DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ck and MYH9

DIOPT Version :10

Sequence 1:NP_523571.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_002464.1 Gene:MYH9 / 4627 HGNCID:7579 Length:1960 Species:Homo sapiens


Alignment Length:2128 Identity:550/2128 - (25%)
Similarity:905/2128 - (42%) Gaps:443/2128 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 IWI-------EPASGREFDVAIGARVVSAE-GRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVE 66
            :|:       ||||.:| :|...|.|...| |::::|..||           |:.|:......||
Human    32 VWVPSDKSGFEPASLKE-EVGEEAIVELVENGKKVKVNKDD-----------IQKMNPPKFSKVE 84

  Fly    67 DMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPH 131
            ||..|..|:||.:|.||..||...|||||:|...|.:|||:.||||:.:.:::||.:|..|:|||
Human    85 DMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPH 149

  Fly   132 IFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKH------SWIEQQILEA 190
            |:||.|.||..|.:.|:||.|:.:|||||||||:||.::||||.::..|      ..:|:|:|:|
Human   150 IYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHKSKKDQGELERQLLQA 214

  Fly   191 NPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYC 255
            ||||||||||||::|||||||||:|.|:|..||.|.||.||.|||||||.:.|...||.:|:||.
Human   215 NPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYY 279

  Fly   256 ILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLL 320
            :|:|.....|:.|.|.....|::|:.|: :|..|:.|...|.:...||:::...::|...:::::
Human   280 LLSGAGEHLKTDLLLEPYNKYRFLSNGH-VTIPGQQDKDMFQETMEAMRIMGIPEEEQMGLLRVI 343

  Fly   321 AALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLS 385
            :.:|..|||.:|..  .|.|...:|::...::|:.|||:.:......:....:....:.|....:
Human   344 SGVLQLGNIVFKKE--RNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQT 406

  Fly   386 RDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCINY 450
            ::|:....:|..|..|.|||..:|.:||.|:.|.:....:.||:|||.|||.||.|||||.||||
Human   407 KEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINY 471

  Fly   451 ANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLI--AIKQLNIMALIDEEARFPK 512
            .||.|||.|...:|.||||||..|.|.|..|:| :|.|..:|||  ......|:||:|||..|||
Human   472 TNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPK 536

  Fly   513 GTDQTMLAKLHKTHGSHKNYLKPKS-DINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVS 576
            .||::.:.|:.:..|:|..:.|||. .....|.:.|:||.|.|....:|.||.|..:.::..|:.
Human   537 ATDKSFVEKVMQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLH 601

  Fly   577 QSTNKFLRQIFAQDIEM----------------GA-ETRK-RTPTLSTQFRKSLDALMKTLSSCQ 623
            ||::||:.::: :|::.                || :||| ...|:...:::.|..||.||.:..
Human   602 QSSDKFVSELW-KDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTN 665

  Fly   624 PFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP-GVP 687
            |.|:|||.||..||....|..|...|||.:|::|.|||.|.|:|.|..|:||.:||..|.| .:|
Human   666 PNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIP 730

  Fly   688 PAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVY 752
            .......||....|.|:.|..:.|::|.:|||.:......||:|||..:|..|:..|...||::.
Human   731 KGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLA 795

  Fly   753 RRRFLRLR---AAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQA 814
            |:.|.:.:   .|...:||....|.:.:.::..|: :.:::.|::                    
Human   796 RKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRL-FTKVKPLLQ-------------------- 839

  Fly   815 HARGYLVRREYGHKMWA----VIKIQSHVRRMIAMRRYRKLR-LEHKQFAEVLQLRK-------- 866
                 :.|:|  .:|.|    ::|::.  :::.|..|..::. |:.:..||.|||::        
Human   840 -----VSRQE--EEMMAKEEELVKVRE--KQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETEL 895

  Fly   867 -LEEQELLHRGNKHAREIAEQHYRDRLHELERREIQEQLENRRRVEVNMNIINDAARKQEEPVDD 930
             .|.:||..|.....:|:.|     ..|:||.| ::|:.|..:.::.....:....::.||.:::
Human   896 CAEAEELRARLTAKKQELEE-----ICHDLEAR-VEEEEERCQHLQAEKKKMQQNIQELEEQLEE 954

  Fly   931 GKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVN-------QDDIIAPI--HISEDEED 986
            .:....... |...:::|.......|..:..|    ||..       .:|.||..  :::|:||.
Human   955 EESARQKLQ-LEKVTTEAKLKKLEEEQIILED----QNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014

  Fly   987 LSEFKFQKFAATYFQGNVNHQYAKKALKHPL----LPLHTQGDQLAAQALWITILRFTGDMPEPK 1047
                              :...||...||..    |....:.::...|.|..|..:..||     
Human  1015 ------------------SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGD----- 1056

  Fly  1048 YHTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNK 1112
              :.|..|..:.:....|.|.....:.:|..:|.|..::.:|..|           ::.||:..:
Human  1057 --STDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQK-----------NMALKKIRE 1108

  Fly  1113 LGEDVRRRLQDDEYTADSYQSWLQSRPTS--NLEKLHFIIGHGI--LRAELRDEIYCQICKQLTN 1173
            |...: ..||:|          |:|...|  ..||....:|..:  |:.||.|.:.....:|   
Human  1109 LESQI-SELQED----------LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQ--- 1159

  Fly  1174 NPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSW 1238
             .|:|..                 |:.||.|:..:.|....:....:|..::      .:|....
Human  1160 -ELRSKR-----------------EQEVNILKKTLEEEAKTHEAQIQEMRQK------HSQAVEE 1200

  Fly  1239 L--ELQAT--------KSKKPIMLPITFMDGNTKTLL---ADSATTARELCNQLSDKISLKDQFG 1290
            |  :|:.|        |:|:.:......:....|.||   .||....:::..||.: :.:|...|
Human  1201 LAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQE-LQVKFNEG 1264

  Fly  1291 FSLYIALFDKVSSLGSGGDHVMDAISQCE----QYAKEQGAQERNAPWRLFFRKEIFAPWHEPTH 1351
            ..:...|.|||:.|....|:|...:||.:    :..|:..|.|.    :|...:|:.   .|...
Human  1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES----QLQDTQELL---QEENR 1322

  Fly  1352 DQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSG 1416
            .:::.:...:||.........:.::||:                                 ....
Human  1323 QKLSLSTKLKQVEDEKNSFREQLEEEEE---------------------------------AKHN 1354

  Fly  1417 VDKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYE---AYRNSGPNLP 1478
            ::|.|....|.|....||   ::|.:..|:..|::....:.....|..|..|   ||    ..|.
Human  1355 LEKQIATLHAQVADMKKK---MEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAY----DKLE 1412

  Fly  1479 KNDVIIAVNWTGVYVVDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAE 1543
            |         |...:..:.:.:|::|.....:|.:.:|..|.|.|..:      ||.|..:..||
Human  1413 K---------TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLA------EEKTISAKYAE 1462

  Fly  1544 DIRDLVVYFLDGLKKRSKYVIALQDYRAPSD-----------GTSFLSFFKGDLIILEDESCGES 1597
            : ||..     ..:.|.|...||...||..:           ...|.:..: ||:..:|: .|:|
Human  1463 E-RDRA-----EAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEME-DLMSSKDD-VGKS 1519

  Fly  1598 VLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPR 1662
            |..    :.:..|:.|      :.|..:.|..:..:|.|      :|....:|.:..|..|:   
Human  1520 VHE----LEKSKRALE------QQVEEMKTQLEELEDEL------QATEDAKLRLEVNLQAM--- 1565

  Fly  1663 DRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAE----E 1723
                              |....:.|....::|||.        |..|:|:::..|...|    :
Human  1566 ------------------KAQFERDLQGRDEQSEEK--------KKQLVRQVREMEAELEDERKQ 1604

  Fly  1724 ACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYCQLMK---QLTDNRNRMSEE 1785
            ...|.||..|...||        .::..|| |...|:   |||...||.|   |:.|....:.:.
Human  1605 RSMAVAARKKLEMDL--------KDLEAHI-DSANKN---RDEAIKQLRKLQAQMKDCMRELDDT 1657

  Fly  1786 RGWELMWLATGLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVEVEAIQH 1850
            |.                          :|...::|         .:..::|....:.|:..:|.
Human  1658 RA--------------------------SREEILAQ---------AKENEKKLKSMEAEMIQLQE 1687

  Fly  1851 KTTQIFHKVYFPDDTDEAFEVDSSTRAK-----------DFCNNISQRLSLRTSEGFSLFVKIA- 1903
                               |:.::.|||           |...|.|.:.:|...|...|..:|| 
Human  1688 -------------------ELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQ 1733

  Fly  1904 -DKVISVPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFFMKKLWTNTVPGKDRNADLIFH 1967
             ::.:...:|:     ...:.|.:|||....|..|.....:....:|........:.:|.:|...
Human  1734 LEEELEEEQGN-----TELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVK 1793

  Fly  1968 YHQELPKLLRGYHKCS-REEAAKLAALVFRVRFGENKQELQAIPQMLR 2014
            . ||:...::..:|.| ....||:|.|..::. .|.|:...|..|:.|
Human  1794 L-QEMEGTVKSKYKASITALEAKIAQLEEQLD-NETKERQAACKQVRR 1839

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_523571.1 MYSc_Myo7 77..721 CDD:276832 269/672 (40%)
MyTH4 <1138..1245 CDD:214535 21/120 (18%)
FERM1_F1_Myosin-VII 1249..1347 CDD:340612 23/104 (22%)
B41 1251..1467 CDD:214604 39/222 (18%)
FERM_C1_MyoVII 1461..1559 CDD:270019 22/100 (22%)
SH3 1560..1624 CDD:473055 15/74 (20%)
MyTH4 1701..1849 CDD:214535 28/154 (18%)
FERM2_F1_Myosin-VII 1854..1951 CDD:340613 20/109 (18%)
B41 1856..2068 CDD:214604 35/173 (20%)
FERM_C2_MyoVII 2064..2159 CDD:270020
MYH9NP_002464.1 Mediates interaction with LIMCH1. /evidence=ECO:0000269|PubMed:28228547 2..838 309/822 (38%)
Myosin_N 27..72 CDD:460670 14/51 (27%)
Motor_domain 95..764 CDD:473979 269/672 (40%)
Actin-binding 654..676 11/21 (52%)
Myosin_tail_1 841..1921 CDD:460256 240/1277 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1035..1057 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1118..1137 6/28 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1877..1960
Blue background indicates that the domain is not in the aligned region.

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