DRSC/TRiP Functional Genomics Resources

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Protein Alignment ck and MYH9

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_002464.1 Gene:MYH9 / 4627 HGNCID:7579 Length:1960 Species:Homo sapiens


Alignment Length:2128 Identity:550/2128 - (25%)
Similarity:905/2128 - (42%) Gaps:443/2128 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 IWI-------EPASGREFDVAIGARVVSAE-GRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVE 66
            :|:       ||||.:| :|...|.|...| |::::|..||           |:.|:......||
Human    32 VWVPSDKSGFEPASLKE-EVGEEAIVELVENGKKVKVNKDD-----------IQKMNPPKFSKVE 84

  Fly    67 DMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPH 131
            ||..|..|:||.:|.||..||...|||||:|...|.:|||:.||||:.:.:::||.:|..|:|||
Human    85 DMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPH 149

  Fly   132 IFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKH------SWIEQQILEA 190
            |:||.|.||..|.:.|:||.|:.:|||||||||:||.::||||.::..|      ..:|:|:|:|
Human   150 IYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHKSKKDQGELERQLLQA 214

  Fly   191 NPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYC 255
            ||||||||||||::|||||||||:|.|:|..||.|.||.||.|||||||.:.|...||.:|:||.
Human   215 NPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYY 279

  Fly   256 ILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLL 320
            :|:|.....|:.|.|.....|::|:.|: :|..|:.|...|.:...||:::...::|...:::::
Human   280 LLSGAGEHLKTDLLLEPYNKYRFLSNGH-VTIPGQQDKDMFQETMEAMRIMGIPEEEQMGLLRVI 343

  Fly   321 AALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLS 385
            :.:|..|||.:|..  .|.|...:|::...::|:.|||:.:......:....:....:.|....:
Human   344 SGVLQLGNIVFKKE--RNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQT 406

  Fly   386 RDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCINY 450
            ::|:....:|..|..|.|||..:|.:||.|:.|.:....:.||:|||.|||.||.|||||.||||
Human   407 KEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINY 471

  Fly   451 ANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLI--AIKQLNIMALIDEEARFPK 512
            .||.|||.|...:|.||||||..|.|.|..|:| :|.|..:|||  ......|:||:|||..|||
Human   472 TNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPK 536

  Fly   513 GTDQTMLAKLHKTHGSHKNYLKPKS-DINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVS 576
            .||::.:.|:.:..|:|..:.|||. .....|.:.|:||.|.|....:|.||.|..:.::..|:.
Human   537 ATDKSFVEKVMQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLH 601

  Fly   577 QSTNKFLRQIFAQDIEM----------------GA-ETRK-RTPTLSTQFRKSLDALMKTLSSCQ 623
            ||::||:.::: :|::.                || :||| ...|:...:::.|..||.||.:..
Human   602 QSSDKFVSELW-KDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTN 665

  Fly   624 PFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP-GVP 687
            |.|:|||.||..||....|..|...|||.:|::|.|||.|.|:|.|..|:||.:||..|.| .:|
Human   666 PNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIP 730

  Fly   688 PAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVY 752
            .......||....|.|:.|..:.|::|.:|||.:......||:|||..:|..|:..|...||::.
Human   731 KGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLA 795

  Fly   753 RRRFLRLR---AAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQA 814
            |:.|.:.:   .|...:||....|.:.:.::..|: :.:::.|::                    
Human   796 RKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRL-FTKVKPLLQ-------------------- 839

  Fly   815 HARGYLVRREYGHKMWA----VIKIQSHVRRMIAMRRYRKLR-LEHKQFAEVLQLRK-------- 866
                 :.|:|  .:|.|    ::|::.  :::.|..|..::. |:.:..||.|||::        
Human   840 -----VSRQE--EEMMAKEEELVKVRE--KQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETEL 895

  Fly   867 -LEEQELLHRGNKHAREIAEQHYRDRLHELERREIQEQLENRRRVEVNMNIINDAARKQEEPVDD 930
             .|.:||..|.....:|:.|     ..|:||.| ::|:.|..:.::.....:....::.||.:::
Human   896 CAEAEELRARLTAKKQELEE-----ICHDLEAR-VEEEEERCQHLQAEKKKMQQNIQELEEQLEE 954

  Fly   931 GKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVN-------QDDIIAPI--HISEDEED 986
            .:....... |...:::|.......|..:..|    ||..       .:|.||..  :::|:||.
Human   955 EESARQKLQ-LEKVTTEAKLKKLEEEQIILED----QNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014

  Fly   987 LSEFKFQKFAATYFQGNVNHQYAKKALKHPL----LPLHTQGDQLAAQALWITILRFTGDMPEPK 1047
                              :...||...||..    |....:.::...|.|..|..:..||     
Human  1015 ------------------SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGD----- 1056

  Fly  1048 YHTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNK 1112
              :.|..|..:.:....|.|.....:.:|..:|.|..::.:|..|           ::.||:..:
Human  1057 --STDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQK-----------NMALKKIRE 1108

  Fly  1113 LGEDVRRRLQDDEYTADSYQSWLQSRPTS--NLEKLHFIIGHGI--LRAELRDEIYCQICKQLTN 1173
            |...: ..||:|          |:|...|  ..||....:|..:  |:.||.|.:.....:|   
Human  1109 LESQI-SELQED----------LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQ--- 1159

  Fly  1174 NPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSW 1238
             .|:|..                 |:.||.|:..:.|....:....:|..::      .:|....
Human  1160 -ELRSKR-----------------EQEVNILKKTLEEEAKTHEAQIQEMRQK------HSQAVEE 1200

  Fly  1239 L--ELQAT--------KSKKPIMLPITFMDGNTKTLL---ADSATTARELCNQLSDKISLKDQFG 1290
            |  :|:.|        |:|:.:......:....|.||   .||....:::..||.: :.:|...|
Human  1201 LAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQE-LQVKFNEG 1264

  Fly  1291 FSLYIALFDKVSSLGSGGDHVMDAISQCE----QYAKEQGAQERNAPWRLFFRKEIFAPWHEPTH 1351
            ..:...|.|||:.|....|:|...:||.:    :..|:..|.|.    :|...:|:.   .|...
Human  1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES----QLQDTQELL---QEENR 1322

  Fly  1352 DQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSG 1416
            .:::.:...:||.........:.::||:                                 ....
Human  1323 QKLSLSTKLKQVEDEKNSFREQLEEEEE---------------------------------AKHN 1354

  Fly  1417 VDKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYE---AYRNSGPNLP 1478
            ::|.|....|.|....||   ::|.:..|:..|::....:.....|..|..|   ||    ..|.
Human  1355 LEKQIATLHAQVADMKKK---MEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAY----DKLE 1412

  Fly  1479 KNDVIIAVNWTGVYVVDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAE 1543
            |         |...:..:.:.:|::|.....:|.:.:|..|.|.|..:      ||.|..:..||
Human  1413 K---------TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLA------EEKTISAKYAE 1462

  Fly  1544 DIRDLVVYFLDGLKKRSKYVIALQDYRAPSD-----------GTSFLSFFKGDLIILEDESCGES 1597
            : ||..     ..:.|.|...||...||..:           ...|.:..: ||:..:|: .|:|
Human  1463 E-RDRA-----EAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEME-DLMSSKDD-VGKS 1519

  Fly  1598 VLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPR 1662
            |..    :.:..|:.|      :.|..:.|..:..:|.|      :|....:|.:..|..|:   
Human  1520 VHE----LEKSKRALE------QQVEEMKTQLEELEDEL------QATEDAKLRLEVNLQAM--- 1565

  Fly  1663 DRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAE----E 1723
                              |....:.|....::|||.        |..|:|:::..|...|    :
Human  1566 ------------------KAQFERDLQGRDEQSEEK--------KKQLVRQVREMEAELEDERKQ 1604

  Fly  1724 ACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYCQLMK---QLTDNRNRMSEE 1785
            ...|.||..|...||        .::..|| |...|:   |||...||.|   |:.|....:.:.
Human  1605 RSMAVAARKKLEMDL--------KDLEAHI-DSANKN---RDEAIKQLRKLQAQMKDCMRELDDT 1657

  Fly  1786 RGWELMWLATGLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVEVEAIQH 1850
            |.                          :|...::|         .:..::|....:.|:..:|.
Human  1658 RA--------------------------SREEILAQ---------AKENEKKLKSMEAEMIQLQE 1687

  Fly  1851 KTTQIFHKVYFPDDTDEAFEVDSSTRAK-----------DFCNNISQRLSLRTSEGFSLFVKIA- 1903
                               |:.::.|||           |...|.|.:.:|...|...|..:|| 
Human  1688 -------------------ELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQ 1733

  Fly  1904 -DKVISVPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFFMKKLWTNTVPGKDRNADLIFH 1967
             ::.:...:|:     ...:.|.:|||....|..|.....:....:|........:.:|.:|...
Human  1734 LEEELEEEQGN-----TELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVK 1793

  Fly  1968 YHQELPKLLRGYHKCS-REEAAKLAALVFRVRFGENKQELQAIPQMLR 2014
            . ||:...::..:|.| ....||:|.|..::. .|.|:...|..|:.|
Human  1794 L-QEMEGTVKSKYKASITALEAKIAQLEEQLD-NETKERQAACKQVRR 1839

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 279/697 (40%)
MYSc_Myo7 77..721 CDD:276832 269/672 (40%)
MyTH4 <1138..1245 CDD:214535 21/120 (18%)
B41 1251..1467 CDD:214604 39/222 (18%)
FERM_B-lobe 1355..1439 CDD:271216 10/83 (12%)
FERM_C1_MyoVII 1461..1559 CDD:270019 22/100 (22%)
SH3 1560..1624 CDD:302595 15/74 (20%)
MyTH4 1701..1849 CDD:214535 28/154 (18%)
B41 1856..2068 CDD:214604 35/173 (20%)
FERM_M 1966..2068 CDD:278785 13/50 (26%)
FERM_C2_MyoVII 2064..2159 CDD:270020
MYH9NP_002464.1 Mediates interaction with LIMCH1. /evidence=ECO:0000269|PubMed:28228547 2..838 309/822 (38%)
Myosin_N 29..68 CDD:367160 11/36 (31%)
Motor_domain 95..764 CDD:354959 269/672 (40%)
Actin-binding 654..676 11/21 (52%)
Myosin_tail_1 841..1921 CDD:366712 240/1277 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1035..1057 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1118..1137 6/28 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1877..1960
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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