Protein Alignment ck and MYO1C

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_001074248.1
• Gene: MYO1C / 4641
• HGNCID: 7597
• Length: 1063
• Species: Homo sapiens
• Alignment Length: 969
• Identity: 333/969 - (34%)
• Similarity: 516/969 - (53%)
• Gaps: 112/969 - (11%)

  Fly    56 AMHASSVQGVEDMISLGDL-HEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKL 119
            |:.|....||:|.:.|.:. .||..:.||..|::|||||||.|.:||:||||:.|.||:...::.
Human    39 ALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMER 103

  Fly   120 YKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLA---AISGKHS 181
            |:.....|:|||:||:.|..|..::..|:||.::|||||||||||:||.:||:.|   ....:..
Human   104 YRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGG 168

  Fly   182 WIEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHS 246
            .:..::|::||:|||||||||:|||||||||||:|:.|...|...|..|..|||||||:|.|||.
Human   169 AVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHG 233

  Fly   247 ERNYHVFYCILAGLSADEKSRLDLGMAAD---YKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLF 308
            |||:|:||.:|.|  .:|::...||:..:   |.||..|........:|.:::..:|.|:.|:.|
Human   234 ERNFHIFYQLLEG--GEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDF 296

  Fly   309 SDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTL 373
            ::.|:.:::.::|::||.|||.:.|....|   .::.....::.:..||.:....|.:|||.|.:
Human   297 TEDEVEDLLSIVASVLHLGNIHFAANEESN---AQVTTENQLKYLTRLLSVEGSTLREALTHRKI 358

  Fly   374 FAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTA-----IFKPRGTSRNAIGVLDIF 433
            .|.||.::|.|:.:|:...|||..|.:|.|.|..:|.|||.:     :..|...|...:|:|||:
Human   359 IAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIY 423

  Fly   434 GFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQL 498
            |||.|..||||||||||.||.|||.|::...|.|||||..|.|.|:.:::.:|:...||:..|..
Human   424 GFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFK 488

  Fly   499 NIMALIDEEARFP-KGTDQTMLAKLHKTHGSHKNYLKPK-SDINT-------SFGLNHFAGVVFY 554
            .|::::|||...| :.||.|.|.||..|...|.::|..| :|..|       .|.|.|:||.|.|
Human   489 GIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTY 553

  Fly   555 DTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTL 619
            ...||||||.|....:|...:..|.|..:.|.|.:. |:  ..:||..|::|||:.||..|::.|
Human   554 SVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRS-EL--SDKKRPETVATQFKMSLLQLVEIL 615

  Fly   620 SSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP 684
            .|.:|.::||||||:.|:|..||..|...|::|.|::|.:|:||||:..|..:..|::||:.|.|
Human   616 QSKEPAYVRCIKPNDAKQPGRFDEVLIRHQVKYLGLLENLRVRRAGFAYRRKYEAFLQRYKSLCP 680

  Fly   685 GVPPAHRTDCQAATSRICAVV--LG--KSDYQLGHTKVFLKDAHDLF-----LEQERDRVLTRKI 740
            ...|   |........:..:|  ||  ..:|::|.||:|::....||     ||..|..:.|:
Human   681 ETWP---TWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDALEVRRQSLATK-- 740

  Fly   741 LILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFR-- 803
              :|.:.||:.:|::|||::.:||.:|.:|:|...|::....:.....::.|||..||.|..|
Human   741 --IQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFVLRHAPRCP 803

  Fly   804 -------HLRGHIVGLQAHARGYL--VRREYGHKM----W----AVIKIQSHVRRMIAMR----R 847
                   |:|          ..:|  :||:....:    |    ..::..|.:.|.:.::    :
Human   804 ENAFFLDHVR----------TSFLLNLRRQLPQNVLDTSWPTPPPALREASELLRELCIKNMVWK 858

  Fly   848 Y-RKLRLEHKQFAEVLQLRKLEEQELLHRGNK--HAREIAEQHYRDRL--HELERREIQ----EQ 903
            | |.:..|.||     ||::......:.:|.|  :.:.:.......||  .|:..|.:|    |.
Human   859 YCRSISPEWKQ-----QLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTDEISPRVLQALGSEP 918

  Fly   904 LE---------------NRRRVEVNMN---IINDAARKQEEPVDDGKLVEAMFDFLPDS 944
            ::               ..|::.:..|   |:.||..||.  :|...|.......|.||
Human   919 IQYAVPVVKYDRKGYKPRSRQLLLTPNAVVIVEDAKVKQR--IDYANLTGISVSSLSDS 975

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	265/667 (40%)
		MyTH4	<1138..1245	CDD:214535
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612
		B41	1251..1467	CDD:214604
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020
MYO1C	NP_001074248.1	MYSc_Myo1	62..718	CDD:276829	264/666 (40%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	608..630		10/21 (48%)
		IQCG	751..781	CDD:467744	10/29 (34%)
		Myosin_TH1	874..1055	CDD:461801	20/104 (19%)