DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and MYH10

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:XP_011522177.1 Gene:MYH10 / 4628 HGNCID:7568 Length:2037 Species:Homo sapiens


Alignment Length:2217 Identity:551/2217 - (24%)
Similarity:933/2217 - (42%) Gaps:509/2217 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 TRGDY-----IWIEPASGREFDVAIGARVVSAEGRRIQVRDDDGDEVW--LAPERR--------I 54
            |:.|:     :|| |:....|:.|             .::::.||||.  ||...:        |
Human    56 TQADWTAKKLVWI-PSERHGFEAA-------------SIKEERGDEVMVELAENGKKAMVNKDDI 106

  Fly    55 KAMHASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKL 119
            :.|:......||||..|..|:||.:|.||..||...|||||:|...|.:|||:.||||:.:.|::
Human   107 QKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEM 171

  Fly   120 YKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSW-- 182
            |:.:|..|:||||:||.::||..|.:.|:||.|:.:|||||||||:||.::||||.::..|..  
Human   172 YRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRK 236

  Fly   183 -----------------IEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKI 230
                             :|:|:|:||||||:||||||::|||||||||:|.|:|...|.|.||.|
Human   237 DHNIPQESPKPVKHQGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANI 301

  Fly   231 EQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAE 295
            |.|||||||.|.|...||.:|:||.:|:|.....||.|.|....:|::|:.| .|...|:.|...
Human   302 ETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNG-YIPIPGQQDKDN 365

  Fly   296 FSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLP 360
            |.:...||.::.||.:||..::|:::::|..|||.:|..  .|.|...:||:...:::..|||:.
Human   366 FQETMEAMHIMGFSHEEILSMLKVVSSVLQFGNISFKKE--RNTDQASMPENTVAQKLCHLLGMN 428

  Fly   361 IQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRN 425
            :.....|:....:....:.|....:::|:....:|..|..|.|:|..:|.:||.|:.:.:....:
Human   429 VMEFTRAILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGAS 493

  Fly   426 AIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDA 489
            .||:|||.|||.|:.|||||.||||.||.|||.|...:|.||||||..|.|.|..|:| :|.|..
Human   494 FIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPC 558

  Fly   490 LDLIAIKQLN---IMALIDEEARFPKGTDQTMLAKLHKTHGSHKNYLKP-----KSDINTSFGLN 546
            :|||. :..|   ::||:|||..|||.||:|.:.||.:..|||..:.||     |:|    |.:.
Human   559 IDLIE-RPANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKAD----FCII 618

  Fly   547 HFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIE------------------- 592
            |:||.|.|....:|.||.|..:.::..|:.||:::|:.:::..:|:                   
Human   619 HYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDEIQNIQRASFYDSVSGLHEPPV 683

  Fly   593 ----------------MGA--ETRK-RTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKP 638
                            .|:  :|:| ...|:...:::||..||.||.:..|.|:|||.||..|:.
Human   684 DRIVGLDQVTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRA 748

  Fly   639 MMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP-GVPPAHRTDCQAATSRIC 702
            ...|..|...|||.:|::|.|||.|.|:|.|..|:||.:||..|.| .:|.......||....|.
Human   749 GKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIR 813

  Fly   703 AVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLR---AAAI 764
            |:.|..:.|::|.:|:|.:......||:|||..:|..|:..|...||::.|:.|.:.:   :|..
Human   814 ALELDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALK 878

  Fly   765 TVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRG------HIVGLQAHARGYLVRR 823
            .:||....|.:.:.::..|| :.:::.|::   ::.:...|:.      .:...|....|.|...
Human   879 VLQRNCAAYLKLRHWQWWRV-FTKVKPLLQ---VTRQEEELQAKDEELLKVKEKQTKVEGELEEM 939

  Fly   824 EYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLR------KLEEQELLHRGNKHARE 882
            |..|:...      ..:.::|    .:|:.|.:.|||..::|      |.|.:|:||  :..:| 
Human   940 ERKHQQLL------EEKNILA----EQLQAETELFAEAEEMRARLAAKKQELEEILH--DLESR- 991

  Fly   883 IAEQHYRDRLHELERREIQ-------EQLEN----RRRVEVNMNIINDAARKQEEPV-----DDG 931
            :.|:..|:::.:.|::::|       |||:.    |:::::.........:|.||.:     .:.
Human   992 VEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNS 1056

  Fly   932 KLV---EAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQ 993
            |.:   :.|.|.:.:.||..     ..|.....:|...:| .|:.:|:.:.....:|:.:..:.:
Human  1057 KFIKEKKLMEDRIAECSSQL-----AEEEEKAKNLAKIRN-KQEVMISDLEERLKKEEKTRQELE 1115

  Fly   994 KFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQ--ALWITILR----FTGDMPEPKYHTMD 1052
            |              ||:.|......|..|..:|.||  .|.:.:.:    ..|.:......|:.
Human  1116 K--------------AKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLH 1166

  Fly  1053 RMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDV 1117
            :.:...|:.::               :||:..|..|.   :..::.|:|    ..|:|..|.|::
Human  1167 KNNALKVVREL---------------QAQIAELQEDF---ESEKASRNK----AEKQKRDLSEEL 1209

  Fly  1118 RRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNN------PL 1176
            .....:.|.|.|:..:..:.|.....|.           |||:..:     ::.|.|      .:
Human  1210 EALKTELEDTLDTTAAQQELRTKREQEV-----------AELKKAL-----EEETKNHEAQIQDM 1258

  Fly  1177 KSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLEL 1241
            :..||.....|         ||:.                    |:.||...|..:|:  ..|| 
Human  1259 RQRHATALEEL---------SEQL--------------------EQAKRFKANLEKNK--QGLE- 1291

  Fly  1242 QATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSD---KISLKDQFGFSLYIALFDKVSS 1303
               ...|.:...:..:    :.:.|:|....::|..|:.:   |:|..|:    |.:.|.:|.|.
Human  1292 ---TDNKELACEVKVL----QQVKAESEHKRKKLDAQVQELHAKVSEGDR----LRVELAEKASK 1345

  Fly  1304 LGSGGDHVMDAISQCE----QYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVV 1364
            |.:..|:|...:.:.|    ::||:..:.|.    :|...:|:.   .|.|..::..:...:|: 
Human  1346 LQNELDNVSTLLEEAEKKGIKFAKDAASLES----QLQDTQELL---QEETRQKLNLSSRIRQL- 1402

  Fly  1365 RGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALV- 1428
                        ||:...:..||. .|.....::|:....|.:.:.|     ..|.::.....: 
Human  1403 ------------EEEKNSLQEQQE-EEEEARKNLEKQVLALQSQLAD-----TKKKVDDDLGTIE 1449

  Fly  1429 -LQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVY 1492
             |:..||......:....:::|..::|.|          .|..:|.                   
Human  1450 SLEEAKKKLLKDAEALSQRLEEKALAYDK----------LEKTKNR------------------- 1485

  Fly  1493 VVDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLK 1557
            :..:.:.:.::|......|.:.:|..|.|.|..:      ||.:..:..||: ||..     ..:
Human  1486 LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLA------EEKSISARYAEE-RDRA-----EAE 1538

  Fly  1558 KRSKYVIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGDFPAETV 1622
            .|.|...||...||..:.......|:.                        ...|.|.|      
Human  1539 AREKETKALSLARALEEALEAKEEFER------------------------QNKQLRAD------ 1573

  Fly  1623 YVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPR-DRPHTLMEYALDHFRLPPKRTMSK 1686
              :..|.....|:..  |:.|....:|        |:|.: :...|.:|...|..:         
Human  1574 --MEDLMSSKDDVGK--NVHELEKSKR--------ALEQQVEEMRTQLEELEDELQ--------- 1617

  Fly  1687 TLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSK---------- 1741
             .|..:|...|:   :...:||...|.||:::|..||   ....::|.:.:|.::          
Human  1618 -ATEDAKLRLEV---NMQAMKAQFERDLQTRDEQNEE---KKRLLIKQVRELEAELEDERKQRAL 1675

  Fly  1742 ----RPRMGNEITDHIFDGPLKHEI-----LRDEIYCQLMK---QLTDNRNRMSEERGWELMWLA 1794
                :.:|..::.|      |:.:|     .|||:..||.|   |:.|.:..:.|.|.     ..
Human  1676 AVASKKKMEIDLKD------LEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA-----SR 1729

  Fly  1795 TGLFACSQ--------------GLLKELLLFLRTRRHPISQ-------------------DSMHR 1826
            ..:||.|:              .|.:||....|.|||...:                   |...|
Human  1730 DEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRR 1794

  Fly  1827 LQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLR 1891
            |:..|...:.:....|..:|.:..:    |.|.....||..| |:.:...|....:|..|:|..:
Human  1795 LEARIAQLEEELEEEQSNMELLNDR----FRKTTLQVDTLNA-ELAAERSAAQKSDNARQQLERQ 1854

  Fly  1892 TSEGFSLFVKIAD----------KVISVPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFF 1946
            ..|   |..|:.:          ..||..|..     :..|.:.:::....|..||.........
Human  1855 NKE---LKAKLQELEGAVKSKFKATISALEAK-----IGQLEEQLEQEAKERAAANKLVRRTEKK 1911

  Fly  1947 MKKLWTNTVPGKDRNADLIFHYHQELPKLLRGYHKCSR--EEAAKLAALVFRVRFGENKQELQAI 2009
            :|:::.. |..:.|:||   .|.:::.|......:..|  |||.:.|     .|...::::||  
Human  1912 LKEIFMQ-VEDERRHAD---QYKEQMEKANARMKQLKRQLEEAEEEA-----TRANASRRKLQ-- 1965

  Fly  2010 PQMLREL 2016
                |||
Human  1966 ----REL 1968

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 280/735 (38%)
MYSc_Myo7 77..721 CDD:276832 270/710 (38%)
MyTH4 <1138..1245 CDD:214535 19/112 (17%)
B41 1251..1467 CDD:214604 38/224 (17%)
FERM_B-lobe 1355..1439 CDD:271216 13/85 (15%)
FERM_C1_MyoVII 1461..1559 CDD:270019 14/97 (14%)
SH3 1560..1624 CDD:302595 9/63 (14%)
MyTH4 1701..1849 CDD:214535 40/202 (20%)
B41 1856..2068 CDD:214604 38/173 (22%)
FERM_M 1966..2068 CDD:278785 13/53 (25%)
FERM_C2_MyoVII 2064..2159 CDD:270020
MYH10XP_011522177.1 Myosin_N 64..102 CDD:280832 11/51 (22%)
Myosin_head 117..832 CDD:278492 277/722 (38%)
MYSc_Myh10 129..832 CDD:276952 270/710 (38%)
Myosin_tail_1 909..1989 CDD:279860 240/1338 (18%)
DUF342 <1105..1194 CDD:302792 18/120 (15%)
DUF2317 <1172..1283 CDD:302887 29/177 (16%)
COG5134 <1399..1527 CDD:227463 26/181 (14%)
GBP_C <1565..1671 CDD:303769 26/163 (16%)
coiled coil 1661..1671 CDD:293879 1/9 (11%)
DUF106 <1706..>1757 CDD:303007 11/55 (20%)
DUF2570 1834..>1928 CDD:305162 19/105 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.