Protein Alignment ck and MYO1E

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_004989.2
• Gene: MYO1E / 4643
• HGNCID: 7599
• Length: 1108
• Species: Homo sapiens
• Alignment Length: 1079
• Identity: 338/1079 - (31%)
• Similarity: 537/1079 - (49%)
• Gaps: 160/1079 - (14%)

  Fly    58 HASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKE 122
            |.....||:||:.|..:.|..|:.||..||.::.|:||.||:|::|||::.:|.:...:|::|:.
Human    14 HNVKHSGVDDMVLLSKITENSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQG 78

  Fly   123 RKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISG---KHSWIE 184
            ....|.||||:|:.||.|.:|...|::||::||||||||||.:.|.|:.|::.:||   |...::
Human    79 AAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGTKVQHVK 143

  Fly   185 QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERN 249
            ..||::||:|||||||||:||:||||||||.:|.||..|..:|.||..:||||||:|.:|..||:
Human   144 DIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERS 208

  Fly   250 YHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVL-LFSDQEI 313
            :|:||.::.|.||::|..|.:.....|.||:...|...:..||..||.:...||.|: :|::::.
Human   209 FHIFYQLIEGASAEQKHSLGITSMDYYYYLSLSGSYKVDDIDDRREFQETLHAMNVIGIFAEEQT 273

  Fly   314 WEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFA--- 375
            . :::::|.:||.|||.:|.  |.|..|.|..|.:...  |.|||:....|.:.||.|.:.:
Human   274 L-VLQIVAGILHLGNISFKE--VGNYAAVESEEFLAFP--AYLLGINQDRLKEKLTSRQMDSKWG 333

  Fly   376 -HGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFD 439
             ..|::..||:.:|:...|||..|.::.|:|..:|..||.|:.|..  ....||||||:|||.|.
Human   334 GKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDH--EEYNIGVLDIYGFEIFQ 396

  Fly   440 QNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLI--AIKQLNIMA 502
            :|.|||||||:.||.|||.|::...|.|||||..|.|.|..||:.:|:...|||  .:....||:
Human   397 KNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVNPPGIMS 461

  Fly   503 LIDEEA----RFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKN 563
            ::|:..    ...:|.|||:|.||....|||:::    :..|..|.::|:||.|.||..||.::|
Human   462 ILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHF----NSWNQGFIIHHYAGKVSYDMDGFCERN 522

  Fly   564 RDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIR 628
            ||....||:.|:..|...|::.:|.::::  |:.:.|..|..::.:|..:.|:.||..|.|.:||
Human   523 RDVLFMDLIELMQSSELPFIKSLFPENLQ--ADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIR 585

  Fly   629 CIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHR-T 692
            ||||||.|||..::......|:.|.|:.|.||:|||||..|..|::|::||..|.....|:.: .
Human   586 CIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGYAYRRIFQKFLQRYAILTKATWPSWQGE 650

  Fly   693 DCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFL 757
            :.|.....:.:|.:....:|||.:|||:|....|||.:|          :.:|...|:
Human   651 EKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEE----------MRERKYDGY------- 698

  Fly   758 RLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAH--ARGYL 820
                 |..:|:.|:.:..||:|..||.....|....:.|..:...|:..|..:|::.|  .:.::
Human   699 -----ARVIQKSWRKFVARKKYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFV 758

  Fly   821 VRREYGHKMWAVIKIQSHVRRMIAMRR---------YRKLRLEHKQ------FAEVLQLRKLEEQ 870
            .:||   |:.....:..:.||...::|         |...|.:.||      ..|||: ||:|.:
Human   759 GKRE---KIDFADTVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLK-RKIEIE 819

  Fly   871 ELLHRGNKHAREIAEQHYRDRLHELERREIQEQLENRRRVEVNMNIINDAARKQEE------PVD 929
            .:|        .::....:|.:..|..:|....||:..:.|    .::..|::.||      |:.
Human   820 RIL--------SVSLSTMQDDIFILHEQEYDSLLESVFKTE----FLSLLAKRYEEKTQKQLPLK 872

  Fly   930 DGKLVEAMFDFLPDSSSDAPTPHGGRETSVF---------------------------NDLPHAQ 967
            ....:|...    ...:..|...||.....|                           |..|..:
Human   873 FSNTLELKL----KKENWGPWSAGGSRQVQFHQGFGDLAVLKPSNKVLQVSIGPGLPKNSRPTRR 933

  Fly   968 NVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKA------------LKHPLLPL 1020
            |..|:                        ..|..|..|..|..:|            :::..:|.
Human   934 NTTQN------------------------TGYSSGTQNANYPVRAAPPPPGYHQNGVIRNQYVPY 974

  Fly  1021 -HTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMDRMDTT 1057
             |..|.|.:.| :|:.::.|  ..:|..:..:.||:..|
Human   975 PHAPGSQRSNQKSLYTSMAR--PPLPRQQSTSSDRVSQT 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	258/658 (39%)
		MyTH4	<1138..1245	CDD:214535
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612
		B41	1251..1467	CDD:214604
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020
MYO1E	NP_004989.2	MYSc_Myo1	33..679	CDD:276829	258/658 (39%)
		Actin-binding. /evidence=ECO:0000255	581..591		7/9 (78%)
		Myosin_TH1	719..920	CDD:461801	39/220 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	919..966		9/70 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	993..1053		5/21 (24%)
		SH3_MyoIe_If_like	1056..1107	CDD:212761