 - (23%)
• Similarity: 1002/2562 - (39%)
• Gaps: 740/2562 - (28%)

  Fly    29 VSAEGRRIQVRDDDGD--------EVWL-APERRIKAMHASSV-----QGVEDMISLGDLHEAGI 79
            :|.|..|..:|:.:.|        :.|| ..|.|.:.|....:     :..:|:.||.||:|..:
Human    98 LSGEDYRFLLREKNLDGSIHYGSLQSWLRVTEERRRMMERGFLPQPQQKDFDDLCSLPDLNEKTL 162

  Fly    80 LRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMK 144
            |.||..|:|...||||.||||:.:||::.||||....:|:|...::|:|.|||:|:.|.||..|.
Human   163 LENLRNRFKHEKIYTYVGSILIVINPFKFLPIYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAML 227

  Fly   145 RYRQDQCIVISGESGAGKTESTKLILQYLAAIS--GKHSWIEQQILEANPILEAFGNAKTIRNDN 207
            :.:::||||||||||:|||:||..::.:|.|:|  |..|.:||.||.|.|:|||||||||..|:|
Human   228 QRKKNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAGPVLEAFGNAKTAHNNN 292

  Fly   208 SSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGM 272
            ||||||:|.:::...|.:.||.:|:|||||||:|.|.|:||||||||.:|||.|.||:|...|..
Human   293 SSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLAGASEDERSAFHLKQ 357

  Fly   273 AADYKYLTGGNSIT------------------C---EGRDDAAEFSDIRSAMKVLLFSDQEIWEI 316
            ..:|.||   |.||                  |   ||.|...:|..::.||:::.|..:...:|
Human   358 PEEYHYL---NQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQI 419

  Fly   317 IKLLAALLHCGNIKYKATVV--DNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGET 379
            ..||:|:||.|||.||....  |::|... ||.:.:  |:.||.:..:.|.:||..|.....||.
Human   420 FSLLSAILHLGNICYKKKTYRDDSIDICN-PEVLPI--VSELLEVKEEMLFEALVTRKTVTVGEK 481

  Fly   380 VVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRN----AIGVLDIFGFENFDQ 440
            ::......::|.||::..|.:|..:|..||.:||.|:...:....|    :||||||||||:::.
Human   482 LILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEHNTKTLSIGVLDIFGFEDYEN 546

  Fly   441 NSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALID 505
            |||||||||:|||.||.:|.|||||||||||..|.|:|.:|:::||...::||:.|...::.|:|
Human   547 NSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLISKKPTGLLHLLD 611

  Fly   506 EEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPD 570
            ||:.||:.|:||:|.|....| ...:|::..:.:..:|.:.|:||.|.|..:.|.:||.|...||
Human   612 EESNFPQATNQTLLDKFKHQH-EDNSYIEFPAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPD 675

  Fly   571 LLHLVSQSTNKF-----------------LRQIFAQ----------------------------- 589
            ::.|:..|.|.|                 ||..|..
Human   676 IVALLRSSKNAFISGMIGIDPVAVFRWAILRAFFRAMVAFREAGKRNIHRKTGHDDTAPCAILKS 740

  Fly   590 --------------------------------------------------------DIEMGAET- 597
                                                                    ||.....|
Human   741 MDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNALNEKNQHDTFDIAWNGRTG 805

  Fly   598 ----------------------------------------------------------------- 597
                                                                             
Human   806 IRQSRLSSGTSLLDKDGIFANSTSSKLLERAHGILTRNKNFKSKPALPKHLLEVNSLKHLTRLTL 870

  Fly   598 -------------RKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQ 649
                         :|:.|::|.||:.||..||:||...:|:|::||:.|..|.|:.|...|..||
Human   871 QDRITKSLLHLHKKKKPPSISAQFQASLSKLMETLGQAEPYFVKCIRSNAEKLPLRFSDVLVLRQ 935

  Fly   650 LRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP-GVPPAHRTDCQAATSRICAVVLGKSDYQL 713
            |||:||:||:|||::||..::.|::||..:..|:| .:.|: :.:.|....:|   .|...:||:
Human   936 LRYTGMLETVRIRQSGYSSKYSFQDFVSHFHVLLPRNIIPS-KFNIQDFFRKI---NLNPDNYQV 996

  Fly   714 GHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKR 778
            |.|.||||:.....|:....:.:.|:|::|||..|..:.|:.||.||.|::.:||||:.|..:|:
Human   997 GKTMVFLKEQERQHLQDLLHQEVLRRIILLQRWFRVLLCRQHFLHLRQASVIIQRFWRNYLNQKQ 1061

  Fly   779 YRN---------MRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRR----------- 823
            .|:         |......|||..|:.:...|:..||...:.:|...|.|..||
Human  1062 VRDAAVQKDAFVMASAAALLQASWRAHLERQRYLELRAAAIVIQQKWRDYYRRRHMAAICIQARW 1126

  Fly   824 -------EYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLE-EQELLHRGNKHA 880
                   .|..:...:|.:||..|...|.:|::.|:.:        :||:.: |..|::.....:
Human  1127 KAYRESKRYQEQRKKIILLQSTCRGFRARQRFKALKEQ--------RLRETKPEVGLVNIKGYGS 1183

  Fly   881 REI--------AEQHYRDRLHELERREIQEQLE-NRRRVEVNMNIINDAARKQEEPVDDGKLVEA 936
            .||        .:..:.:|:..:|  |.:..:| ||...|.:::.:.::..||:|.......|:.
Human  1184 LEIQGSDPSGWEDCSFDNRIKAIE--ECKSVIESNRISRESSVDCLKESPNKQQERAQSQSGVDL 1246

  Fly   937 MFDFL----PDSSSDAPTPHGGR-----------ETSVFN-DLPHAQNVNQDDIIAPIHISEDEE 985
            ..|.|    |.|..|......||           |.::|: :|...:::..   |:|   |||..
Human  1247 QEDVLVRERPRSLEDLHQKKVGRAKRESRRMRELEQAIFSLELLKVRSLGG---ISP---SEDRR 1305

  Fly   986 DLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLPL-HTQGDQLAAQALWITILRFTGDM--PEPK 1047
            ..:|...:...:.  :|..:.:.::.:|:  ||.. .:|..:|.      :::...||:  |.||
Human  1306 WSTELVPEGLQSP--RGTPDSESSQGSLE--LLSYEESQKSKLE------SVISDEGDLQFPSPK 1360

  Fly  1048 YHTMDRMDT-TSVMSKVTATLGRNFIRSKEFQEAQLMGLD--------PDAFLKQKPRSIRHKLV 1103
            ..:..:.|: .:.:|....|.....::....:|..:...:        .|:|:.....:..:...
Human  1361 ISSSPKFDSRDNALSASNETSSAEHLKDGTMKEMVVCSSESITCKPQLKDSFISNSLPTFFYIPQ 1425

  Fly  1104 SLTLKRKNKLGEDVRR-RLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQI 1167
            ...||..::|...::| :|.::|.||....:...:|.|   .:.|         ...:|:|...:
Human  1426 QDPLKTNSQLDTSIQRNKLLENEDTAGEALTLDINRET---RRYH---------CSGKDQIVPSL 1478

  Fly  1168 CKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTR 1232
            ..:.:|..||......             :||                    |||.|:......:
Human  1479 NTESSNPVLKKLEKLN-------------TEK--------------------EERQKQLQQQNEK 1510

  Fly  1233 ------NQPPSWLELQATKSK---KP-----IMLPITFMD----GNTKTLLADSATTARELCNQL 1279
                  .|....||.:....|   ||     ::.|.::..    ....:||:.:.:...|| |.|
Human  1511 EMMEQIRQQTDILEKERKAFKTIEKPRIGECLVAPSSYQSKQRVERPSSLLSLNTSNKGEL-NVL 1574

  Fly  1280 SDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFA 1344
            . .:||||       .||..|.||    ..|:                ..::.|..:||.:: .:
Human  1575 G-SLSLKD-------AALAQKDSS----SAHL----------------PPKDRPVTVFFERK-GS 1610

  Fly  1345 PWHEPTHDQVA-TNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNF 1408
            |....|..::: |:.:..|:....|....|..|.|.   ....|.:...|.|:|.|      .|.
Human  1611 PCQSSTVKELSKTDRMGTQLNVACKLSNNRISKREH---FRPTQSYSHNSDDLSRE------GNA 1666

  Fly  1409 IPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIA-PLKIKEDIVSYAKYKWPLLFSRFYEAYRN 1472
            .|.|                       :..||.:: ||..|                   ||..:
Human  1667 RPIF-----------------------FTPKDNMSIPLVSK-------------------EALNS 1689

  Fly  1473 SGPNLPKNDVIIAVNWTGVYVV--DDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEF 1535
            ..|.|.|.|   ...|..|.:.  ..:|||          |..:.|......:|.|....||...
Human  1690 KNPQLHKED---EPAWKPVKLAGPGQREQV----------ARPAHKKKARMARTRSDFLTRGTFA 1741

  Fly  1536 TFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAPSDGTS-----------FLSFFKGDLIIL 1589
            ..:....||..|.::..|..|.:.|...:.    .|||.|.:           |.|        :
Human  1742 DGEGDTEEDDYDDIIEPLLSLDQASHCELG----PAPSLGQASHSDSEMTSQRFSS--------V 1794

  Fly  1590 EDESCGESVLNNG-------------------------WCIGRCDRSQERGDFPAETVYVLPTLS 1629
            ::::.....::.|                         |..|:      :|:  .:|..|.||..
Human  1795 DEQAKLHKTMSQGEITKLAVRQKASDSDIRPQRAKMRFWAKGK------QGE--KKTTRVKPTTQ 1851

  Fly  1630 KPPQDILALFNIEEAHHGRRLSMASNGGAVEPR-----DRPHTLMEYALDHFRLPPKRTMSKTLT 1689
            .....:.|..::..||     .......|..|.     :.|.:..:...::....||....:::.
Human  1852 SEVSPLFAGTDVIPAH-----QFPDELAAYHPTPPLSPELPGSCRKEFKENKEPSPKAKRKRSVK 1911

  Fly  1690 LSSKRSEEL-WRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHI 1753
            :|:...:.: |:.....|.|. :..|:|.:||          :||.:.||.::..:. :.:.|.:
Human  1912 ISNVALDSMHWQNDSVQIIAS-VSDLKSMDEF----------LLKKVNDLDNEDSKK-DTLVDVV 1964

  Fly  1754 FDGPLKH-------------------EILRDEIYCQLMKQLTDNRNRMSEE----RGWELMWLAT 1795
            |...||.                   .|...::|. |.:|:.:...|:.:.    .....:|:.|
Human  1965 FKKALKEFRQNIFSFYSSALAMDDGKSIRYKDLYA-LFEQILEKTMRLEQRDSLGESPVRVWVNT 2028

  Fly  1796 GLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVE------VEAIQH---- 1850
                 .:..|.|.:...:|     |..:..::.||.|..:||.....||      .:|.|:
Human  2029 -----FKVFLDEYMNEFKT-----SDCTATKVPKTERKKRRKKETDLVEEHNGHIFKATQYSIPT 2083

  Fly  1851 -------------------------------KTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNI 1884
                                           |||....|.|.|:.:...|.|:
Human  2084 YCEYCSSLIWIMDRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVE------------ 2136

  Fly  1885 SQRLSLRTSEGFSLFVKIADKVISVPE--GDFFFDFVRH--LTDWIKKARP-------------- 1931
               ||..|||..::.: :.:|:|:..|  |.:.....|.  .|:.||:.|.
Human  2137 ---LSRLTSEDRTVPL-VVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLDDY 2197

  Fly  1932 ------------IRDGANPQFTYQVF--FMKKLWTNTVPGKDRNADLIFHYHQELPKLLRGYH-- 1980
                        :||..||..|::::  |::.:..                 ||..:.:||.:
Human  2198 NIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGL-----------------QERKETIRGVYSV 2245

  Fly  1981 --KCSREEAAKLAALVF---RVRFGENKQELQAIPQMLRELIPSDIMKIQSTSEWKRSIVASYNQ 2040
              :.||.....|..|:|   |:...|:...:.|  ..|..:....|::...|::..:|:     |
Human  2246 IDQLSRTHLNTLERLIFHLVRIALQEDTNRMSA--NALAIVFAPCILRCPDTTDPLQSV-----Q 2303

  Fly  2041 DGGMTSEDAKVAFLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSLIHPVTKDILVTH 2105
            |...|:...::..::.:.::..      .:|..:...:.|...    |..:|||....|.:|:..
Human  2304 DISKTTTCVELIVVEQMNKYKA------RLKDISSLEFAENKA----KTRLSLIRRSMKPVLIAV 2358

  Fly  2106 PFTRIS-NWSSGNTYFHMTIGNLVRGS 2131
            .|..|: |..||.       |.:.||:
Human  2359 RFMNITRNSVSGK-------GRIRRGN 2378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	284/854 (33%)
		MyTH4	<1138..1245	CDD:214535	17/112 (15%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	22/106 (21%)
		B41	1251..1467	CDD:214604	41/221 (19%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	22/99 (22%)
		SH3	1560..1624	CDD:473055	12/99 (12%)
		MyTH4	1701..1849	CDD:214535	33/176 (19%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	25/128 (20%)
		B41	1856..2068	CDD:214604	44/250 (18%)
		FERM_C2_MyoVII	2064..2159	CDD:270020	16/69 (23%)
MYO9A	XP_011519915.1	RA_Myosin-IXa	15..110	CDD:340736	4/11 (36%)
		MYSc_Myo9	160..1004	CDD:276836	284/854 (33%)
		C1_Myosin-IXa	2067..2124	CDD:410433	7/56 (13%)
		RhoGAP_myosin_IX	2133..2318	CDD:239842	41/224 (18%)