DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and MYH11

DIOPT Version :10

Sequence 1:NP_523571.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_001035203.1 Gene:MYH11 / 4629 HGNCID:7569 Length:1979 Species:Homo sapiens


Alignment Length:2205 Identity:548/2205 - (24%)
Similarity:893/2205 - (40%) Gaps:511/2205 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 VTRGDY-----IWIEPASGREFDVAI-----GARVV---SAEGRRIQVRDDDGDEVWLAPERRIK 55
            |.:.|:     :|: |:..:.|:.|.     |..||   ...|:::.|..||           |:
Human    25 VAQADWAAKRLVWV-PSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDD-----------IQ 77

  Fly    56 AMHASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLY 120
            .|:......||||..|..|:||.:|.||..||...|||||:|...|.||||:.||||:...:.:|
Human    78 KMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMY 142

  Fly   121 KERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSW--- 182
            |.:|..|:||||:||.|.||..|.:.|:||.|:.:|||||||||:||.::||||.::..|..   
Human   143 KGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKD 207

  Fly   183 -------------IEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYL 234
                         :|:|:|:|||||||||||||::|||||||||:|.|:|...|.|.||.||.||
Human   208 TSITQGPSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYL 272

  Fly   235 LEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAA--DYKYLTGGNSITCEGRDDAAEFS 297
            |||||.:.|...||.:|:||.::||  |.||.|.||.:..  :|.:|:.| .:......|...|.
Human   273 LEKSRAIRQARDERTFHIFYYMIAG--AKEKMRSDLLLEGFNNYTFLSNG-FVPIPAAQDDEMFQ 334

  Fly   298 DIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQ 362
            :...||.::.||::|...|:|:::::|..|||.:|..  .|.|...:|::...::|..|:|:.:.
Human   335 ETVEAMAIMGFSEEEQLSILKVVSSVLQLGNIVFKKE--RNTDQASMPDNTAAQKVCHLMGINVT 397

  Fly   363 PLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAI 427
            ....::....:....:.|....:::|:....:|..|..|.|:|..|:.::|.|:.|......:.:
Human   398 DFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFRWILTRVNKALDKTHRQGASFL 462

  Fly   428 GVLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALD 491
            |:|||.|||.|:.|||||.||||.||.|||.|...:|.||||||..|.|.|..|:| :|.|..::
Human   463 GILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIE 527

  Fly   492 LIAIKQLN----IMALIDEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKS-DINTSFGLNHFAGV 551
            |  |::.|    ::||:|||..|||.||::.:.||....|||..:.|||. ...|.|.:.|:||.
Human   528 L--IERPNNPPGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGK 590

  Fly   552 VFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDI-------EMGAETRKRTP------- 602
            |.|:...:|.||.|..:.::..|::.|::||:..:: :|:       :|...|....|       
Human   591 VDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLW-KDVDRIVGLDQMAKMTESSLPSASKTKK 654

  Fly   603 ----TLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRR 663
                |:...:::.|..||.||.:..|.|:|||.||..|:....|..|...|||.:|::|.|||.|
Human   655 GMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICR 719

  Fly   664 AGYPIRHGFREFVERYRFLIP-GVPPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLF 727
            .|:|.|..|:||.:||..|.. .:|.......||....|.|:.|..:.|::|.:|:|.:......
Human   720 QGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAH 784

  Fly   728 LEQERDRVLTRKILILQRSIRGWVYRRRFLRLR---AAAITVQRFWKGYAQRKRYRNMRVGYMRL 789
            ||:|||..:|..|:..|...||::.|:.|.:.:   .|...:||....|.:.:.::..|: :.::
Human   785 LEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRL-FTKV 848

  Fly   790 QALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLE 854
            :.|::   ::.:...::.....||                      ::..|:..|....::|..:
Human   849 KPLLQ---VTRQEEEMQAKEDELQ----------------------KTKERQQKAENELKELEQK 888

  Fly   855 HKQFAE---VLQLRKLEEQELLHRGNKHAREIA--EQHYRDRLHELERR---------------- 898
            |.|..|   :||.:...|.||.....:....:|  :|...:.|||:|.|                
Human   889 HSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 953

  Fly   899 -------EIQEQLEN----RRRVEVNMNIINDAARKQEEPV----DDGKLVEAMFDFLPDSSSDA 948
                   :::||||.    |:::::.........:|.|:.:    |....:......|.:..||.
Human   954 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018

  Fly   949 PTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKKAL 1013
            .|.....|....| |...:| ..:.:|:.:.:...:|:.|..:.:|.              |:.|
Human  1019 TTNLAEEEEKAKN-LTKLKN-KHESMISELEVRLKKEEKSRQELEKL--------------KRKL 1067

  Fly  1014 KHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGR--------- 1069
            :......|.|...|.||...:                  :|.......::.|.|.|         
Human  1068 EGDASDFHEQIADLQAQIAEL------------------KMQLAKKEEELQAALARLDDEIAQKN 1114

  Fly  1070 NFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSW 1134
            |.::.....|..:..|..|.   ...|:.|:|    ..|:|..|||::.....:.|.|.||    
Human  1115 NALKKIRELEGHISDLQEDL---DSERAARNK----AEKQKRDLGEELEALKTELEDTLDS---- 1168

  Fly  1135 LQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEK 1199
                 |:..::         |||:...|:  .:.|:..:...:|..|:                 
Human  1169 -----TATQQE---------LRAKREQEV--TVLKKALDEETRSHEAQ----------------- 1200

  Fly  1200 FVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTL 1264
                    ::|....:|...||..:               :|:..|..|      ..:|.|.:||
Human  1201 --------VQEMRQKHAQAVEELTE---------------QLEQFKRAK------ANLDKNKQTL 1236

  Fly  1265 LADSATTAREL--------------------CNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGD 1309
            ..::|..|.||                    ..:|..|.|    .|......|.|||..|.:..:
Human  1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS----DGERARAELNDKVHKLQNEVE 1297

  Fly  1310 HVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRC 1374
            .|...:::.|..|.:......:...:|...:|:.   .|.|..::..:...:|:           
Human  1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL---QEETRQKLNVSTKLRQL----------- 1348

  Fly  1375 DKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALV--LQAYKKSYY 1437
              ||:...: ..|...|.....::||..:.|     :..||...|.::.:|:.|  |:..||.:.
Human  1349 --EEERNSL-QDQLDEEMEAKQNLERHISTL-----NIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405

  Fly  1438 VKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPK--NDVIIAVNWTGVYVVDDQEQV 1500
            .:.:....:.:|...:|.|          .|..:|   .|.:  :|:::.        :|:|.|:
Human  1406 KEIENLTQQYEEKAAAYDK----------LEKTKN---RLQQELDDLVVD--------LDNQRQL 1449

  Fly  1501 LLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIA 1565
            :..|          :|..:.|.|..:      ||....|..|:: ||..     ..:.|.|...|
Human  1450 VSNL----------EKKQRKFDQLLA------EEKNISSKYADE-RDRA-----EAEAREKETKA 1492

  Fly  1566 LQDYRAPSDG----------TSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGDFPAE 1620
            |...||..:.          ...|.....||:..:|:            :|:.....|:.....|
Human  1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD------------VGKNVHELEKSKRALE 1545

  Fly  1621 T-VYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKRTM 1684
            | :..:.|..:..:|.|      :|....:|.:..|..|:                     |...
Human  1546 TQMEEMKTQLEELEDEL------QATEDAKLRLEVNMQAL---------------------KGQF 1583

  Fly  1685 SKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAE----EACFAFAAILKYMGDLPSKRPRM 1745
            .:.|....:::||..|        .|.|:|...|...|    :...|.||..|..|||.....:.
Human  1584 ERDLQARDEQNEEKRR--------QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA 1640

  Fly  1746 GNEITDHIFDGPLKHEILRDEIYCQLMK---QLTDNRNRMSEERG-------------------- 1787
            .:.|..            |:|...||.|   |:.|.:..:.:.|.                    
Human  1641 DSAIKG------------REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693

  Fly  1788 WELMWLATGLFACSQG----------LLKELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQ 1842
            .:||.|...|.|..:.          |.:||...|..|.  ..||...||:..|...:.:....|
Human  1694 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN--ALQDEKRRLEARIAQLEEELEEEQ 1756

  Fly  1843 VEVEAIQ---HKTTQIFHKVYFPDDTDEA-FEVDSSTRAKDFCNNISQRLSLRTSEG-------- 1895
            ..:||:.   .|.||...::.....|:.: .:.:.|.|.:....|...|..|...||        
Human  1757 GNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1821

  Fly  1896 --FSLFVKIADKVISVPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFFMKKLWTNTVPGK 1958
              .:|..|||.....|.:                :||.                |:..|.::..|
Human  1822 TIAALEAKIAQLEEQVEQ----------------EARE----------------KQAATKSLKQK 1854

  Fly  1959 DRNADLIFHYHQELPKLLRGYHKCSREEAAKLAALVFRVR--FGENKQELQAIPQMLREL 2016
            |:....|....::..|:...|    :|:|.|..|.|.:::  ..|.::|.|.|....|:|
Human  1855 DKKLKEILLQVEDERKMAEQY----KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_523571.1 MYSc_Myo7 77..721 CDD:276832 265/686 (39%)
MyTH4 <1138..1245 CDD:214535 13/106 (12%)
FERM1_F1_Myosin-VII 1249..1347 CDD:340612 22/117 (19%)
B41 1251..1467 CDD:214604 43/237 (18%)
FERM_C1_MyoVII 1461..1559 CDD:270019 17/99 (17%)
SH3 1560..1624 CDD:473055 13/74 (18%)
MyTH4 1701..1849 CDD:214535 39/184 (21%)
FERM2_F1_Myosin-VII 1854..1951 CDD:340613 17/107 (16%)
B41 1856..2068 CDD:214604 33/174 (19%)
FERM_C2_MyoVII 2064..2159 CDD:270020
MYH11NP_001035203.1 Myosin_N 31..76 CDD:460670 11/56 (20%)
MYSc_class_II 99..778 CDD:276951 265/686 (39%)
Actin-binding. /evidence=ECO:0000250 668..690 11/21 (52%)
Actin-binding. /evidence=ECO:0000250 769..783 3/13 (23%)
Myosin_tail_1 855..1935 CDD:460256 243/1351 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 865..889 5/45 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1751..1807 11/55 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1873..1979 12/42 (29%)
C-terminal 1942..1979
Blue background indicates that the domain is not in the aligned region.

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