DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and MYO1E

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_004989.2 Gene:MYO1E / 4643 HGNCID:7599 Length:1108 Species:Homo sapiens


Alignment Length:1079 Identity:338/1079 - (31%)
Similarity:537/1079 - (49%) Gaps:160/1079 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 HASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKE 122
            |.....||:||:.|..:.|..|:.||..||.::.|:||.||:|::|||::.:|.:...:|::|:.
Human    14 HNVKHSGVDDMVLLSKITENSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQG 78

  Fly   123 RKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISG---KHSWIE 184
            ....|.||||:|:.||.|.:|...|::||::||||||||||.:.|.|:.|::.:||   |...::
Human    79 AAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGTKVQHVK 143

  Fly   185 QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERN 249
            ..||::||:|||||||||:||:||||||||.:|.||..|..:|.||..:||||||:|.:|..||:
Human   144 DIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERS 208

  Fly   250 YHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVL-LFSDQEI 313
            :|:||.::.|.||::|..|.:.....|.||:...|...:..||..||.:...||.|: :|::::.
Human   209 FHIFYQLIEGASAEQKHSLGITSMDYYYYLSLSGSYKVDDIDDRREFQETLHAMNVIGIFAEEQT 273

  Fly   314 WEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFA--- 375
            . :::::|.:||.|||.:|.  |.|..|.|..|.:...  |.|||:....|.:.||.|.:.:   
Human   274 L-VLQIVAGILHLGNISFKE--VGNYAAVESEEFLAFP--AYLLGINQDRLKEKLTSRQMDSKWG 333

  Fly   376 -HGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFD 439
             ..|::..||:.:|:...|||..|.::.|:|..:|..||.|:.|..  ....||||||:|||.|.
Human   334 GKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDH--EEYNIGVLDIYGFEIFQ 396

  Fly   440 QNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLI--AIKQLNIMA 502
            :|.|||||||:.||.|||.|::...|.|||||..|.|.|..||:.:|:...|||  .:....||:
Human   397 KNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVNPPGIMS 461

  Fly   503 LIDEEA----RFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKN 563
            ::|:..    ...:|.|||:|.||....|||:::    :..|..|.::|:||.|.||..||.::|
Human   462 ILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHF----NSWNQGFIIHHYAGKVSYDMDGFCERN 522

  Fly   564 RDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIR 628
            ||....||:.|:..|...|::.:|.::::  |:.:.|..|..::.:|..:.|:.||..|.|.:||
Human   523 RDVLFMDLIELMQSSELPFIKSLFPENLQ--ADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIR 585

  Fly   629 CIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHR-T 692
            ||||||.|||..::......|:.|.|:.|.||:|||||..|..|::|::||..|.....|:.: .
Human   586 CIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGYAYRRIFQKFLQRYAILTKATWPSWQGE 650

  Fly   693 DCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFL 757
            :.|.....:.:|.:....:|||.:|||:|....|||.:|          :.:|...|:       
Human   651 EKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEE----------MRERKYDGY------- 698

  Fly   758 RLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAH--ARGYL 820
                 |..:|:.|:.:..||:|..||.....|....:.|..:...|:..|..:|::.|  .:.::
Human   699 -----ARVIQKSWRKFVARKKYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFV 758

  Fly   821 VRREYGHKMWAVIKIQSHVRRMIAMRR---------YRKLRLEHKQ------FAEVLQLRKLEEQ 870
            .:||   |:.....:..:.||...::|         |...|.:.||      ..|||: ||:|.:
Human   759 GKRE---KIDFADTVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLK-RKIEIE 819

  Fly   871 ELLHRGNKHAREIAEQHYRDRLHELERREIQEQLENRRRVEVNMNIINDAARKQEE------PVD 929
            .:|        .::....:|.:..|..:|....||:..:.|    .::..|::.||      |:.
Human   820 RIL--------SVSLSTMQDDIFILHEQEYDSLLESVFKTE----FLSLLAKRYEEKTQKQLPLK 872

  Fly   930 DGKLVEAMFDFLPDSSSDAPTPHGGRETSVF---------------------------NDLPHAQ 967
            ....:|...    ...:..|...||.....|                           |..|..:
Human   873 FSNTLELKL----KKENWGPWSAGGSRQVQFHQGFGDLAVLKPSNKVLQVSIGPGLPKNSRPTRR 933

  Fly   968 NVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKA------------LKHPLLPL 1020
            |..|:                        ..|..|..|..|..:|            :::..:|.
Human   934 NTTQN------------------------TGYSSGTQNANYPVRAAPPPPGYHQNGVIRNQYVPY 974

  Fly  1021 -HTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMDRMDTT 1057
             |..|.|.:.| :|:.::.|  ..:|..:..:.||:..|
Human   975 PHAPGSQRSNQKSLYTSMAR--PPLPRQQSTSSDRVSQT 1011

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 269/683 (39%)
MYSc_Myo7 77..721 CDD:276832 258/658 (39%)
MyTH4 <1138..1245 CDD:214535
B41 1251..1467 CDD:214604
FERM_B-lobe 1355..1439 CDD:271216
FERM_C1_MyoVII 1461..1559 CDD:270019
SH3 1560..1624 CDD:302595
MyTH4 1701..1849 CDD:214535
B41 1856..2068 CDD:214604
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
MYO1ENP_004989.2 MYSc 14..692 CDD:214580 270/700 (39%)
MYSc_Myo1 33..679 CDD:276829 258/658 (39%)
Actin-binding. /evidence=ECO:0000255 581..591 7/9 (78%)
Myosin_TH1 719..902 CDD:283635 39/202 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 919..966 9/70 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 993..1053 5/21 (24%)
SH3_MyoIe_If_like 1056..1107 CDD:212761
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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