DRSC/TRiP Functional Genomics Resources

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Protein Alignment ck and MYH8

DIOPT Version :9

Sequence 1:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster
Sequence 2:NP_002463.2 Gene:MYH8 / 4626 HGNCID:7578 Length:1937 Species:Homo sapiens


Alignment Length:2086 Identity:529/2086 - (25%)
Similarity:882/2086 - (42%) Gaps:422/2086 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 ASGREFDVA------------IGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVED 67
            |..:.||..            :.:.:.|.||.::.|:.:.|..:.:. |.::..|:......:||
Human    29 AQNKPFDAKTSVFVAEPKESYVKSTIQSKEGGKVTVKTEGGATLTVR-EDQVFPMNPPKYDKIED 92

  Fly    68 MISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHI 132
            |..:..|||.|:|.||..||...:||||:|...|.||||:.||:|..:.:..|:.:|..|.||||
Human    93 MAMMTHLHEPGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVAAYRGKKRQEAPPHI 157

  Fly   133 FAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAI----------SGK-HSWIEQQ 186
            |:|.||||..|...|::|.|:|:||||||||.:||.::||.|.|          ||| ...:|.|
Human   158 FSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKDESGKMQGTLEDQ 222

  Fly   187 ILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYH 251
            |:.|||:|||||||||:||||||||||:|.|||...|.:..|.||.|||||||:..|..:||:||
Human   223 IISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYH 287

  Fly   252 VFYCILAGLSADEKSRLDLGM-AADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWE 315
            :||.|.:....|....|.:.. ..||.:::.| .||....||..|.....||:.:|.|:.:|...
Human   288 IFYQITSNKKPDLIEMLLITTNPYDYAFVSQG-EITVPSIDDQEELMATDSAIDILGFTPEEKVS 351

  Fly   316 IIKLLAALLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHG 377
            |.||..|::|.||:|:|....:..   |.||:     .::.|.|..|....|:.||....:....
Human   352 IYKLTGAVMHYGNMKFKQKQREEQAEPDGTEV-----ADKAAYLQSLNSADLLKALCYPRVKVGN 411

  Fly   378 ETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAI--FKPRGTSRNAIGVLDIFGFENFDQ 440
            |.|....:..|..:...|..|.:|.:||:.:|.:||..:  .:||   :..||||||.|||.||.
Human   412 EYVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPR---QYFIGVLDIAGFEIFDF 473

  Fly   441 NSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMALI 504
            ||.||.|||:.||.|||||..|:|.||||||..|.|.|..|:| :|....::||. |.|.|.:::
Human   474 NSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIE-KPLGIFSIL 537

  Fly   505 DEEARFPKGTDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRGFLDKNRD 565
            :||..|||.||.:...||:..| |...|:.||   |......|.|.|:||.|.|:..|:||||:|
Human   538 EEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHFSLIHYAGTVDYNITGWLDKNKD 602

  Fly   566 TFSPDLLHLVSQSTNKFLRQIFA--------QDIEMGAETRKRT-PTLSTQFRKSLDALMKTLSS 621
            ..:..::.|..:|..|.|..:|:        ...:.||:.:..: .|:|..||::|:.||..|.|
Human   603 PLNDTVVGLYQKSAMKTLASLFSTYASAEADSSAKKGAKKKGSSFQTVSALFRENLNKLMTNLRS 667

  Fly   622 CQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFL-IPG 685
            ..|.|:|||.|||.|.|...:..|...|||.:|::|.|||.|.|:|.|..:.:|.:||:.| ...
Human   668 THPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASA 732

  Fly   686 VPPAHRTDCQAATSRICAVV-LGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRG 749
            :|.....|.:.|:.::.|.: :..:.|:.||||||.|......||:.||..|.:.|...|...||
Human   733 IPEGQFIDSKKASEKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAVCRG 797

  Fly   750 WVYR---RRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRS-------RVLSHRFRH 804
            ::.|   ::.|:.|.|...:|...:.:...|.:..|:: :.:::.|::|       ..:...|:.
Human   798 FLMRVEYQKMLQRREALFCIQYNVRAFMNVKHWPWMKL-FFKIKPLLKSAETEKEMATMKEEFQK 861

  Fly   805 LRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMI---------AMRR-----YRKLRLEH 855
            .:..:      |:....|:|...||..::|.::.::..:         |..|     ..|::||.
Human   862 TKDEL------AKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEA 920

  Fly   856 K-----QFAE---------VLQLRKLEEQ--ELLH------------RGNKHAREIAEQHYRDRL 892
            |     :.||         ..:.||||::  ||..            ...|||.|...::..:.:
Human   921 KIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM 985

  Fly   893 HEL---------ERREIQE----QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDS 944
            ..|         |::.:||    .|::.:..|..:||:..|..|.|:.|||   :|...:     
Human   986 AGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDD---LEGSLE----- 1042

  Fly   945 SSDAPTPHGGRETSVFNDLPHAQNVNQDDI----IAPIHISEDEEDLSEFKFQK--FAATYFQGN 1003
                      :|..:..||..|:...:.|:    .:.:.:..|::.|.| |.:|  |..:.....
Human  1043 ----------QEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDE-KLEKKEFEISNLISK 1096

  Fly  1004 VNHQYA-----KKALKHPLLPLHTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMDRMDTTSVMSK 1062
            :..:.|     :|.:|.....:...|:::.|: |......:...|:........:|::.....:.
Human  1097 IEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1161

  Fly  1063 VTATLGRNFIRSKEFQEAQLMGLDPDAFLKQ--KPRSIRHKLVSLTLKRKN-----KLGED---- 1116
            ....|.:.  |..|||:           |::  :..:::|:.:...|::|:     :|||.    
Human  1162 AQVELNKK--REAEFQK-----------LRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNL 1213

  Fly  1117 --VRRRLQDD----EYTADSYQSWLQ--SRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTN 1173
              |:::|:.:    :...|...|..:  |:...||||:                     |:.|.:
Human  1214 QRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKM---------------------CRSLED 1257

  Fly  1174 --NPLKSSHARGWILLSLCVGCFAPSEKFVNYL---RAFIREGPPGYAPYCEERLKRTFNNGTRN 1233
              :.||:....              .::.:|.|   ||.::.....|:...:|:           
Human  1258 QVSELKTKEEE--------------QQRLINDLTAQRARLQTEAGEYSRQLDEK----------- 1297

  Fly  1234 QPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALF 1298
               ..|..|.::||:.                  |.....||.:||.::...|:....:|     
Human  1298 ---DALVSQLSRSKQA------------------STQQIEELKHQLEEETKAKNALAHAL----- 1336

  Fly  1299 DKVSSLGSGGDHVMDAISQCEQYAKEQ-----------GAQERNAPWRLFFRKEIFAPWH--EPT 1350
                   ....|..|.:.  |||.:||           .|....|.||..:..:......  |..
Human  1337 -------QSSRHDCDLLR--EQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEA 1392

  Fly  1351 HDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLS 1415
            ..::|..|  |:....|:....:|                     .|:|:....|.|.:.|..|.
Human  1393 KKKLAQRL--QEAEEHVEAVNAKC---------------------ASLEKTKQRLQNEVEDLMLD 1434

  Fly  1416 GVDKAIERWAAL---------VLQAYKKSYYVKDKIAPLKIKED---IVSYAKYKWPLLFSRF-- 1466
             |:::....|||         ||..:|:.|  ::..|.|:..:.   .:|...:|...::...  
Human  1435 -VERSNAACAALDKKQRNFDKVLSEWKQKY--EETQAELEASQKESRSLSTELFKVKNVYEESLD 1496

  Fly  1467 -YEAYRNSGPNLPK--NDVI--IAVNWTGVYVVD------DQEQVLLELSFPEITAVSSQKTNKV 1520
             .|..|....||.:  :|:.  ||.....::.::      :||:..::.:..|..|....:..|:
Human  1497 QLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKI 1561

  Fly  1521 FTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQ------DYRAPSDGTSFL 1579
            ......|:.|:.|.....:...|:|        |.||:....|:...      :.|:.:|.....
Human  1562 LRIQLELNQVKSEVDRKIAEKDEEI--------DQLKRNHTRVVETMQSTLDAEIRSRNDALRVK 1618

  Fly  1580 SFFKGDLIILE------DESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDI--- 1635
            ...:|||..:|      :....||:.|          .:.......||...|....:..:|:   
Human  1619 KKMEGDLNEMEIQLNHANRLAAESLRN----------YRNTQGILKETQLHLDDALRGQEDLKEQ 1673

  Fly  1636 LALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYAL--DHFRLPPKRTMSKTLTLSSKRSEEL 1698
            ||:  :|...:..:..:......:|..:|...:.|..|  ...|:....|.:.:|..:.|:.|..
Human  1674 LAI--VERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLEND 1736

  Fly  1699 WRYSRDPIKAPLLRKLQSKEEFAEEA---CFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKH 1760
            ....:..:: .::::.::.||.|::|   ....|..||...|..:...||...:...:.|  |:|
Human  1737 VSQLQSEVE-EVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKD--LQH 1798

  Fly  1761 EILRDEIYCQL-----MKQLTDNRNRMSE---------ERGWELMWLATGLFACSQGL------L 1805
            .:...|   ||     .||:.....|:.|         :|..|.:          :||      :
Human  1799 RLDEAE---QLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAV----------KGLRKHERRV 1850

  Fly  1806 KELLLFLRTRRHPI--SQDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEA 1868
            |||.......|..:  .||.:.:||..::..:|:....:.:..|...|..::.|::   ::.:|.
Human  1851 KELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHEL---EEAEER 1912

  Fly  1869 FEVDSS 1874
            .::..|
Human  1913 ADIAES 1918

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ckNP_001285949.1 MYSc 64..733 CDD:214580 283/701 (40%)
MYSc_Myo7 77..721 CDD:276832 274/676 (41%)
MyTH4 <1138..1245 CDD:214535 16/111 (14%)
B41 1251..1467 CDD:214604 42/243 (17%)
FERM_B-lobe 1355..1439 CDD:271216 19/92 (21%)
FERM_C1_MyoVII 1461..1559 CDD:270019 20/110 (18%)
SH3 1560..1624 CDD:302595 12/75 (16%)
MyTH4 1701..1849 CDD:214535 34/172 (20%)
B41 1856..2068 CDD:214604 3/19 (16%)
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
MYH8NP_002463.2 Myosin_N 38..75 CDD:280832 5/36 (14%)
Myosin_head 90..769 CDD:278492 280/688 (41%)
MYSc_Myh8 102..769 CDD:276882 274/676 (41%)
Actin-binding 658..680 11/21 (52%)
Actin-binding 760..774 7/13 (54%)
Myosin_tail_1 849..1926 CDD:279860 220/1254 (18%)
eIF-4B <1042..1099 CDD:283846 11/72 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1146 3/19 (16%)
COG6 1375..>1510 CDD:303003 29/160 (18%)
DUF342 <1505..1581 CDD:302792 13/75 (17%)
TMPIT 1741..>1828 CDD:285135 20/92 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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