Protein Alignment ck and MYO5A

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_001369277.1
• Gene: MYO5A / 4644
• HGNCID: 7602
• Length: 1904
• Species: Homo sapiens
• Alignment Length: 1941
• Identity: 533/1941 - (27%)
• Similarity: 821/1941 - (42%)
• Gaps: 481/1941 - (24%)

  Fly    42 DGDEVWLA--------PERRIKAMHASS-----------------------VQGVEDMISLGDLH 75
            |.:|||.:        |..::..:|...                       :.|..|:.:|..||
Human    41 DPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYHLDPKTKELPHLRNPDILVGENDLTALSYLH 105

  Fly    76 EAGILRNLLIRYKEN-LIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNA 139
            |..:|.||.:|:.:: |||||.|.:|||:|||:.||||..|.|..|..:.:|::.|||||:.:.|
Human   106 EPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEA 170

  Fly   140 YAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSW--IEQQILEANPILEAFGNAKT 202
            |..|.|..::|.|::|||||||||.|.|..::|.|.:||..|.  :|:::|.:|||:|:.|||||
Human   171 YKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVEEKVLASNPIMESIGNAKT 235

  Fly   203 IRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSR 267
            .||||||||||||:|.|.....|.||.:..|||||||:|.|...|||||:||.:.|.....|...
Human   236 TRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAKLPEFKM 300

  Fly   268 LDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYK 332
            |.||.|.::.|...|.|...||.|||.|.:..|.|..:|..|:.....|.::||.:||.||:.:.
Human   301 LRLGNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGIFRILAGILHLGNVGFT 365

  Fly   333 ATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFV 397
            :...|:  .|..|:|..:.....|:|:..:.:...|..|.|....||.:..:|:.|:.:.|||..
Human   366 SRDADS--CTIPPKHEPLCIFCELMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALA 428

  Fly   398 KGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQH 462
            |.||.::|..||..:|.|:.. .....:.||||||:|||.|:.|||||||||||||.|||.|..|
Human   429 KHIYAKLFNWIVDNVNQALHS-AVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMH 492

  Fly   463 IFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHKTH- 526
            :||||||||..|.|.|..|:|.|||..::||..| |.|:.|:|||.:.|||||.|...||:.||
Human   493 VFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESK-LGILDLLDEECKMPKGTDDTWAQKLYNTHL 556

  Fly   527 GSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQD- 590
            .....:.||:.. |.:|.:.|||..|.|...|||:||:||...:.:.::..|..|.|.::|..|
Human   557 NKCALFEKPRLS-NKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDE 620

  Fly   591 --------IEMGAETRKRTP-----------------TLSTQFRKSLDALMKTLSSCQPFFIRCI 630
                    ...|.....|||                 |:..|||.||..||:||::..|.::|||
Human   621 KAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKEHKKTVGHQFRNSLHLLMETLNATTPHYVRCI 685

  Fly   631 KPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLI--PGVPPAHRTD 693
            |||:.|.|..||.....:|||..|::|||||..||:|.|..::||..|||.|:  ..|....:..
Human   686 KPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVLSDRKQT 750

  Fly   694 CQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLR 758
            |:....::   :|.|..||.|.||:|.:.....:||:.|...|....:.:|::||||:.|:::||
Human   751 CKNVLEKL---ILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKKYLR 812

  Fly   759 LRAAAITVQR-------------------------FWKGYAQRKRYRNMRVGYMRLQALIRSRVL 798
            :|.||||:||                         :|:.|..|:||:..|...:.||:.:|..:.
Human   813 MRKAAITMQRYVRGYQARCYAKFLRRTKAATIIQKYWRMYVVRRRYKIRRAATIVLQSYLRGFLA 877

  Fly   799 SHRFRH-LRGH-IVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFA-- 859
            .:|:|. ||.| .|.:|...||:|.|..|...|.|:|.:|...|||:|.|..:||::|.:...
Human   878 RNRYRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIYLQCCFRRMMAKRELKKLKIEARSVERY 942

  Fly   860 ---------EVLQL-RKLEEQ-----------------------------ELLHRGNKHAR---- 881
                     :::|| ||::||                             |.|....:.|:
Human   943 KKLHIGMENKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQLSEEEAKVATG 1007

  Fly   882 -------EIA----------------EQH---YRDRLHEL------------------------E 896
                   |||                |:|   |:....:|                        :
Human  1008 RVLSLQEEIAKLRKDLEQTRSEKKCIEEHADRYKQETEQLVSNLKEENTLLKQEKEALNHRIVQQ 1072

  Fly   897 RREIQEQLENR-----RRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSS---DAPTPHG 953
            .:|:.|.:|.:     :::|::   :||...:.:..:::...:|..:|.|.:..:   ..|.| |
Human  1073 AKEMTETMEKKLVEETKQLELD---LNDERLRYQNLLNEFSRLEERYDDLKEEMTLMVHVPKP-G 1133

  Fly   954 GRETSVFNDLPHAQNVNQ----------DDIIAPIHISEDEE-----DLSEF-KFQKFAATYFQG 1002
            .:.|    |..|:.|.::          :||  |....|..|     |:|.| |.||......|
Human  1134 HKRT----DSTHSSNESEYIFSSEIAEMEDI--PSRTEEPSEKKVPLDMSLFLKLQKRVTELEQ- 1191

  Fly  1003 NVNHQYAKKALKHPLLPLHTQGDQLAAQALWITILRFTG---DMP-----EPKYHTMDRMDTTSV 1059
                  .|:.::..|       |:...|     :||...   :.|     |.:|.::.|.:..|.
Human  1192 ------EKQVMQDEL-------DRKEEQ-----VLRSKAKEEERPQIRGAELEYESLKRQELESE 1238

  Fly  1060 MSKVTATLG--RNFIRSKEFQEAQLMGLDPDAFLKQKPRSI--------------RHKLVSL--- 1105
            ..|:...|.  |..:..|...|....|......|.::..|:              |.:|||.
Human  1239 NKKLKNELNELRKALSEKSAPEVTAPGAPAYRVLMEQLTSVSEELDVRKEEVLILRSQLVSQKEA 1303

  Fly  1106 --------TLKRKNKLGEDVRRRLQDDEYTADSYQSWLQSRPTSNLE--KLH-----FIIGHGIL 1155
                    |:.....|.||| ::::|....|.:|....::..:|.|:  :|:     :::..|:.
Human  1304 IQPKDDKNTMTDSTILLEDV-QKMKDKGEIAQAYIGLKETNRSSALDYHELNEDGELWLVYEGLK 1367

  Fly  1156 RAELRDEIYCQICKQLTNN----------PLKSSHARGWILLSLCVGCFAPSEKFVN-------- 1202
            :|....|...|..|:...|          .||..:.|...||:  .....|.|..:.
Human  1368 QANRLLESQLQSQKRSHENEAEALRGEIQSLKEENNRQQQLLA--QNLQLPPEARIEASLQHEIT 1430

  Fly  1203 -------YLRAFIREGPPGYAPYCEERLKRTFN--------NGTRNQPPSWLELQATK------- 1245
                   |......:.|..|..|.....||..:        :.|..:....|::.|.|
Human  1431 RLTNENLYFEELYADDPKKYQSYRISLYKRMIDLMEQLEKQDKTVRKLKKQLKVFAKKIGELEVG 1495

  Fly  1246 -------------SKKPIMLPITFMD--GNTKTLLADSATTARELCNQLSDK-ISLKDQFGFSLY 1294
                         ..:|:.:|....|  |..:....|.....:.|..:|..: :::....|...|
Human  1496 QMENISPGQIIDEPIRPVNIPRKEKDFQGMLEYKKEDEQKLVKNLILELKPRGVAVNLIPGLPAY 1560

  Fly  1295 IALF------------DKVSSLGSG------------GDHVMDAIS----------QC-EQYAKE 1324
            | ||            .||.||.:.            ||. .:.:|          .| :||:.|
Human  1561 I-LFMCVRHADYLNDDQKVRSLLTSTINSIKKVLKKRGDD-FETVSFWLSNTCRFLHCLKQYSGE 1623

  Fly  1325 QGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNL---IYQQVVRGVKFGEYRCDKEEDLAMIAAQ 1386
            :|..:.|...:   .:.....:....:.||.::|   ||||:||.:          |::......
Human  1624 EGFMKHNTSRQ---NEHCLTNFDLAEYRQVLSDLAIQIYQQLVRVL----------ENILQPMIV 1675

  Fly  1387 QYFIEYST-----------------DMSMERLFTL------LPNFIPDFCLSGVDKAIERWAALV 1428
            ...:|:.|                 .::.|..:||      |.:|....|..|:|      ..|:
Human  1676 SGMLEHETIQGVSGVKPTGLRKRTSSIADEGTYTLDSILRQLNSFHSVMCQHGMD------PELI 1734

  Fly  1429 LQAYKKSYYVKDKIA--PLKIKEDIVSYAK-----YKWPLLFSRFYEAYR-----NSGPNLPKND 1481
            .|..|:.:|:...|.  .|.:::|:.|::|     |.    .|:..|..|     |||.......
Human  1735 KQVVKQMFYIIGAITLNNLLLRKDMCSWSKGMQIRYN----VSQLEEWLRDKNLMNSGAKETLEP 1795

  Fly  1482 VIIAVNWTGV-YVVDDQEQVLLELSFPEITAVSSQKTNKV---------FTQTFSLSTVRGEEFT 1536
            :|.|.....| ...||..:.:..:    ..|:::.:..||         |.:..|:|.:|    |
Human  1796 LIQAAQLLQVKKKTDDDAEAICSM----CNALTTAQIVKVLNLYTPVNEFEERVSVSFIR----T 1852

  Fly  1537 FQSPNAEDIRDLVVYFLDGLKKRSKYV-----------IALQDYRAPSD-GTSFLS 1580
            .|. ...|.:|.....:|     :|::           :||:..:.|:. |..|:|
Human  1853 IQM-RLRDRKDSPQLLMD-----AKHIFPVTFPFNPSSLALETIQIPASLGLGFIS 1902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	283/675 (42%)
		MyTH4	<1138..1245	CDD:214535	25/146 (17%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	25/135 (19%)
		B41	1251..1467	CDD:214604	55/286 (19%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	23/112 (21%)
		SH3	1560..1624	CDD:473055	7/33 (21%)
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020
MYO5A	NP_001369277.1	COG5022	35..1472	CDD:227355	444/1470 (30%)
		MYSc_Myo5	107..775	CDD:276831	283/675 (42%)
		Myo5a_CBD	1530..1904	CDD:271262	81/412 (20%)